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USA. Study indicates opioid overdose reversal products chemically stable past expiration date

A widely used naloxone nasal spray (NNS) and naloxone injection (NIJ), otherwise known as Narcan and Evzio, which are administered to prevent opioid overdose deaths, were found to be chemically stable up for at least ten months and beyond one year of the expiration date, respectively. According to the National Institute on Drug Abuse, from 1996 to 2014, at least 26,500 opioid overdoses in the U.S. were reversed by laypersons using naloxone. The research, Evaluation of Chemical Stability of Naloxone Products Beyond Their Labeled Expiration Dates, was presented today at the 2018 American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 Annual Meeting. (American Association of Pharmaceutical Scientists, 06.11.2018)

https://medicalxpress.com/news/2018-11-opioid-overdose-reversal-products-chemically.html

USA. FDA Considers Requiring Co-Prescribing Overdose Antidote to Go Along With Opioids

The Food and Drug Administration is considering requiring doctors to prescribe an overdose reversal drug with prescription painkillers such as OxyCodone, Commissioner Scott Gottlieb announced Tuesday. (AT Forum, USA, 29.10.2018)

http://atforum.com/2018/10/fda-considers-requiring-co-prescribing-overdose-antidote-to-go-along-with-opioids/

USA. Major opioid maker to pay for overdose-antidote development

A company whose prescription opioid marketing practices are being blamed for sparking the addiction and overdose crisis says it's helping to fund an effort to make a lower-cost overdose antidote. 

OxyContin maker Purdue Pharma announced Wednesday that it's making a $3.4 million grant to Harm Reduction Therapeutics, a Pittsburgh-based nonprofit, to help develop a low-cost naloxone nasal spray. (medicalxpress.com, USA, 05.09.2018)

https://medicalxpress.com/news/2018-09-major-opioid-maker-overdose-antidote.html

USA. Prescribing opioids and antidote at the same time to prevent overdose deaths

A growing number of states are requiring doctors to prescribe a drug overdose antidote alongside prescription opioid painkillers to try to reduce drug deaths. (Washington Examiner, 08.05.2018)

https://www.washingtonexaminer.com/policy/healthcare/prescribing-opioids-and-antidote-at-the-same-time-to-prevent-overdose-deaths

On the front lines of the opioid epidemic: Rescue by naloxone.

Skolnick P.

Eur J Pharmacol. 2018 Sep 15;835:147-153. doi: 10.1016/j.ejphar.2018.08.004.

https://www.sciencedirect.com/science/article/pii/S0014299918304394

USA. Naloxone Retail Dispensing Is Up 70 Percent

An awareness campaign by the U.S. Surgeon General has led to a surge in demand for the overdose-reversal drug. (The Atlantic, USA, 05.10.2018)

https://www.theatlantic.com/health/archive/2018/10/us-surgeon-general-jerome-adamss-naloxone-mission/572233/

Naloxone Administration Frequency During Emergency Medical Service Events - United States, 2012-2016.

Cash RE, Kinsman J, Crowe RP, Rivard MK, Faul M, Panchal AR.

MMWR Morb Mortal Wkly Rep. 2018 Aug 10;67(31):850-853. doi: 10.15585/mmwr.mm6731a2.

https://www.cdc.gov/mmwr/volumes/67/wr/mm6731a2.htm

Naloxone - Training Video (injection)

(Drugreporter, Ungarn, 08.10.2018, Video, 08:29)

https://www.youtube.com/watch?v=2sep2lwYndo&feature

USA. Overdose Reversal Toolkit

Addiction Policy Forum’s Overdose Reversal Toolkit contains training videos on how to recognize and respond to an overdose, information about how to administer naloxone, harm reduction education, resources and further reading. This toolkit is open source, and we encourage you to share it with your communities and loved ones who could benefit from this information. (Addiction Policy Forum, USA, August 2018)

https://www.addictionpolicy.org/overdosereversal

Bayern startet Modellprojekt mit Naloxon

München – Anfang Oktober ist in Bayern ein Naloxon-Modellprojekt gestartet. Das hat das bayerische Gesundheitsministerium bekanntgegeben. Das Projekt zielt darauf ab, die Abgabe des Notfallmedikaments Naloxan durch speziell geschulte medizinische Laien zu ermöglichen. Bislang darf Naloxon nur von Ärzten angewandt werden. (aerzteblatt.de, 04.10.2018)

https://www.aerzteblatt.de/nachrichten/98276/Bayern-startet-Modellprojekt-mit-Naloxon

USA. In Memoriam: Dan Bigg, a Giant of Harm Reduction Gone Much Too Soon

Harm reductionists, drug policy reformers, and many others are mourning the unexpected passing of Dan Bigg at age 59 this week.

