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USA. Allegheny County Jail to use inmate funds to supply overdose reversal kits

The Allegheny County Jail Oversight Board has approved a $75,000 disbursement from the Inmate Welfare Fund to buy 1,000 Narcan nasal spray kits to be provided to inmates as they are released from the jail. (triblive.com, USA, 05.12.2019)

https://triblive.com/local/pittsburgh-allegheny/allegheny-county-jail-board-oks-using-inmate-money-to-pay-for-overdoserecovery-kits

Take-home naloxone rescue kits following heroin overdose in the emergency department to prevent opioid overdose related repeat emergency department visits, hospitalization and death - a pilot study.

Papp J, Vallabhaneni M, Morales A, Schrock JW.

BMC Health Serv Res. 2019 Dec 11;19(1):957. doi: 10.1186/s12913-019-4734-5.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907348/

USA. Deal will let more companies make overdose antidote spray

More companies could begin making an easy-to-use version of an opioid overdose antidote under a deal announced Thursday by New York's attorney general. (MedicalXpress, USA, 02.01.2020)

https://medicalxpress.com/news/2020-01-companies-overdose-antidote.html

Treatment of acute naloxone-precipitated opioid withdrawal with buprenorphine.

Chhabra N, Aks SE.

Am J Emerg Med. 2019 Nov 16. pii: S0735-6757(19)30627-8. doi: 10.1016/j.ajem.2019.09.014. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/31753622

Use of nebulized naloxone to reverse methadone overdose - A case report and review of literature.

Sameed M, Teague H.

J Community Hosp Intern Med Perspect. 2019 Nov 1;9(5):422-424. doi: 10.1080/20009666.2019.1659664. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830244/

Effect of Intranasal vs Intramuscular Naloxone on Opioid Overdose: A Randomized Clinical Trial.

Dietze P, Jauncey M, Salmon A, Mohebbi M, Latimer J, van Beek I, McGrath C, Kerr D.

JAMA Netw Open. 2019 Nov 1;2(11):e1914977. doi: 10.1001/jamanetworkopen.2019.14977.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902775/

One opioid user saving another: the first study of an opioid overdose-reversal and naloxone distribution program addressing hard-to-reach drug scenes in Denmark.

Thylstrup, B., Hesse, M., Jørgensen, M. et al. 

Harm Reduct J 16, 66 (2019) doi:10.1186/s12954-019-0328-0

https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-019-0328-0

Sackler-owned opioid maker goes global with OD treatment

The gleaming white booth towered over the medical conference in Italy in October, advertising a new brand of antidote for opioid overdoses. “Be prepared. Get naloxone. Save a life,” the slogan on its walls said.

Some conference attendees were stunned when they saw the company logo: Mundipharma, the international affiliate of Purdue Pharma — the maker of the blockbuster opioid, OxyContin, widely blamed for unleashing the American overdose epidemic.

Here they were cashing in on a cure. (Businees Insider, 15.12.2019)

https://www.businessinsider.com/sackler-owned-opioid-maker-goes-global-with-od-treatment-2019-12

USA. New weapon in war against opioids: An implanted device that automatically releases lifesaving naloxone

An opioid overdose can be a lonely death. People who use drugs often do so in private, and should they get a dose stronger than they can tolerate, no one will be there to save them with the overdose-reversing medication naloxone. 

But now, a researcher at Northwestern University is developing a technological fix to that lethal conundrum. (MedicalXpress, USA, 05.12.2019)

https://medicalxpress.com/news/2019-12-weapon-war-opioids-implanted-device.html

Drogennotfallprophylaxe: Naloxon und Substitution - Neue Chancen?! (Präsentation)

Olaf Ostermann, Condrobs e.V. - NaSuKo – 5.Nationale Substitutionskonferenz, 27.09.2019, Berlin

https://www.akzept.eu/wp-content/uploads/2019/10/NaloxonOstermann.pdf

Australien. Personal Stories of Opioid Overdose and the Use of Take-Home Naloxone to Save Lives

Welcome to Overdose Lifesavers. This website has two aims. First, it aims to support people affected by opioid overdose and thinking about using take-home naloxone. Second, it aims to inform the public about overdose and what can be done about it. (overdoselifesavers.org, Australien, November 2019)

https://overdoselifesavers.org/

Evaluation of an interprofessional naloxone didactic and skills session with medical residents and physician assistant learners.

