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Jetzt neu: Nyxoid® – das erste Naloxon-Nasenspray in Deutschland. Notfalltherapie bei Opioid-Überdosierung

Erste Hilfe für Patienten mit Opioid-Überdosierung / Intranasal statt Injektion: keine Stichverletzungs- und Infektionsgefahr / auch im Rahmen von Naloxon-Take-Home-Projekten einsetzbar 

Limburg, 4. September 2018 (mes) – Seit 1. September 2018 ist Nyxoid®, ein Naloxon-Nasenspray, auch in Deutschland verfügbar und kann auch von geschulten medizinischen Laien appliziert werden.1 Somit können auch Angehörige und Betreuende noch vor dem Eintreffen des Notarztes schnell und wirksam auf eine Opioid-Überdosierung reagieren. Ein weiterer Vorteil der neuen Applikationsform: Nadelstichverletzungen und daraus resultierende Infektionen sind ausgeschlossen. (mundipharma, Deutschland, 04.09.2018)

PI Mundipharma Nyxoid-Launch 04092018

USA. As opioid crisis rages, cost of overdose antidote spikes

As the opioid epidemic continues to kill tens of thousands of Americans each year, the drug naloxone has proved invaluable in preventing overdose-related deaths. Yet a spike in its cost in recent years has constrained access to naloxone, potentially depriving health care professionals, emergency responders and families of a critical treatment than can save lives. (CBS-News, Money Watch, USA, 14.08.2018)

https://www.cbsnews.com/news/as-opioids-kill-more-americans-cost-of-overdose-antidote-spikes/

Naloxone. "My first 48 hours out“ - Comprehensive approaches to pre and post prison release interventions for drug users in the criminal justice system

Projektbeschreibung: For prisoners with a history of drug use, in particular opioid use, the risks related to drug use, in particular overdose and death are extremely high in the immediate period after release due to high rates of relapse and lower opioid tolerance (Farrell and Marsden, 2008). Much still needs to be done in order to ensure that people with a severe history of drug use are sufficiently cared for, when released from prisons. Harm reduction measures need to be in place for ex-prisoners to be able to readjust to freedom without relapsing back into drug use and extreme risk of fatal overdose when released. 

The immediate time after release (“my first 48 hours out”) is a critical time for action, when the cooperation between prisons, healthcare providers and NGOs is key in ensuring continuity of care and where targeted interventions can save lives from overdose and build a path towards engagement into further treatment and rehabilitation for drug users. (Frankfurt University for Applied Sciences, o.D.)

https://typo3-alt.cit.frankfurt-university.de/fachbereiche/fb4/forschung/forschungsinstitute/isff/forschungsprojekte/my-first-48-hours-out.html

Acceptability of prison-based take-home naloxone programmes among a cohort of incarcerated men with a history of regular injecting drug use

Michael Curtis, Paul Dietze, Campbell Aitken, Amy Kirwan, Stuart A. Kinner, Tony Butler and Mark Stoové

Harm Reduction Journal 2018, 15:48, doi.org/10.1186/s12954-018-0255-5

https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-018-0255-5

Kanada. Toronto Police Service deploying naloxone

Today, the Toronto Police Service has started to phase in deployment of naloxone, a life-saving medication which can be used to temporarily block the effects of opioids and prevent an overdose death, to uniformed police officers in the downtown core where overdose calls for service are highest. (Toronto Police Service, 05.07.2018)

http://torontopolice.on.ca/newsreleases/41548

Österreich. Anwendung von Nyxoid (Video)

Dieses Video beschreibt die zu ergreifenden Maßnahmen bei der Reaktion auf einen Verdacht einer Überdosierung an Opioiden, einschließlich folgender Aspekte:

Wie man die Symptome einer Überdosierung an Opioiden erkennen kann

Wie man auf eine Überdosierung an Opioiden reagieren sollte

Wie Nyxoid angewendet wird

Wie man akute Entzugserscheinungen erkennen kann

Denken Sie bitte auch daran, dass Sie eine Kurzanleitung auf der Rückseite der Nyxoid - Faltschachtel finden. (nyxoid.com/at, Österreich, 2018, Video, 05:55)

https://nyxoid.com/at/public/using-nyxoid-video

At-a-glance - Lessons learned from launching the Manitoba Take-Home Naloxone Program.

