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USA. Researchers find 2.8% of pregnancies were exposed to opioids

Opioid use during pregnancy may lead to adverse long-term infant and child outcomes. Targeted public health strategies have been employed to reduce opioid use in reproductive-aged persons, but there has been a lack of research that adequately describes the individuals in the United States who actually use opioids during pregnancy. The first nationwide, geographically diverse study of pregnant people to describe the epidemiology of opioid use, including the demographic and medical characteristics of these people, helps to fill this gap. (University of Minnesota, USA, 21.11.2022)

https://medicalxpress.com/news/2022-11-pregnancies-exposed-opioids.html

A Systematic Scoping Review of Peridelivery Pain Management for Pregnant People With Opioid Use Disorder: From the Society for Obstetric Anesthesia and Perinatology and Society for Maternal Fetal Medicine. 

Lim G, Soens M, Wanaselja A, Chyan A, Carvalho B, Landau R, George RB, Klem ML, Osmundson SS, Krans EE, Terplan M, Bateman BT. 

Anesth Analg. 2022 Nov 1;135(5):912-925. doi: 10.1213/ANE.0000000000006167. Epub 2022 Sep 22. PMID: 36135926; PMCID: PMC9588509.

https://journals.lww.com/anesthesia-analgesia/Fulltext/2022/11000/A_Systematic_Scoping_Review_of_Peridelivery_Pain.5.aspx

Methamphetamine Use During the First or Second Half of Pregnancy Worsens Cardiac Ischemic Injury in Adult Female Offspring. 

Chavva H, Rorabaugh BR. 

Physiol Res. 2022 Aug 31;71(4):501-508. Epub 2022 Jul 28. PMID: 35899942.

http://www.biomed.cas.cz/physiolres/pdf/71/71_501.pdf

Association of Maternal Tobacco Use During Pregnancy With Preadolescent Brain Morphology Among Offspring. 

Zou R, Boer OD, Felix JF, et al. 

JAMA Netw Open. 2022;5(8):e2224701. doi:10.1001/jamanetworkopen.2022.24701

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2794811

Maternal cigarette smoking before or during pregnancy increases the risk of birth congenital anomalies: a population-based retrospective cohort study of 12 million mother-infant pairs. 

Yang, L., Wang, H., Yang, L. et al.

BMC Med 20, 4 (2022). doi.org/10.1186/s12916-021-02196-x

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-021-02196-x

Peripartum and Postpartum Analgesia and Pain in Women Prescribed Buprenorphine for Opioid Use Disorder Who Deliver by Cesarean Section. 

O'Connor AB, Smith J, O'Brien LM, Lamarche K, Byers N, Nichols SD. 

Subst Abuse. 2022 Jun 21;16:11782218221107936. doi: 10.1177/11782218221107936. PMID: 35754980; PMCID: PMC9218889.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218889/

Buprenorphine Compared with Methadone in Pregnancy: A Systematic Review and Meta-Analysis. 

Kinsella M, Halliday LOE, Shaw M, Capel Y, Nelson SM, Kearns RJ. 

Subst Use Misuse. 2022 Jun 25:1-17. doi: 10.1080/10826084.2022.2083174. Epub ahead of print. PMID: 35758300.

https://www.tandfonline.com/doi/full/10.1080/10826084.2022.2083174

Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy. 

Lee H, Koh JW, Kim YA, Chun KC, Han JY, Hwang JH, Choi JS, Joo SH, Kwon HY. 

Front Pharmacol. 2022 Apr 25;13:854562. doi: 10.3389/fphar.2022.854562. PMID: 35548333; PMCID: PMC9081603.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081603/

A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome. 

van Hoogdalem MW, Wexelblatt SL, Akinbi HT, Vinks AA, Mizuno T. 

Pharmacol Ther. 2022 Jun;234:108045. doi: 10.1016/j.pharmthera.2021.108045. Epub 2021 Nov 20. PMID: 34813863.

Abstract

https://pubmed.ncbi.nlm.nih.gov/34813863/

Buprenorphine Exposure Alters the Development and Migration of Interneurons in the Cortex. 

Nieto-Estévez V, Donegan JJ, McMahon CL, Elam HB, Chavera TA, Varma P, Berg KA, Lodge DJ, Hsieh J. 

Front Mol Neurosci. 2022 May 4;15:889922. doi: 10.3389/fnmol.2022.889922. PMID: 35600077; PMCID: PMC9115473.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115473/

Buprenorphine Uptake During Pregnancy Following the 2017 Guidelines Update on Prenatal Opioid Use Disorder. 

