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Buprenorphin-Naloxone: Mundipharma bringt Zubsolv®

Berlin- Die Substitutionstherapie opioidabhängiger Patienten erfolgt durch medizinische, soziale und psychotherapeutische Maßnahmen. Mundipharma bringt mit Zubsolv neue Sublingualtabletten mit Buprenorphin und Naloxon auf den Markt. (apotheke adhoc, 17.05.2018)


Pharmacokinetic and pharmaceutical properties of a novel buprenorphine/naloxone sublingual tablet for opioid substitution therapy versus conventional buprenorphine/naloxone sublingual tablet in healthy volunteers.

Jönsson M, Mundin G, Sumner M.

Eur J Pharm Sci. 2018 Jun 22;122:125-133. doi: 10.1016/j.ejps.2018.06.024.



Effectiveness of Tapering from Methadone or Buprenorphine Maintenance Treatment Compared to Traditional Maintenance Treatment for People with Opiate Addiction: Systematic Review [Internet].

Dalsbø TK, Steiro A, Strømme H, Reinar LM.

Oslo, Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2017 Mar 2.


Primary Care and the Opioid-Overdose Crisis — Buprenorphine Myths and Realities

Sarah E. Wakeman, M.D., and Michael L. Barnett, M.D.

N Engl J Med 2018; 379:1-4, DOI: 10.1056/NEJMp1802741


Buprenorphine Maintenance Subjects Are Hyperalgesic and Have No Antinociceptive Response to a Very High Morphine Dose.

Athanasos P, Ling W, Bochner F, White JM, Somogyi AA.

Pain Med. 2018 Mar 5. doi: 10.1093/pm/pny025.



Weekly and Monthly Subcutaneous Buprenorphine Depot Formulations vs Daily Sublingual Buprenorphine With Naloxone for Treatment of Opioid Use Disorder: A Randomized Clinical Trial.

Lofwall MR, Walsh SL, Nunes EV, Bailey GL, Sigmon SC, Kampman KM, Frost M, Tiberg F, Linden M, Sheldon B, Oosman S, Peterson S, Chen M, Kim S.

JAMA Intern Med. 2018 May 14. doi: 10.1001/jamainternmed.2018.1052.



Transferring Patients From Methadone to Buprenorphine: The Feasibility and Evaluation of Practice Guidelines.

Lintzeris N, Monds LA, Rivas C, Leung S, Dunlop A, Newcombe D, Walters C, Galea S, White N, Montebello M, Demirkol A, Swanson N, Ali R.

J Addict Med. 2018 Mar 5. doi: 10.1097/ADM.0000000000000396.



Die Umstellung von y-Agonisten auf Buprenorphin

Dr.med.F. Matschinski, Schwerpunktpraxis für Suchtmedizin Ravensburg

Präsentation (Folien) von der DSÄ-Fortbildungsveranstaltung vom 14.04. in Köln-Sürth


Umstellung von Methadon / Polamidon auf Buprenorphin – die Ravensburger Strategie

Dr.med. Frank Matschinski; SchwerPunktPraxis Ravensburg, 2013


Frontline Science: Buprenorphine decreases CCL2-mediated migration of CD14+ CD16+ monocytes.

Jaureguiberry-Bravo M, Lopez L, Berman JW.

J Leukoc Biol. 2018 May 23. doi: 10.1002/JLB.3HI0118-015R. 



Buprenorphin-Depot: FDA issues complete response letter for CAM2038 for opioid use disorder

Lund, Sweden — 21 January 2018 — Camurus (NASDAQ STO: CAMX) today announced that the US Food and Drug Administration (FDA) has issued a complete response letter (CRL) for the new drug application (NDA) for CAM2038, investigational buprenorphine weekly and monthly depot injections, for the treatment of adults with opioid use disorder (OUD). The FDA has requested additional information to complete the review. There is no need for new clinical studies and the Agency’s requests will be addressed in a timely manner.

“The FDA has issued a complete response letter that will serve as road map for approval and we are confident that the questions raised by the Agency can be effectively managed and resolved”, said Fredrik Tiberg, President & CEO of Camurus. ”Our US partner Braeburn Pharmaceuticals will work closely with the FDA with the goal of bringing CAM2038 to market as quickly as possible.”

CAM2038 has received Fast Track status for treatment of OUD. The NDA was granted FDA Priority Review on 18 September 2017 and FDA Advisory Committee recommended approval on 1 November 2017. If approved, CAM2038 would be the first and only long-acting injectable for individualized treatment of OUD that can be used from start of treatment Day 1 and throughout patients' recovery. (Camurus, Lund/Schweden, 21.01.2018)


USA. San Francisco will bring anti-addiction medication to users on the streets

(...) The city announced Thursday that its medical providers will offer buprenorphine and naltrexone prescriptions at needle exchanges, in parks and in other places where people with opioid disorders congregate. Users will be able to pick up the medications, which block the craving for opioids and the painful symptoms of withdrawal, at a centrally located city-run pharmacy. (Washington Post, 17.05.2018)


Buprenorphine alone or with naloxone: Which is safer?