Bozat-Emre S, Marshall SG, Zhong C, Reimer J.

Health Promot Chronic Dis Prev Can. 2018 Jun;38(6):252-255. doi: 10.24095/hpcdp.38.6.06.

https://www.canada.ca/en/public-health/services/reports-publications/health-promotion-chronic-disease-prevention-canada-research-policy-practice/vol-38-no-6-2018/at-a-glance-lessons-learned-manitoba-take-home-naloxone-program.html

Österreich. Nyxoid: Patienten- Informationskarte

Diese Informationen werden Ihnen dabei helfen, mehr über eine Überdosierung an Opioiden sowie über Nyxoid zu erfahren. Falls Sie spezifische Fragen zu Ihrer Gesundheit oder zur Notfallsbehandlung einer Überdosierung haben, fragen Sie bitte Ihren Arzt/Ärztin, Ihren Apotheker/in oder medizinische Fachpersonal. (nyxoid.com/at, Österreich, 2018)

https://nyxoid.com/at/public/patient-information-card

Successful bystander-administered intranasal naloxone reversal of opioid overdose between two veterans: A case report.

Ouyang S, Moore T.

Ment Health Clin. 2018 Mar 23;7(6):287-289. doi: 10.9740/mhc.2017.11.287. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007730/

Österreich. Herzlich willkommen auf unserer Informations- und Trainingswebsite zu Nyxoid!

Finden Sie heraus, wie man eine Überdosierung an Opioiden erkennen kann und wie man auf eine derartige Überdosierung unter Nutzung des Nyxoid-Nasensprays reagieren sollte. (nyxoid.com/at, Österreich, 2018)

https://nyxoid.com/at/public/about

Leben retten mit Naloxon Erfahrungen aus Deutschland, Europa und den USA 
Das Buch berichtet über aktuelle Erfahrungen mit der Take-Home Naloxon-Vergabe (THN) in Deutschland, Europa und den USA. Jahrelang wurde die Drogennotfallprophylaxe mit Naloxon von Trägern und Verbänden der Drogenhilfe vernachlässigt. Erst seit ca. 5 Jahren wird sie in Deutschland intensiver diskutiert und punktuell umgesetzt. Dabei liegen ermutigende Praxiserfahrungen und überzeugende Forschungsergebnisse aus Berlin und europäischen Städten seit fast 20 Jahren vor. Dass darüber hinaus auch eine nationale Verbreitung möglich ist, beweist das weltweit erste Nationale THN-Programm in Schottland. Dennoch ist die Naloxonabgabe an medizinische Laien immer noch umstritten und wird bisher nicht flächendeckend eingesetzt. Das Buch beschreibt Gemeinsamkeiten und Besonderheiten des Einsatzes von THN durch Träger niedrigschwelliger Drogenhilfe und der Selbsthilfe sowie seine Bedeutung für das Leben und Überleben von Betroffenen. Die Beispiele aus Bayern, dem Saarland und Nordrhein-Westfalen zeigen, dass sich seit unserer ersten deutschen Veröffentlichung zum Thema Naloxon im Jahr 2015 nun auch Landesregierungen dazu entschlossen haben, THN-Projekte zu fördern und wissenschaftlich begleiten zu lassen.

Anna Dichtl, Heino Stöver, Kerstin Dettmer (Hrsg.), ISBN: 978-3-947273-01.0, April 2018

http://fhverlag.de/show.php?action=show&record=24.0&thema=6&page=1&from=th&UID=v651DS67A9

Nyxoid® - Produktseite (mundipharma)

Profil, Gebrauchsinformationen, Schulungsmaterial Notfalltherapie bei einer Opioid Überdosis und EducationalMaterial (Zugang nur für Fachkreise). (mundipharma.de, 2018)

https://www.mundipharma.de/protected/indikationen/substitutionstherapie/nyxoid-R.html

Opioid Overdose Prevention Toolkit

This toolkit offers strategies to health care providers, communities, and local governments for developing practices and policies to help prevent opioid-related overdoses and deaths. Access reports for community members, prescribers, patients and families, and those recovering from opioid overdose. (SAMHSA, 11.06.2018)

https://store.samhsa.gov/product/Opioid-Overdose-Prevention-Toolkit/All-New-Products/SMA18-4742

USA. Major opioid maker to pay for overdose-antidote development

A company whose prescription opioid marketing practices are being blamed for sparking the addiction and overdose crisis says it's helping to fund an effort to make a lower-cost overdose antidote. 