Nguemeni Tiako MJ, Meinhofer A, Friedman A, South EC, Epstein RL, Meisel ZF, Morgan JR. 

Am J Obstet Gynecol. 2022 May 22:S0002-9378(22)00392-1. doi: 10.1016/j.ajog.2022.05.041. Epub ahead of print. PMID: 35613648.

https://www.ajog.org/article/S0002-9378(22)00392-1/pdf

Clearing the Smoke on Cannabis: Cannabis Use During Pregnancy and Breastfeeding 

Presents the latest clinical evidence on how cannabis use during pregnancy and breastfeeding can affect a developing fetus and infant. Key points include: the effects of cannabis can be passed onto the fetus through the placenta or onto the baby through breastmilk, exposure to cannabis can impact the baby’s mental and physical development, and there is not enough evidence to support using cannabis to treat morning sickness nor pain. Healthcare providers will find this resource helpful for advising patients. Researchers will also find it useful for understanding gaps in the knowledge needed to support harm reduction efforts for this population. (Canadian Centre on Substance Use and Addiction, 2022)

https://www.ccsa.ca/sites/default/files/2022-05/CCSA-Clearing-the-Smoke-on-Cannabis-Highlights-2022-en_0.pdf

Evidence for the normalization effects of medication for opioid use disorder on functional connectivity in neonates with prenatal opioid exposure. 

Liu J, Grewen K, Gao W. 

J Neurosci. 2022 Apr 29:JN-RM-2232-21. doi: 10.1523/JNEUROSCI.2232-21.2022. Epub ahead of print. PMID: 35552232.

Abstract

https://pubmed.ncbi.nlm.nih.gov/35552232/

Prenatal exposure to benzodiazepines and Z-drugs in humans and risk of adverse neurodevelopmental outcomes in offspring: A systematic review. 

Wang X, Zhang T, Ekheden I, Chang Z, Hellner C, Jan Hasselström, Jayaram-Lindström N, M D'Onofrio B, Larsson H, Mataix-Cols D, Sidorchuk A. 

Neurosci Biobehav Rev. 2022 Apr 1;137:104647. doi: 10.1016/j.neubiorev.2022.104647. Epub ahead of print. PMID: 35367514.

https://www.sciencedirect.com/science/article/pii/S0149763422001361

Postpartum and addiction recovery of women in opioid use disorder treatment: A qualitative study.

Martin CE, Almeida T, Thakkar B, Kimbrough T. 

Subst Abus. 2022;43(1):389-396. doi: 10.1080/08897077.2021.1944954. Epub 2021 Jul 2. PMID: 34214405; PMCID: PMC8720325.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720325/

A contingency management approach for treatment of methamphetamine use disorder and human immunodeficiency virus antiretroviral treatment adherence in pregnancy to prevent mother-to-child transmission: a case report. 

Turner S, Nader M, Lurie E. 

J Med Case Rep. 2022 Apr 27;16(1):165. doi: 10.1186/s13256-022-03391-x. PMID: 35473945; PMCID: PMC9044665.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044665/

Pregabalin (Lyrica): findings of safety study on risks during pregnancy 

A new study has suggested pregabalin may slightly increase the risk of major congenital malformations if used in pregnancy. Patients should continue to use effective contraception during treatment and avoid use in pregnancy unless clearly necessary. (gov.uk, UK, 19.04.2022)

https://www.gov.uk/drug-safety-update/pregabalin-lyrica-findings-of-safety-study-on-risks-during-pregnancy

“You have to take this medication, but then you get punished for taking it:” lack of agency, choice, and fear of medications to treat opioid use disorder across the perinatal period

Schiff, Davida M. et al.

Journal of Substance Abuse Treatment, Volume 0, Issue 0, 108765 

https://www.journalofsubstanceabusetreatment.com/article/S0740-5472(22)00047-2/fulltext

Scoping Review of Best Practice Guidelines for Care in the Labor and Birth Setting of Pregnant Women Who Use Methamphetamines. 

Gulbransen K, Thiessen K, Pidutti J, Watson H, Winkler J. 

J Obstet Gynecol Neonatal Nurs. 2022 Mar;51(2):141-152. doi: 10.1016/j.jogn.2021.10.008. Epub 2021 Dec 13. PMID: 34914926.

https://www.jognn.org/article/S0884-2175(21)00305-1/fulltext

Prevalence of Licit and Illicit Drugs Use during Pregnancy in Mexican Women. 

