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Improving Hospital Care of Opioid-Exposed Newborns: Successes and Remaining Questions. 

Goyal NK, Kair LR. 

Hosp Pediatr. 2020 Sep;10(9):823-825. doi: 10.1542/hpeds.2020-001149. Epub 2020 Aug 7. PMID: 32769085; PMCID: PMC7446543.

https://hosppeds.aappublications.org/content/10/9/823.long

Improving the Assessment of Neonatal Abstinence Syndrome (NAS). 

Chin Foo CA, Dansereau LM, Hawes K, Oliveira EL, Lester BM. 

Children (Basel). 2021 Aug 9;8(8):685. doi: 10.3390/children8080685. PMID: 34438576; PMCID: PMC8394483.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394483/

Neonatal Abstinence Syndrome Practices in the United States. 

Byerley EM, Mohamed MW, Grindeland CJ, Muzzy Williamson JD. 

J Pediatr Pharmacol Ther. 2021;26(6):577-583. doi: 10.5863/1551-6776-26.6.577. Epub 2021 Aug 16. PMID: 34421406; PMCID: PMC8372852.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372852/

Predictors of Length of Stay and Cost of Hospitalization of Neonatal Abstinence Syndrome in the United States. 

Bhatt P, Umscheid J, Parmar N, Vasudeva R, Patel KG, Ameley A, Donda K, Policano B, Dapaah-Siakwan F. 

Cureus. 2021 Jul 7;13(7):e16248. doi: 10.7759/cureus.16248. PMID: 34373810; PMCID: PMC8346607.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346607/

Effect of Low Lactose Formula on the Short-Term Outcomes of Neonatal Abstinence Syndrome: A Systematic Review. 

Alsaleem M, Dusin J, Akangire G. 

Glob Pediatr Health. 2021 Jul 22;8:2333794X211035258. doi: 10.1177/2333794X211035258. PMID: 34368403; PMCID: PMC8312188.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312188/

Dextromethorphan Dampens Neonatal Astrocyte Activation and Endoplasmic Reticulum Stress Induced by Prenatal Exposure to Buprenorphine. 

Lin CH, Tao PL, Tsay HJ, Chiang YC, Chang WT, Ho IK, Shie FS. 

Behav Neurol. 2021 Jul 10;2021:6301458. doi: 10.1155/2021/6301458. PMID: 34336001; PMCID: PMC8289573.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289573/

Ear Acupuncture Points in Neonates From Drug-Dependent Mothers: A Prospective Study. 

Stähler van Amerongen K, Kuhn A, Surbek D, Nelle M. 

Front Pediatr. 2021 Jun 17;9:668248. doi: 10.3389/fped.2021.668248. PMID: 34222143; PMCID: PMC8247637.

https://www.frontiersin.org/articles/10.3389/fped.2021.668248/full

Cochrane. Opioid treatment for opioid withdrawal in newborn infants. 

Zankl A, Martin J, Davey JG, Osborn DA. 

Cochrane Database of Systematic Reviews 2021, Issue 7. Art. No.: CD002059. DOI: 10.1002/14651858.CD002059.pub4.

Abstract

https://www.cochrane.org/CD002059/NEONATAL_opioid-treatment-opioid-withdrawal-newborn-infants

Prenatal Methamphetamine Exposure: Effects on Child Development. 

Harst L, Deckert S, Haarig F, Reichert J, Dinger J, Hellmund P, Schmitt J, Rüdiger M.

Dtsch Arztebl Int. 2021 May 7;118(18):313-319. doi: 10.3238/arztebl.m2021.0128. PMID: 34140080.

https://www.aerzteblatt.de/int/archive/article/218924

Poverty and Excess Length of Hospital Stay in Neonatal Opioid Withdrawal Syndrome. 

Vesoulis ZA, Lust CE, Cohlan BA, Liao SM, Mathur AM. 

J Addict Med. 2020 Mar/Apr;14(2):113-118. doi: 10.1097/ADM.0000000000000540. PMID: 31149915; PMCID: PMC6881526.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881526/

The Negative Impact of Maternal Perinatal Opioid Use on Neonatal Outcomes. 