Kelty E, Cumming C, Troeung L, Hulse G.

J Psychopharmacol. 2018 Feb 1:269881118756015. doi: 10.1177/0269881118756015.



The OPTIMA study, buprenorphine/naloxone and methadone models of care for the treatment of prescription opioid use disorder: Study design and rationale.

Socias ME, Ahamad K, Le Foll B, Lim R, Bruneau J, Fischer B, Wild TC, Wood E, Jutras-Aswad D.

Contemp Clin Trials. 2018 Apr 5;69:21-27. doi: 10.1016/j.cct.2018.04.001.



Conversion of chronic pain patients from full-opioid agonists to sublingual buprenorphine.

Daitch J, Frey ME, Silver D, Mitnick C, Daitch D, Pergolizzi J Jr.

Pain Physician. 2012 Jul;15(3 Suppl):ES59-66.


Using ecological momentary assessment to examine the relationship between craving and affect with opioid use in a clinical trial of clonidine as an adjunct medication to buprenorphine treatment.

Kowalczyk WJ, Moran LM, Bertz JW, Phillips KA, Ghitza UE, Vahabzadeh M, Lin JL, Epstein DH, Preston KL.

Am J Drug Alcohol Abuse. 2018 Apr 10:1-10. doi: 10.1080/00952990.2018.1454933.



The Pharmacokinetics and Local Tolerability of a Novel Sublingual Formulation of Buprenorphine.

Lim SCB, Schug S, Krishnarajah J.

Pain Med. 2018 Jan 3. doi: 10.1093/pm/pnx321.



Risky Sexual Behavior among Individuals receiving Buprenorphine/Naloxone Opiate Dependency Treatment: HIV Prevention Trials Network (HPTN) 058.

Shava E, Lipira LE, Beauchamp GG, Donnell DJ, Lockman S, Ruan Y, Shao Y.

J Acquir Immune Defic Syndr. 2018 Mar 19. doi: 10.1097/QAI.0000000000001683.

Abstract/accepted article


Buprenorphine Formulations: Clinical Best Practice Strategies Recommendations for Perioperative Management of Patients Undergoing Surgical or Interventional Pain Procedures.

Jonan AB, Kaye AD, Urman RD.

Pain Physician. 2018 Jan;21(1):E1-E12.


Does Cannabis Use Influence Opioid Outcomes and Quality of Life Among Buprenorphine Maintained Patients? A Cross-sectional, Comparative Study.

Bagra I, Krishnan V, Rao R, Agrawal A.

J Addict Med. 2018 Mar 14. doi: 10.1097/ADM.0000000000000406.



Breathing Problems Linked to Drug that Treats Opioid Addiction

A drug used to treat opioid addiction could cause breathing problems in some obese patients, according to a new study from UT scientists.

Buprenorphine is a Schedule III drug with a lower abuse potential than methadone. It is one of three drugs approved by the US Food and Drug Administration to help patients undergoing treatment for opioid abuse. The UT study found that the drug impairs the ability of obese mice to vary their breathing. These findings in mice may encourage similar studies in humans, since the ability to vary breathing helps us achieve tasks such as climbing stairs and respond to challenges such as disease and surgical stress. (University of Tennessee, 01.02.2018)


Atomoxetine for amphetamine-type stimulant dependence during buprenorphine treatment: A randomized controlled trial.

Schottenfeld RS, Chawarski MC, Sofuoglu M, Chooi WT, Zaharim NM, M Yasin MA, Ahmad I, Syed Jaapar SZ, Vicknasingam BK.

Drug Alcohol Depend. 2018 Mar 10;186:130-137. doi: 10.1016/j.drugalcdep.2018.01.017.



Buprenorphine Depresses Respiratory Variability in Obese Mice with Altered Leptin Signaling

Chelsea Angel; Zachary T. Glovak; Wateen Alami; Sara Mihalko; Josh Price; Yandong Jiang; Helen A. Baghdoyan; Ralph Lydic

Anesthesiology. Publish Ahead of Print():, FEB 2018, DOI: 10.1097/ALN.0000000000002073

Issn Print: 0003-3022, Publication Date: 2018/02/02



Perceptions and practices addressing diversion among US buprenorphine prescribers.

Lin LA, Lofwall MR, Walsh SL, Gordon AJ, Knudsen HK.

Drug Alcohol Depend. 2018 Mar 10;186:147-153. doi: 10.1016/j.drugalcdep.2018.01.015.



Sexual Dysfunction in Heroin Dependents: A Comparison between Methadone and Buprenorphine Maintenance Treatment.

Yee A, Danaee M, Loh HS, Sulaiman AH, Ng CG (2016)

PLoS ONE 11(1): e0147852. doi.org/10.1371/journal.pone.0147852


Addressing discordant quantitative urine buprenorphine and norbuprenorphine levels: Case examples in opioid use disorder.

Holt SR, Donroe JH, Cavallo DA, Tetrault JM.

Drug Alcohol Depend. 2018 Mar 2;186:171-174. doi: 10.1016/j.drugalcdep.2017.12.040.