Dan, a cofounder and the long-term executive director of the Chicago Recovery Alliance, played a leading role advancing syringe exchange in the United States, and more recently naloxone distribution to prevent heroin overdoses. He was a 2017 Chicago Magazine Chicagoan of the Year, and received the Drug Policy Alliance's 2015 Norman ZInberg Award. (Stopthe DrugWar.com, Issue #1033, 24.08.2018)

https://stopthedrugwar.org/chronicle/2018/aug/24/dan_bigg_gone_too_soon

Huml: Naloxon-Modellprojekt ist gestartet – Bayerns Gesundheitsministerin fördert neues Hilfsangebot für Drogenabhängige mit knapp 330.000 Euro

Bayern baut die Suchthilfeangebote und die medizinische Versorgung für Drogenabhängige weiter aus. Bayerns Gesundheitsministerin Melanie Huml betonte am Mittwoch: "Das bayerische Naloxon-Modellprojekt ist Anfang Oktober gestartet. Speziell geschulte Laien können nun höchstgefährdeten Menschen im Heroin-Notfall mit Naloxon entscheidend helfen. Denn Naloxon kann die atemlähmende Wirkung von Heroin innerhalb kürzester Zeit aufheben."

Das bayerische Gesundheitsministerium fördert das Modellprojekt "BayTHN – Take-Home-Naloxon in Bayern" in den kommenden drei Jahren mit 330.000 Euro. Dabei wird ein Schulungsprogramm für medizinische Laien zum Einsatz von nasalem Take-Home-Naloxon in Notfallsituationen bei drogenabhängigen Menschen wissenschaftlich begleitet und evaluiert. (Bayerisches Staatsministerium für Gesundheit und Pflege, 03.10.2018)

https://www.stmgp.bayern.de/presse/huml-naloxon-modellprojekt-ist-gestartet-bayerns-gesundheitsministerin-foerdert-neues/

Meeting Opioid Users Where They Are: A Service Referral Approach to Law Enforcement.

Paul L.

N C Med J. 2018 May-Jun;79(3):172-173. doi: 10.18043/ncm.79.3.172. 

http://www.ncmedicaljournal.com/content/79/3/172.long

Schottland. Fear of police stop and search can deter opioid users from carrying anti-overdose kits

(...) In Scotland, around 40,000 naloxone kits have been supplied to date. (...) This points to an urgent need for the police to reassure people that no action will be taken if they are found carrying the kits – and more generally to raise awareness around the code of practice. (theconversation.com, UK, 11.09.2018)

http://theconversation.com/fear-of-police-stop-and-search-can-deter-opioid-users-from-carrying-anti-overdose-kits-102955

Naloxone

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

https://www.ncbi.nlm.nih.gov/books/NBK501681/

Acceptability of prison-based take-home naloxone programmes among a cohort of incarcerated men with a history of regular injecting drug use

Michael Curtis, Paul Dietze, Campbell Aitken, Amy Kirwan, Stuart A. Kinner, Tony Butler and Mark Stoové

Harm Reduction Journal 2018, 15:48, doi.org/10.1186/s12954-018-0255-5

https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-018-0255-5

Naloxon: Drogennotfallprophylaxe bei Opioidkonsumenten - Informationsportal von akzept e.V.

Ein Informationsportal von akzept e.V., gefördert von mundipharma (24.07.2018)

https://naloxoninfo.de/

USA. As opioid crisis rages, cost of overdose antidote spikes

As the opioid epidemic continues to kill tens of thousands of Americans each year, the drug naloxone has proved invaluable in preventing overdose-related deaths. Yet a spike in its cost in recent years has constrained access to naloxone, potentially depriving health care professionals, emergency responders and families of a critical treatment than can save lives. (CBS-News, Money Watch, USA, 14.08.2018)

https://www.cbsnews.com/news/as-opioids-kill-more-americans-cost-of-overdose-antidote-spikes/

Naloxone-on-Release - Guidelines for naloxone provision upon release from custodial settings.

(...) The project, led by the Frankfurt University of Applied Science, received funding from the European Union for the period 2017-2018. It aims at addressing the gaps in the continuity of care for long-term drug users in prison and upon release, by supporting life-saving interventions for the prevention of overdoses and reduction of other risks related to drug use and for the establishment of a treatment path, which does not get interrupted upon release.

(Frankfurt University of Applied Science und ISFF – Institut für Suchtforschung Frankfurt, 2018)

https://typo3-alt.cit.frankfurt-university.de/fileadmin/de/Fachbereiche/FB4/Forschung/ISFF/Ver%C3%B6ffentlichungen/My_first_48_hours_out.pdf

Jetzt neu: Nyxoid® – das erste Naloxon-Nasenspray in Deutschland. Notfalltherapie bei Opioid-Überdosierung

Erste Hilfe für Patienten mit Opioid-Überdosierung / Intranasal statt Injektion: keine Stichverletzungs- und Infektionsgefahr / auch im Rahmen von Naloxon-Take-Home-Projekten einsetzbar 

Limburg, 4. September 2018 (mes) – Seit 1. September 2018 ist Nyxoid®, ein Naloxon-Nasenspray, auch in Deutschland verfügbar und kann auch von geschulten medizinischen Laien appliziert werden.1 Somit können auch Angehörige und Betreuende noch vor dem Eintreffen des Notarztes schnell und wirksam auf eine Opioid-Überdosierung reagieren. Ein weiterer Vorteil der neuen Applikationsform: Nadelstichverletzungen und daraus resultierende Infektionen sind ausgeschlossen. (mundipharma, Deutschland, 04.09.2018)

PI Mundipharma Nyxoid-Launch 04092018

UK. High risk strategy - Failure to provide naloxone at the point of release for most prisoners is putting lives at risk, says John Jolly.

