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A Study on the Efficacy of a Naloxone Training Program. 

Beauchamp GA, Cuadrado HM, Campbell S, Eliason BB, Jones CL, Fedor AT, Grantz L, Roth P, Greenberg MR. 

Cureus. 2021 Nov 23;13(11):e19831. doi: 10.7759/cureus.19831. PMID: 34963847; PMCID: PMC8697700.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8697700/

Urban Expansion of the SAFE-Home Opioid Management Education (SAFE-HOME) Naloxone Awareness Initiative for Home Health Workers and Older Adults. 

Elmes AT, McQuade BM, Koronkowski M, Emery-Tiburcio E, Jarrett JB. 

Pharmacy (Basel). 2021 Dec 15;9(4):200. doi: 10.3390/pharmacy9040200. PMID: 34941632; PMCID: PMC8704238.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704238/

SAFE - Home Opioid Management Education (SAFE-HOME) in older adults: a naloxone awareness program for home health workers. 

McQuade BM, Koronkowski M, Emery-Tiburcio E, Golden R, Jarrett JB. 

Drugs Context. 2021 Dec 15;10:2021-7-6. doi: 10.7573/dic.2021-7-6. PMID: 34970322; PMCID: PMC8687098.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687098/

Opioide: Tragbares Gerät injiziert Gegenmittel Naloxon bei Bedarf

Seattle – Ein Closed-Loop-System aus 2 Akzelerometern, die Atempausen erkennen, einem Chip, der Alarm schlägt, und einer Medikamentenpumpe, wie dann das Antidot Naloxon injiziert, könnte Opioidabhängigen nach einer Überdosis das Leben retten. US-Ingenieure haben ihren Prototyp in einer Studie in Scientific Reports (2021; DOI: 10.1038/s41598-021-01990-0) an Gesunden und Drogenkonsumenten getestet. (aerzteblatt.de, 06.01.2022)

https://www.aerzteblatt.de/nachrichten/129376/Opioide-Tragbares-Geraet-injiziert-Gegenmittel-Naloxon-bei-Bedarf

Closed-loop wearable naloxone injector system. 

Chan, J., Iyer, V., Wang, A. et al.

Sci Rep 11, 22663 (2021). doi.org/10.1038/s41598-021-01990-0

https://www.nature.com/articles/s41598-021-01990-0

‘We’re making harm reduction cool’: overdose reversal Narcan becomes a rave essential

As recreational drugs like cocaine are increasingly cut with fentanyl, a movement has sprung up to prevent deaths in nightclubs. (The Guardian, UK, 31.12.2021)

https://www.theguardian.com/society/2021/dec/31/us-overdose-antidote-narcan-rave-essential

USA. NYC Vending Machines to Distribute Free Naloxone and Other Supplies

Before the end of 2022, New York City residents should be able to access naloxone, sterile syringes and other harm reduction supplies from a handful of public vending machines—for free. It’s a new approach from the city, where drug overdoses are continuing to rise, especially for Black residents. (Filter, USA, 06.01.2022)

https://filtermag.org/naloxone-vending-machines-new-york/

Increasingly powerful opioid antagonists are not necessary. 

Hill LG, Zagorski CM, Loera LJ. 

Int J Drug Policy. 2021 Sep 21;99:103457. doi: 10.1016/j.drugpo.2021.103457. Epub ahead of print. PMID: 34560623; PMCID: PMC8454200.

https://www.sciencedirect.com/science/article/pii/S0955395921003625

Take-Home Naloxone and the Prevention of Deaths from Heroin Overdose: Pursuing Strong Science, Fuller Understanding, Greater Impact. 

Strang J. 

Eur Addict Res. 2021 Dec 28:1-15. doi: 10.1159/000519939. Epub ahead of print. PMID: 34963112.

https://www.karger.com/Article/FullText/519939#

USA. To save lives, overdose antidote should be sold over-the-counter, advocates argue

Louise Vincent figures her group, the North Carolina Survivors Union, saves at least 1,690 lives a year.

The harm-reduction and syringe service program in Greensboro, N.C., distributes the opioid overdose reversal medication naloxone to people who use drugs. Research suggests this approach is effective, since people who use drugs are most likely to witness an overdose and administer naloxone. (npr – National Public Radio, USA, 14.12.2021)

https://www.npr.org/sections/health-shots/2021/12/14/1063865914/to-save-lives-overdose-antidote-should-be-sold-over-the-counter-advocates-argue

Community Distribution of Naloxone: A Systematic Review of Economic Evaluations. 

