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At-a-glance - Lessons learned from launching the Manitoba Take-Home Naloxone Program.

Bozat-Emre S, Marshall SG, Zhong C, Reimer J.

Health Promot Chronic Dis Prev Can. 2018 Jun;38(6):252-255. doi: 10.24095/hpcdp.38.6.06.


Successful bystander-administered intranasal naloxone reversal of opioid overdose between two veterans: A case report.

Ouyang S, Moore T.

Ment Health Clin. 2018 Mar 23;7(6):287-289. doi: 10.9740/mhc.2017.11.287. 


Pharmacokinetic properties of intranasal and injectable formulations of naloxone for community use: a systematic review.

Ryan SA, Dunne RB.

Pain Manag. 2018 Apr 23. doi: 10.2217/pmt-2017-0060.


Leben retten mit Naloxon Erfahrungen aus Deutschland, Europa und den USA 
Das Buch berichtet über aktuelle Erfahrungen mit der Take-Home Naloxon-Vergabe (THN) in Deutschland, Europa und den USA. Jahrelang wurde die Drogennotfallprophylaxe mit Naloxon von Trägern und Verbänden der Drogenhilfe vernachlässigt. Erst seit ca. 5 Jahren wird sie in Deutschland intensiver diskutiert und punktuell umgesetzt. Dabei liegen ermutigende Praxiserfahrungen und überzeugende Forschungsergebnisse aus Berlin und europäischen Städten seit fast 20 Jahren vor. Dass darüber hinaus auch eine nationale Verbreitung möglich ist, beweist das weltweit erste Nationale THN-Programm in Schottland. Dennoch ist die Naloxonabgabe an medizinische Laien immer noch umstritten und wird bisher nicht flächendeckend eingesetzt. Das Buch beschreibt Gemeinsamkeiten und Besonderheiten des Einsatzes von THN durch Träger niedrigschwelliger Drogenhilfe und der Selbsthilfe sowie seine Bedeutung für das Leben und Überleben von Betroffenen. Die Beispiele aus Bayern, dem Saarland und Nordrhein-Westfalen zeigen, dass sich seit unserer ersten deutschen Veröffentlichung zum Thema Naloxon im Jahr 2015 nun auch Landesregierungen dazu entschlossen haben, THN-Projekte zu fördern und wissenschaftlich begleiten zu lassen.

Anna Dichtl, Heino Stöver, Kerstin Dettmer (Hrsg.), ISBN: 978-3-947273-01.0, April 2018


Cost-Effectiveness of Take-Home Naloxone for the Prevention of Overdose Fatalities among Heroin Users in the United Kingdom.

Langham S, Wright A, Kenworthy J, Grieve R, Dunlop WCN.

Value Health. 2018 Apr;21(4):407-415. doi: 10.1016/j.jval.2017.07.014. 


Opioid Overdose Prevention Toolkit

This toolkit offers strategies to health care providers, communities, and local governments for developing practices and policies to help prevent opioid-related overdoses and deaths. Access reports for community members, prescribers, patients and families, and those recovering from opioid overdose. (SAMHSA, 11.06.2018)


Comment: Take-home naloxone: while good, it is far from good enough.

Comiskey CM.

Lancet Public Health. 2018 Apr 17. pii: S2468-2667(18)30054-9. doi: 10.1016/S2468-2667(18)30054-9.


Naloxone in Europe: a focus report

15th annual ‘Improving Outcomes in the Treatment of Opioid Dependence’ (IOTOD), Berlin, 17./18.05.2017


Prescribing naloxone for opioid overdose intervention.

Dunne RB.

Pain Manag. 2018 Apr 18. doi: 10.2217/pmt-2017-0065.


Naloxone-Induced Non-Cardiogenic Pulmonary Edema: A Case Report.

Jiwa N, Sheth H, Silverman R.

Drug Saf Case Rep. 2018 May 10;5(1):20. doi: 10.1007/s40800-018-0088-x.


Lay responder naloxone access and Good Samaritan law compliance: postcard survey results from 20 Indiana counties.

Watson DP, Ray B, Robison L, Huynh P, Sightes E, Walker S, Brucker K, Duwve J.

Harm Reduct J. 2018 Apr 6;15(1):18. doi: 10.1186/s12954-018-0226-x.


"Once I'd done it once it was like writing your name": Lived experience of take-home naloxone administration by people who inject drugs.

McAuley A, Munro A, Taylor A.

Int J Drug Policy. 2018 May 23;58:46-54. doi: 10.1016/j.drugpo.2018.05.002. 



