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Perinatal Opioid Exposure Primes the Peripheral Immune System Toward Hyperreactivity. 

Newville J, Maxwell JR, Kitase Y, Robinson S, Jantzie LL. 

Front Pediatr. 2020;8:272. Published 2020 Jun 26. doi:10.3389/fped.2020.00272

Perinatal Opioid Exposure Primes the Peripheral Immune System Toward Hyperreactivity. 

Identification of Substance-Exposed Newborns and Neonatal Abstinence Syndrome Using ICD-10-CM - 15 Hospitals, Massachusetts, 2017. 

Goyal S, Saunders KC, Moore CS, et al. 

MMWR Morb Mortal Wkly Rep. 2020;69(29):951-955. Published 2020 Jul 24. doi:10.15585/mmwr.mm6929a2

Identification of Substance-Exposed Newborns and Neonatal Abstinence Syndrome Using ICD-10-CM - 15 Hospitals, Massachusetts, 2017. 

Sex Differences in Early Cognitive Development After Prenatal Exposure to Opioids

Martine Skumlien, MRES; Inge Olga Ibsen, MD; Ulrik Schiøler Kesmodel, PHD; Egil Nygaard, PHD

J Pediatr Psychol. 2020;45(5):475-485. 

Sex Differences in Early Cognitive Development After Prenatal Exposure to Opioids

Strategies for the Prevention and Treatment of Iatrogenic Withdrawal from Opioids and Benzodiazepines in Critically Ill Neonates, Children and Adults: A Systematic Review of Clinical Studies 

Sneyers B, Duceppe MA, Frenette AJ, et al. 

[published online ahead of print, 2020 Jun 26]. Drugs. 2020;1-23. doi:10.1007/s40265-020-01338-4


Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates. 

Kovar L, Schräpel C, Selzer D, et al. 

Pharmaceutics. 2020;12(6):E578. Published 2020 Jun 23. doi:10.3390/pharmaceutics12060578


Associations of Maternal Prenatal Drug Abuse With Measures of Newborn Brain Structure, Tissue Organization, and Metabolite Concentrations 

Peterson BS, Rosen T, Dingman S, et al. 

[published online ahead of print, 2020 Jun 15]. JAMA Pediatr. 2020;e201622. 


Association of a Simplified Finnegan Neonatal Abstinence Scoring Tool With the Need for Pharmacologic Treatment for Neonatal Abstinence Syndrome.

Devlin LA, Breeze JL, Terrin N, Gomez Pomar E, Bada H, Finnegan LP, O'Grady KE, Jones HE, Lester B, Davis JM.

JAMA Netw Open. 2020 Apr 1;3(4):e202275. doi: 10.1001/jamanetworkopen.2020.2275.


Prenatal exposure to methadone or buprenorphine and long-term outcomes: A meta-analysis.

Andersen JM, Høiseth G, Nygaard E.

Early Hum Dev. 2020 Apr;143:104997. doi: 10.1016/j.earlhumdev.2020.104997. 


Cognitive Outcomes of Young Children After Prenatal Exposure to Medications for Opioid Use Disorder: A Systematic Review and Meta-analysis.

Nelson LF, Yocum VK, Patel KD, Qeadan F, Hsi A, Weitzen S.

JAMA Netw Open. 2020 Mar 2;3(3):e201195. doi: 10.1001/jamanetworkopen.2020.1195.


Outcome reporting in neonates experiencing withdrawal following opioid exposure in pregnancy: a systematic review.

Shan F, MacVicar S, Allegaert K, Offringa M, Jansson LM, Simpson S, Moulsdale W, Kelly LE.

Trials. 2020 Mar 12;21(1):262. doi: 10.1186/s13063-020-4183-9. 


Assessment and treatment of the withdrawal syndrome in paediatric intensive care units: Systematic review.

Ávila-Alzate JA, Gómez-Salgado J, Romero-Martín M, Martínez-Isasi S, Navarro-Abal Y, Fernández-García D.

Medicine (Baltimore). 2020 Jan;99(5):e18502. doi: 10.1097/MD.0000000000018502.


Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities.

Conradt E, Flannery T, Aschner JL, Annett RD, Croen LA, Duarte CS, Friedman AM, Guille C, Hedderson MM, Hofheimer JA, Jones MR, Ladd-Acosta C, McGrath M, Moreland A, Neiderhiser JM, Nguyen RHN, Posner J, Ross JL, Savitz DA, Ondersma SJ, Lester BM.

Pediatrics. 2019 Sep;144(3). pii: e20190128. doi: 10.1542/peds.2019-0128. Review.


Neonatal abstinence syndrome management in California birth hospitals: results of a statewide survey.

Clemans-Cope, L., Holla, N., Lee, H.C. et al. 

J Perinatol (2020). doi.org/10.1038/s41372-019-0568-6


Development and application of a primer and reference assessment tool for neonatal abstinence syndrome: A phase I pilot study.

Burduli E, Smith CL, Tham P, Shogan M, Johnson RK, McPherson SM.

Contemp Clin Trials Commun. 2019 Dec 3;17:100494. doi: 10.1016/j.conctc.2019.100494. 