Cherrier N, Kearon J, Tetreault R, Garasia S, Guindon E. 

Pharmacoecon Open. 2021 Nov 11:1–14. doi: 10.1007/s41669-021-00309-z. Epub ahead of print. PMID: 34762276; PMCID: PMC8581604.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581604/

Frequently asked questions about naloxone: Part 2. 

Cid A, Patten A, Grindrod K, Beazely MA. 

Can Pharm J (Ott). 2021 Oct 4;154(6):385-387. doi: 10.1177/17151635211045966. PMID: 34777648; PMCID: PMC8581805.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581805/

Reversal of Opioid Intoxication in an Infant With Intrauterine Growth Restriction With a Single Dose of Naloxone. 

Timalsina U, Andrasovich A, Kupferman FE, Viswanathan K, Ericksen K. 

Cureus. 2021 Oct 19;13(10):e18908. doi: 10.7759/cureus.18908. PMID: 34804741; PMCID: PMC8599436.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599436/

Do naloxone access laws affect perceived risk of heroin use? Evidence from national US data. 

Kelly, BC, Vuolo, M. 

Addiction. 2021; 1– 11. doi.org/10.1111/add.15682

https://onlinelibrary.wiley.com/doi/10.1111/add.15682

UK. Weston-super-Mare: Former drug user being trained to save lives

Former drug users are being trained in how to use medication which can save the lives of people who have overdosed. (BBC, UK, 30.11.2021)

https://www.bbc.com/news/uk-england-somerset-59482427

Australien. Improved naloxone access can prevent prescription opioid overdose deaths

Making the opioid overdose antidote naloxone easily accessible and available free-of-charge to people who are prescribed opioids in Australia would be cost-effective and save hundreds of lives, new Burnet Institute research demonstrates. (Burnet Institute, Australien, 19.11.2021)

https://www.burnet.edu.au/news/1546_improved_naloxone_access_can_prevent_prescription_opioid_overdose_deaths

Does naloxone provision lead to increased substance use? A systematic review to assess if there is evidence of a 'moral hazard' associated with naloxone supply. 

Tse WC, Djordjevic F, Borja V, Picco L, Lam T, Olsen A, Larney S, Dietze P, Nielsen S. 

Int J Drug Policy. 2021 Nov 16;100:103513. doi: 10.1016/j.drugpo.2021.103513. Epub ahead of print. PMID: 34798434.

https://www.sciencedirect.com/science/article/abs/pii/S095539592100431X?dgcid=coauthor#!

Long-term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox. 

Zamora JC, Smith HR, Jennings EM, Chavera TS, Kotipalli V, Jay A, Husbands SM, Disney A, Berg KA, Clarke WP. 

Pharmacol Res Perspect. 2021 Dec;9(6):e00887. doi: 10.1002/prp2.887. PMID: 34713624; PMCID: PMC8554411.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554411/

Adverse events related to bystander naloxone administration in cases of suspected opioid overdose in British Columbia: An observational study. 

Moustaqim-Barrette A, Papamihali K, Williams S, Ferguson M, Moe J, Purssell R, Buxton JA. 

PLoS One. 2021 Oct 29;16(10):e0259126. doi: 10.1371/journal.pone.0259126. PMID: 34714854; PMCID: PMC8555799.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555799/

Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators. 

Ayoub SM, Piscitelli F, Silvestri C, Limebeer CL, Rock EM, Smoum R, Farag M, de Almeida H, Sullivan MT, Lacroix S, Boubertakh B, Nallabelli N, Lichtman AH, Leri F, Mechoulam R, Di Marzo V, Parker LA. 

Front Pharmacol. 2021 Sep 15;12:706703. doi: 10.3389/fphar.2021.706703. PMID: 34603019; PMCID: PMC8479102.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479102/

Multi-informant Implementation and Intervention Outcomes of Opioid Overdose Education and Naloxone Distribution in New York City. 

Brandt L, Yanagida T, Campbell ANC, Jones JD, Schultes MT, Martinez S, Comer SD. 

