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Project Console: a quality improvement initiative for neonatal abstinence syndrome in a children's hospital level IV neonatal intensive care unit. 

Ponder KL, Egesdal C, Kuller J, Joe P. 

BMJ Open Qual. 2021 May;10(2):e001079. doi: 10.1136/bmjoq-2020-001079. PMID: 33941537; PMCID: PMC8098972.


Stability-indicating LC-MS Method for Determination of Stability of Extemporaneously Compounded Buprenorphine Oral Syringes for Neonatal Abstinence Syndrome. 

Rochani A, Nguyen V, Becker R, Kraft W, Kaushal G. 

J Pediatr Pharmacol Ther. 2021;26(4):395-404. doi: 10.5863/1551-6776-26.4.395. Epub 2021 May 19. PMID: 34035685; PMCID: PMC8139563.


Utilizing Pediatric Physiologically Based Pharmacokinetic Models to Examine Factors That Contribute to Methadone Pharmacokinetic Variability in Neonatal Abstinence Syndrome Patients. 

McPhail BT, Emoto C, Fukuda T, Butler D, Wiles JR, Akinbi H, Vinks AA. 

J Clin Pharmacol. 2020 Apr;60(4):453-465. doi: 10.1002/jcph.1538. Epub 2019 Dec 9. PMID: 31820437; PMCID: PMC7336467.


Pränatale Methamphetamin-Exposition: Auswirkungen auf die kindliche Entwicklung - Ein systematisches Review

Prenatal methamphetamine exposure: effects on child development

Dtsch Arztebl Int 2021; 118: 313-9; DOI: 10.3238/arztebl.m2021.0128

Harst, Lorenz; Deckert, Stefanie; Haarig, Frederik; Reichert, Jörg; Dinger, Jürgen; Hellmund, Peter; Schmitt, Jochen; Rüdiger, Mario


The Time is NOW: Filling the Gaps in Treatment of Opioid-Exposed Infants: A Prospective, Pragmatic, Randomized Control Drug Trial. 

Czynski AJ, Laptook AR. 

R I Med J (2013). 2021 Apr 1;104(3):17-21. PMID: 33789403.


Preschool Language Development of Children Born to Women with an Opioid Use Disorder. 

Kim HM, Bone RM, McNeill B, Lee SJ, Gillon G, Woodward LJ. 

Children (Basel). 2021 Mar 31;8(4):268. doi: 10.3390/children8040268. PMID: 33807265.


Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study. 

Wachman EM, Wang A, Isley BC, Boateng J, Beierle JA, Hansbury A, Shrestha H, Bryant C, Zhang H. 

Explor Med. 2020 Jun;1(3):124-135. doi: 10.37349/emed.2020.00009. Epub 2020 Jun 29. PMID: 33763662; PMCID: PMC7985727.


Using buprenorphine to treat neonatal abstinence syndrome: a quality improvement study. 

Bhandary S, Lambeth T, Holmes A, Pylipow M. J Perinatol. 2021 Mar 23. doi: 10.1038/s41372-021-01035-4. Epub ahead of print. PMID: 33758394.



Paralytic ileus in the neonate as a rare complication of maternal methadone treatment - a case report. 

Emery JD, Samedi VM, Bingham WT. 

Oxf Med Case Reports. 2021 Mar 8;2021(3):omab004. doi: 10.1093/omcr/omab004. PMID: 33732483; PMCID: PMC7947274.


Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression. 

Hocker AD, Morrison NR, Selby ML, Huxtable AG. 

Front Physiol. 2021 Feb 25;12:604593. doi: 10.3389/fphys.2021.604593. PMID: 33716765; PMCID: PMC7946987.


Necrotizing enterocolitis and its association with the neonatal abstinence syndrome. 

Andrews L, Davies TH, Haas J, Loudin S, Heyward A, Werthammer J. 

J Neonatal Perinatal Med. 2020;13(1):81-85. doi: 10.3233/NPM-180154. PMID: 32280068; PMCID: PMC7242835.


Prenatal Opioid Exposure and ADHD Childhood Symptoms: A Meta-Analysis. 

Schwartz AN, Reyes LM, Meschke LL, Kintziger KW. 

Children (Basel). 2021 Feb 4;8(2):106. doi: 10.3390/children8020106. PMID: 33557208; PMCID: PMC7913969.


Pharmacometric Evaluation of Umbilical Cord Blood Concentration-Based Early Initiation of Treatment in Methadone-Exposed Preterm Neonates. 

Samiee-Zafarghandy S, van Donge T, Allegaert K, van den Anker J. 

Children (Basel). 2021 Feb 25;8(3):174. doi: 10.3390/children8030174. PMID: 33668712.


The Complexities Associated with Caring for Hospitalised Infants with Neonatal Abstinence Syndrome: The Perspectives of Nurses and Midwives. 

Shannon J, Blythe S, Peters K. 

Children (Basel). 2021 Feb 17;8(2):152. doi: 10.3390/children8020152. PMID: 33671297; PMCID: PMC7922259.


The Challenges to Promoting Attachment for Hospitalised Infants with NAS. 

Shannon J, Peters K, Blythe S. 

Children (Basel). 2021 Feb 22;8(2):167. doi: 10.3390/children8020167. PMID: 33671576; PMCID: PMC7926699.


Toward the use of buprenorphine in infants for neonatal opioid withdrawal syndrome: summary of an NIH workshop. 

Simon AE, Freund MP, Archer SW, Bremer AA. 

