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Comparison of two algorithms to support medication surveillance for drug-drug interactions between QTc-prolonging drugs. 

Berger FA, van der Sijs H, van Gelder T, Kuijper AFM, van den Bemt PMLA, Becker ML. 

Int J Med Inform. 2021 Jan;145:104329. doi: 10.1016/j.ijmedinf.2020.104329. Epub 2020 Nov 4. PMID: 33181445.


Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use. 

Tam WC, Lam UP, Mok TM, Chang T, Ho W, De Brito Lima Evora MA 

Case Rep Cardiol. 2020 Sep 23;2020:4504657. doi: 10.1155/2020/4504657. PMID: 33029432; PMCID: PMC7532395.


Development and validation of a tool to assess the risk of QT drug-drug interactions in clinical practice. 

Berger FA, van der Sijs H, Becker ML, van Gelder T, van den Bemt PMLA. 

BMC Med Inform Decis Mak. 2020;20(1):171. Published 2020 Jul 23. doi:10.1186/s12911-020-01181-3

Development and validation of a tool to assess the risk of QT drug-drug interactions in clinical practice. 

QT prolongation in HIV-positive patients: Review article. 

Liu J, Shah SK, Basu-Ray I, Garcia-Diaz J, Khalid K, Saeed M. 

Indian Heart J. 2019;71(6):434-439. doi:10.1016/j.ihj.2019.11.259


QTc Prolongation Secondary to Zolpidem Use.

Suarez L, Kolla BP, Hall-Flavin D, Mansukhani MP.

Prim Care Companion CNS Disord. 2020 Mar 19;22(2). pii: 19l02506. doi: 10.4088/PCC.19l02506. 


Effect of direct-acting antivirals on corrected QT interval and cardiac functions in patients with chronic hepatitis C virus infection.

Ibrahim MG, Sharafeldin AA, Mousa NI, Mousa TK, El Missiri AM.

Egypt Heart J. 2020 Feb 7;72(1):7. doi: 10.1186/s43044-020-0042-y.


Loperamide overdose causing torsades de pointes and requiring Impella temporary mechanical support: a case report.

Cicci JD, Jagielski SM, Clarke MM, Rayson RA, Cavender MA.

Eur Heart J Case Rep. 2019 Dec;3(4):1-6. doi: 10.1093/ehjcr/ytz150. 


Liver Stiffness, Not Fat Liver Content, Predicts the Length of QTc Interval in Patients with Chronic Liver Disease.

Bellan M, Rigamonti C, Giacomini GM, Makmur G, Marconi C, Nicosia F, Panero A, De Benedittis C, Burlone ME, Minisini R, Pirisi M.

Gastroenterol Res Pract. 2019 Dec 23;2019:6731498. doi: 10.1155/2019/6731498.


Mirtazapine's effect on the QT interval in medically hospitalized patients.

Allen ND, Leung JG, Palmer BA.

Ment Health Clin. 2020 Jan 9;10(1):30-33. doi: 10.9740/mhc.2020.01.030. 


Prevalence of ECG abnormalities and risk factors for QTc interval prolongation in hospitalized psychiatric patients.

Ansermot N, Bochatay M, Schläpfer J, Gholam M, Gonthier A, Conus P, Eap CB.

Ther Adv Psychopharmacol. 2019 Dec 12;9:2045125319891386. doi: 10.1177/2045125319891386. 


Electrocardiographic Corrected QT (QTc) Dispersion Value as a Predictor for Estimation of Neonatal Mortality in Pre-Term Neonates.

Shabestari AA, Dalirrooyfard M, Mazloomzadeh S.

Acta Inform Med. 2019 Sep;27(3):158-161. doi: 10.5455/aim.2019.27.158-161.


Risk Factors and Prevalence of QTc Prolongation in Adult Burn Patients Receiving Methadone.

Walroth TA, Boyd AN, Hester AM, Schoenle M, Hartman BC, Sood R.

J Burn Care Res. 2019 Dec 6. pii: irz200. doi: 10.1093/jbcr/irz200. 



Effect of lofexidine on cardiac repolarization during treatment of opioid withdrawal.

Darpö B, Pirner M, Longstreth J, Ferber G.

Drug Alcohol Depend. 2019 Sep 27;205:107596. doi: 10.1016/j.drugalcdep.2019.107596.


Direct-acting antiviral interactions with opioids, alcohol or illicit drugs of abuse in HCV-infected patients.

Ing Lorenzini K, Girardin F.

Liver Int. 2019 Oct 26. doi: 10.1111/liv.14283. 



Prevalence of prolonged QT interval in patients with HCV-related chronic liver disease.

Gaafar AE, Abd El-Aal A, Alboraie M, Hassan HM, ElTahan A, AbdelRahman Y, Wifi MN, Omran D, Mansour SA, Hassan WM, Ismail M, ElKassas M.

Egypt Heart J. 2019 Sep 7;71(1):15. doi: 10.1186/s43044-019-0016-0. Erratum in: Egypt Heart J. 2019 Oct 29;71(1):21. 



Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings.

Zwartsen A, de Korte T, Nacken P, de Lange DW, Westerink RHS, Hondebrink L.

J Mol Cell Cardiol. 2019 Sep 14. pii: S0022-2828(19)30189-0. doi: 10.1016/j.yjmcc.2019.09.007. 


