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Cue-induced cocaine craving enhances psychosocial stress and vice versa in chronic cocaine users. 

Kexel AK, Kluwe-Schiavon B, Baumgartner MR, Engeli EJE, Visentini M, Kirschbaum C, Seifritz E, Ditzen B, Soravia LM, Quednow BB. 

Transl Psychiatry. 2022 Oct 11;12(1):443. doi: 10.1038/s41398-022-02204-5. PMID: 36220809; PMCID: PMC9554190.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554190/

Zürich kokst - Eine Stadt auf Drogen (Podcast)

In Zürich ist Koks zur Volksdroge geworden, seit die Preise gesunken sind. In kaum einer Stadt Europas wird so viel Kokain konsumiert wie in der Finanzmetropole. Nicht legalisiert, aber akzeptiert. (Deutschlandfunk, 25.10.2022, Audio, 55:01)

https://www.deutschlandfunk.de/zueri-kokst-eine-stadt-auf-drogen-dlf-bd885663-100.html

Cocaine Use Disorder (CUD): Current Clinical Perspectives. 

Schwartz EKC, Wolkowicz NR, De Aquino JP, MacLean RR, Sofuoglu M. 

Subst Abuse Rehabil. 2022 Sep 3;13:25-46. doi: 10.2147/SAR.S337338. PMID: 36093428; PMCID: PMC9451050.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451050/

The Prospects for TNX-1300, a Drug to Reverse Cocaine Overamps

Amid the overdose crisis, the bulk of national attention lies on opioids like fentanyl. This has seen the opioid-overdose reversal drug naloxone become a household name, and become more widely available.

However, as it stands, there aren’t any “overdose” reversal drugs that work for other classifications of drugs, like stimulants. To address this, the company Tonix Pharmaceuticals has developed TNX-1300, a novel drug to halt the effects of cocaine intoxication. (Filter, USA, 02.09.2022)

https://filtermag.org/tnx-1300-naloxone-cocaine

Meta-Analysis of Structural and Functional Brain Abnormalities in Cocaine Addiction. 

Dang J, Tao Q, Niu X, Zhang M, Gao X, Yang Z, Yu M, Wang W, Han S, Cheng J, Zhang Y. 

Front Psychiatry. 2022 Jun 24;13:927075. doi: 10.3389/fpsyt.2022.927075. PMID: 35815007; PMCID: PMC9263080.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263080/

Exploring e-psychonauts perspectives towards cocaine effects and toxicity. 

Assi S, Keenan A, Al Hamid A. 

Subst Abuse Treat Prev Policy. 2022 Jun 27;17(1):48. doi: 10.1186/s13011-022-00455-5. PMID: 35761409; PMCID: PMC9238119.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238119/

REM Sleep Engages MCH Neurons to Reduce Cocaine Seeking

Guo, Rong et al.

Biological Psychiatry, Volume 0, Issue 0 

https://www.biologicalpsychiatryjournal.com/article/S0006-3223(22)01321-X/fulltext

Role of Mitochondrial Dynamics in Cocaine's Neurotoxicity. 

Wen S, Aki T, Funakoshi T, Unuma K, Uemura K. 

Int J Mol Sci. 2022 May 12;23(10):5418. doi: 10.3390/ijms23105418. PMID: 35628228; PMCID: PMC9145816.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9145816/

Kurzbericht "Konsumgewohnheiten, soziale Hintergründe und Hilfebedarfe von Erwachsenen mit einem riskanten oder abhängigen Kokainkonsum (KOKOS)" 

Kokainsicherstellungen erreichen jedes Jahr neue Rekordhöhen. Bisher kommen Konsumierende in der Suchthilfe nicht häufiger an. Wer sind also die Konsumierenden von Kokain?

Das Projekt „Konsumgewohnheiten, soziale Hintergründe und Hilfebedarfe von Erwachsenen mit einem riskanten oder abhängigen Kokainkonsum (KOKOS)“ liefert Erkenntnisse zu Konsumierenden mit einem moderaten, riskanten oder abhängigen Kokainkonsum. Es hat auf Basis der Ergebnisse vier typische Konsumtypen identifiziert und Ansatzpunkte für zielgruppenspezifische präventive Maßnahmen formuliert. (Bundesministerium für Gesundheit, März 2022)

https://www.bundesgesundheitsministerium.de/service/publikationen/details/kurzbericht-kokos.html

Cocaethylene: When Cocaine and Alcohol Are Taken Together. 

