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Future Newborns with Opioid-Induced Neonatal Abstinence Syndrome (NAS) Could Be Assessed with the Genetic Addiction Risk Severity (GARS) Test and Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (KB220) as a Frontline Modality Instead of Potent Opioids. 

Ceccanti M, Blum K, Bowirrat A, Dennen CA, Braverman ER, Baron D, Mclaughlin T, Giordano J, Gupta A, Downs BW, Bagchi D, Barh D, Elman I, Thanos PK, Badgaiyan RD, Edwards D, Gold MS. 

J Pers Med. 2022 Dec 6;12(12):2015. doi: 10.3390/jpm12122015. PMID: 36556236; PMCID: PMC9782293.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782293/

Association of medication-assisted treatment and short acting opioids with newborn head circumference and birth weight. 

Cutler, A.J., Cox, D.F., Gabrielson, S.M.B. et al.

J Perinatol (2022). doi.org/10.1038/s41372-022-01579-z

Abstract

https://www.nature.com/articles/s41372-022-01579-z#citeas

Understanding the effects of opioids vs non-opioids in the treatment of neonatal abstinence syndrome, an in vitro model. 

Sithisarn T, Legan SJ, Westgate PM, Bada HS, Wilson ME. 

Front Pediatr. 2022 Nov 22;10:1068330. doi: 10.3389/fped.2022.1068330. PMID: 36483468; PMCID: PMC9723166.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9723166/

Neonatal abstinence syndrome hospitalizations in Canada: a descriptive study. 

Plouffe R, Grywacheski V, Luo W, Nelson C, Orpana H. 

Can J Public Health. 2022 Dec 8:1–10. doi: 10.17269/s41997-022-00726-5. Epub ahead of print. PMID: 36482143; PMCID: PMC9734797.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9734797/

Behavioral Outcomes of Children With In-Utero Opioid Exposure Age 2-7 and Parenting Self-Efficacy. 

Arter S, Kiel E, McAllister J, Hay MC. 

J Am Psychiatr Nurses Assoc. 2022 Dec 7:10783903221139840. doi: 10.1177/10783903221139840. Epub ahead of print. PMID: 36475408.

https://journals.sagepub.com/doi/10.1177/10783903221139840

Quality Improvement Targeting Non-pharmacologic Care and As-needed Morphine Improves Outcomes in Neonatal Abstinence Syndrome. 

McMorrow TJ, Byrnes K, Gates M, Hairston T, Jawed A, Keydash M, Steele SU, Thorndike D, van Londen L, Bodnar BE. 

Pediatr Qual Saf. 2022 Nov 10;7(6):e612. doi: 10.1097/pq9.0000000000000612. PMID: 36382144; PMCID: PMC9649270.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649270/

A Preliminary Assessment of the Effects of Pharmacist-Driven Methadone Stewardship for the Treatment of Neonatal Abstinence Syndrome at a Tertiary Children's Hospital. 

Celestin G, Balding M, Para JL, Utley A, Shaddix BP. 

J Pediatr Pharmacol Ther. 2022;27(8):720-724. doi: 10.5863/1551-6776-27.8.720. Epub 2022 Nov 17. PMID: 36415769; PMCID: PMC9674361.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674361/

The immediate and long-term effects of prenatal opioid exposure. 

Yen E, Davis JM. 

Front Pediatr. 2022 Nov 7;10:1039055. doi: 10.3389/fped.2022.1039055. PMID: 36419918; PMCID: PMC9676971.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676971/

The effect of prenatal cannabis exposure on offspring preterm birth: a cumulative meta-analysis, 

Duko, B., Dachew, B. A., Pereira, G., and Alati, R. (2022) 

Addiction. doi.org/10.1111/add.16072

https://onlinelibrary.wiley.com/doi/epdf/10.1111/add.16072

Newborn Cry Acoustics in the Assessment of Neonatal Opioid Withdrawal Syndrome Using Machine Learning. 

Manigault AW, Sheinkopf SJ, Silverman HF, Lester BM. 

