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The Time is NOW: Filling the Gaps in Treatment of Opioid-Exposed Infants: A Prospective, Pragmatic, Randomized Control Drug Trial. 

Czynski AJ, Laptook AR. 

R I Med J (2013). 2021 Apr 1;104(3):17-21. PMID: 33789403.

http://rimed.org/rimedicaljournal/2021/04/2021-04-17-research-czynski.pdf

Preschool Language Development of Children Born to Women with an Opioid Use Disorder. 

Kim HM, Bone RM, McNeill B, Lee SJ, Gillon G, Woodward LJ. 

Children (Basel). 2021 Mar 31;8(4):268. doi: 10.3390/children8040268. PMID: 33807265.

https://www.mdpi.com/2227-9067/8/4/268

Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study. 

Wachman EM, Wang A, Isley BC, Boateng J, Beierle JA, Hansbury A, Shrestha H, Bryant C, Zhang H. 

Explor Med. 2020 Jun;1(3):124-135. doi: 10.37349/emed.2020.00009. Epub 2020 Jun 29. PMID: 33763662; PMCID: PMC7985727.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985727/

Using buprenorphine to treat neonatal abstinence syndrome: a quality improvement study. 

Bhandary S, Lambeth T, Holmes A, Pylipow M. J Perinatol. 2021 Mar 23. doi: 10.1038/s41372-021-01035-4. Epub ahead of print. PMID: 33758394.

Abstract

https://www.nature.com/articles/s41372-021-01035-4

Paralytic ileus in the neonate as a rare complication of maternal methadone treatment - a case report. 

Emery JD, Samedi VM, Bingham WT. 

Oxf Med Case Reports. 2021 Mar 8;2021(3):omab004. doi: 10.1093/omcr/omab004. PMID: 33732483; PMCID: PMC7947274.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947274/

Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression. 

Hocker AD, Morrison NR, Selby ML, Huxtable AG. 

Front Physiol. 2021 Feb 25;12:604593. doi: 10.3389/fphys.2021.604593. PMID: 33716765; PMCID: PMC7946987.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946987/

Necrotizing enterocolitis and its association with the neonatal abstinence syndrome. 

Andrews L, Davies TH, Haas J, Loudin S, Heyward A, Werthammer J. 

J Neonatal Perinatal Med. 2020;13(1):81-85. doi: 10.3233/NPM-180154. PMID: 32280068; PMCID: PMC7242835.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242835/

Prenatal Opioid Exposure and ADHD Childhood Symptoms: A Meta-Analysis. 

Schwartz AN, Reyes LM, Meschke LL, Kintziger KW. 

Children (Basel). 2021 Feb 4;8(2):106. doi: 10.3390/children8020106. PMID: 33557208; PMCID: PMC7913969.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913969/

Pharmacometric Evaluation of Umbilical Cord Blood Concentration-Based Early Initiation of Treatment in Methadone-Exposed Preterm Neonates. 

Samiee-Zafarghandy S, van Donge T, Allegaert K, van den Anker J. 

Children (Basel). 2021 Feb 25;8(3):174. doi: 10.3390/children8030174. PMID: 33668712.

https://www.mdpi.com/2227-9067/8/3/174/htm

The Complexities Associated with Caring for Hospitalised Infants with Neonatal Abstinence Syndrome: The Perspectives of Nurses and Midwives. 

Shannon J, Blythe S, Peters K. 

Children (Basel). 2021 Feb 17;8(2):152. doi: 10.3390/children8020152. PMID: 33671297; PMCID: PMC7922259.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922259/

The Challenges to Promoting Attachment for Hospitalised Infants with NAS. 

Shannon J, Peters K, Blythe S. 

Children (Basel). 2021 Feb 22;8(2):167. doi: 10.3390/children8020167. PMID: 33671576; PMCID: PMC7926699.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926699/

Toward the use of buprenorphine in infants for neonatal opioid withdrawal syndrome: summary of an NIH workshop. 