OxyContin maker Purdue Pharma announced Wednesday that it's making a $3.4 million grant to Harm Reduction Therapeutics, a Pittsburgh-based nonprofit, to help develop a low-cost naloxone nasal spray. (medicalxpress.com, USA, 05.09.2018)

https://medicalxpress.com/news/2018-09-major-opioid-maker-overdose-antidote.html

Naloxone in Europe: a focus report

15th annual ‘Improving Outcomes in the Treatment of Opioid Dependence’ (IOTOD), Berlin, 17./18.05.2017

http://www.iotodeducation.com/wp-content/uploads/2017/10/Naloxone_Focus_Report.pdf

On the front lines of the opioid epidemic: Rescue by naloxone.

Skolnick P.

Eur J Pharmacol. 2018 Sep 15;835:147-153. doi: 10.1016/j.ejphar.2018.08.004.

https://www.sciencedirect.com/science/article/pii/S0014299918304394

Naloxone-Induced Non-Cardiogenic Pulmonary Edema: A Case Report.

Jiwa N, Sheth H, Silverman R.

Drug Saf Case Rep. 2018 May 10;5(1):20. doi: 10.1007/s40800-018-0088-x.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945567/

Naloxone Administration Frequency During Emergency Medical Service Events - United States, 2012-2016.

Cash RE, Kinsman J, Crowe RP, Rivard MK, Faul M, Panchal AR.

MMWR Morb Mortal Wkly Rep. 2018 Aug 10;67(31):850-853. doi: 10.15585/mmwr.mm6731a2.

https://www.cdc.gov/mmwr/volumes/67/wr/mm6731a2.htm

"Once I'd done it once it was like writing your name": Lived experience of take-home naloxone administration by people who inject drugs.

McAuley A, Munro A, Taylor A.

Int J Drug Policy. 2018 May 23;58:46-54. doi: 10.1016/j.drugpo.2018.05.002. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29803097

USA. Overdose Reversal Toolkit

Addiction Policy Forum’s Overdose Reversal Toolkit contains training videos on how to recognize and respond to an overdose, information about how to administer naloxone, harm reduction education, resources and further reading. This toolkit is open source, and we encourage you to share it with your communities and loved ones who could benefit from this information. (Addiction Policy Forum, USA, August 2018)

https://www.addictionpolicy.org/overdosereversal

USA. Naloxone: Save a Life - Learn how to respond to an overdose emergency

Get Naloxone Now is an online resource to train people to respond effectively to an opioid-associated overdose emergency. Get Naloxone Now advocates for widespread access to overdose education and training in how to administer naloxone, the life-saving antidote for opioid-associated overdose. Get Naloxone Now seeks to increase the number of lives saved by bystanders and professional first responders (police officers, firefighters and EMTs). Find out how you can contribute to reducing overdose deaths by accessing our online training modules.

http://www.getnaloxonenow.org/index.aspx

USA. In Memoriam: Dan Bigg, a Giant of Harm Reduction Gone Much Too Soon

Harm reductionists, drug policy reformers, and many others are mourning the unexpected passing of Dan Bigg at age 59 this week.