Pergolizzi J, Breve F, Magnusson P, LeQuang JAK, Varrassi G. 

Cureus. 2022 Feb 22;14(2):e22498. doi: 10.7759/cureus.22498. PMID: 35345678; PMCID: PMC8956485.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956485/

Shifting Pathways of Stimulant Use Among Individuals With Opioid Use Disorder: A Retrospective Analysis of the Last Thirty Years. 

Ellis MS, Kasper ZA, Scroggins S. 

Front Psychiatry. 2021 Dec 20;12:786056. doi: 10.3389/fpsyt.2021.786056. PMID: 34987431; PMCID: PMC8721201.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721201/

Intranasal oxytocin may improve odds of abstinence in cocaine-dependent patients: results from a preliminary study

Wilfrid Noël Raby, MatthewHeller, Demetrios Milliaressis, C.Jean Choi, Cale Basaraba, Martina Pavlicova, Daniel M.Alschuler, Frances R.Levin,, Sarah Church, Edward V.Nunes

Drug and Alcohol Dependence Reports, Volume 2, March 2022, doi.org/10.1016/j.dadr.2021.100016

https://www.sciencedirect.com/science/article/pii/S2772724621000160

The cocaine-e-cigarette – A theoretical concept of a harm reduction device for current users of smokable cocaine forms. 

Steinmetz FP, Stöver H.

Drug Science, Policy and Law. January 2021. doi:10.1177/20503245211049310

https://journals.sagepub.com/doi/full/10.1177/20503245211049310

Transcranial Magnetic Stimulation for the Treatment of Cocaine Addiction: A Systematic Review. 

Torres-Castaño A, Rivero-Santana A, Perestelo-Pérez L, Duarte-Díaz A, Toledo-Chávarri A, Ramos-García V, Álvarez-Pérez Y, Cudeiro-Mazaira J, Padrón-González I, Serrano-Pérez P. 

J Clin Med. 2021 Nov 28;10(23):5595. doi: 10.3390/jcm10235595. PMID: 34884297; PMCID: PMC8658408.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658408/

Ibrutinib as a potential therapeutic for cocaine use disorder. 

Huggett SB, Hatfield JS, Walters JD, McGeary JE, Welsh JW, Mackay TFC, Anholt RRH, Palmer RHC. 

Transl Psychiatry. 2021 Dec 8;11(1):623. doi: 10.1038/s41398-021-01737-5. PMID: 34880215; PMCID: PMC8654982.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654982/

Associations amongst form of cocaine used (powder vs crack vs both) and HIV-related outcomes. 

Liu Y, Richards VL, Gebru NM, Spencer EC, Cook RL. 

Addict Behav Rep. 2021 Sep 4;14:100374. doi: 10.1016/j.abrep.2021.100374. PMID: 34938835; PMCID: PMC8664776.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664776/

SAMHSA. Treatment Improvement Protocol (TIP) 33: Treatment for Stimulant Use Disorders

This updated TIP reviews what is known about treating the medical, psychiatric, and SUD-related problems associated with the use of cocaine and methamphetamine, as well as the misuse of prescription stimulants. The TIP offers recommendations on treatment approaches and maximizing treatment engagement and retention, and strategies for initiating and maintaining abstinence. (SAMHSA - Substance Abuse and Mental Health Services Administration, USA, 2021)

https://store.samhsa.gov/sites/default/files/SAMHSA_Digital_Download/PEP21-02-01-004.pdf

Association between alcohol and crack: Prevalence, effects, associated factors and experiences of combined use. 

Teodósio Valois-Santos N, Almeida RBFd, Jacques IdJAA, Santos DdP, Silva KSdBe, Nappo SA, et al. (2021) 

PLoS ONE 16(9): e0256414. doi.org/10.1371/journal.pone.0256414

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0256414

Pilot study of extended-release lorcaserin for cocaine use disorder among men who have sex with men: A double-blind, placebo-controlled randomized trial. 

