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USA. FDA Statement: Statement from FDA Commissioner Scott Gottlieb, M.D., on unprecedented new efforts to support development of over-the-counter naloxone to help reduce opioid overdose deaths

(...) To encourage drug companies to enter the OTC market and increase access to naloxone, the FDA took an unprecedented step: we developed a model DFL with easy-to-understand pictograms on how to use the drug. We also conducted label comprehension testing to ensure the instructions were simple to follow. (FDA - U.S. Food and Drug Administration, 17.01.2019)

https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm629571.htm

USA. FDA Moves to Fast-Track OTC Naloxone for Opioid Overdose

The US Food and Drug Administration (FDA) today announced "unprecedented" steps to support companies in developing over-the-counter (OTC) naloxone to help reduce opioid overdose deaths. (Medscape, 17.01.2019)

https://www.medscape.com/viewarticle/907885

USA. Naloxone Retail Dispensing Is Up 70 Percent

An awareness campaign by the U.S. Surgeon General has led to a surge in demand for the overdose-reversal drug. (The Atlantic, USA, 05.10.2018)

https://www.theatlantic.com/health/archive/2018/10/us-surgeon-general-jerome-adamss-naloxone-mission/572233/

Australien. An update on take-home naloxone knowledge amongst people who inject drugs

The Illicit Drug Reporting System (IDRS) is an ongoing illicit drug monitoring system which has been conducted in all states and territories of Australia since 2000, and forms part of Drug Trends. 

Naloxone is an opioid antagonist that is a safe and effective agent for reversing the effects of opioids, such as heroin and morphine. Since 2012, take-home programs have been established to make naloxone more widely available so that it can be administered by people other than medical professionals.

Using IDRS data from 2013 to 2018, this briefing note aims to examine knowledge of these take-home programs and naloxone more broadly, among a sample of PWID recruited as part of the IDRS in Victoria, Australia. (NDARC – National Drug & Alcohol Research Center, Australien, Januar 2019)

https://ndarc.med.unsw.edu.au/resource/update-take-home-naloxone-knowledge-amongst-people-who-inject-drugs

Naloxone - Training Video (injection)

(Drugreporter, Ungarn, 08.10.2018, Video, 08:29)

https://www.youtube.com/watch?v=2sep2lwYndo&feature

After naloxone, when can opioid overdose patients be safely discharged?

Naloxone has saved thousands of lives. But can patients be safely discharged from the Emergency Department (ED) just an hour after they receive the medication that curtails drug overdoses? (University at Buffalo, USA, 02.01.2019)

https://medicalxpress.com/news/2018-12-naloxone-opioid-overdose-patients-safely.html

Bayern startet Modellprojekt mit Naloxon

München – Anfang Oktober ist in Bayern ein Naloxon-Modellprojekt gestartet. Das hat das bayerische Gesundheitsministerium bekanntgegeben. Das Projekt zielt darauf ab, die Abgabe des Notfallmedikaments Naloxan durch speziell geschulte medizinische Laien zu ermöglichen. Bislang darf Naloxon nur von Ärzten angewandt werden. (aerzteblatt.de, 04.10.2018)

https://www.aerzteblatt.de/nachrichten/98276/Bayern-startet-Modellprojekt-mit-Naloxon

Hospital Observation Upon Reversal (HOUR) With Naloxone: A Prospective Clinical Prediction Rule Validation Study

Brian M. Clemency DO, William Eggleston PharmD, Evan W. Shaw, Michael Cheung, Nicholas S. Pokoj, Michael A. Manka MD, Donald J. Giordano, Laura Serafin, Han Yu MA, Heather A. Lindstrom PhD, David Hostler PhD

Academic Emergency Medicine 2018;00:1–9. First published: 28 December 2018, doi.org/10.1111/acem.13567

https://onlinelibrary.wiley.com/doi/10.1111/acem.13567

Huml: Naloxon-Modellprojekt ist gestartet – Bayerns Gesundheitsministerin fördert neues Hilfsangebot für Drogenabhängige mit knapp 330.000 Euro

