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Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy. 

Lee H, Koh JW, Kim YA, Chun KC, Han JY, Hwang JH, Choi JS, Joo SH, Kwon HY. 

Front Pharmacol. 2022 Apr 25;13:854562. doi: 10.3389/fphar.2022.854562. PMID: 35548333; PMCID: PMC9081603.


A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome. 

van Hoogdalem MW, Wexelblatt SL, Akinbi HT, Vinks AA, Mizuno T. 

Pharmacol Ther. 2022 Jun;234:108045. doi: 10.1016/j.pharmthera.2021.108045. Epub 2021 Nov 20. PMID: 34813863.



Buprenorphine Exposure Alters the Development and Migration of Interneurons in the Cortex. 

Nieto-Estévez V, Donegan JJ, McMahon CL, Elam HB, Chavera TA, Varma P, Berg KA, Lodge DJ, Hsieh J. 

Front Mol Neurosci. 2022 May 4;15:889922. doi: 10.3389/fnmol.2022.889922. PMID: 35600077; PMCID: PMC9115473.


Buprenorphine Uptake During Pregnancy Following the 2017 Guidelines Update on Prenatal Opioid Use Disorder. 

Nguemeni Tiako MJ, Meinhofer A, Friedman A, South EC, Epstein RL, Meisel ZF, Morgan JR. 

Am J Obstet Gynecol. 2022 May 22:S0002-9378(22)00392-1. doi: 10.1016/j.ajog.2022.05.041. Epub ahead of print. PMID: 35613648.


Clearing the Smoke on Cannabis: Cannabis Use During Pregnancy and Breastfeeding 

Presents the latest clinical evidence on how cannabis use during pregnancy and breastfeeding can affect a developing fetus and infant. Key points include: the effects of cannabis can be passed onto the fetus through the placenta or onto the baby through breastmilk, exposure to cannabis can impact the baby’s mental and physical development, and there is not enough evidence to support using cannabis to treat morning sickness nor pain. Healthcare providers will find this resource helpful for advising patients. Researchers will also find it useful for understanding gaps in the knowledge needed to support harm reduction efforts for this population. (Canadian Centre on Substance Use and Addiction, 2022)


Evidence for the normalization effects of medication for opioid use disorder on functional connectivity in neonates with prenatal opioid exposure. 

Liu J, Grewen K, Gao W. 

J Neurosci. 2022 Apr 29:JN-RM-2232-21. doi: 10.1523/JNEUROSCI.2232-21.2022. Epub ahead of print. PMID: 35552232.



Prenatal exposure to benzodiazepines and Z-drugs in humans and risk of adverse neurodevelopmental outcomes in offspring: A systematic review. 

Wang X, Zhang T, Ekheden I, Chang Z, Hellner C, Jan Hasselström, Jayaram-Lindström N, M D'Onofrio B, Larsson H, Mataix-Cols D, Sidorchuk A. 

Neurosci Biobehav Rev. 2022 Apr 1;137:104647. doi: 10.1016/j.neubiorev.2022.104647. Epub ahead of print. PMID: 35367514.


Postpartum and addiction recovery of women in opioid use disorder treatment: A qualitative study.

Martin CE, Almeida T, Thakkar B, Kimbrough T. 

Subst Abus. 2022;43(1):389-396. doi: 10.1080/08897077.2021.1944954. Epub 2021 Jul 2. PMID: 34214405; PMCID: PMC8720325.


A contingency management approach for treatment of methamphetamine use disorder and human immunodeficiency virus antiretroviral treatment adherence in pregnancy to prevent mother-to-child transmission: a case report. 

Turner S, Nader M, Lurie E. 

J Med Case Rep. 2022 Apr 27;16(1):165. doi: 10.1186/s13256-022-03391-x. PMID: 35473945; PMCID: PMC9044665.


Pregabalin (Lyrica): findings of safety study on risks during pregnancy 

A new study has suggested pregabalin may slightly increase the risk of major congenital malformations if used in pregnancy. Patients should continue to use effective contraception during treatment and avoid use in pregnancy unless clearly necessary. (gov.uk, UK, 19.04.2022)


“You have to take this medication, but then you get punished for taking it:” lack of agency, choice, and fear of medications to treat opioid use disorder across the perinatal period

Schiff, Davida M. et al.

Journal of Substance Abuse Treatment, Volume 0, Issue 0, 108765 


Scoping Review of Best Practice Guidelines for Care in the Labor and Birth Setting of Pregnant Women Who Use Methamphetamines. 

Gulbransen K, Thiessen K, Pidutti J, Watson H, Winkler J. 

J Obstet Gynecol Neonatal Nurs. 2022 Mar;51(2):141-152. doi: 10.1016/j.jogn.2021.10.008. Epub 2021 Dec 13. PMID: 34914926.


Prevalence of Licit and Illicit Drugs Use during Pregnancy in Mexican Women. 

Gómez-Ruiz LM, Marchei E, Rotolo MC, Brunetti P, Mannocchi G, Acosta-López A, Ramos-Gutiérrez RY, Varela-Busaka MB, Pichini S, Garcia-Algar O. 

Pharmaceuticals (Basel). 2022 Mar 21;15(3):382. doi: 10.3390/ph15030382. PMID: 35337179; PMCID: PMC8953434.


The Effects of Prenatal Exposure to Pregabalin on the Development of Ventral Midbrain Dopaminergic Neurons. 

Alsanie WF, Alhomrani M, Gaber A, Habeeballah H, Alkhatabi HA, Felimban RI, Abdelrahman S, Hauser CAE, Chaudhary AG, Alamri AS, Raafat BM, Alamri A, Anwar S, Alswat KA, Althobaiti YS, Asiri YA. 

