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USA. California Can’t Afford Its Free Narcan Program. Will It Embrace Generic?

A California naloxone delivery program is struggling to meet rising demand due to the expense of nasal spray Narcan. The situation highlights the the absurdity of state governments continuing to ignore the generic intramuscular version of naloxone—vastly more affordable, but demonized because it involves a syringe. (Filter, USA, 22.11.2022)

https://filtermag.org/california-naloxone-distribution-program

Comparing Projected Fatal Overdose Outcomes and Costs of Strategies to Expand Community-Based Distribution of Naloxone in Rhode Island. 

USA. Zang X, Bessey SE, Krieger MS, et al. 

JAMA Netw Open. 2022;5(11):e2241174. doi:10.1001/jamanetworkopen.2022.41174

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2798220

USA. FDA Announces Preliminary Assessment that Certain Naloxone Products Have the Potential to be Safe and Effective for Over-the-Counter Use

Agency Continues to Encourage Sponsor Applications for Over-the-Counter Naloxone Products. (FDA – US Food&Drug Administration, USA, 15.11.2022)

https://www.fda.gov/news-events/press-announcements/fda-announces-preliminary-assessment-certain-naloxone-products-have-potential-be-safe-and-effective

Providing naloxone to people who are prescribed opioids is a cost-effective way of preventing opioid overdose deaths

Much of the research on the effects of naloxone distribution has focused on people with opioid use disorder. This study investigated the public health impact and cost-effectiveness of naloxone access for individuals prescribed opioid medications, more generally, to help inform a comprehensive naloxone distribution strategy. (Recovery Research Institute, USA, November 2022)

https://www.recoveryanswers.org/research-post/providing-naloxone-people-prescribed-opioids-cost-effective-prevention-opioid-overdose-deaths/

A systematic review of the distribution of take-home naloxone in low- and middle-income countries and barriers to the implementation of take-home naloxone programs. 

Sajwani HS, Williams AV. 

Harm Reduct J. 2022 Oct 20;19(1):117. doi: 10.1186/s12954-022-00700-x. PMID: 36266701; PMCID: PMC9585764.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585764/

A measurement invariance analysis of selected Opioid Overdose Knowledge Scale (OOKS) items among bystanders and first responders. 

Swartz JA, Lin Q, Kim Y (2022) 

PLoS ONE 17(10): e0271418. doi.org/10.1371/journal.pone.0271418

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271418

'It's the same thing as giving them CPR training': rural first responders' perspectives on naloxone. 

Filteau MR, Green B, Kim F, McBride KA. 

Harm Reduct J. 2022 Oct 3;19(1):111. doi: 10.1186/s12954-022-00688-4. PMID: 36192736; PMCID: PMC9531424.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531424/

Risks and overdose responses: Participant characteristics from the first seven years of a national take-home naloxone program. 

Ericson ØB, Eide D, Lobmaier P, Clausen T. 

Drug Alcohol Depend. 2022 Nov 1;240:109645. doi: 10.1016/j.drugalcdep.2022.109645. Epub 2022 Sep 27. PMID: 36191532.

https://www.sciencedirect.com/science/article/pii/S0376871622003829

Opioid Antagonists from the Orvinol Series as Potential Reversal Agents for Opioid Overdose. 

Disney A, Olson KM, Shafer AM, Moore SC, Anand JP, Traynor JR, Husbands SM. 

ACS Chem Neurosci. 2022 Nov 2;13(21):3108-3117. doi: 10.1021/acschemneuro.2c00464. Epub 2022 Oct 12. PMID: 36223082; PMCID: PMC9634796.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634796/

Die 7. Nationale Substitutionskonferenz (NaSuKo) 21.09.2022 in Berlin - Beiträge zum Nachlesen oder Download

Hier stehen Ihnen die Beiträge der 7. NaSuKo zum Nachlesen oder Download zur Verfügung:

– NALtrain – Rettet Leben; Simon Fleissner & Dirk Schäffer

– Psychosoziale Betreuung (PSB) –neue Modelle der Finanzierung von Beratung und Betreuung; Stefanie Gellert-Beckmann

– Substitutionsbehandlung im Maßregel- und Justizvollzug; Nils-David Hirsch & Karlheinz Keppler

– Evaluation der 3. BtMVVÄndV; Silke Kuhn

– Evaluation der Corona-bedingt befristeten BtM-VV- und EBM-Änderungen; Babette Müllerschön

– Substitution im Justiz- und Maßregelvollzug Versorgung, Bedarfe und Schnittstellenprobleme; Heino Stöver

– Opioid-Substitution in der stationären Entwöhnungstherapie in Österreich; Barbara Schreder-Gegenhuber

Substitution in der medizinischen Rehabilitation Abhängigkeitskranker- Stand der Dinge und Bedarfe; Heino Stöver 

https://www.akzept.eu/akzept-konferenzen-und-fachtage/

Attitude changes following short-form opioid overdose video education: a pilot study. 