Neonatal Abstinence Syndrome.

Anbalagan S, Mendez MD.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-.
2019 Dec 10.


Antepartum Drug Dependence and Pregnancy- or Birth-related Complications: A Cross-sectional Study of 19 Million Inpatients.

Ahmad N, Robert CA, Jampa A, Ashraf S, Patel RS.

Cureus. 2019 Nov 10;11(11):e6117. doi: 10.7759/cureus.6117.


Multigenerational Approaches to Fostering Children's Health and Well-Being: The Opioid Crisis as a Case Study: Proceedings of a Workshop.

National Academies of Sciences, Engineering, and Medicine. 2019. National Academies of Sciences, Engineering, and Medicine. 2019. 

Washington, DC: The National Academies Press., doi.org/10.17226/25574.


USA. In The Fight For Money For The Opioid Crisis, Will The Youngest Victims Be Left Out?

Babies born to mothers who used opioids during pregnancy represent one of the most distressing legacies of an opioid epidemic that has claimed almost 400,000 lives and ravaged communities.

In fact, many of the ongoing lawsuits filed against drug companies refer to these babies, fighting through withdrawal in hospital nurseries.

The cluster of symptoms they experience, which include tremors, seizures and respiratory distress, is known as neonatal abstinence syndrome, or NAS. Until recently, doctors rarely looked for the condition. Then case numbers quadrupled over a decade. Hospital care for newborns with NAS has cost Medicaid billions of dollars. (KHN – Kaiser Health News, USA, 13.12.2019)


A New Scoring System for the Assessment of Neonatal Abstinence Syndrome.

Kocherlakota P, Qian EC, Patel VC, Mandru C, Vilar RE, Alpan G, La Gamma EF.

Am J Perinatol. 2019 Nov 27. doi: 10.1055/s-0039-3400310. 




Lee SJ, Bora S, Austin N, Westerman A, Henderson JMT.

Acad Pediatr. 2019 Nov 14. pii: S1876-2859(19)30457-7. doi: 10.1016/j.acap.2019.11.005.



Abnormal Presentation of Hypoxic Ischemic Encephalopathy Attributed to Polysubstance Exposure.

Maddox TR, Haas J, Andrews L, Miller B, Davies TH.

Am J Case Rep. 2019 Nov 20;20:1715-1718. doi: 10.12659/AJCR.918091.


Improving Recognition and Reporting of Adverse Drug Reactions in the NICU: A Quality Improvement Project.

Cammack B, Oschman A, Lewis T.

Pediatr Qual Saf. 2019 Aug 30;4(5):e203. doi: 10.1097/pq9.0000000000000203.


Long-term mortality in mothers of infants with neonatal abstinence syndrome: A population-based parallel-cohort study in England and Ontario, Canada.

Guttmann A, Blackburn R, Amartey A, Zhou L, Wijlaars L, Saunders N, et al. (2019) 

PLoS Med 16(11): e1002974. doi.org/10.1371/journal.pmed.1002974


Clinical Decision Support to Improve Dosing Weight Use in Infants with Neonatal Abstinence Syndrome.

Bertoni CB, Prusakov P, Merandi J, Bartman T.

Pediatr Qual Saf. 2019 Jun 28;4(4):e184. doi: 10.1097/pq9.0000000000000184. 


Treatment of Neonatal Abstinence Syndrome due to Crystal Methamphetamine: A Review of Clinical Effectiveness and Guidelines [Internet].

Wells C, Loshak H.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Jun 7. PMID: 31525001


Salivary cortisol levels relate to cognitive performance in children prenatally exposed to methadone or buprenorphine.

Konijnenberg C, Melinder A.

Dev Psychobiol. 2019 Sep 28. doi: 10.1002/dev.21921.



Association of Punitive and Reporting State Policies Related to Substance Use in Pregnancy With Rates of Neonatal Abstinence Syndrome.

Faherty LJ, Kranz AM, Russell-Fritch J, Patrick SW, Cantor J, Stein BD. 

JAMA Netw Open. 2019;2(11):e1914078. doi.org/10.1001/jamanetworkopen.2019.14078


The evaluation of lymphopenia in infants exposed to opioids in-utero.

Romanos-Sirakis E, Zureikat-Obeid R, Chein T, Demissie S.

J Neonatal Perinatal Med. 2019 Oct 8. doi: 10.3233/NPM-190279. 



A state-level study of opioid use disorder treatment access and neonatal abstinence syndrome.

Wolf ER, Tong ST, Sabo RT, Woolf SH, Abbinanti K, Pecsok J, Krist AH.

BMC Pediatr. 2019 Oct 23;19(1):371. doi: 10.1186/s12887-019-1718-x.


Prenatal methamphetamine exposure is associated with reduced subcortical volumes in neonates.

Warton FL, Meintjes EM, Warton CMR, Molteno CD, Lindinger NM, Carter RC, Zöllei L, Wintermark P, Jacobson JL, van der Kouwe A, Jacobson SW.

Neurotoxicol Teratol. 2018 Jan - Feb;65:51-59. doi: 10.1016/j.ntt.2017.10.005.