| Hans-Günter Meyer-Thompson | Wechselwirkungen mit Substitutionsmitteln
Pain and antidepressant drug combo linked to increased seizure risk in older adults
Pain and antidepressant drug combo linked to increased seizure risk in older adults
Highlights • When taken together, the pain medication tramadol and certain antidepressants may raise seizure risk in older adults, according to a new study. • Researchers studied people living in nursing homes taking tramadol and some antidepressants that inhibit the CYP2D6 enzyme called CYP2D6 inhibitors. • These antidepressants, such as fluoxetine, paroxetine and bupropion, block the CYP2D6 enzyme needed to metabolize tramadol. • People taking tramadol and CYP2D6 inhibitors had up to a 9% higher seizure risk than people taking tramadol and antidepressants that do not inhibit the enzyme. (American Academy of Neurology, USA, 04.10.2025)