Hargraves D, White CC, Mauger MR, Puthota A, Pallerla H, Wigle P, Brubaker SL, Schlaudecker JD.

Pharm Pract (Granada). 2019 Jul-Sep;17(3):1591. doi: 10.18549/PharmPract.2019.3.1591.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763304/

Naloxon – Medizinische Grundlagen und internationale Erfahrungen / Naloxon – Medical basics and international experience 

Norbert Wodarz, Jörg Wolstein , Heike Wodarz-von Essen und Oliver Pogarell  

SUCHT (2019), 65, pp. 335-342. doi.org/10.1024/0939-5911/a000624

Abstract

https://econtent.hogrefe.com/doi/abs/10.1024/0939-5911/a000624

Kanada. Get naloxone – no matter how you choose to consume 

The BC Centre for Disease Control (BCCDC) is advising people who use drugs to get trained in overdose response and pick up a Take Home Naloxone kit, regardless of how they choose to consume, after new research reveals that people who smoke or snort drugs are half as likely to carry life-saving naloxone medication. (BC Centre for Disease Control, Kanada, 23.10.2019)

http://www.bccdc.ca/get-naloxone-%E2%80%93-no-matter-how-you-choose-to-consume

Kanada. Rapid increase in naloxone distribution after kits became available at Ontario pharmacies 

Almost 68,000 people received a naloxone kit from a pharmacy in the two-year study period. (eurekalert.org, 18.10.2019)

https://www.eurekalert.org/pub_releases/2019-10/smh-rii101819.php

Schottland. Police oppose naloxone overdose kits: 'not our job to save lives'

CAMPAIGNERS calling for Police Scotland officers to carry naloxone – a medication used to block the effects of opiates and save the lives of people overdosing from drugs – have reacted with anger to claims from the Scottish Police Federation that their ask goes beyond the call of duty. (The National, UK, 02.10.2019)

https://www.thenational.scot/news/17949636.police-oppose-naloxone-overdose-kits-not-job-save-lives/

Covalent Poly(lactic acid) Nanoparticles for the Sustained Delivery of Naloxone.

Kassick AJ, Allen HN, Yerneni SS, Pary F, Kovaliov M, Cheng C, Pravetoni M, Tomycz ND, Whiting DM, Nelson TL, Feasel M, Campbell PG, Kolber B, Averick S.

ACS Appl Bio Mater. 2019 Aug 19;2(8):3418-3428. doi: 10.1021/acsabm.9b00380. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731033/

Survey of Southern Wisconsin Needle Exchange Clients Regarding Opioid Overdose and Naloxone Use.

Baltes A, Devo B, Kaiser M, Birstler J, Brown RT.

WMJ. 2019 Jul;118(2):84-87. PMID: 31532934

http://www.wisconsinmedicalsociety.org/_WMS/publications/wmj/pdf/118/2/84.pdf

Naloxone nasal spray - bioavailability and absorption pattern in a phase 1 study.

Tylleskar I, Skulberg AK, Nilsen T, Skarra S, Dale O.

Tidsskr Nor Laegeforen. 2019 Sep 23;139(13). doi: 10.4045/tidsskr.19.0162. Print 2019 Sep 24. 

https://tidsskriftet.no/en/2019/09/originalartikkel/naloxone-nasal-spray-bioavailability-and-absorption-pattern-phase-1-study

Noradrenergic Mechanisms in Fentanyl-Mediated Rapid Death Explain Failure of Naloxone in the Opioid Crisis.

Torralva PR, Janowsky A.