Cells. 2022 Mar 1;11(5):852. doi: 10.3390/cells11050852. PMID: 35269474; PMCID: PMC8909856.


Lupattelli A, Trinh NTH. Polysubstance Exposure During Pregnancy and Attention-Deficit/Hyperactivity Disorder in Offspring—Methodological Challenges and Opportunities for Future Research. 

Lupattelli A, Trinh NTH. 

JAMA Netw Open. 2022;5(3):e221964. doi:10.1001/jamanetworkopen.2022.1964


Reduced Child-Oriented Face Mirroring Brain Responses in Mothers With Opioid Use Disorder: An Exploratory Study. 

Swain JE, Ho SS. 

Front Psychol. 2022 Feb 4;12:770093. doi: 10.3389/fpsyg.2021.770093. PMID: 35185679; PMCID: PMC8854864.


Association of alcohol and other substance-related diagnoses with severe maternal morbidity. 

Courchesne NS, Smith LR, Zúñiga ML, Chambers CD, Reed MB, Ballas J, Marienfeld CB. 

Alcohol Clin Exp Res. 2021 Sep;45(9):1829-1839. doi: 10.1111/acer.14671. Epub 2021 Sep 19. PMID: 34341999; PMCID: PMC8831116.


Implementation of a Prenatal Naloxone Distribution Program to Decrease Maternal Mortality from Opioid Overdose. 

Duska M, Goodman D. 

Matern Child Health J. 2022 Jan 14:1–9. doi: 10.1007/s10995-021-03307-z. Epub ahead of print. PMID: 35029805; PMCID: PMC8759060.


Availability of Medications for the Treatment of Opioid Use Disorder Among Pregnant and Postpartum Individuals in US Jails. 

Sufrin C, Kramer CT, Terplan M, Fiscella K, Olson S, Voegtline K, Latkin C. 

JAMA Netw Open. 2022 Jan 4;5(1):e2144369. doi: 10.1001/jamanetworkopen.2021.44369. PMID: 35050354; PMCID: PMC8777564.


Maternal use of a combination of recreational and antiretroviral drugs (nyaope/whoonga): Case reports of their effects on the respiratory system in infants. 

Mashiloane CP, Jeena PH, Thula SA, Singh SA, Masekela R. 

Afr J Thorac Crit Care Med. 2021 Oct 4;27(3):10.7196/AJTCCM.2021.v27i3.112. doi: 10.7196/AJTCCM.2021.v27i3.112. PMID: 34761210; PMCID: PMC8573815.


Addiction curriculum design for medical students. 

Hostetter K, Thakkar B, Edwards C, Martin CE. 

Clin Teach. 2021 Nov 22. doi: 10.1111/tct.13438. Epub ahead of print. PMID: 34808694.



Association of Comorbid Behavioral and Medical Conditions With Cannabis Use Disorder in Pregnancy. 

Meinhofer A, Hinde JM, Keyes KM, Lugo-Candelas C. 

JAMA Psychiatry. Published online November 03, 2021. doi:10.1001/jamapsychiatry.2021.3193



Precision dosing of methadone during pregnancy: A pharmacokinetics virtual clinical trials study. 

Badhan RKS, Gittins R. 

J Subst Abuse Treat. 2021 Nov;130:108521. doi: 10.1016/j.jsat.2021.108521. Epub 2021 Jun 3. PMID: 34118695.



Committee Opinion No. 722: Marijuana Use During Pregnancy and Lactation. 

Obstet Gynecol. 2017 Oct;130(4):e205-e209. doi: 10.1097/AOG.0000000000002354. PMID: 28937574.


Histological Changes Observed in Placentas Exposed to Medication-Assisted Treatment. 

Staszewski C, Herrera KM, Kertowidjojo E, Ly V, Iovino N, Garretto D, Kaplan C, Persad MD, Garry DJ. 

J Pregnancy. 2021 Oct 7;2021:2175026. doi: 10.1155/2021/2175026. PMID: 34659831; PMCID: PMC8516570.


Linkage to Hepatitis C Virus Treatment Following Pregnancy in Women Identified During Perinatal Care. 

Epstein RL, Moloney C, Garfinkel J, Saia K, Wachman EM, Lodi S, Pelton SI. Enhancing 

Hepatol Commun. 2021 Sep;5(9):1543-1554. doi: 10.1002/hep4.1748. Epub 2021 Jul 1. PMID: 34510828; PMCID: PMC8435278.


Smoking cessation interventions for pregnant women attending treatment for substance use disorders: A systematic review. 

Jackson, MA, Baker, AL, Gould, GS, Brown, AL, Dunlop, AJ, McCarter, K. 

Addiction. 2021; 1– 14. doi.org/10.1111/add.15663


Integrated versus non-integrated treatment for perinatal opioid use disorder: Retrospective cohort study

Goodman, Dr. Daisy J. et al.

American Journal of Obstetrics & Gynecology MFM, Volume 0, Issue 0, 100489 


"The elephant in the room;" a qualitative study of perinatal fears in opioid use disorder treatment in Southern Appalachia. 

Leiner C, Cody T, Mullins N, Ramage M, Ostrach BMM. 

BMC Pregnancy Childbirth. 2021 Feb 17;21(1):143. doi: 10.1186/s12884-021-03596-w. PMID: 33596843; PMCID: PMC7890815.


Puffy hand syndrome secondary to intravenous drug use presenting in pregnancy and persisting postpartum. 

Gaghan LJ, Bode HP, Mervak JE. 

JAAD Case Rep. 2021 Jul 10;14:124-126. doi: 10.1016/j.jdcr.2021.06.025. PMID: 34355053; PMCID: PMC8325063.