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Successful Buprenorphine/Naloxone Low-dose Induction in Pregnancy: A Case Report. 

Coish R, Hardial J. 

J Addict Med. 2023 Jan-Feb 01;17(1):114-116. doi: 10.1097/ADM.0000000000001042. Epub 2022 Aug 2. PMID: 35916416; PMCID: PMC9897269.


Safety and Efficacy of Buprenorphine-Naloxone in Pregnancy: A Systematic Review of the Literature. 

Ordean A, Tubman-Broeren M. 

Pathophysiology. 2023 Feb 11;30(1):27-36. doi: 10.3390/pathophysiology30010004. PMID: 36810423; PMCID: PMC9944489.


Cluster analysis to identify patient profiles and substance use patterns among pregnant persons with opioid use disorder. 

Charron E, Yu Z, Lundahl B, Silipigni J, Okifuji A, Gordon AJ, Baylis JD, White A, Carlston K, Abdullah W, Haaland B, Krans EE, Smid MC, Cochran G. 

Addict Behav Rep. 2023 Feb 15;17:100484. doi: 10.1016/j.abrep.2023.100484. PMID: 36844693; PMCID: PMC9950438.


Obstetric pain management for pregnant women with opioid use disorder: A qualitative and quantitative comparison of patient and provider perspectives (QUEST study). 

Nowakowski, E, Dayananda, S, Morgan, M, Jarvis, O, Altamirano, V, LaSorda, KR, et al. Addiction. 2023. doi.org/10.1111/add.16134


Psychiatric comorbidities and their treatment predict buprenorphine continuation among postpartum people with opioid use disorder. 

Shadowen H, Violante S, Gataric A, Goulding AN, Martin CE. 

Drug Alcohol Depend Rep. 2022 Dec;5:100121. doi: 10.1016/j.dadr.2022.100121. Epub 2022 Nov 19. PMID: 36644222; PMCID: PMC9835555.


How does a clinician approach the pharmacological management of opioid use disorders in pregnant women and pregnant people? 

Jones HE. 

Expert Opin Pharmacother. 2023 Jan 12:1-5. doi: 10.1080/14656566.2023.2165909. Epub ahead of print. PMID: 36628440.


Harm Reduction Approach to Increasing Self-reported Safe Medication Storage Among Pregnant and Parenting People Receiving Opioid Use Disorder Treatment. 

Grist E, Thakkar B, Dacha P, Lutins E, Maxwell M, Martin CE. 

J Addict Med. 2022 Oct 27. doi: 10.1097/ADM.0000000000001087. Epub ahead of print. PMID: 36730907.



Heavy prenatal alcohol exposure and overall morbidities: a Danish nationwide cohort study from 1996 to 2018

Broccia, Marcella et al.

The Lancet Public Health, Volume 8, Issue 1, e36 - e46 


Heavy prenatal alcohol exposure and obstetric and birth outcomes: a Danish nationwide cohort study from 1996 to 2018

Broccia, Marcella et al.

The Lancet Public Health, Volume 8, Issue 1, e28 - e35 


Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder. 

Kanervo MM, Tupola SJ, Nikkola EM, Rantakari KM, Kahila HK. 

Acta Obstet Gynecol Scand. 2022 Dec 23. doi: 10.1111/aogs.14497. Epub ahead of print. PMID: 36562462.


USA. Overdose Deaths up 81% in Pregnant, Postpartum

Women Drug overdose deaths in pregnant and postpartum women rose by about 81% from 2017 to 2020, researchers report in a JAMA research letter published online Dec. 6. (Medscape, USA, 07.12.2022)


Association of Prenatal Exposure to Benzodiazepines With Development of Autism Spectrum and Attention-Deficit/Hyperactivity Disorders. 

VeChen VC, Wu SI, Lin CF, Lu ML, Chen YL, Stewart R. 

JAMA Netw Open. 2022 Nov 1;5(11):e2243282. doi: 10.1001/jamanetworkopen.2022.43282. PMID: 36413366.


Maternal methadone split dosing in pregnancy 

Cindy Flores, Usman Riaz

Heroin Addict Relat Clin Probl, Published Ahead of Print November 22, 2022


Project BETTER: Preliminary Feasibility and Acceptability of a Technology-Delivered Educational Program for Pregnant and Postpartum People with Opioid Use Disorder. 

Martin S, Parlier-Ahmad AB, Eglovitch M, Ondersma SJ, Svikis DS, Martin CE. 

Womens Health Rep (New Rochelle). 2022 Oct 20;3(1):834-843. doi: 10.1089/whr.2022.0046. PMID: 36340476; PMCID: PMC9629978.


Maternal use of methamphetamine induces sex-dependent changes in myocardial gene expression in adult offspring. 

Dague A, Chavva H, Brazeau DA, Denvir J, Rorabaugh BR. 

Physiol Rep. 2022 Nov;10(22):e15509. doi: 10.14814/phy2.15509. PMID: 36426716; PMCID: PMC9693808.


Prenatal methamphetamine exposure causes dysfunction in glucose metabolism and low birthweight. 

Doi M, Nakama N, Sumi T, Usui N, Shimada S. 

Front Endocrinol (Lausanne). 2022 Oct 24;13:1023984. doi: 10.3389/fendo.2022.1023984. PMID: 36353228; PMCID: PMC9637823.


Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy. 

Suarez EA, Huybrechts KF, Straub L, Hernández-Díaz S, Jones HE, Connery HS, Davis JM, Gray KJ, Lester B, Terplan M, Mogun H, Bateman BT. 