Bayern baut die Suchthilfeangebote und die medizinische Versorgung für Drogenabhängige weiter aus. Bayerns Gesundheitsministerin Melanie Huml betonte am Mittwoch: "Das bayerische Naloxon-Modellprojekt ist Anfang Oktober gestartet. Speziell geschulte Laien können nun höchstgefährdeten Menschen im Heroin-Notfall mit Naloxon entscheidend helfen. Denn Naloxon kann die atemlähmende Wirkung von Heroin innerhalb kürzester Zeit aufheben."

Das bayerische Gesundheitsministerium fördert das Modellprojekt "BayTHN – Take-Home-Naloxon in Bayern" in den kommenden drei Jahren mit 330.000 Euro. Dabei wird ein Schulungsprogramm für medizinische Laien zum Einsatz von nasalem Take-Home-Naloxon in Notfallsituationen bei drogenabhängigen Menschen wissenschaftlich begleitet und evaluiert. (Bayerisches Staatsministerium für Gesundheit und Pflege, 03.10.2018)

https://www.stmgp.bayern.de/presse/huml-naloxon-modellprojekt-ist-gestartet-bayerns-gesundheitsministerin-foerdert-neues/

Kanada. Drug users, families advised to keep naloxone kits handy 

Island Health is advising illicit drug users and their family and friends to keep life-saving naloxone kits close at hand. (Times Colonist, Kanada, 16.12.2018)

https://www.timescolonist.com/news/local/drug-users-families-advised-to-keep-naloxone-kits-handy-1.23540053

Schottland. Fear of police stop and search can deter opioid users from carrying anti-overdose kits

(...) In Scotland, around 40,000 naloxone kits have been supplied to date. (...) This points to an urgent need for the police to reassure people that no action will be taken if they are found carrying the kits – and more generally to raise awareness around the code of practice. (theconversation.com, UK, 11.09.2018)

http://theconversation.com/fear-of-police-stop-and-search-can-deter-opioid-users-from-carrying-anti-overdose-kits-102955

USA. Drug company to offer cheaper opioid overdose treatment after hiking price 600 percent

(...) A report from the Senate’s Permanent Subcommittee on Investigations last month found that the company, Kaléo, hiked the price of its drug Evzio to $4,100 for two injectors, raising the price by more than 600 percent between 2014 and 2017. (The Hill, USA, 12.12.2018)

https://thehill.com/policy/healthcare/420971-drug-company-to-offer-cheaper-opioid-overdose-treatment-after-hiking-price

Acceptability of prison-based take-home naloxone programmes among a cohort of incarcerated men with a history of regular injecting drug use

Michael Curtis, Paul Dietze, Campbell Aitken, Amy Kirwan, Stuart A. Kinner, Tony Butler and Mark Stoové

Harm Reduction Journal 2018, 15:48, doi.org/10.1186/s12954-018-0255-5

https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-018-0255-5

Naloxone distribution and possession following a large-scale naloxone programme.

Madah-Amiri, D., Gjersing, L., and Clausen, T. (2019) 

Addiction, 114: 92–100., doi.org/10.1111/add.14425.

https://onlinelibrary.wiley.com/doi/10.1111/add.14425

USA. As opioid crisis rages, cost of overdose antidote spikes

As the opioid epidemic continues to kill tens of thousands of Americans each year, the drug naloxone has proved invaluable in preventing overdose-related deaths. Yet a spike in its cost in recent years has constrained access to naloxone, potentially depriving health care professionals, emergency responders and families of a critical treatment than can save lives. (CBS-News, Money Watch, USA, 14.08.2018)

https://www.cbsnews.com/news/as-opioids-kill-more-americans-cost-of-overdose-antidote-spikes/