Dan, a cofounder and the long-term executive director of the Chicago Recovery Alliance, played a leading role advancing syringe exchange in the United States, and more recently naloxone distribution to prevent heroin overdoses. He was a 2017 Chicago Magazine Chicagoan of the Year, and received the Drug Policy Alliance's 2015 Norman ZInberg Award. (Stopthe DrugWar.com, Issue #1033, 24.08.2018)

https://stopthedrugwar.org/chronicle/2018/aug/24/dan_bigg_gone_too_soon

USA. NIH/NIDA: Opioid Overdose Reversal with Naloxone (Narcan, Evzio)

(NIH – National Institute of Health / NIDA - National Institute on Drug Abuse,USA, Revised April 2018)

https://www.drugabuse.gov/related-topics/opioid-overdose-reversal-naloxone-narcan-evzio

Meeting Opioid Users Where They Are: A Service Referral Approach to Law Enforcement.

Paul L.

N C Med J. 2018 May-Jun;79(3):172-173. doi: 10.18043/ncm.79.3.172. 

http://www.ncmedicaljournal.com/content/79/3/172.long

Facilitators and Barriers to Naloxone Kit Use Among Opioid-Dependent Patients Enrolled in Medication Assisted Therapy Clinics in North Carolina.

Khatiwoda P, Proeschold-Bell RJ, Meade CS, Park LP, Proescholdbell S.

N C Med J. 2018 May-Jun;79(3):149-155. doi: 10.18043/ncm.79.3.149.

http://www.ncmedicaljournal.com/content/79/3/149.long

Naloxone

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

https://www.ncbi.nlm.nih.gov/books/NBK501681/

USA. Overdose 101: New York inmates trained to use opioid antidote kit

NEW YORK. The inmates filed into a room at a New York prison, squeezed into classroom-style desks, and watched a guard demonstrate how a small plastic tube could help them save lives when they return to the streets of a nation gripped by an opioid epidemic. (Reuters, 10.05.2018)

https://www.reuters.com/article/us-new-york-prisons-overdoses/overdose-101-new-york-inmates-trained-to-use-opioid-antidote-kit-idUSKBN1IB2N9

Naloxon: Drogennotfallprophylaxe bei Opioidkonsumenten - Informationsportal von akzept e.V.

Ein Informationsportal von akzept e.V., gefördert von mundipharma (24.07.2018)

https://naloxoninfo.de/

Take-home naloxone toolkit

The IOTOD take-home naloxone (THN) toolkit contains guidance and resources on how to set up a THN programme, in order to reduce overdoses and save lives. (Improving Outcomes in the Treatment of Opioid Dependence (IOTOD), Mai 2018)

http://www.iotodeducation.com/resources-and-tools/thn-toolkit/

Naloxone-on-Release - Guidelines for naloxone provision upon release from custodial settings.

(...) The project, led by the Frankfurt University of Applied Science, received funding from the European Union for the period 2017-2018. It aims at addressing the gaps in the continuity of care for long-term drug users in prison and upon release, by supporting life-saving interventions for the prevention of overdoses and reduction of other risks related to drug use and for the establishment of a treatment path, which does not get interrupted upon release.

(Frankfurt University of Applied Science und ISFF – Institut für Suchtforschung Frankfurt, 2018)

https://typo3-alt.cit.frankfurt-university.de/fileadmin/de/Fachbereiche/FB4/Forschung/ISFF/Ver%C3%B6ffentlichungen/My_first_48_hours_out.pdf

Methods for delivering the UK's multi-centre prison-based naloxone-on-release pilot randomised trial (N-ALIVE): Europe's largest prison-based randomised controlled trial.

Meade AM, Bird SM, Strang J, Pepple T, Nichols LL, Mascarenhas M, Choo L, Parmar MKB.

Drug Alcohol Rev. 2018 May;37(4):487-498. doi: 10.1111/dar.12592.

https://onlinelibrary.wiley.com/doi/full/10.1111/dar.12592

UK. High risk strategy - Failure to provide naloxone at the point of release for most prisoners is putting lives at risk, says John Jolly.

Those leaving prison having had an opiate problem are seriously at risk of having a life-threatening overdose or dying as a result of one. Both Public Health England (PHE) and the government have been clear in their recommendation that all local areas need to have appropriate naloxone provision in place. However, prisons have so far failed to implement provision at the point of release across much of the estate, and this is putting lives at risk. (DDN – Drink and Drugs News, UK, 09.07.2018)

https://drinkanddrugsnews.com/high-risk-strategy