N Engl J Med. 2022 Dec 1;387(22):2033-2044. doi: 10.1056/NEJMoa2203318. PMID: 36449419.



Cannabis use in pregnancy and maternal and infant outcomes: A Canadian cross-jurisdictional population-based cohort study. 

Luke S, Hobbs AJ, Smith M, Riddell C, Murphy P, Agborsangaya C, et al. (2022) 

PLoS ONE 17(11): e0276824. doi.org/10.1371/journal.pone.0276824


USA. Researchers find 2.8% of pregnancies were exposed to opioids

Opioid use during pregnancy may lead to adverse long-term infant and child outcomes. Targeted public health strategies have been employed to reduce opioid use in reproductive-aged persons, but there has been a lack of research that adequately describes the individuals in the United States who actually use opioids during pregnancy. The first nationwide, geographically diverse study of pregnant people to describe the epidemiology of opioid use, including the demographic and medical characteristics of these people, helps to fill this gap. (University of Minnesota, USA, 21.11.2022)


A Systematic Scoping Review of Peridelivery Pain Management for Pregnant People With Opioid Use Disorder: From the Society for Obstetric Anesthesia and Perinatology and Society for Maternal Fetal Medicine. 

Lim G, Soens M, Wanaselja A, Chyan A, Carvalho B, Landau R, George RB, Klem ML, Osmundson SS, Krans EE, Terplan M, Bateman BT. 

Anesth Analg. 2022 Nov 1;135(5):912-925. doi: 10.1213/ANE.0000000000006167. Epub 2022 Sep 22. PMID: 36135926; PMCID: PMC9588509.


Methamphetamine Use During the First or Second Half of Pregnancy Worsens Cardiac Ischemic Injury in Adult Female Offspring. 

Chavva H, Rorabaugh BR. 

Physiol Res. 2022 Aug 31;71(4):501-508. Epub 2022 Jul 28. PMID: 35899942.


Association of Maternal Tobacco Use During Pregnancy With Preadolescent Brain Morphology Among Offspring. 

Zou R, Boer OD, Felix JF, et al. 

JAMA Netw Open. 2022;5(8):e2224701. doi:10.1001/jamanetworkopen.2022.24701


Maternal cigarette smoking before or during pregnancy increases the risk of birth congenital anomalies: a population-based retrospective cohort study of 12 million mother-infant pairs. 

Yang, L., Wang, H., Yang, L. et al.

BMC Med 20, 4 (2022). doi.org/10.1186/s12916-021-02196-x


Peripartum and Postpartum Analgesia and Pain in Women Prescribed Buprenorphine for Opioid Use Disorder Who Deliver by Cesarean Section. 

O'Connor AB, Smith J, O'Brien LM, Lamarche K, Byers N, Nichols SD. 

Subst Abuse. 2022 Jun 21;16:11782218221107936. doi: 10.1177/11782218221107936. PMID: 35754980; PMCID: PMC9218889.


Buprenorphine Compared with Methadone in Pregnancy: A Systematic Review and Meta-Analysis. 

Kinsella M, Halliday LOE, Shaw M, Capel Y, Nelson SM, Kearns RJ. 

Subst Use Misuse. 2022 Jun 25:1-17. doi: 10.1080/10826084.2022.2083174. Epub ahead of print. PMID: 35758300.


Pregnancy and Neonatal Outcomes After Exposure to Alprazolam in Pregnancy. 

Lee H, Koh JW, Kim YA, Chun KC, Han JY, Hwang JH, Choi JS, Joo SH, Kwon HY. 

Front Pharmacol. 2022 Apr 25;13:854562. doi: 10.3389/fphar.2022.854562. PMID: 35548333; PMCID: PMC9081603.


A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome. 

van Hoogdalem MW, Wexelblatt SL, Akinbi HT, Vinks AA, Mizuno T. 

Pharmacol Ther. 2022 Jun;234:108045. doi: 10.1016/j.pharmthera.2021.108045. Epub 2021 Nov 20. PMID: 34813863.



Buprenorphine Exposure Alters the Development and Migration of Interneurons in the Cortex. 

Nieto-Estévez V, Donegan JJ, McMahon CL, Elam HB, Chavera TA, Varma P, Berg KA, Lodge DJ, Hsieh J. 

Front Mol Neurosci. 2022 May 4;15:889922. doi: 10.3389/fnmol.2022.889922. PMID: 35600077; PMCID: PMC9115473.


Buprenorphine Uptake During Pregnancy Following the 2017 Guidelines Update on Prenatal Opioid Use Disorder. 

Nguemeni Tiako MJ, Meinhofer A, Friedman A, South EC, Epstein RL, Meisel ZF, Morgan JR. 

Am J Obstet Gynecol. 2022 May 22:S0002-9378(22)00392-1. doi: 10.1016/j.ajog.2022.05.041. Epub ahead of print. PMID: 35613648.


Clearing the Smoke on Cannabis: Cannabis Use During Pregnancy and Breastfeeding 

Presents the latest clinical evidence on how cannabis use during pregnancy and breastfeeding can affect a developing fetus and infant. Key points include: the effects of cannabis can be passed onto the fetus through the placenta or onto the baby through breastmilk, exposure to cannabis can impact the baby’s mental and physical development, and there is not enough evidence to support using cannabis to treat morning sickness nor pain. Healthcare providers will find this resource helpful for advising patients. Researchers will also find it useful for understanding gaps in the knowledge needed to support harm reduction efforts for this population. (Canadian Centre on Substance Use and Addiction, 2022)