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Impact of policy changes on the provision of naloxone by pharmacies in Ontario, Canada: a population‐based time–series analysis. 

Antoniou, T., Martins, D., Campbell, T., Tadrous, M., Munro, C., Leece, P., Mamdani, M., Juurlink, D. N., and Gomes, T. (2020) 

Addiction, doi.org/10.1111/add.15324.

https://onlinelibrary.wiley.com/doi/full/10.1111/add.15324

NYC Revamps Pharmacies’ Role in Preventing Overdose Deaths

New York City, like the rest of the country, is facing a historic overdose crisis driven by illicit fentanyl adulterating the unregulated drug supply and exacerbated by the COVID-19 pandemic. In response, the city’s health department has made naloxone, the overdose-reversal medication, available free-of-charge at chain pharmacies in highly impacted neighborhoods from which the city has historically divested. (Filter Magazine, USA, 06.01.2021)

https://filtermag.org/nyc-pharmacy-overdose/

Schottland. Take-home Naloxone to save lives.

Take-home Naloxone will be given to people at high risk of accidental overdoses, in a move designed to reduce the number of drug deaths.  This will include those who have been resuscitated by the Scottish Ambulance Service (SAS) following an accidental overdose. (Scottish Government, 06.01.2021)

https://www.gov.scot/news/take-home-naloxone-to-save-lives/

NTNU intranasal naloxone trial (NINA-1) study protocol for a double-blind, double-dummy, non-inferiority randomised controlled trial comparing intranasal 1.4 mg to intramuscular 0.8 mg naloxone for prehospital use. 

Skulberg AK, Tylleskär I, Braarud AC, Dale J, Heyerdahl F, Mellesmo S, Valberg M, Dale O. 

BMJ Open. 2020 Nov 12;10(11):e041556. doi: 10.1136/bmjopen-2020-041556. PMID: 33184084; PMCID: PMC7662429.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662429/

Schottland. Naloxone: Police to carry emergency drug overdose spray

An emergency antidote to treat drug overdose victims will be carried by police officers in Scotland as part of a pilot project.

The nasal spray Naloxone counters the effects of overdoses from opioids such as heroin. (BBC, UK, 18.11.2020)

https://www.bbc.com/news/uk-scotland-54962349

Naloxon-Nasenspray kann bei Überdosierungen Leben retten

Regensburg/Berlin – Im vergangenen Jahr sind 650 Menschen in Deutschland an einer Opioidvergiftung gestorben. Schätzungen zufolge sind bei Überdosierungen in zwei von drei Fällen jedoch andere Personen anwesend, die mit dem Nasenspray Naloxon helfen könnten und helfen wollen. (aerzteblatt.de, 19.11.2020)

https://www.aerzteblatt.de/nachrichten/118514/Naloxon-Nasenspray-kann-bei-Ueberdosierungen-Leben-retten

USA. find naloxone near you

The Naloxone Finder is intended for people who use drugs to access naloxone in their community. (National Harm Reduction Coalition, USA, November 2020)

https://harmreduction.org/resource-center/harm-reduction-near-you

The PLOS ONE Staff (2020) Correction: Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level. 

PLoS ONE 15(9): e0240148. doi.org/10.1371/journal.pone.0240148

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240148

A qualitative study of repeat naloxone administrations during opioid overdose intervention by people who use opioids in New York City.

Stephen Parkin, Joanne Neale, Caral Brown, Jermaine D. Jones, Laura Brandt, Felipe Castillo, Aimee N.C. Campbell, JohnStrang, Sandra D.Comer

International Journal of Drug Policy, Volume 87, January 2021, 102968, doi.org/10.1016/j.drugpo.2020.102968

https://www.sciencedirect.com/science/article/pii/S0955395920303066?dgcid=author

USA. At least 10 times a day, someone on the brink of death from a drug overdose is saved in S.F.

At least 10 times a day, someone on the brink of death from a drug overdose is saved in San Francisco, according to new data provided to The Chronicle.

And that’s likely a massive undercount.

