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Naloxon
- Higher doses of naloxone are needed in the synthetic opiod era
Frankfurt/M. Verabreichung des Medikaments Naloxon als Nasenspray (Handelsname Nyxoid®) im Notfall durch idh-Mitarbeiter*innen
Mit der verschärften Lage auf dem Markt für illegale Drogen ist auch mit dem vermehrten Auftreten von Überdosierungen zu rechnen. In den Konsumräumen, Notschlafstellen, im Streetwork und im Nachtbus des Frankfurter Trägers Integrative Drogenhilfe e.V. (idh) stehen bereits Nyxoid-Nasensprays (Naloxon) als leicht zu handhabendes Notfallmedikament zur Verfügung. “Sobald wir genügend Nasensprays haben, erhalten es auch unsere anderen Angebote,“ schreibt Gabi Bescker, Geschäftsführerin bei idh.
Am 20.03.2020 hat sie dieses Informationsschreiben an ihre Mitarbeiter*innen gerichtet.
Frankkfurt idh Naloxon Anschreiben.pdf
Association of Take-Home Naloxone and Opioid Overdose Reversals Performed by Patients in an Opioid Treatment Program.
Katzman JG, Takeda MY, Greenberg N, Moya Balasch M, Alchbli A, Katzman WG, Salvador JG, Bhatt SR.
JAMA Netw Open. 2020 Feb 5;3(2):e200117. doi: 10.1001/jamanetworkopen.2020.0117.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2761870
Association Between a State Law Allowing Pharmacists to Dispense Naloxone Without a Prescription and Naloxone Dispensing Rates.
Gangal NS, Hincapie AL, Jandarov R, Frede SM, Boone JM, MacKinnon NJ, Koechlin K, DeFiore-Hyrmer J, Holthusen A, Heaton PC.
JAMA Netw Open. 2020 Jan 3;3(1):e1920310. doi: 10.1001/jamanetworkopen.2019.20310.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2759842
USA. Life-Saving Naloxone from Pharmacies - More dispensing needed despite progress (free CE)
FREE webinar featuring the U.S. Surgeon General and a CDC opioid expert. CDC - U.S. Centers for Disease Control and Prevention, Vital Signs, August 2019)
https://www.cdc.gov/vitalsigns/naloxone/
Take-home naloxone program is a priority in Iran.
Mehrpour O.
J Res Med Sci. 2019 Dec 23;24:111. doi: 10.4103/jrms.JRMS_480_19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950333/
Naloxone dosing in the era of ultra-potent opioid overdoses: a systematic review.
Moe J, Godwin J, Purssell R, O'Sullivan F, Hau JP, Purssell E, Curran J, Doyle-Waters MM, Brasher PMA, Buxton JA, Hohl CM.
CJEM. 2020 Jan 20:1-9. doi: 10.1017/cem.2019.471.
Abstract
https://www.ncbi.nlm.nih.gov/pubmed/31955714
Preventing opioid overdose with peer-administered naloxone: findings from a rural state.
Hanson BL, Porter RR, Zöld AL, Terhorst-Miller H.
Harm Reduct J. 2020 Jan 9;17(1):4. doi: 10.1186/s12954-019-0352-0.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953279/
USA. Could a Naloxone Implant Have a Major Impact on the Overdose Crisis?
Researchers in Illinois are developing a novel device to rapidly and automatically administer the opioid overdose antidote naloxone. Smaller than a pacemaker, it would be implanted in a person’s body. When it detects signs of an overdose, it would release naloxone—and even place a 911 call. (Filter, USA, 28.01.2020)
https://filtermag.org/naloxone-implant/
USA. Allegheny County Jail to use inmate funds to supply overdose reversal kits
The Allegheny County Jail Oversight Board has approved a $75,000 disbursement from the Inmate Welfare Fund to buy 1,000 Narcan nasal spray kits to be provided to inmates as they are released from the jail. (triblive.com, USA, 05.12.2019)
https://triblive.com/local/pittsburgh-allegheny/allegheny-county-jail-board-oks-using-inmate-money-to-pay-for-overdoserecovery-kits
Take-home naloxone rescue kits following heroin overdose in the emergency department to prevent opioid overdose related repeat emergency department visits, hospitalization and death - a pilot study.
