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Managing infants born to mothers who have used opioids during pregnancy 

Canadian Paediatric Society, 28.06.2018


Newborns exposed to opioids need mothers more than NICU, say pediatricians.

Vogel L.

CMAJ. 2018 Jan 29;190(4):E123-E124. doi: 10.1503/cmaj.109-5550. 


Associations between Orofacial Clefting and Neonatal Abstinence Syndrome.

Mullens CL, McCulloch IL, Hardy KM, Mathews RE, Mason AC.

Plast Reconstr Surg Glob Open. 2019 Jan 11;7(1):e2095. doi: 10.1097/GOX.0000000000002095. 


Systematic mixed-study review of nonpharmacological management of neonatal abstinence syndrome.

MacVicar S, Kelly LE.

Birth. 2019 Apr 2. doi: 10.1111/birt.12427. 



Opioid Use in Pregnant Women and Neonatal Abstinence Syndrome-A Review of the Literature.

Martins F, Oppolzer D, Santos C, Barroso M, Gallardo E.

Toxics. 2019 Feb 16;7(1). pii: E9. doi: 10.3390/toxics7010009. Review.


The Possibility of Early Discharge for Newborns Being Monitored for Neonatal Abstinence Syndrome Based on Modified Finnegan Score Distributions.

Oji-Mmuo CN, Schaefer EW, Liao L, Kaiser JR, Sekhar DL.

Clin Pediatr (Phila). 2019 Feb 27:9922819832022. doi: 10.1177/0009922819832022.



Beyond the Finnegan scoring system: Novel assessment and diagnostic techniques for the opioid-exposed infant.

Schiff DM, Grossman MR.

Semin Fetal Neonatal Med. 2019 Jan 28. pii: S1744-165X(19)30012-5. doi: 10.1016/j.siny.2019.01.003.



Amplitude-integrated EEG use in neonatal abstinence syndrome: a pilot study.

Limjoco J, Zawadzki L, Belden M, Eickhoff J, Ikonomidou C.

J Matern Fetal Neonatal Med. 2019 Mar 1:1-6. doi: 10.1080/14767058.2019.1579190.



Supporting breastfeeding for infants born to opioid dependent mothers June 18, 2018.

Groer M; Breastfeeding Expert Panel,, Maguire D; Breastfeeding Expert Panel,, Taylor K.

Nurs Outlook. 2018 Sep;66(5):496-498. doi: 10.1016/j.outlook.2018.07.003. 


An unusual cause for neonatal abstinence syndrome.

Murthy P, Clark D.

Paediatr Child Health. 2019 Feb;24(1):12-14. doi: 10.1093/pch/pxy084. Epub 2018 Jun 29.



Hospitalization of children after prenatal exposure to opioid maintenance therapy during pregnancy: a national registry study from the Czech Republic.

Skurtveit S, Nechanská B, Handal M, Mahic M, Mravčík V, Gabrhelík R.

Addiction. 2019 Feb 6. doi: 10.1111/add.14576. 



Methadone dosing strategies in preterm neonates can be simplified.

van Donge T, Samiee-Zafarghandy S, Pfister M, Koch G, Kalani M, Bordbar A, van den Anker J.

Br J Clin Pharmacol. 2019 Feb 25. doi: 10.1111/bcp.13906.



[Increasing Consumption of Crystal Meth in Saxony and its Risks for Mother and Child - Experiences at a Level I Perinatal Center from a Pediatric Viewpoint].

Dinger J, Näther N, Wimberger P, Zimmermann US, Schmitt J, Reichert J, Rüdiger M.

Z Geburtshilfe Neonatol. 2017 Apr;221(2):73-80. doi: 10.1055/s-0043-102953. Epub 2017 May 23. German. 



Evaluation of the Cardiovascular Effects of Clonidine in Neonates Treated for Neonatal Abstinence Syndrome.

Meddock RP, Bloemer D.

J Pediatr Pharmacol Ther. 2018 Nov-Dec;23(6):473-478. doi: 10.5863/1551-6776-23.6.473.


Survey of Neonatal Intensive Care Unit Nurses' Use of a Motion/Sound Infant Seat.

Holmes M, Wright ME.

Adv Neonatal Care. 2019 Jan 11. doi: 10.1097/ANC.0000000000000579. 



NIDA. Higher rates of NAS linked with economic conditions

A NIDA-funded analysis of eight states showed a significant association between rates of neonatal abstinence syndrome (NAS) and poor economic conditions. (NIDA News, USA, 29.01.2019)


Pharmacological Treatments for Neonatal Abstinence Syndrome: A Systematic Review and Network Meta-analysis.

Disher T, Gullickson C, Singh B, Cameron C, Boulos L, Beaubien L, Campbell-Yeo M.

JAMA Pediatr. 2019 Jan 22. doi: 10.1001/jamapediatrics.2018.5044.


Neonatal Head Circumference in Newborns With Neonatal Abstinence Syndrome.