San Francisco’s drug epidemic has skyrocketed this year, claiming about 470 lives in just the first eight months of the year, according to preliminary data from the medical examiner. In a similar time period, at least 2,155 potentially fatal overdoses were prevented by the opioid reversal medication Narcan, which is commonly sprayed up the nose. (San Francisco Chronicle, USA, 15.10.2020)

https://www.sfchronicle.com/bayarea/article/S-F-s-overdose-numbers-are-staggeringly-high-15648878.php

Evaluation of a personally-tailored opioid overdose prevention education and naloxone distribution intervention to promote harm reduction and treatment readiness in individuals actively using illicit opioids. 

Winhusen T, Wilder C, Lyons MS, Theobald J, Kropp F, Lewis D. 

Drug Alcohol Depend. 2020 Aug 31;216:108265. doi: 10.1016/j.drugalcdep.2020.108265. Epub ahead of print. PMID: 32919098; PMCID: PMC7458095.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458095/

Accessing Take-Home Naloxone in British Columbia and the role of community pharmacies: Results from the analysis of administrative data. 

Moustaqim-Barrette A, Papamihali K, Mamdani Z, Williams S, Buxton JA (2020) 

PLoS ONE 15(9): e0238618. https://doi.org/10.1371/journal.pone.0238618

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0238618

Prehospital naloxone administration - what influences choice of dose and route of administration? 

Tylleskar I, Gjersing L, Bjørnsen LP, Braarud AC, Heyerdahl F, Dale O, Skulberg AK. 

BMC Emerg Med. 2020 Sep 5;20(1):71. doi: 10.1186/s12873-020-00366-3. PMID: 32891142; PMCID: PMC7487505.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487505/

Kanada. Ottawa opioid crisis still very real as OPS officers revive two with naloxone

Police officers have successfully revived residents using naloxone 80 times this year. 8 ottawamatters.com, 24.09.2020)

https://www.ottawamatters.com/local-news/ottawa-opioid-crisis-still-very-real-as-ops-officers-revive-two-with-naloxone-2740454

Facts and myths about overdose and take-home naloxone — EMCDDA publishes new resources

Over the past five years, more than 40 000 people have died of a drug-related overdose in the European Union and the UK; around 80% of these being linked to the use of heroin or other opioids. Yet, with effective intervention, they could have been prevented. (EMCDDA, Lissabon, 31.08.2020)

https://www.emcdda.europa.eu/news/2020/facts-and-myths-about-overdose-and-take-home-naloxone-emcdda-publishes-new-resources_en

Australien. Naloxone National Reference Group (NNRG)

Current resources from the Naloxone National Reference Group or NNRG

https://creidu.edu.au/naloxone

Overdose Education and Naloxone Distribution Within Syringe Service Programs - United States, 2019. 

Lambdin BH, Bluthenthal RN, Wenger LD, et al. 

MMWR Morb Mortal Wkly Rep. 2020;69(33):1117-1121. Published 2020 Aug 21. doi:10.15585/mmwr.mm6933a2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439981/

Pharmacists' attitudes toward dispensing naloxone and medications for opioid use disorder: A scoping review of the literature. 

Muzyk A, Smothers ZPW, Collins K, MacEachern M, Wu LT. 

Subst Abus. 2019;40(4):476-483. doi:10.1080/08897077.2019.1616349

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920531/

31. August Internationaler Tag gegen Überdosierungen

Im Jahr 2019 sind in Deutschland 650 Menschen an einer Überdosierung unter Beteiligung von Opioiden verstorben. Diese schlichte Zahl bedeutet hundertfaches Leid in Familien, bei Freund_innen und Bekannten.

Es gilt festzuhalten, dass diese Todesfälle in vielen Fällen sehr einfach zu vermeiden gewesen wären. Mit dem medikament Naloxon als Nasenspray steht ein sicheres Medikament zur verfügung, dass aber bis heute nicht bei Drogengebraucher_innen angekommen ist. (JES – Junkies, Ehemalige und Substituierte, Bundesverband, 28.08.2020)

https://www.jes-bundesverband.de/2020/08/31-august-internationaler-tag-gegen-ueberdosierungen/

EMCDDA. Take-home naloxone programmes in Europe — overdose prevention

EMCDDA, Lissabon, August 2020

https://www.emcdda.europa.eu/publications/topic-overviews/take-home-naloxone

Overdose Education and Naloxone Distribution Within Syringe Service Programs — United States, 2019. 