Comprehensive review on methadone-induced QT prolongation and torsades.

Treece JM, Al Madani M, El Khoury G, Khraisha O, Martin JE, Baumrucker SJ, Neglia CA, Paul TK. 

J Pharmacol Pharmacother 2018;9:66-75


Prevalence and risk factors of prolonged QT interval and electrocardiographic abnormalities in persons living with HIV.

Knudsen AD, Kofoed KF, Gelpi M, Sigvardsen PE, Mocroft A, Kühl JT, Fuchs A, Køber L, Nordestgaard BG, Benfield T, Graff C, Skov MW, Lundgren J, Nielsen SD; Copenhagen Comorbidity in HIV Infection (COCOMO) Study.

AIDS. 2019 Aug 1. doi: 10.1097/QAD.0000000000002327. 


Association between Use of Methadone, Other Central Nervous System Depressants, and QTc Interval-Prolonging Medications and Risk of Mortality in a Large Cohort of Women Living with or at Risk for Human Immunodeficiency Virus Infection.

Tamraz B, Reisner L, French AL, King ST, Fischl MA, Ofotokun I, Kashuba A, Milam J, Murphy K, Augenbraun M, Liu C, Finley PR, Aouizerat B, Cocohoba J, Gange S, Bacchetti P, Greenblatt RM.

Pharmacotherapy. 2019 Jul 22. doi: 10.1002/phar.2312. 



QT prolongation predicts short-term mortality independent of comorbidity.

Gibbs C, Thalamus J, Kristoffersen DT, Svendsen MV, Holla ØL, Heldal K, Haugaa KH, Hysing J.

Europace. 2019 Apr 8. pii: euz058. doi: 10.1093/europace/euz058. 



Long QT and death in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease is not related to electrolyte disorders.

Zilberman-Itskovich S, Rahamim E, Tsiporin-Havatinsky F, Ziv-Baran T, Golik A, Zaidenstein R.

Int J Chron Obstruct Pulmon Dis. 2019 May 20;14:1053-1061. doi: 10.2147/COPD.S196428. 


Grapefruit juice prolongs the QT interval of healthy volunteers and patients with long QT syndrome.

Chorin E, Hochstadt A, Granot Y, Khoury S, Schwartz AL, Margolis G, Barashi R, Viskin D, Ghantous E, Schnapper M, Mekori T, Fourey D, Guevara-Valdivia ME, Marquez MF, Zeltzer D, Rosso R, Viskin S.

Heart Rhythm. 2019 May 8. pii: S1547-5271(19)30368-6. doi: 10.1016/j.hrthm.2019.04.039.



Prolonged QTc in HIV-Infected Patients: A Need for Routine ECG Screening.

Myerson M, Kaplan-Lewis E, Poltavskiy E, Ferris D, Bang H.

J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958219833926. doi: 10.1177/2325958219833926.


Assessment of the risk of QT-interval prolongation associated with potential drug-drug interactions in patients admitted to Intensive Care Units.

Fernandes FM, da Silva Paulino AM, Sedda BC, da Silva EP, Martins RR, Oliveira AG.

Saudi Pharm J. 2019 Feb;27(2):229-234. doi: 10.1016/j.jsps.2018.11.003. 


Drug-induced prolonged corrected QT interval in patients with methadone and opium overdose

Davood Soroosh, Mahbubeh Neamatshahi, Bahram Zarmehri, Samaneh Nakhaee and Omid Mehrpour

Substance Abuse Treatment, Prevention, and Policy 2019, 14:8, doi.org/10.1186/s13011-019-0196-3


Methadone Safety: A Clinical Practice Guideline From the American Pain Society and College on Problems of Drug Dependence, in Collaboration With the Heart Rhythm Society

Chou, Roger et al.

The Journal of Pain , Volume 15 , Issue 4 , 321 - 337 


A literature-based algorithm for the assessment, management, and monitoring of drug-induced QTc prolongation in the psychiatric population.

Zolezzi M, Cheung L.

Neuropsychiatr Dis Treat. 2018 Dec 24;15:105-114. doi: 10.2147/NDT.S186474. eCollection 2019. Review.


Trends in reporting methadone-associated cardiac arrhythmia, 1997-2011: an analysis of registry data. 

Kao D, Bucher Bartelson B, Khatri V, Dart R, Mehler PS, Katz D, Krantz MJ.

Ann Intern Med. 2013 May 21;158(10):735-40. doi: 10.7326/0003-4819-158-10-201305210-00008.


Substitution of (R,S)-methadone by (R)-methadone: Impact on QTc interval.

Ansermot N, Albayrak O, Schläpfer J, Crettol S, Croquette-Krokar M, Bourquin M, Déglon JJ, Faouzi M, Scherbaum N, Eap CB.

Arch Intern Med. 2010 Mar 22;170(6):529-36. 


QT length during methadone maintenance treatment: gene × dose interaction.

Zerdazi EH, Vorspan F, Marees AT, Naccache F, Lepine JP, Laplanche JL, Prince N, Marie-Claire C, Bellivier F, Mouly S, Bloch V.

Fundam Clin Pharmacol. 2019 Feb;33(1):96-106. doi: 10.1111/fcp.12405.