Those leaving prison having had an opiate problem are seriously at risk of having a life-threatening overdose or dying as a result of one. Both Public Health England (PHE) and the government have been clear in their recommendation that all local areas need to have appropriate naloxone provision in place. However, prisons have so far failed to implement provision at the point of release across much of the estate, and this is putting lives at risk. (DDN – Drink and Drugs News, UK, 09.07.2018)

https://drinkanddrugsnews.com/high-risk-strategy

Österreich. Anwendung von Nyxoid (Video)

Dieses Video beschreibt die zu ergreifenden Maßnahmen bei der Reaktion auf einen Verdacht einer Überdosierung an Opioiden, einschließlich folgender Aspekte:

Wie man die Symptome einer Überdosierung an Opioiden erkennen kann

Wie man auf eine Überdosierung an Opioiden reagieren sollte

Wie Nyxoid angewendet wird

Wie man akute Entzugserscheinungen erkennen kann

Denken Sie bitte auch daran, dass Sie eine Kurzanleitung auf der Rückseite der Nyxoid - Faltschachtel finden. (nyxoid.com/at, Österreich, 2018, Video, 05:55)

https://nyxoid.com/at/public/using-nyxoid-video

Naloxone. "My first 48 hours out“ - Comprehensive approaches to pre and post prison release interventions for drug users in the criminal justice system

Projektbeschreibung: For prisoners with a history of drug use, in particular opioid use, the risks related to drug use, in particular overdose and death are extremely high in the immediate period after release due to high rates of relapse and lower opioid tolerance (Farrell and Marsden, 2008). Much still needs to be done in order to ensure that people with a severe history of drug use are sufficiently cared for, when released from prisons. Harm reduction measures need to be in place for ex-prisoners to be able to readjust to freedom without relapsing back into drug use and extreme risk of fatal overdose when released. 

The immediate time after release (“my first 48 hours out”) is a critical time for action, when the cooperation between prisons, healthcare providers and NGOs is key in ensuring continuity of care and where targeted interventions can save lives from overdose and build a path towards engagement into further treatment and rehabilitation for drug users. (Frankfurt University for Applied Sciences, o.D.)

https://typo3-alt.cit.frankfurt-university.de/fachbereiche/fb4/forschung/forschungsinstitute/isff/forschungsprojekte/my-first-48-hours-out.html

Österreich. Nyxoid: Patienten- Informationskarte

Diese Informationen werden Ihnen dabei helfen, mehr über eine Überdosierung an Opioiden sowie über Nyxoid zu erfahren. Falls Sie spezifische Fragen zu Ihrer Gesundheit oder zur Notfallsbehandlung einer Überdosierung haben, fragen Sie bitte Ihren Arzt/Ärztin, Ihren Apotheker/in oder medizinische Fachpersonal. (nyxoid.com/at, Österreich, 2018)

https://nyxoid.com/at/public/patient-information-card

Kanada. Toronto Police Service deploying naloxone

Today, the Toronto Police Service has started to phase in deployment of naloxone, a life-saving medication which can be used to temporarily block the effects of opioids and prevent an overdose death, to uniformed police officers in the downtown core where overdose calls for service are highest. (Toronto Police Service, 05.07.2018)

http://torontopolice.on.ca/newsreleases/41548

Österreich. Herzlich willkommen auf unserer Informations- und Trainingswebsite zu Nyxoid!

Finden Sie heraus, wie man eine Überdosierung an Opioiden erkennen kann und wie man auf eine derartige Überdosierung unter Nutzung des Nyxoid-Nasensprays reagieren sollte. (nyxoid.com/at, Österreich, 2018)

https://nyxoid.com/at/public/about

At-a-glance - Lessons learned from launching the Manitoba Take-Home Naloxone Program.

Bozat-Emre S, Marshall SG, Zhong C, Reimer J.

Health Promot Chronic Dis Prev Can. 2018 Jun;38(6):252-255. doi: 10.24095/hpcdp.38.6.06.

https://www.canada.ca/en/public-health/services/reports-publications/health-promotion-chronic-disease-prevention-canada-research-policy-practice/vol-38-no-6-2018/at-a-glance-lessons-learned-manitoba-take-home-naloxone-program.html

Nyxoid® - Produktseite (mundipharma)

Profil, Gebrauchsinformationen, Schulungsmaterial Notfalltherapie bei einer Opioid Überdosis und EducationalMaterial (Zugang nur für Fachkreise). (mundipharma.de, 2018)

https://www.mundipharma.de/protected/indikationen/substitutionstherapie/nyxoid-R.html