USA. How Can U.S. Fight the Opioid Crisis? Try Antidote Patents

Baltimore, consumer group demand U.S. take action on epidemic 

Step could lower cost, increase availability of naloxone 

The Trump administration should fight the opioid epidemic with a novel weapon, say the city of Baltimore and a consumer advocacy group: overriding patents on the widely-used overdose antidote naloxone. (Bloomberg, USA. 03.05.2018)


USA. Naloxone: Save a Life - Learn how to respond to an overdose emergency

Get Naloxone Now is an online resource to train people to respond effectively to an opioid-associated overdose emergency. Get Naloxone Now advocates for widespread access to overdose education and training in how to administer naloxone, the life-saving antidote for opioid-associated overdose. Get Naloxone Now seeks to increase the number of lives saved by bystanders and professional first responders (police officers, firefighters and EMTs). Find out how you can contribute to reducing overdose deaths by accessing our online training modules.


Distribution of take-home opioid antagonist kits during a synthetic opioid epidemic in British Columbia, Canada: a modelling study

Irvine, Michael A et al.

The Lancet Public Health , Volume 0 , Issue 0 , Published: 17 April 2018, doi.org/10.1016/S2468-2667(18)30044-6


USA. NIH/NIDA: Opioid Overdose Reversal with Naloxone (Narcan, Evzio)

(NIH – National Institute of Health / NIDA - National Institute on Drug Abuse,USA, Revised April 2018)


Kanada: Naloxon-Spritze in der Hausapotheke senkt Todesfälle durch Opiate

Vancouver – Ein „Take-Home Naloxon“-Programm, wie es derzeit auch in Deutschland als Mittel gegen Überdosierungen von Opiaten diskutiert wird, hat in Kanada ein Drittel aller Todesfälle vermieden. Zu diesem Ergebnis kommt eine Studie in Lancet Public Health (2018; doi: 10.1016/S2468-2667(18)30044-6). (aerzteblatt.de, 19.04.2018)


Facilitators and Barriers to Naloxone Kit Use Among Opioid-Dependent Patients Enrolled in Medication Assisted Therapy Clinics in North Carolina.

Khatiwoda P, Proeschold-Bell RJ, Meade CS, Park LP, Proescholdbell S.

N C Med J. 2018 May-Jun;79(3):149-155. doi: 10.18043/ncm.79.3.149.


What is EVZIO? (naloxone auto-injector)

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up.

EVZIO is safe and effective in children for known or suspected opioid overdose.


USA. Overdose 101: New York inmates trained to use opioid antidote kit

NEW YORK. The inmates filed into a room at a New York prison, squeezed into classroom-style desks, and watched a guard demonstrate how a small plastic tube could help them save lives when they return to the streets of a nation gripped by an opioid epidemic. (Reuters, 10.05.2018)


Evzio (naloxone auto-injector) Approved to Reverse Opioid Overdose

FDA approved Evzio (naloxone hydrochloride injection), a prescription treatment that can be used by family members or caregivers to treat a person known or suspected to have had an opioid overdose. Evzio rapidly delivers a single dose of the drug naloxone via a hand-held auto-injector.

Evzio is the first auto-injector designed to deliver a dose of naloxone outside of a health care setting. (FDA, USA, 2014)


Take-home naloxone toolkit

The IOTOD take-home naloxone (THN) toolkit contains guidance and resources on how to set up a THN programme, in order to reduce overdoses and save lives. (Improving Outcomes in the Treatment of Opioid Dependence (IOTOD), Mai 2018)


Biotech: The next naloxone? Companies, academics search for better overdose-reversal drugs

ATLANTA — Dr. Nora Volkow has heard a frightening scenario play out around the country. People are administering naloxone to synthetic opioid drug users who have overdosed. But the antidote doesn’t work well. So they give another dose. And it’s only after multiple doses — four, five, even six times — that drug users finally come to their senses.

Naloxone is the only widely available drug to reverse opioid overdoses. But anecdotal reports of its limitations against synthetic opioids are on the rise. Spurred by that public health threat — as well as a booming commercial market for the antidote — drug companies, researchers, and health officials are eagerly eyeing the development of new treatments to augment the use of naloxone or, in some cases, potentially replace it. (statnews.com, USA, 10.04.2018)


Methods for delivering the UK's multi-centre prison-based naloxone-on-release pilot randomised trial (N-ALIVE): Europe's largest prison-based randomised controlled trial.

Meade AM, Bird SM, Strang J, Pepple T, Nichols LL, Mascarenhas M, Choo L, Parmar MKB.

Drug Alcohol Rev. 2018 May;37(4):487-498. doi: 10.1111/dar.12592.


Management of Suspected Opioid Overdose With Naloxone by Emergency Medical Services Personnel [Internet].

Chou R, Korthuis PT, McCarty D, Coffin P, Griffin J, Davis-O’Reilly C, Grusing S, Daya M.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 Nov.


Guidance: Fentanyl: preparing for a future threat - Incident planning for potent opioids arriving into the illicit drug market - Local authority naloxone modelling

PHE – Public Health England, 08.05.2018