Lambdin BH, Bluthenthal RN, Wenger LD, et al. 

MMWR Morb Mortal Wkly Rep 2020;69:1117–1121. DOI: doi.org/10.15585/mmwr.mm6933a2

https://www.cdc.gov/mmwr/volumes/69/wr/mm6933a2.htm

Schottland. Access to take-home naloxone increased through paramedic supply

Ambulance paramedics are to supply to patients at risk of an opiate overdose take-home naloxone as part of a pilot scheme in Glasgow. (SDF – Scottish Drugs Forum, UK, August 2020)

Schottland. Access to take-home naloxone increased through paramedic supply

Protocol for Take-home naloxone In Multicentre Emergency (TIME) settings: feasibility study. 

Jones M, Bell F, Benger J, et al. 

Pilot Feasibility Stud. 2020;6:96. Published 2020 Jul 9. doi:10.1186/s40814-020-00626-w

 

Schottland. National Naloxone programme Scotland 

Monitoring report 2018/19, An Official Statistics publication for Scotland

Published: 11 August 2020 (Latest release)

This release by Public Health Scotland presents information on the number of take-home naloxone kits issued by the National Naloxone Programme in Scotland. Figures are presented separately for kits issued from community outlets, kits issued in prisons at the point of prisoner release and kits dispensed via community prescription.

Schottland. National Naloxone programme Scotland 

Addressing co-occurring public health emergencies: The importance of naloxone distribution in the era of COVID-19 

Collins AB, Ndoye CD, Arene-Morley D, Marshall BDL. 

[published online ahead of print, 2020 Jul 21]. Int J Drug Policy. 2020;102872. doi:10.1016/j.drugpo.2020.102872

Addressing co-occurring public health emergencies: The importance of naloxone distribution in the era of COVID-19 

Layperson reversal of opioid overdose supported by smartphone alert: A prospective observational cohort study

Schwartz, David G. et al.

EClinicalMedicine, Volume 0, Issue 0, 100474 

www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30218-2/fulltext

Legal requirements and recommendations to prescribe naloxone. 

Haffajee RL, Cherney S, Smart R. 

Drug Alcohol Depend. 2020;209:107896. doi:10.1016/j.drugalcdep.2020.107896

Legal requirements and recommendations to prescribe naloxone. 

USA. FDA recommends health care professionals discuss naloxone with all patients when prescribing opioid pain relievers or medicines to treat opioid use disorder 

Consider prescribing naloxone to those at increased risk of opioid overdose.

07-23-2020 FDA Drug Safety Communication.

www.fda.gov/drugs/drug-safety-and-availability/fda-recommends-health-care-professionals-discuss-naloxone-all-patients-when-prescribing-opioid-pain

Bayern. Nasenspray gegen Drogentod: Fast 500 Menschen geschult

München – Fast 500 Menschen sind in Bayern mittlerweile für den Einsatz von lebensret­tendem Nasenspray für Heroinabhängige geschult worden. „In 70 Notfallsituationen kam Naloxon gezielt zum Einsatz und konnte somit Leben retten“, sagte Gesundheitsministerin Melanie Huml (CSU) vorgestern laut Mitteilung. (aerzteblatt.de, 04.08.2020)

Bayern. Nasenspray gegen Drogentod: Fast 500 Menschen geschult

Spectrometric Imaging of the Brain Demonstrates the Regional Displacement of 6-Monoacetylmorphine by Naloxone. 

Teklezgi BG, Pamreddy A, Ntshangase S, et al. Mass 

ACS Omega. 2020;5(22):12596-12602. Published 2020 May 27. doi:10.1021/acsomega.9b03570

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288357/