USA. Generic Opioid Overdose Antidote Treatment to be Available in 2019

An authorized generic for kaléo’s naloxone HCl injection (Evzio®) will be availabile midyear in 2019, and will come with a list price of $178 per carton, each containing 2 auto-injectors. Offered through kaléo subsidiary IJ Therapeutics, the new authorized generic is the same formulation and design as the branded drug, but will have a different label. (Pharmacy Times, USA, 13.12.2018)

https://www.pharmacytimes.com/news/generic-opioid-overdose-antidote-treatment-to-be-available-in-2019

Jetzt neu: Nyxoid® – das erste Naloxon-Nasenspray in Deutschland. Notfalltherapie bei Opioid-Überdosierung

Erste Hilfe für Patienten mit Opioid-Überdosierung / Intranasal statt Injektion: keine Stichverletzungs- und Infektionsgefahr / auch im Rahmen von Naloxon-Take-Home-Projekten einsetzbar 

Limburg, 4. September 2018 (mes) – Seit 1. September 2018 ist Nyxoid®, ein Naloxon-Nasenspray, auch in Deutschland verfügbar und kann auch von geschulten medizinischen Laien appliziert werden.1 Somit können auch Angehörige und Betreuende noch vor dem Eintreffen des Notarztes schnell und wirksam auf eine Opioid-Überdosierung reagieren. Ein weiterer Vorteil der neuen Applikationsform: Nadelstichverletzungen und daraus resultierende Infektionen sind ausgeschlossen. (mundipharma, Deutschland, 04.09.2018)

PI Mundipharma Nyxoid-Launch 04092018

The Emergency Department as an Opportunity for Naloxone Distribution.

Gunn AH, Smothers ZPW, Schramm-Sapyta N, Freiermuth CE, MacEachern M, Muzyk AJ.

West J Emerg Med. 2018 Nov;19(6):1036-1042. doi: 10.5811/westjem.2018.8.38829. Epub 2018 Sep 10. Review.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225944/

Österreich. Anwendung von Nyxoid (Video)

Dieses Video beschreibt die zu ergreifenden Maßnahmen bei der Reaktion auf einen Verdacht einer Überdosierung an Opioiden, einschließlich folgender Aspekte:

Wie man die Symptome einer Überdosierung an Opioiden erkennen kann

Wie man auf eine Überdosierung an Opioiden reagieren sollte

Wie Nyxoid angewendet wird

Wie man akute Entzugserscheinungen erkennen kann

Denken Sie bitte auch daran, dass Sie eine Kurzanleitung auf der Rückseite der Nyxoid - Faltschachtel finden. (nyxoid.com/at, Österreich, 2018, Video, 05:55)

https://nyxoid.com/at/public/using-nyxoid-video

"Once I'd done it once it was like writing your name": Lived experience of take-home naloxone administration by people who inject drugs. (Zusammenfassung)

McAuley A, Munro A, Taylor A.

Int J Drug Policy. 2018 Aug;58:46-54. doi: 10.1016/j.drugpo.2018.05.002.

Zusammengefasst und kommentiert in Findings.org (UK)

https://findings.org.uk/PHP/dl.php?file=McAuley_A_8.abs&s=eb

Österreich. Nyxoid: Patienten- Informationskarte

Diese Informationen werden Ihnen dabei helfen, mehr über eine Überdosierung an Opioiden sowie über Nyxoid zu erfahren. Falls Sie spezifische Fragen zu Ihrer Gesundheit oder zur Notfallsbehandlung einer Überdosierung haben, fragen Sie bitte Ihren Arzt/Ärztin, Ihren Apotheker/in oder medizinische Fachpersonal. (nyxoid.com/at, Österreich, 2018)

https://nyxoid.com/at/public/patient-information-card

Schottland. National Naloxone Programme Scotland - Monitoring Report 2017/18

(Information Services Division - An Official Statistics publication for Scotland, 27.11.2018)

http://www.isdscotland.org/Health-Topics/Drugs-and-Alcohol-Misuse/Publications/2018-11-27/2018-11-27-Naloxone-Report.pdf

Österreich. Herzlich willkommen auf unserer Informations- und Trainingswebsite zu Nyxoid!

