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USA. Slow-release oral morphine could expand options for treating opioid abuse

Slow-release oral Morphine (SROM) has emerged as a promising candidate for oral opioid agonist therapy. However, more research is needed before it can be incorporated into U.S. treatment guidelines. A commentary from the British Columbia Centre on Substance Use is published in Annals of Internal Medicine. (American College of Physicians, 25.12.2017)

https://medicalxpress.com/news/2017-12-slow-release-oral-morphine-options-opioid.html

Alternative Opioid Agonists in the Treatment of Opioid Dependence: A Systematic Review [Internet].

Mosdøl A, Ding KY, Hov L.

Oslo, Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2017 Mar 8.

https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0098799/

Mental symptoms and drug use in maintenance treatment with slow-release oral morphine compared to methadone: results of a randomized crossover study. Verthein U, Beck T, Haasen C, Reimer J. Eur Addict Res. 2015;21(2):97-104. doi: 10.1159/000368572. Epub 2014 Nov 22.

http://www.karger.com/Article/FullText/368572

Maintenance treatment for opioid dependence with slow-release oral morphine: a randomized cross-over, non-inferiority study versus methadone.

Beck T, Haasen C, Verthein U, Walcher S, Schuler C, Backmund M, Ruckes C, Reimer J.

Addiction. 2014 Apr;109(4):617-26. doi: 10.1111/add.12440.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226326/

Morphin in der Substitutionsbehandlung: Verbreitung und Auswirkung auf substitutionsgestützte Behandlungen. VON CARLOS NORDT, CARLO CAFLISCH & MARCUS HERDENER; Forschungsgruppe Substanzstörungen der Psychiatrischen Universitätsklinik Zürich; RESULTATE AUS DER BEGLEITEVALUATION DER METHADONBEHANDLUNGEN IM KANTON ZÜRICH NR. 21, August 2015

http://www.dppp.uzh.ch/dam/jcr:00000000-287c-7592-0000-000072d6e28e/MethiInfo21.pdf

Ob (retardiertes Morphin) eine geeignete Ergänzung für die bisherigen Substitute auf dem deutschen Markt ist, müssen vor allem herstellerneutrale Studien beweisen. (doccheck, 06.09.2016)

http://news.doccheck.com/de/141506/substitutionstherapie-morphin-schult-um/