Gandhi KD, Schak KM, Vande JL, Shekunov J, Lynch BA, Rummans TA, Geske JR, Pease ER, Limbeck MG, Desai J, Croarkin PE, Romanowicz M. 

Prim Care Companion CNS Disord. 2021 Jun 10;23(3):20m02737. doi: 10.4088/PCC.20m02737. PMID: 34115451.

https://www.psychiatrist.com/pcc/addiction/negative-impact-maternal-perinatal-opioid-use-neonatal-outcomes/

A Retrospective Review Following the Addition of Clonidine to a Neonatal Abstinence Syndrome Treatment Algorithm. 

Bader MY, Zaghloul N, Repholz A, Nagy N, Ahmed MN, Thompson L, Kylat RI. 

Front Pediatr. 2021 Jun 7;9:632836. doi: 10.3389/fped.2021.632836. PMID: 34164354; PMCID: PMC8215153.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215153/

Project Console: a quality improvement initiative for neonatal abstinence syndrome in a children's hospital level IV neonatal intensive care unit. 

Ponder KL, Egesdal C, Kuller J, Joe P. 

BMJ Open Qual. 2021 May;10(2):e001079. doi: 10.1136/bmjoq-2020-001079. PMID: 33941537; PMCID: PMC8098972.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098972/

Stability-indicating LC-MS Method for Determination of Stability of Extemporaneously Compounded Buprenorphine Oral Syringes for Neonatal Abstinence Syndrome. 

Rochani A, Nguyen V, Becker R, Kraft W, Kaushal G. 

J Pediatr Pharmacol Ther. 2021;26(4):395-404. doi: 10.5863/1551-6776-26.4.395. Epub 2021 May 19. PMID: 34035685; PMCID: PMC8139563.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139563/

Utilizing Pediatric Physiologically Based Pharmacokinetic Models to Examine Factors That Contribute to Methadone Pharmacokinetic Variability in Neonatal Abstinence Syndrome Patients. 

McPhail BT, Emoto C, Fukuda T, Butler D, Wiles JR, Akinbi H, Vinks AA. 

J Clin Pharmacol. 2020 Apr;60(4):453-465. doi: 10.1002/jcph.1538. Epub 2019 Dec 9. PMID: 31820437; PMCID: PMC7336467.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336467/

Pränatale Methamphetamin-Exposition: Auswirkungen auf die kindliche Entwicklung - Ein systematisches Review

Prenatal methamphetamine exposure: effects on child development

Dtsch Arztebl Int 2021; 118: 313-9; DOI: 10.3238/arztebl.m2021.0128

Harst, Lorenz; Deckert, Stefanie; Haarig, Frederik; Reichert, Jörg; Dinger, Jürgen; Hellmund, Peter; Schmitt, Jochen; Rüdiger, Mario

https://www.aerzteblatt.de/archiv/218922

The Time is NOW: Filling the Gaps in Treatment of Opioid-Exposed Infants: A Prospective, Pragmatic, Randomized Control Drug Trial. 

Czynski AJ, Laptook AR. 

R I Med J (2013). 2021 Apr 1;104(3):17-21. PMID: 33789403.

http://rimed.org/rimedicaljournal/2021/04/2021-04-17-research-czynski.pdf

Preschool Language Development of Children Born to Women with an Opioid Use Disorder. 

Kim HM, Bone RM, McNeill B, Lee SJ, Gillon G, Woodward LJ. 

Children (Basel). 2021 Mar 31;8(4):268. doi: 10.3390/children8040268. PMID: 33807265.

https://www.mdpi.com/2227-9067/8/4/268

Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study. 

Wachman EM, Wang A, Isley BC, Boateng J, Beierle JA, Hansbury A, Shrestha H, Bryant C, Zhang H. 

Explor Med. 2020 Jun;1(3):124-135. doi: 10.37349/emed.2020.00009. Epub 2020 Jun 29. PMID: 33763662; PMCID: PMC7985727.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985727/

Using buprenorphine to treat neonatal abstinence syndrome: a quality improvement study. 