Santos G-M, Ikeda J, Coffin P, Walker JE, Matheson T, McLaughlin M, et al. (2021) 

PLoS ONE 16(7): e0254724. doi.org/10.1371/journal.pone.0254724

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254724

Oral changes in cocaine abusers: an integrative review. 

Melo CAA, Guimarães HRG, Medeiros RCF, Souza GCA, Santos PBDD, Tôrres ACSP. 

Braz J Otorhinolaryngol. 2021 May 14:S1808-8694(21)00083-5. doi: 10.1016/j.bjorl.2021.04.011. Epub ahead of print. PMID: 34034978.

https://www.sciencedirect.com/science/article/pii/S1808869421000835

Cocaine and Cardiotoxicity: A Literature Review. 

Pergolizzi JV Jr, Magnusson P, LeQuang JAK, Breve F, Varrassi G. 

Cureus. 2021 Apr 20;13(4):e14594. doi: 10.7759/cureus.14594. PMID: 34036012; PMCID: PMC8136464.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136464/

Crack Cocaine with Professor Carl Hart (Podcast)

The Drug Science Podcast, Episode 35, UK, 28.04.2021)

https://www.drugscience.org.uk/podcast/35-crack-cocaine/

Long-Term Outcomes of Patients With Cocaine Use Disorder: A 18-years Addiction Cohort Study. 

Sanvisens A, Hernández-Rubio A, Zuluaga P, Fuster D, Papaseit E, Galan S, Farré M, Muga R. 

Front Pharmacol. 2021 Feb 18;12:625610. doi: 10.3389/fphar.2021.625610. PMID: 33679404; PMCID: PMC7930813.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930813/

Cocaine Body Packing: A New Record. 

Tanna R, Bostina R, Lloyd G, Patel NM, Bastianpillai J. 

Cureus. 2020 Nov 27;12(11):e11728. doi: 10.7759/cureus.11728. PMID: 33269176; PMCID: PMC7704267.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704267/

Cocaine vaccine dAd5GNE protects against moderate daily and high-dose “binge” cocaine use. 

Havlicek DF, Rosenberg JB, De BP, Hicks MJ, Sondhi D, Kaminsky SM, et al. (2020) 

PLoS ONE 15(11): e0239780. doi.org/10.1371/journal.pone.0239780

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239780

Cocaine and methamphetamine: Pharmacology and dental implications. 

Nassar P, Ouanounou A. 

Can J Dent Hyg. 2020 Jun 1;54(2):75-82. PMID: 33240367; PMCID: PMC7668266.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668266/

Cocaine, cardiomyopathy, and heart failure: a systematic review and meta-analysis. 

Arenas DJ, Beltran S, Zhou S, Goldberg LR. 

Sci Rep. 2020 Nov 13;10(1):19795. doi: 10.1038/s41598-020-76273-1. PMID: 33188223; PMCID: PMC7666138.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666138/

Cocaine-Related Aortic Dissection: what do we know? 

Greve D, Funke J, Khairi T, Montagner M, Starck C, Falk V, Sá MPBO, Kurz SD. 

Braz J Cardiovasc Surg. 2020 Oct 1;35(5):764-769. doi: 10.21470/1678-9741-2020-0333. PMID: 33118742; PMCID: PMC7598981.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598981/

Cocaine treatment demands in 10 western European countries: observed trends between 2011 and 2018. 

Antoine, J., Berndt, N., Astudillo, M., Cairns, D., Jahr, S., Jones, A., Kuijpers, W., Llorens, N., Lyons, S., Maffli, E., Magliocchetti, N., Molina Olivas, M., Palle, C., Schwarzkopf, L., Wisselink, J., and Montanari, L. (2020) 

Addiction, doi.org/10.1111/add.15237

https://onlinelibrary.wiley.com/doi/full/10.1111/add.15237

Cocaine added to heroin fails to affect heroin-induced brain hypoxia 

Thomas SA, Perekopskiy D, Kiyatkin EA. 

[published online ahead of print, 2020 Jul 6]. Brain Res. 2020;1746:147008. doi:10.1016/j.brainres.2020.147008

Abstract

Cocaine added to heroin fails to affect heroin-induced brain hypoxia