Gómez-Ruiz LM, Marchei E, Rotolo MC, Brunetti P, Mannocchi G, Acosta-López A, Ramos-Gutiérrez RY, Varela-Busaka MB, Pichini S, Garcia-Algar O. 

Pharmaceuticals (Basel). 2022 Mar 21;15(3):382. doi: 10.3390/ph15030382. PMID: 35337179; PMCID: PMC8953434.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953434/

The Effects of Prenatal Exposure to Pregabalin on the Development of Ventral Midbrain Dopaminergic Neurons. 

Alsanie WF, Alhomrani M, Gaber A, Habeeballah H, Alkhatabi HA, Felimban RI, Abdelrahman S, Hauser CAE, Chaudhary AG, Alamri AS, Raafat BM, Alamri A, Anwar S, Alswat KA, Althobaiti YS, Asiri YA. 

Cells. 2022 Mar 1;11(5):852. doi: 10.3390/cells11050852. PMID: 35269474; PMCID: PMC8909856.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909856/

Lupattelli A, Trinh NTH. Polysubstance Exposure During Pregnancy and Attention-Deficit/Hyperactivity Disorder in Offspring—Methodological Challenges and Opportunities for Future Research. 

Lupattelli A, Trinh NTH. 

JAMA Netw Open. 2022;5(3):e221964. doi:10.1001/jamanetworkopen.2022.1964

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789927

Reduced Child-Oriented Face Mirroring Brain Responses in Mothers With Opioid Use Disorder: An Exploratory Study. 

Swain JE, Ho SS. 

Front Psychol. 2022 Feb 4;12:770093. doi: 10.3389/fpsyg.2021.770093. PMID: 35185679; PMCID: PMC8854864.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854864/

Association of alcohol and other substance-related diagnoses with severe maternal morbidity. 

Courchesne NS, Smith LR, Zúñiga ML, Chambers CD, Reed MB, Ballas J, Marienfeld CB. 

Alcohol Clin Exp Res. 2021 Sep;45(9):1829-1839. doi: 10.1111/acer.14671. Epub 2021 Sep 19. PMID: 34341999; PMCID: PMC8831116.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831116/

Implementation of a Prenatal Naloxone Distribution Program to Decrease Maternal Mortality from Opioid Overdose. 

Duska M, Goodman D. 

Matern Child Health J. 2022 Jan 14:1–9. doi: 10.1007/s10995-021-03307-z. Epub ahead of print. PMID: 35029805; PMCID: PMC8759060.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8759060/

Availability of Medications for the Treatment of Opioid Use Disorder Among Pregnant and Postpartum Individuals in US Jails. 

Sufrin C, Kramer CT, Terplan M, Fiscella K, Olson S, Voegtline K, Latkin C. 

JAMA Netw Open. 2022 Jan 4;5(1):e2144369. doi: 10.1001/jamanetworkopen.2021.44369. PMID: 35050354; PMCID: PMC8777564.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777564/

Maternal use of a combination of recreational and antiretroviral drugs (nyaope/whoonga): Case reports of their effects on the respiratory system in infants. 

Mashiloane CP, Jeena PH, Thula SA, Singh SA, Masekela R. 

Afr J Thorac Crit Care Med. 2021 Oct 4;27(3):10.7196/AJTCCM.2021.v27i3.112. doi: 10.7196/AJTCCM.2021.v27i3.112. PMID: 34761210; PMCID: PMC8573815.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573815/

Addiction curriculum design for medical students. 

Hostetter K, Thakkar B, Edwards C, Martin CE. 

Clin Teach. 2021 Nov 22. doi: 10.1111/tct.13438. Epub ahead of print. PMID: 34808694.

Abstract

https://pubmed.ncbi.nlm.nih.gov/34808694/

Association of Comorbid Behavioral and Medical Conditions With Cannabis Use Disorder in Pregnancy. 

Meinhofer A, Hinde JM, Keyes KM, Lugo-Candelas C. 

JAMA Psychiatry. Published online November 03, 2021. doi:10.1001/jamapsychiatry.2021.3193

Abstract

https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2785860

Precision dosing of methadone during pregnancy: A pharmacokinetics virtual clinical trials study. 

Badhan RKS, Gittins R. 

J Subst Abuse Treat. 2021 Nov;130:108521. doi: 10.1016/j.jsat.2021.108521. Epub 2021 Jun 3. PMID: 34118695.

Abstract

https://pubmed.ncbi.nlm.nih.gov/34118695/