J Perinatol. 2021 Jan 25:1–3. doi: 10.1038/s41372-020-00886-7. Epub ahead of print. PMID: 33495535; PMCID: PMC7829319.


Definitions of neonatal abstinence syndrome in clinical studies of mothers and infants: an expert literature review. 

Jilani SM, Jordan CJ, Jansson LM, Davis JM. 

J Perinatol. 2021 Jan 29. doi: 10.1038/s41372-020-00893-8. Epub ahead of print. PMID: 33514878.


Assessment of Neonatal Abstinence Syndrome Surveillance - Pennsylvania, 2019. 

Krause KH, Gruber JF, Ailes EC, Anderson KN, Fields VL, Hauser K, Howells CL, Longenberger A, McClung N, Oakley LP, Reefhuis J, Honein MA, Watkins SM. 

MMWR Morb Mortal Wkly Rep. 2021 Jan 15;70(2):40-45. doi: 10.15585/mmwr.mm7002a3. PMID: 33444296; PMCID: PMC7808717.


Emotional and Behavioral Trajectories of 2 to 9 Years Old Children Born to Opioid-Dependent Mothers. 

Jaekel, J., Kim, H.M., Lee, S.J. et al.

Res Child Adolesc Psychopathol (2021). https://doi.org/10.1007/s10802-020-00766-w


Exposure-Based Methadone and Lorazepam Weaning Protocol Reduces Wean Length in Children. 

Wilson AK, Ragsdale CE, Sehgal I, Vaughn M, Padilla-Tolentino E, Barczyk AN, Lawson KA. 

J Pediatr Pharmacol Ther. 2021;26(1):42-49. doi: 10.5863/1551-6776-26.1.42. Epub 2021 Jan 4. PMID: 33424499; PMCID: PMC7792140.


Non-pharmacological care for opioid withdrawal in newborns. 

Pahl A, Young L, Buus-Frank ME, Marcellus L, Soll R. 

Cochrane Database Syst Rev. 2020 Dec 21;12:CD013217. doi: 10.1002/14651858.CD013217.pub2. PMID: 33348423.


Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome. 

Lappen JR, Stark S, Bailit JL, Gibson KS. 

Am J Obstet Gynecol MFM. 2020 Feb;2(1):100075. doi: 10.1016/j.ajogmf.2019.100075. Epub 2019 Dec 10. PMID: 33345989.


Medication-assisted treatment vs. detoxification for women who misuse opioids in pregnancy: Associations with dropout, relapse, neonatal opioid withdrawal syndrome (NOWS), and childhood sexual abuse. 

Macfie J, Towers CV, Fortner KB, Stuart GL, Zvara BJ, Kurdziel-Adams G, Kors SB, Noose SK, Gorrondona AM, Cohen CT. 

Addict Behav Rep. 2020 Nov 12;12:100315. doi: 10.1016/j.abrep.2020.100315. PMID: 33364323; PMCID: PMC7752716.


Opioid Addiction/Pregnancy and Neonatal Abstinence Syndrome (NAS): A Preliminary Open-Label Study of Buprenorphine Maintenance and Drug Use Targeted Psychotherapy (DUST) on Cessation of Addictive Drug Use. 

Tabi S, Heitner SA, Shivale S, Minchenberg S, Faraone SV, Johnson B. 

Front Psychiatry. 2020 Sep 23;11:563409. doi: 10.3389/fpsyt.2020.563409. PMID: 33173512; PMCID: PMC7538830.


Methadone interrupts neural growth and function in human cortical organoids. 

Yao H, Wu W, Cerf I, Zhao HW, Wang J, Negraes PD, Muotri AR, Haddad GG. 

Stem Cell Res. 2020 Dec;49:102065. doi: 10.1016/j.scr.2020.102065. Epub 2020 Oct 27. PMID: 33137567.


Opioid Litigation and Maternal-Child Health-Investing in the Future. 

Patrick SW, Davis CS, Stein BD. 

JAMA Pediatr. 2020 Feb 1;174(2):119-120. doi: 10.1001/jamapediatrics.2019.5009. PMID: 31841585; PMCID: PMC7295661.


Rooming-in for Infants at Risk for Neonatal Abstinence Syndrome: Outcomes 5 Years following Its Introduction as the Standard of Care at One Hospital. 

Newman AI, Mauer-Vakil D, Coo H, Newton L, Wilkerson E, McKnight S, Brogly SB. 

Am J Perinatol. 2020 Nov 17. doi: 10.1055/s-0040-1719182. Epub ahead of print. PMID: 33202425.


The Infant Cuddler Study: Evaluating the effectiveness of volunteer cuddling in infants with neonatal abstinence syndrome. 

Hignell A, Carlyle K, Bishop C, Murphy M, Valenzano T, Turner S, Sgro M. 

Paediatr Child Health. 2019 Oct 9;25(7):414-418. doi: 10.1093/pch/pxz127. PMID: 33173551; PMCID: PMC7606161.


Neurobehavior of newborn infants exposed prenatally to methadone and identification of a neurobehavioral profile linked to poorer neurodevelopmental outcomes at age 24 months. 

Wouldes TA, Woodward LJ (2020) 

PLoS ONE 15(10): e0240905. doi.org/10.1371/journal.pone.0240905


Navigating NAS - Themenseite der American Academy of Pediatrics

The #NavigatingNAS Campaign will feature four quarters, each devoted to a different aspect of the continuum of neonatal abstinence syndrome (NAS). Each quarter will provide educational materials for clinical practice and resources for families in addition to webinars, podcasts, and social media outreach.