Bhandary S, Lambeth T, Holmes A, Pylipow M. J Perinatol. 2021 Mar 23. doi: 10.1038/s41372-021-01035-4. Epub ahead of print. PMID: 33758394.

Abstract

https://www.nature.com/articles/s41372-021-01035-4

Paralytic ileus in the neonate as a rare complication of maternal methadone treatment - a case report. 

Emery JD, Samedi VM, Bingham WT. 

Oxf Med Case Reports. 2021 Mar 8;2021(3):omab004. doi: 10.1093/omcr/omab004. PMID: 33732483; PMCID: PMC7947274.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947274/

Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression. 

Hocker AD, Morrison NR, Selby ML, Huxtable AG. 

Front Physiol. 2021 Feb 25;12:604593. doi: 10.3389/fphys.2021.604593. PMID: 33716765; PMCID: PMC7946987.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946987/

Necrotizing enterocolitis and its association with the neonatal abstinence syndrome. 

Andrews L, Davies TH, Haas J, Loudin S, Heyward A, Werthammer J. 

J Neonatal Perinatal Med. 2020;13(1):81-85. doi: 10.3233/NPM-180154. PMID: 32280068; PMCID: PMC7242835.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242835/

Prenatal Opioid Exposure and ADHD Childhood Symptoms: A Meta-Analysis. 

Schwartz AN, Reyes LM, Meschke LL, Kintziger KW. 

Children (Basel). 2021 Feb 4;8(2):106. doi: 10.3390/children8020106. PMID: 33557208; PMCID: PMC7913969.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913969/

Pharmacometric Evaluation of Umbilical Cord Blood Concentration-Based Early Initiation of Treatment in Methadone-Exposed Preterm Neonates. 

Samiee-Zafarghandy S, van Donge T, Allegaert K, van den Anker J. 

Children (Basel). 2021 Feb 25;8(3):174. doi: 10.3390/children8030174. PMID: 33668712.

https://www.mdpi.com/2227-9067/8/3/174/htm

The Complexities Associated with Caring for Hospitalised Infants with Neonatal Abstinence Syndrome: The Perspectives of Nurses and Midwives. 

Shannon J, Blythe S, Peters K. 

Children (Basel). 2021 Feb 17;8(2):152. doi: 10.3390/children8020152. PMID: 33671297; PMCID: PMC7922259.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922259/

The Challenges to Promoting Attachment for Hospitalised Infants with NAS. 

Shannon J, Peters K, Blythe S. 

Children (Basel). 2021 Feb 22;8(2):167. doi: 10.3390/children8020167. PMID: 33671576; PMCID: PMC7926699.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926699/

Toward the use of buprenorphine in infants for neonatal opioid withdrawal syndrome: summary of an NIH workshop. 

Simon AE, Freund MP, Archer SW, Bremer AA. 

J Perinatol. 2021 Jan 25:1–3. doi: 10.1038/s41372-020-00886-7. Epub ahead of print. PMID: 33495535; PMCID: PMC7829319.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829319/

Definitions of neonatal abstinence syndrome in clinical studies of mothers and infants: an expert literature review. 

Jilani SM, Jordan CJ, Jansson LM, Davis JM. 

J Perinatol. 2021 Jan 29. doi: 10.1038/s41372-020-00893-8. Epub ahead of print. PMID: 33514878.

https://www.nature.com/articles/s41372-020-00893-8

Assessment of Neonatal Abstinence Syndrome Surveillance - Pennsylvania, 2019. 

Krause KH, Gruber JF, Ailes EC, Anderson KN, Fields VL, Hauser K, Howells CL, Longenberger A, McClung N, Oakley LP, Reefhuis J, Honein MA, Watkins SM. 

MMWR Morb Mortal Wkly Rep. 2021 Jan 15;70(2):40-45. doi: 10.15585/mmwr.mm7002a3. PMID: 33444296; PMCID: PMC7808717.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808717/