Glob Implement Res Appl. 2021 Sep 20;1(3):1-14. doi: 10.1007/s43477-021-00021-4. Epub ahead of print. PMID: 34622215; PMCID: PMC8450721.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450721/

UK. Lifesaving antidote to be given to drug users as they leave custody

West Midlands Police has begun offering people with Class A drug addictions a lifesaving overdose antidote as they are released from custody as part of our wider harm reduction strategy.

The scheme, which is funded by the Police and Crime Commissioner Simon Foster, will hand drug users a medicine called Naloxone, which can reverse the effects of an overdose. (west midlands police and crime commissioner, UK, 03.11.2021)

https://www.westmidlands-pcc.gov.uk/lifesaving-antidote-to-be-given-to-drug-users-as-they-leave-custody/

NALtrain. 1. NALtrain Newsletter erschienen

Der Newsletter des Bundesmodellprojekts NALtrain informiert alle Kooperationspartner*innen und alle Interessierten über den Projektverlauf, die bisher erreichten Meilensteine und Ziele. Wir freuen uns sehr Ihnen den erten Newsletter vorstellen zu können. (DAH – Deutsche AIDS-Hilfe, 01.11.2021)

https://www.naloxontraining.de/wp-content/uploads/2021/11/NALtrainNewsletter1OktNov2021f1.pdf

USA. FDA approves naloxone injection to counteract opioid overdoses

Action: FDA has approved ZIMHI (naloxone hydrochloride) injection as an additional option to treat opioid overdose. ZIMHI is administered using a single-dose, prefilled syringe that delivers 5 milligrams (mg) of naloxone hydrochloride solution through intramuscular (in the muscle) or subcutaneous (under the skin) injection.

FDA has previously approved injectable naloxone hydrochloride products in 0.4 mg and 2 mg doses under the trade name, NARCAN. (FDA – US Food and Drug Administration, USA, 18.10.2021)

https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-naloxone-injection-counteract-opioid-overdoses

USA. Price for drug that reverses opioid overdoses soars amid record deaths

Pfizer manufacturing problems leave nonprofits paying exorbitant prices for dwindling supplies of life-saving naloxone. (The Guardian, UK, 19.10.2021)

https://www.theguardian.com/us-news/2021/oct/19/naloxone-price-soars-opioid-overdoses

Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent. 

Hedrick SL, Luo D, Kaska S, Niloy KK, Jackson K, Sarma R, Horn J, Baynard C, Leggas M, Butelman ER, Kreek MJ, Prisinzano TE. 

J Biomed Sci. 2021 Sep 9;28(1):62. doi: 10.1186/s12929-021-00758-y. PMID: 34503531; PMCID: PMC8427951.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427951/

Frequently asked questions about naloxone: Part 1. 

Cid A, Patten A, Grindrod K, Beazely MA. 

Can Pharm J (Ott). 2021 Aug 16;154(5):301-304. doi: 10.1177/17151635211034528. PMID: 34484479; PMCID: PMC8408911.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408911/

Fentanyl causes naloxone-resistant vocal cord closure: A platform for testing opioid overdose treatments. 

Miner NB, Schutzer WE, Zarnegarnia Y, Janowsky A, Torralva R. 

Drug Alcohol Depend. 2021 Oct 1;227:108974. doi: 10.1016/j.drugalcdep.2021.108974. Epub 2021 Aug 28. PMID: 34492557.

Abstract

https://pubmed.ncbi.nlm.nih.gov/34492557/

UK. Community pharmacy pilot provides hundreds of take-home naloxone kits in one year

Exclusive: The naloxone pilot, set up by charity Turning Point, in Somerset and Wakefield has reported providing more than 330 kits to patients in its first year. (The Pharmaceutical Journal, UK, 07.09.2021)

https://pharmaceutical-journal.com/article/news/community-pharmacy-pilot-provides-hundreds-of-take-home-naloxone-kits-in-one-year

Naloxon: Modellprojekt in Bayern erfolgreich verlaufen

München – Ein Naloxon-Modellprojekt ist nach Aussagen der Landesregierung in Bayern erfolgreich verlaufen. Das teilte heute der bayerische Gesundheitsminister Klaus Holetschek (CSU) mit. Demnach hat das Nasenspray 92 Menschen in Bayern bei Heroin- und anderen Opiatüberdosen das Leben gerettet. (arzteblatt.de, 09.09.2021)

https://www.aerzteblatt.de/nachrichten/127159/Naloxon-Modellprojekt-in-Bayern-erfolgreich-verlaufen