Towers CV, Hyatt BW, Visconti KC, Chernicky L, Chattin K, Fortner KB.

Pediatrics. 2019 Jan;143(1). pii: e20180541. doi: 10.1542/peds.2018-0541. 


Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review.

Slowiczek L, Hein DJ, Risoldi Cochrane Z, Gregory PJ.

Neonatal Netw. 2018 Nov;37(6):365-371. doi: 10.1891/0730-0832.37.6.365.



Opioid tapering and weaning protocols in pediatric critical care units: a systematic review.

Bichaff P, Setani KT, Motta EHG, Delgado AF, Carvalho WB, Luglio M.

Rev Assoc Med Bras (1992). 2018 Oct;64(10):909-915. doi: 10.1590/1806-9282.64.10.909.


Impact of In-utero Exposure to Selective Serotonin Reuptake Inhibitors and Opioids on Neonatal Opioid Withdrawal Syndrome.

Bhatt-Mehta V, Richards J, Sturza J, Schumacher RE.

J Addict Med. 2018 Nov 21. doi: 10.1097/ADM.0000000000000484. 



Care-by-parent model as a tool for reduction in neonatal opioid withdrawal syndrome in neonates exposed to buprenorphine maintenance therapy in-utero.

Lawlor ML, Shook L, McQuerry K, Srinivasan A, Johnson QB, Chavan NR, Critchfield AS.

J Matern Fetal Neonatal Med. 2018 Dec 18:1-111. doi: 10.1080/14767058.2018.1558201.



USA. MATER Center Director, on the Importance of Dr. Finnegan’s Work—Which Continues—and the Need to Treat Mothers for Trauma

Loretta Finnegan, MD, a champion of medication-assisted treatment with methadone, developed her scoring system for newborns more than 40 years ago. The Finnegan Neonatal Abstinence Scoring System (FNASS) assigns a numerical score to 21 clinical signs, and babies are treated accordingly. Developing the test was an important step in making sure that these babies were treated with morphine, if necessary, to manage the symptoms of withdrawal.

But the work of Dr. Finnegan goes far beyond the Finnegan score. When she first started an opioid treatment program (OTP) at Thomas Jefferson University in Philadelphia, 44 years ago, Dr. Finnegan opened a landmark program for pregnant women addicted to opioids. Since then, the program, called Maternal Addiction Treatment Education & Research (MATER), has included intensive outpatient treatment as well as residential treatment.

Diane Abatemarco, PhD, MSW, director of MATER and associate professor of OB/GYN and Pediatrics at the Sidney Kimmel Medical College at Jefferson, talked with AT Forum about the scope and importance of Dr. Finnegan’s work. (ATForum, USA, 17.12.2019)


USA. Healthy Pregnancy Healthy Baby Fact Sheets

This series of four fact sheets emphasizes the importance of continuing a mother's treatment for opioid use disorder (OUD) throughout pregnancy. The series includes information on OUD and pregnancy, OUD treatment, neonatal abstinence syndrome, and considerations to address before hospital discharge. (SAMSHA - Substance Abuse and Mental Health Services Administration, USA, August 2018)


Growth during the first year in infants affected by neonatal abstinence syndrome.

Corr TE, Schaefer EW, Paul IM.

BMC Pediatr. 2018 Nov 5;18(1):343. doi: 10.1186/s12887-018-1327-0.


The Impact of Breastfeeding on Health Outcomes for Infants Diagnosed with Neonatal Abstinence Syndrome: A Review.

Wu D, Carre C.

Cureus. 2018 Jul 28;10(7):e3061. doi: 10.7759/cureus.3061. Review.


Novel Withdrawal Symptoms of a Neonate Prenatally Exposed to a Fentanyl Analog.

Nellhaus EM, Murray S, Hansen Z, Loudin S, Davies TH.

J Pediatr Health Care. 2018 Nov 8. pii: S0891-5245(18)30204-9. doi: 10.1016/j.pedhc.2018.08.014.



Impact of timing of methadone initiation on perinatal outcomes following delivery among pregnant women on methadone maintenance therapy in Ontario.

Guan, Q., Sproule, B. A., Vigod, S. N., Cadarette, S. M., Greaves, S., Martins, D., and Gomes, T. (2018) 

Addiction, doi.org/10.1111/add.14453.



Opium use during pregnancy and infant size at birth: a cohort study.

Maghsoudlou S, Cnattingius S, Montgomery S, Aarabi M, Semnani S, Wikström AK, Bahmanyar S.

BMC Pregnancy Childbirth. 2018 Oct 1;18(1):358. doi: 10.1186/s12884-018-1994-8.


Outcome Differences in Neonates Exposed In-Utero to Opioids Managed in the NICU Versus Pediatric Floor.

Lembeck AL, Tuttle D, Locke R, Lawler L, Jimenez P, Mackley A, Paul DA.

J Addict Med. 2018 Sep 24. doi: 10.1097/ADM.0000000000000455.