Finden Sie heraus, wie man eine Überdosierung an Opioiden erkennen kann und wie man auf eine derartige Überdosierung unter Nutzung des Nyxoid-Nasensprays reagieren sollte. (nyxoid.com/at, Österreich, 2018)

https://nyxoid.com/at/public/about

USA. This drug saves Americans from opioid overdoses. Its price has been hiked 600 percent. 

Amid the worst drug overdose crisis in US history, a life-saving drug’s price keeps going higher. (vox.com, USA, 19.11.2018)

https://www.vox.com/policy-and-politics/2018/11/19/18103361/opioid-overdose-naloxone-evzio-drug-prices

Nyxoid® - Produktseite (mundipharma)

Profil, Gebrauchsinformationen, Schulungsmaterial Notfalltherapie bei einer Opioid Überdosis und EducationalMaterial (Zugang nur für Fachkreise). (mundipharma.de, 2018)

https://www.mundipharma.de/protected/indikationen/substitutionstherapie/nyxoid-R.html

USA. Study indicates opioid overdose reversal products chemically stable past expiration date

A widely used naloxone nasal spray (NNS) and naloxone injection (NIJ), otherwise known as Narcan and Evzio, which are administered to prevent opioid overdose deaths, were found to be chemically stable up for at least ten months and beyond one year of the expiration date, respectively. According to the National Institute on Drug Abuse, from 1996 to 2014, at least 26,500 opioid overdoses in the U.S. were reversed by laypersons using naloxone. The research, Evaluation of Chemical Stability of Naloxone Products Beyond Their Labeled Expiration Dates, was presented today at the 2018 American Association of Pharmaceutical Scientists (AAPS) PharmSci 360 Annual Meeting. (American Association of Pharmaceutical Scientists, 06.11.2018)

https://medicalxpress.com/news/2018-11-opioid-overdose-reversal-products-chemically.html

USA. Major opioid maker to pay for overdose-antidote development

A company whose prescription opioid marketing practices are being blamed for sparking the addiction and overdose crisis says it's helping to fund an effort to make a lower-cost overdose antidote. 

OxyContin maker Purdue Pharma announced Wednesday that it's making a $3.4 million grant to Harm Reduction Therapeutics, a Pittsburgh-based nonprofit, to help develop a low-cost naloxone nasal spray. (medicalxpress.com, USA, 05.09.2018)

https://medicalxpress.com/news/2018-09-major-opioid-maker-overdose-antidote.html

USA. FDA Considers Requiring Co-Prescribing Overdose Antidote to Go Along With Opioids

The Food and Drug Administration is considering requiring doctors to prescribe an overdose reversal drug with prescription painkillers such as OxyCodone, Commissioner Scott Gottlieb announced Tuesday. (AT Forum, USA, 29.10.2018)

http://atforum.com/2018/10/fda-considers-requiring-co-prescribing-overdose-antidote-to-go-along-with-opioids/

On the front lines of the opioid epidemic: Rescue by naloxone.

Skolnick P.

Eur J Pharmacol. 2018 Sep 15;835:147-153. doi: 10.1016/j.ejphar.2018.08.004.

https://www.sciencedirect.com/science/article/pii/S0014299918304394

USA. Prescribing opioids and antidote at the same time to prevent overdose deaths

A growing number of states are requiring doctors to prescribe a drug overdose antidote alongside prescription opioid painkillers to try to reduce drug deaths. (Washington Examiner, 08.05.2018)

https://www.washingtonexaminer.com/policy/healthcare/prescribing-opioids-and-antidote-at-the-same-time-to-prevent-overdose-deaths