J Pharmacol Exp Ther. 2019 Sep 6. pii: jpet.119.258566. doi: 10.1124/jpet.119.258566. 

http://jpet.aspetjournals.org/content/early/2019/09/13/jpet.119.258566.long

Bayern zieht positive Bilanz für Modellprojekt mit Naloxon

München – Mit Naloxon kann Heroin- beziehungsweisen Opioidabhängigen bei einem Atemstillstand schnell geholfen werden – seit einem Jahr unterstützt der Freistaat Bayern ein Modellprojekt, bei dem Laien der Umgang mit dem Gegenmittel beigebracht wird. Bayerns Gesundheitsministerin Melanie Huml (CSU) zog vorgestern in München eine positive Bilanz. (aerzteblatt.de, 30.09.2019)

https://www.aerzteblatt.de/nachrichten/106366/Bayern-zieht-positive-Bilanz-fuer-Modellprojekt-mit-Naloxon

Naloxon: Evaluation der Peer-Informations-Veranstaltungen -- Münster, Februar 2019

Eva Gesigora, Ralf Gerlach 

Institut zur Förderung qualitativer Drogenforschung, akzeptierender Drogenarbeit und rationaler Drogenpolitik (INDRO) e.V.

http://www.landesstellesucht-nrw.de/tl_files/Projektdatenbank/Naloxonevaluation.pdf

NYXOID®– Naloxon Nasenspray: Schulungsvideo

Mundipharma, 2019, Video, 05:50

https://www.mundipharma.de/wp-content/uploads/schulungsmaterial/nyoxid/Nyxoid_Langversion_mit_Sprecher.mp4

Bayern. Naloxon Take-Home Kits: Schulung Betroffener (und Peers) – ein Modellprojekt in Bayern

N.Wodarz, H. Wodarz-von Essen, j.Wollstein, O.Pogarell

Präsentation auf dem 20. Interdisziplinären Kongress für Sucht-Medizin, 04.07. bis 06.07.2019 in München

Wodarz Take Home Naloxon Modellprojekt Bayern2019.pdf

Vital Signs: Pharmacy-Based Naloxone Dispensing - United States, 2012-2018.

Guy GP Jr, Haegerich TM, Evans ME, Losby JL, Young R, Jones CM.

MMWR Morb Mortal Wkly Rep. 2019 Aug 9;68(31):679-686. doi: 10.15585/mmwr.mm6831e1.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687198/

Naloxone as a technology of solidarity: history of opioid overdose prevention

Nancy D. Campbell

CMAJ August 26, 2019 191 (34) E945-E946; doi.org/10.1503/cmaj.190257 

http://www.cmaj.ca/content/191/34/E945

USA. Drug Overdose Prevention & Education (DOPE) Project: San Francisco

Currently, the DOPE Project is the largest single-city naloxone distribution program in the country, responsible for training over 13,000 people in San Francisco(with that number growing every day!). People who use drugs, their loved ones, and surrounding community are responsible for reversing on average 1,500 overdoses a year with DOPE Project naloxone. (2019)

https://harmreduction.org/issues/overdose-prevention/dope-sf

EMCDDA. Take-home naloxone

Introduction: What is naloxone and why is it important?

Drug overdose continues to be the main cause of death among problem drug users. Heroin or other opioids — often consumed alongside other central nervous system depressants such as benzodiazepines and alcohol — are present in the majority of reported fatal overdoses (1). Overdose is common among opioid users: many of them have experienced a non-fatal overdose and most have witnessed one. Death from opioid overdose is caused primarily by respiratory depression leading to cardiac arrest.

Opioid overdose deaths can be prevented through timely administration of naloxone, a potent opioid antagonist drug that rapidly reverses the effects of opioid analgesics by binding to the opioid receptors in the central nervous system (see Spotlight: Naloxone). Because of its effectiveness, naloxone is used by emergency personnel worldwide (2). (EMCDDA, Lissabon, August 2019)

http://www.emcdda.europa.eu/publications/topic-overviews/take-home-naloxone_en

USA. Naloxone: Wide distribution effective in preventing deaths

ANN ARBOR—Broad distribution of the opioid reversal drug naloxone is highly cost-effective in reducing fatal overdoses, according to a new University of Michigan study.

The researchers examined the cost-effectiveness of increased distribution of naloxone to laypeople likely to witness or experience overdose, police and firefighters, and emergency medical services. (University of Michigan, USA, 20.08.2019)

https://news.umich.edu/naloxone-wide-distribution-effective-in-preventing-deaths/

The relationship between pupil diameter and other measures of opioid withdrawal during naloxone precipitated withdrawal.

Bergeria CL, Huhn AS, Tompkins DA, Bigelow GE, Strain EC, Dunn KE.

Drug Alcohol Depend. 2019 Sep 1;202:111-114. doi: 10.1016/j.drugalcdep.2019.05.010.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/31336328