Galiher MV, Huffman M. 

Harm Reduct J. 2022 Oct 14;19(1):114. doi: 10.1186/s12954-022-00696-4. PMID: 36241995; PMCID: PMC9562080.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562080/

Naloxone administration by law enforcement officers in New York State (2015-2020). 

Pourtaher E, Payne ER, Fera N, Rowe K, Leung SJ, Stancliff S, Hammer M, Vinehout J, Dailey MW. 

Harm Reduct J. 2022 Sep 19;19(1):102. doi: 10.1186/s12954-022-00682-w. PMID: 36123614; PMCID: PMC9483860.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483860/

Characteristics of events in which police responded to overdoses: an examination of incident reports in Rhode Island. 

Macmadu A, Yolken A, Frueh L, Toussaint JR, Newman R, Jacka BP, Collins AB, Marshall BDL. 

Harm Reduct J. 2022 Oct 18;19(1):116. doi: 10.1186/s12954-022-00698-2. PMID: 36258209; PMCID: PMC9578237.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578237/

Enhancing Patient Choice: Using Self-administered Intranasal Naloxone for Novel Rapid Buprenorphine Initiation. 

Randall A, Hull I, Martin SA. 

J Addict Med. 2022 Sep 23. doi: 10.1097/ADM.0000000000001073. Epub ahead of print. PMID: 36149001.

https://journals.lww.com/journaladdictionmedicine/Fulltext/9900/Enhancing_Patient_Choice__Using_Self_administered.83.aspx

Patient perspectives on naloxone receipt in the emergency department: a qualitative exploration. 

Lowenstein M, Sangha HK, Spadaro A, Perrone J, Delgado MK, Agarwal AK. 

Harm Reduct J. 2022 Aug 26;19(1):97. doi: 10.1186/s12954-022-00677-7. PMID: 36028882; PMCID: PMC9412772.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9412772/

USA. FDA Exempts Harm Reduction From Biggest Naloxone Access Restrictions

On September 22, the Food and Drug Administration announced that harm reduction naloxone suppliers are exempt from wholesale pharmaceutical distribution restrictions, effective immediately. This de facto waives naloxone’s prescription requirement at the federal level, allowing the broader harm reduction community to purchase and distribute naloxone in bulk for the first time. (FILTER, USA, 26.09.2022)

https://filtermag.org/fda-naloxone-exemption-harm-reduction

Naloxone administration by law enforcement officers in New York State (2015-2020). 

Pourtaher E, Payne ER, Fera N, Rowe K, Leung SJ, Stancliff S, Hammer M, Vinehout J, Dailey MW. 

Harm Reduct J. 2022 Sep 19;19(1):102. doi: 10.1186/s12954-022-00682-w. PMID: 36123614; PMCID: PMC9483860.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483860/

Trends in Out-of-Pocket Costs for Naloxone by Drug Brand and Payer in the US, 2010-2018. 

Peet ED, Powell D, Pacula RL. 

JAMA Health Forum. 2022;3(8):e222663. doi:10.1001/jamahealthforum.2022.2663

https://jamanetwork.com/journals/jama-health-forum/fullarticle/2795473

NALOXONE ADMINISTRATION BY ADDICTION & HOMELESS SERVICE PROVIDERS IN
IRELAND: 2018-2020

Dr David Evans, Tim Bingham, Sarah Hamza, Prof Eamon Keenan

DRUG INSIGHTS REPORT 2, National Social Inclusion Office, 2022

https://www.hse.ie/eng/services/publications/socialinclusion/hse-naloxone-drug-insights-report.pdf

Resuscitation simulation among people who are likely to witness opioid overdose: Experiences from the SOONER Trial. 

Whittall JP, Orkin AM, Handford C, Klaiman M, Leece P, Charles M, et al. (2022) 

PLoS ONE 17(7): e0270829. https://doi.org/10.1371/journal.pone.0270829

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270829

A longitudinal study of naloxone opioid overdose awareness and reversal training for first-year medical students: specific elements require reinforcement. 

Sandhu RK, Heller MV, Buckanavage J, Haslund-Gourley B, Leckron J, Kupersmith B, Goss NC, Samson K, Gadegbeku AB. 

Harm Reduct J. 2022 Jul 2;19(1):70. doi: 10.1186/s12954-022-00656-y. PMID: 35780103; PMCID: PMC9250225.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250225/

Design details for overdose education and take-home naloxone kits: Codesign with family medicine, emergency department, addictions medicine and community. 