Papp J, Vallabhaneni M, Morales A, Schrock JW.
BMC Health Serv Res. 2019 Dec 11;19(1):957. doi: 10.1186/s12913-019-4734-5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907348/
USA. Deal will let more companies make overdose antidote spray
More companies could begin making an easy-to-use version of an opioid overdose antidote under a deal announced Thursday by New York's attorney general. (MedicalXpress, USA, 02.01.2020)
https://medicalxpress.com/news/2020-01-companies-overdose-antidote.html
Treatment of acute naloxone-precipitated opioid withdrawal with buprenorphine.
Chhabra N, Aks SE.
Am J Emerg Med. 2019 Nov 16. pii: S0735-6757(19)30627-8. doi: 10.1016/j.ajem.2019.09.014.
Abstract
https://www.ncbi.nlm.nih.gov/pubmed/31753622
Use of nebulized naloxone to reverse methadone overdose - A case report and review of literature.
Sameed M, Teague H.
J Community Hosp Intern Med Perspect. 2019 Nov 1;9(5):422-424. doi: 10.1080/20009666.2019.1659664.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830244/
Effect of Intranasal vs Intramuscular Naloxone on Opioid Overdose: A Randomized Clinical Trial.
Dietze P, Jauncey M, Salmon A, Mohebbi M, Latimer J, van Beek I, McGrath C, Kerr D.
JAMA Netw Open. 2019 Nov 1;2(11):e1914977. doi: 10.1001/jamanetworkopen.2019.14977.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902775/
One opioid user saving another: the first study of an opioid overdose-reversal and naloxone distribution program addressing hard-to-reach drug scenes in Denmark.
Thylstrup, B., Hesse, M., Jørgensen, M. et al.
Harm Reduct J 16, 66 (2019) doi:10.1186/s12954-019-0328-0
https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-019-0328-0
Sackler-owned opioid maker goes global with OD treatment
The gleaming white booth towered over the medical conference in Italy in October, advertising a new brand of antidote for opioid overdoses. “Be prepared. Get naloxone. Save a life,” the slogan on its walls said.
Some conference attendees were stunned when they saw the company logo: Mundipharma, the international affiliate of Purdue Pharma — the maker of the blockbuster opioid, OxyContin, widely blamed for unleashing the American overdose epidemic.
Here they were cashing in on a cure. (Businees Insider, 15.12.2019)
https://www.businessinsider.com/sackler-owned-opioid-maker-goes-global-with-od-treatment-2019-12
USA. New weapon in war against opioids: An implanted device that automatically releases lifesaving naloxone
An opioid overdose can be a lonely death. People who use drugs often do so in private, and should they get a dose stronger than they can tolerate, no one will be there to save them with the overdose-reversing medication naloxone.
But now, a researcher at Northwestern University is developing a technological fix to that lethal conundrum. (MedicalXpress, USA, 05.12.2019)
https://medicalxpress.com/news/2019-12-weapon-war-opioids-implanted-device.html
Drogennotfallprophylaxe: Naloxon und Substitution - Neue Chancen?! (Präsentation)
Olaf Ostermann, Condrobs e.V. - NaSuKo – 5.Nationale Substitutionskonferenz, 27.09.2019, Berlin
https://www.akzept.eu/wp-content/uploads/2019/10/NaloxonOstermann.pdf
Australien. Personal Stories of Opioid Overdose and the Use of Take-Home Naloxone to Save Lives
Welcome to Overdose Lifesavers. This website has two aims. First, it aims to support people affected by opioid overdose and thinking about using take-home naloxone. Second, it aims to inform the public about overdose and what can be done about it. (overdoselifesavers.org, Australien, November 2019)
https://overdoselifesavers.org/
Evaluation of an interprofessional naloxone didactic and skills session with medical residents and physician assistant learners.
Hargraves D, White CC, Mauger MR, Puthota A, Pallerla H, Wigle P, Brubaker SL, Schlaudecker JD.