JAMA Netw Open. 2022 Oct 3;5(10):e2238783. doi: 10.1001/jamanetworkopen.2022.38783. PMID: 36301544.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2797784

Neonatal outcomes of preterm infants with in-utero exposure to drugs of substance use: US national data. 

Puthuraya S, Karnati S, Othman H, Sripathi R, Nandakumar V, Aly H. 

Pediatr Neonatol. 2022 Sep 9:S1875-9572(22)00191-7. doi: 10.1016/j.pedneo.2022.03.021. Epub ahead of print. PMID: 36283910.

https://linkinghub.elsevier.com/retrieve/pii/S1875-9572(22)00191-7

Comparison of neonatal outcomes in pregnant women undergoing medication-assisted treatment of opioid use disorder with methadone or buprenorphine/naloxone,

Michelle Petrich, Megan Battin, Erin Walker, Morgan Brown, Mahmoud Abdelwahab, Marwan Ma’ayeh & Kara M. Rood (2022)

The Journal of Maternal-Fetal & Neonatal Medicine, DOI: 10.1080/14767058.2022.2130238

Abstract

https://www.tandfonline.com/doi/abs/10.1080/14767058.2022.2130238

One-Year Neurodevelopmental Outcomes After Neonatal Opioid Withdrawal Syndrome: A Prospective Cohort Study. 

Benninger KL, Richard C, Conroy S, Newton J, Taylor HG, Sayed A, Pietruszewski L, Nelin MA, Batterson N, Maitre NL. 

Perspect ASHA Spec Interest Groups. 2022 Aug;7(4):1019-1032. doi: 10.1044/2022_PERSP-21-00270. Epub 2022 Jun 27. PMID: 36211832; PMCID: PMC9539823.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539823/

Addressing drivers of healthcare utilization for neonatal opioid withdrawal syndrome. 

Glait M, Moyer A, Saudek K, Cabacungan E, Ryan K. 

J Perinatol. 2022 Oct 6:1–10. doi: 10.1038/s41372-022-01533-z. Epub ahead of print. PMID: 36203084; PMCID: PMC9540302.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540302/

Fostering Hope: Comprehensive Accessible Mother-Infant Dyad Care for Neonatal Abstinence (CAIN). 

Clarke D, Foss K, Lifeso N, Hicks M. 

Children (Basel). 2022 Oct 4;9(10):1517. doi: 10.3390/children9101517. PMID: 36291453; PMCID: PMC9600445.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600445/

Methamphetamine Use During the First or Second Half of Pregnancy Worsens Cardiac Ischemic Injury in Adult Female Offspring. 

Chavva H, Rorabaugh BR. 

Physiol Res. 2022 Aug 31;71(4):501-508. Epub 2022 Jul 28. PMID: 35899942.

http://www.biomed.cas.cz/physiolres/pdf/71/71_501.pdf

Prenatal marijuana exposure and neonatal outcomes: a retrospective cohort study. 

Jones MJ, Lotfi A, Lin A, Gievers LL, Hendrickson R, Sheridan DC. 

BMJ Open. 2022 Sep 28;12(9):e061167. doi: 10.1136/bmjopen-2022-061167. PMID: 36171027; PMCID: PMC9528601.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528601/

Comparison of Ocular and Brain Abnormalities Among Neonates With In Utero Exposure to Opium or Other Drugs. 

Khoshnood-Shariaati M, Ashrafzadeh S, Dastjani-Farahani A, Zamani R, Naseh A. 

Cureus. 2022 Aug 3;14(8):e27648. doi: 10.7759/cureus.27648. PMID: 36072164; PMCID: PMC9439622.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439622/

Prenatal Buprenorphine/Naloxone or Methadone Use on Neonatal Outcomes in Michigan. 

Goshgarian G, Jawad R, O'Brien L, Muterspaugh R, Zikos D, Ezhuthachan S, Newman C, Hsu CD, Bailey B, Ragina N. 

Cureus. 2022 Aug 8;14(8):e27790. doi: 10.7759/cureus.27790. PMID: 36106254; PMCID: PMC9451596.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451596/

What’s in a name? The ethical implications and opportunities in diagnosing an infant with neonatal abstinence syndrome (NAS). 