Sellen K, Goso N, Halleran L, Mulvale A, Sarmiento F, Ligabue F, Handford C, Klaiman M, Milos G, Wright A, Charles M, Sniderman R, Hunt R, Parsons JA, Leece P, Hopkins S, Shahin R, Yüni P, Morrison L, Campbell DM, Strike C, Orkin A; SOONER Investigators. 

Health Expect. 2022 Jul 31. doi: 10.1111/hex.13559. Epub ahead of print. PMID: 35909312.

https://onlinelibrary.wiley.com/doi/10.1111/hex.13559

USA. Music Festivals Embrace Overdose Reversal Drugs, but Fentanyl Testing Kits Remain Taboo

(…) Music festivals once frowned upon naloxone, and some banned it. But even though what’s known as harm reduction — the concept of minimizing the negative effects of illicit drug use without trying to stop it altogether — has gained acceptance, it’s far from embraced. Less accepted than naloxone among concert promoters is helping people test their drugs for fentanyl. Companies don’t want to be seen as condoning drug use. They’re also navigating a legal gray area and battling public perceptions. (Kaiser Health News, USA, 03.08.2022)

https://khn.org/news/article/music-festivals-overdose-reversal-drugs-fentanyl-testing-kits-naloxone/

Priority setting for Canadian Take-Home Naloxone best practice guideline development: an adapted online Delphi method. 

Ferguson M, Medley A, Rittenbach K, Brothers TD, Strike C, Ng J, Leece P, Elton-Marshall T, Ali F, Lorenzetti DL, Buxton JA. 

Harm Reduct J. 2022 Jul 2;19(1):71. doi: 10.1186/s12954-022-00650-4. PMID: 35780136; PMCID: PMC9250272.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250272/

USA. Exclusive: For the First Time, Harm Reduction Gets a Naloxone of Its Own

In late April 2021, a manufacturing disruption brought Pfizer’s naloxone production to a standstill, leaving more than half the country’s harm reduction programs without access as overdose reached an all-time high. Now, a new naloxone product is being manufactured for harm reduction programs exclusively. (Filter, USA, 01.08.2022)

https://filtermag.org/naloxone-shortage-hikma-pfizer-remedy-alliance/

State naloxone co-prescribing laws show mixed effects on overdose mortality rates. 

Duska M, Rhoads JM, Saunders EC, Onega T. 

Drug Science, Policy and Law. January 2022. doi:10.1177/20503245221112575

https://journals.sagepub.com/doi/full/10.1177/20503245221112575

USA. Thousands of Free Naloxone Doses Hitting Music Events This Summer

Music events feel like one of the last safe, unifying cultural gatherings in a country ravaged by divisions and stresses, including the pressures of a multi-year pandemic. Most of these events were canceled in 2020 and 2021, but this year packed clubs, arenas and festival grounds are back in full force, and folks are heading out—searching for that connection they have so missed, through the music they love.

Just last week, at a music event in Olympia, Washington, a woman was found dead. As we know, tragic deaths are increasingly frequent as fentanyl and its analogs continue to make their way into unexpected substances, including counterfeit prescription pills. People in the 18-45 age range are most vulnerable—and these are the people most likely to attend a music event this summer.

Thanks to a bit of innovation and a lot of collaboration, there will be some protection from the devastation of overdose in these spaces. Three groups are using the dynamic that music events create to distribute naloxone, the opioid-overdose reversal drug, on an unprecedented scale. (Filter, USA, 19.07.2022)

https://filtermag.org/naloxone-overdose-music-events/

Kanada. B.C. doctor hands naloxone to dealers, rents bus to get users to care

Dr. Aseem Grover found innovative ways to help drug users in Hope — including handing naloxone to dealers and renting a bus to get people to care — until he could create a clinic that offers more services to rural patients. (Vancouver Sun, Kanada, 10.07.2022)

https://vancouversun.com/health/local-health/the-rural-hole-in-b-c-s-addiction-services

Schottland. Edinburgh prisoners to receive training for drug that counters heroin overdose

Over 300 prisoners at HMP Edinburgh are being primed to take on special training to apply naloxone, which has been rolled out to treat those suffering a heroin overdose. (edinburghlive, UK, 11.07.2022)

https://www.edinburghlive.co.uk/news/edinburgh-news/edinburgh-prisoners-receive-training-drug-24452933

Use, awareness and uptake of take-home naloxone among a sample of people who regularly inject drugs and use opioids in South Australia

Antonia Karlsson, Amy Peacock and Rachel Sutherland

NDARC – National Drug and Alcohol Research Centre, Australien, 2022

https://ndarc.med.unsw.edu.au/sites/default/files/ndarc/resources/Use%2C%20awareness%20and%20uptake%20of%20take-home%20naloxone_Bulletin.pdf