Pharm Pract (Granada). 2019 Jul-Sep;17(3):1591. doi: 10.18549/PharmPract.2019.3.1591.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763304/
Naloxon – Medizinische Grundlagen und internationale Erfahrungen / Naloxon – Medical basics and international experience
Norbert Wodarz, Jörg Wolstein , Heike Wodarz-von Essen und Oliver Pogarell
SUCHT (2019), 65, pp. 335-342. doi.org/10.1024/0939-5911/a000624
Abstract
https://econtent.hogrefe.com/doi/abs/10.1024/0939-5911/a000624
Kanada. Get naloxone – no matter how you choose to consume
The BC Centre for Disease Control (BCCDC) is advising people who use drugs to get trained in overdose response and pick up a Take Home Naloxone kit, regardless of how they choose to consume, after new research reveals that people who smoke or snort drugs are half as likely to carry life-saving naloxone medication. (BC Centre for Disease Control, Kanada, 23.10.2019)
http://www.bccdc.ca/get-naloxone-%E2%80%93-no-matter-how-you-choose-to-consume
Kanada. Rapid increase in naloxone distribution after kits became available at Ontario pharmacies
Almost 68,000 people received a naloxone kit from a pharmacy in the two-year study period. (eurekalert.org, 18.10.2019)
https://www.eurekalert.org/pub_releases/2019-10/smh-rii101819.php
Schottland. Police oppose naloxone overdose kits: 'not our job to save lives'
CAMPAIGNERS calling for Police Scotland officers to carry naloxone – a medication used to block the effects of opiates and save the lives of people overdosing from drugs – have reacted with anger to claims from the Scottish Police Federation that their ask goes beyond the call of duty. (The National, UK, 02.10.2019)
https://www.thenational.scot/news/17949636.police-oppose-naloxone-overdose-kits-not-job-save-lives/
Covalent Poly(lactic acid) Nanoparticles for the Sustained Delivery of Naloxone.
Kassick AJ, Allen HN, Yerneni SS, Pary F, Kovaliov M, Cheng C, Pravetoni M, Tomycz ND, Whiting DM, Nelson TL, Feasel M, Campbell PG, Kolber B, Averick S.
ACS Appl Bio Mater. 2019 Aug 19;2(8):3418-3428. doi: 10.1021/acsabm.9b00380.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731033/
Survey of Southern Wisconsin Needle Exchange Clients Regarding Opioid Overdose and Naloxone Use.
Baltes A, Devo B, Kaiser M, Birstler J, Brown RT.
WMJ. 2019 Jul;118(2):84-87. PMID: 31532934
http://www.wisconsinmedicalsociety.org/_WMS/publications/wmj/pdf/118/2/84.pdf
Naloxone nasal spray - bioavailability and absorption pattern in a phase 1 study.
Tylleskar I, Skulberg AK, Nilsen T, Skarra S, Dale O.
Tidsskr Nor Laegeforen. 2019 Sep 23;139(13). doi: 10.4045/tidsskr.19.0162. Print 2019 Sep 24.
Noradrenergic Mechanisms in Fentanyl-Mediated Rapid Death Explain Failure of Naloxone in the Opioid Crisis.
Torralva PR, Janowsky A.
J Pharmacol Exp Ther. 2019 Sep 6. pii: jpet.119.258566. doi: 10.1124/jpet.119.258566.
http://jpet.aspetjournals.org/content/early/2019/09/13/jpet.119.258566.long
Bayern zieht positive Bilanz für Modellprojekt mit Naloxon
München – Mit Naloxon kann Heroin- beziehungsweisen Opioidabhängigen bei einem Atemstillstand schnell geholfen werden – seit einem Jahr unterstützt der Freistaat Bayern ein Modellprojekt, bei dem Laien der Umgang mit dem Gegenmittel beigebracht wird. Bayerns Gesundheitsministerin Melanie Huml (CSU) zog vorgestern in München eine positive Bilanz. (aerzteblatt.de, 30.09.2019)
Naloxon: Evaluation der Peer-Informations-Veranstaltungen -- Münster, Februar 2019
Eva Gesigora, Ralf Gerlach
Institut zur Förderung qualitativer Drogenforschung, akzeptierender Drogenarbeit und rationaler Drogenpolitik (INDRO) e.V.
http://www.landesstellesucht-nrw.de/tl_files/Projektdatenbank/Naloxonevaluation.pdf
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