Simon AE, Freund MP, Archer SW, Bremer AA. 

J Perinatol. 2021 Jan 25:1–3. doi: 10.1038/s41372-020-00886-7. Epub ahead of print. PMID: 33495535; PMCID: PMC7829319.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829319/

Definitions of neonatal abstinence syndrome in clinical studies of mothers and infants: an expert literature review. 

Jilani SM, Jordan CJ, Jansson LM, Davis JM. 

J Perinatol. 2021 Jan 29. doi: 10.1038/s41372-020-00893-8. Epub ahead of print. PMID: 33514878.

https://www.nature.com/articles/s41372-020-00893-8

Assessment of Neonatal Abstinence Syndrome Surveillance - Pennsylvania, 2019. 

Krause KH, Gruber JF, Ailes EC, Anderson KN, Fields VL, Hauser K, Howells CL, Longenberger A, McClung N, Oakley LP, Reefhuis J, Honein MA, Watkins SM. 

MMWR Morb Mortal Wkly Rep. 2021 Jan 15;70(2):40-45. doi: 10.15585/mmwr.mm7002a3. PMID: 33444296; PMCID: PMC7808717.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808717/

Emotional and Behavioral Trajectories of 2 to 9 Years Old Children Born to Opioid-Dependent Mothers. 

Jaekel, J., Kim, H.M., Lee, S.J. et al.

Res Child Adolesc Psychopathol (2021). https://doi.org/10.1007/s10802-020-00766-w

https://link.springer.com/article/10.1007/s10802-020-00766-w

Exposure-Based Methadone and Lorazepam Weaning Protocol Reduces Wean Length in Children. 

Wilson AK, Ragsdale CE, Sehgal I, Vaughn M, Padilla-Tolentino E, Barczyk AN, Lawson KA. 

J Pediatr Pharmacol Ther. 2021;26(1):42-49. doi: 10.5863/1551-6776-26.1.42. Epub 2021 Jan 4. PMID: 33424499; PMCID: PMC7792140.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792140/

Non-pharmacological care for opioid withdrawal in newborns. 

Pahl A, Young L, Buus-Frank ME, Marcellus L, Soll R. 

Cochrane Database Syst Rev. 2020 Dec 21;12:CD013217. doi: 10.1002/14651858.CD013217.pub2. PMID: 33348423.

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013217.pub2/full

Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome. 

Lappen JR, Stark S, Bailit JL, Gibson KS. 

Am J Obstet Gynecol MFM. 2020 Feb;2(1):100075. doi: 10.1016/j.ajogmf.2019.100075. Epub 2019 Dec 10. PMID: 33345989.

https://www.ajogmfm.org/article/S2589-9333(19)30115-6/fulltext

Medication-assisted treatment vs. detoxification for women who misuse opioids in pregnancy: Associations with dropout, relapse, neonatal opioid withdrawal syndrome (NOWS), and childhood sexual abuse. 

Macfie J, Towers CV, Fortner KB, Stuart GL, Zvara BJ, Kurdziel-Adams G, Kors SB, Noose SK, Gorrondona AM, Cohen CT. 

Addict Behav Rep. 2020 Nov 12;12:100315. doi: 10.1016/j.abrep.2020.100315. PMID: 33364323; PMCID: PMC7752716.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752716/

Opioid Addiction/Pregnancy and Neonatal Abstinence Syndrome (NAS): A Preliminary Open-Label Study of Buprenorphine Maintenance and Drug Use Targeted Psychotherapy (DUST) on Cessation of Addictive Drug Use. 

Tabi S, Heitner SA, Shivale S, Minchenberg S, Faraone SV, Johnson B. 

Front Psychiatry. 2020 Sep 23;11:563409. doi: 10.3389/fpsyt.2020.563409. PMID: 33173512; PMCID: PMC7538830.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538830/

Methadone interrupts neural growth and function in human cortical organoids. 

Yao H, Wu W, Cerf I, Zhao HW, Wang J, Negraes PD, Muotri AR, Haddad GG. 