Oei, J.L., Blythe, S., Dicair, L., Didden, D., Preisz, A. and Lantos, J. (2022), 

Addiction. doi.org/10.1111/add.16022

https://onlinelibrary.wiley.com/doi/full/10.1111/add.16022

Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns. 

Esposito DB, Huybrechts KF, Werler MM, Straub L, Hernández-Díaz S, Mogun H, Bateman BT. 

JAMA Netw Open. 2022 Aug 1;5(8):e2228588. doi: 10.1001/jamanetworkopen.2022.28588. PMID: 36001312; PMCID: PMC9403776.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403776/

Establishing evidence-based pharmacologic treatments for neonatal abstinence syndrome: A retrospective case study. 

Brewer SK, Davis JM, Singh R, Welch LC. 

J Clin Transl Sci. 2022 Jul 25;6(1):e96. doi: 10.1017/cts.2022.431. PMID: 36003213; PMCID: PMC9393572.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393572/

Whole body massage for newborns: A report on non-invasive methodology for neonatal opioid withdrawal syndrome. 

Rana D, Garde K, Elabiad MT, Pourcyrous M. 

J Neonatal Perinatal Med. 2022;15(3):559-565. doi: 10.3233/NPM-220989. PMID: 35599503.

Abstract

https://pubmed.ncbi.nlm.nih.gov/35599503/

Neonatal Abstinence Syndrome: Prevention, Management and Outcomes: From Birth to Adulthood. 

Allegaert K, Oei JL. 

Children (Basel). 2022 Jul 30;9(8):1151. doi: 10.3390/children9081151. PMID: 36010042; PMCID: PMC9406822.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406822/

Improving Public Health Surveillance for Neonatal Abstinence Syndrome in Rhode Island. 

St John K, Arias W. 

R I Med J (2013). 2022 Aug 1;105(6):57-59. PMID: 35882003.

http://rimed.org/rimedicaljournal/2022/08/2022-08-57-health-stjohn.pdf

Do small for gestational age infants have less severe neonatal abstinence syndrome? 

Friedman D, Zubair N, Favara MT, Lafferty M, Carola D, Adeniyi-Jones S, Solarin K, Aghai ZH. 

J Neonatal Perinatal Med. 2022 Jul 6. doi: 10.3233/NPM-221053. Epub ahead of print. PMID: 35811547.

Abstract

https://content.iospress.com/articles/journal-of-neonatal-perinatal-medicine/npm221053

Development of an abbreviated symptom score for the neonatal abstinence syndrome. 

Chervoneva I, Adeniyi-Jones SC, Blanco F, Kraft WK. 

J Perinatol. 2020 Jul;40(7):1031-1040. doi: 10.1038/s41372-020-0606-4. Epub 2020 Feb 19. PMID: 32076111; PMCID: PMC7319884.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319884/

Current research in pathophysiology of opioid-induced respiratory depression, neonatal opioid withdrawal syndrome, and neonatal antidepressant exposure syndrome. 

Baldo BA. 

Curr Res Toxicol. 2022 Jun 6;3:100078. doi: 10.1016/j.crtox.2022.100078. PMID: 35734228; PMCID: PMC9207297.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207297/

Global research production in neonatal abstinence syndrome: A bibliometric analysis. 

Zyoud SH, Al-Jabi SW, Shahwan MJ, Jairoun AA. 

World J Clin Pediatr. 2022 May 9;11(3):307-320. doi: 10.5409/wjcp.v11.i3.307. PMID: 35663005; PMCID: PMC9134155.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134155/

Morphine versus methadone for neonatal opioid withdrawal syndrome: a randomized controlled pilot study. 

Sutter MB, Watson H, Yonke N, Weitzen S, Leeman L. 

BMC Pediatr. 2022 Jun 15;22(1):345. doi: 10.1186/s12887-022-03401-3. PMID: 35705944; PMCID: PMC9202148.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202148/