Stem Cell Res. 2020 Dec;49:102065. doi: 10.1016/j.scr.2020.102065. Epub 2020 Oct 27. PMID: 33137567.

https://www.sciencedirect.com/science/article/pii/S1873506120303664

Opioid Litigation and Maternal-Child Health-Investing in the Future. 

Patrick SW, Davis CS, Stein BD. 

JAMA Pediatr. 2020 Feb 1;174(2):119-120. doi: 10.1001/jamapediatrics.2019.5009. PMID: 31841585; PMCID: PMC7295661.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295661/

Rooming-in for Infants at Risk for Neonatal Abstinence Syndrome: Outcomes 5 Years following Its Introduction as the Standard of Care at One Hospital. 

Newman AI, Mauer-Vakil D, Coo H, Newton L, Wilkerson E, McKnight S, Brogly SB. 

Am J Perinatol. 2020 Nov 17. doi: 10.1055/s-0040-1719182. Epub ahead of print. PMID: 33202425.

https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0040-1719182.pdf

The Infant Cuddler Study: Evaluating the effectiveness of volunteer cuddling in infants with neonatal abstinence syndrome. 

Hignell A, Carlyle K, Bishop C, Murphy M, Valenzano T, Turner S, Sgro M. 

Paediatr Child Health. 2019 Oct 9;25(7):414-418. doi: 10.1093/pch/pxz127. PMID: 33173551; PMCID: PMC7606161.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606161/

Neurobehavior of newborn infants exposed prenatally to methadone and identification of a neurobehavioral profile linked to poorer neurodevelopmental outcomes at age 24 months. 

Wouldes TA, Woodward LJ (2020) 

PLoS ONE 15(10): e0240905. doi.org/10.1371/journal.pone.0240905

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240905

Navigating NAS - Themenseite der American Academy of Pediatrics

The #NavigatingNAS Campaign will feature four quarters, each devoted to a different aspect of the continuum of neonatal abstinence syndrome (NAS). Each quarter will provide educational materials for clinical practice and resources for families in addition to webinars, podcasts, and social media outreach.

https://www.aap.org/en-us/about-the-aap/aap-press-room/campaigns/navigating-nas/Pages/default.aspx

Will Simplifying the Finnegan Neonatal Abstinence Scoring Tool Improve Outcomes for Infants With Opioid Exposure? 

Oei JL, Wouldes T. 

JAMA Netw Open. 2020 Apr 1;3(4):e202271. doi: 10.1001/jamanetworkopen.2020.2271. PMID: 32267511.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2764194

Prenatal Exposures Are Associated With Worse Neurodevelopmental Outcomes in Infants With Neonatal Opioid Withdrawal Syndrome. 

Benninger KL, Borghese T, Kovalcik JB, Moore-Clingenpeel M, Isler C, Bonachea EM, Stark AR, Patrick SW, Maitre NL. 

Front Pediatr. 2020 Aug 27;8:462. doi: 10.3389/fped.2020.00462. PMID: 32974241; PMCID: PMC7481438.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481438/

Characteristics and causes of death in children with neonatal abstinence syndrome. 

Uebel H, Wright IM, Burns L, Hilder L, Bajuk B, Breen C, Abdel-Latif ME, Falconer J, Clews S, Ward M, Eastwood J, Oei JL. 

J Paediatr Child Health. 2020 Aug 20. doi: 10.1111/jpc.15091. Epub ahead of print. PMID: 32815631.

Abstract

https://pubmed.ncbi.nlm.nih.gov/32815631/

The Role of Stigma in the Nursing Care of Families Impacted by Neonatal Abstinence Syndrome. 

Recto P, McGlothen-Bell K, McGrath J, Brownell E, Cleveland LM. 

Adv Neonatal Care. 2020 Oct;20(5):354-363. doi: 10.1097/ANC.0000000000000778. PMID: 32868585; PMCID: PMC7467149.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467149/