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Accuracy of a single-lead mobile smartphone electrocardiogram for QT interval measurement in patients undergoing maintenance methadone therapy. 

Titus-Lay, E.N., Jaynes, H.A., Tomaselli Muensterman, E., Ott, C.A., Walroth, T.A., Williams, G., Moe, P.R., Wilbrandt, M. and Tisdale, J.E. (2021), 

Pharmacotherapy, 41: 494-500. doi.org/10.1002/phar.2521



Methadone Destabilizes Cardiac Repolarization During Sleep. 

Solhjoo S, Punjabi NM, Ivanescu AE, Crainiceanu C, Gaynanova I, Wicken C, Buckenmaier C 3rd, Haigney MC. 

Clin Pharmacol Ther. 2021 Jul 19. doi: 10.1002/cpt.2368. Epub ahead of print. PMID: 34287835.


Methadone-Induced Polymorphic Ventricular Tachycardia Complicated by Takotsubo Cardiomyopathy in a Malnourished Patient. 

Ali M, Adam O, Subahi A, Awadelkarim A, Fatiwala L, Singh MM, Alhusain R, Lieberman R. 

J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211005100. doi: 10.1177/23247096211005100. PMID: 33843317; PMCID: PMC8042543.


Opium Addiction and Correlation with Early and Six-month Outcomes of Presenting with ST Elevation Myocardial Infarction Treated Initially with Thrombolytic Therapy. 

Mousavi M, Kalhor S, Alizadeh M, Movahed MR. 

Am J Cardiovasc Dis. 2021 Feb 15;11(1):115-123. PMID: 33815927; PMCID: PMC8012279.


Loperamide: an emerging drug of abuse and cause of prolonged QTc. 

Whittaker G, Newman J. 

Clin Med (Lond). 2021 Mar;21(2):150-152. doi: 10.7861/clinmed.2020-1046. PMID: 33762378; PMCID: PMC8002798.


Antipsychotics in routine treatment are minor contributors to QT prolongation compared to genetics and age. 

Hommers L, Scherf-Clavel M, Stempel R, Roth J, Falter M, Deckert J, Mattheisen M, Unterecker S, Gawlik M. 

J Psychopharmacol. 2021 Mar 28:2698811211003477. doi: 10.1177/02698811211003477. Epub ahead of print. PMID: 33779379.


Methadone, Metoclopramide and Metronidazole Interaction Causing Torsades de Pointes. 

Gnanapandithan K, Karthik N, Gerber J. 

Clin Pract. 2021 Feb 7;11(1):101-105. doi: 10.3390/clinpract11010015. PMID: 33562182; PMCID: PMC7931031.


Safety of ibogaine administration in detoxification of opioid dependent individuals: a descriptive open-label observational study. 

Knuijver T, Schellekens A, Belgers M, Donders R, van Oosteren T, Kramers C, Verkes RJ. 

Addiction. 2021 Feb 23. doi: 10.1111/add.15448. Epub ahead of print. PMID: 33620733.



Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study. 

Javadi HR, Mirakbari SM, Allami A, Yazdi Z, Katebi K. 

Indian J Crit Care Med. 2021 Jan;25(1):43-47. doi: 10.5005/jp-journals-10071-23596. PMID: 33603300; PMCID: PMC7874289.


Effect of heroin on right ventricular cardiac performance. 

Selcuk M, Yildirim E, Saylik F, Deniz O, Mutluer FO. 

Cardiovasc J Afr. 2020 Sep/Oct;31(5):241-244. doi: 10.5830/CVJA-2020-002. Epub 2020 Mar 5. PMID: 32140699.


Effect of Heroin on Electrocardiographic Parameters. 

Yildirim E, Selcuk M, Saylik F, Mutluer FO, Deniz O. 

Arq Bras Cardiol. 2020 Dec;115(6):1135-1141. English, Portuguese. doi: 10.36660/abc.20190296. PMID: 33470313.


Comparison of two algorithms to support medication surveillance for drug-drug interactions between QTc-prolonging drugs. 

Berger FA, van der Sijs H, van Gelder T, Kuijper AFM, van den Bemt PMLA, Becker ML. 

Int J Med Inform. 2021 Jan;145:104329. doi: 10.1016/j.ijmedinf.2020.104329. Epub 2020 Nov 4. PMID: 33181445.


Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use. 

Tam WC, Lam UP, Mok TM, Chang T, Ho W, De Brito Lima Evora MA 

Case Rep Cardiol. 2020 Sep 23;2020:4504657. doi: 10.1155/2020/4504657. PMID: 33029432; PMCID: PMC7532395.


Development and validation of a tool to assess the risk of QT drug-drug interactions in clinical practice. 

Berger FA, van der Sijs H, Becker ML, van Gelder T, van den Bemt PMLA. 

BMC Med Inform Decis Mak. 2020;20(1):171. Published 2020 Jul 23. doi:10.1186/s12911-020-01181-3

Development and validation of a tool to assess the risk of QT drug-drug interactions in clinical practice. 

QT prolongation in HIV-positive patients: Review article. 

Liu J, Shah SK, Basu-Ray I, Garcia-Diaz J, Khalid K, Saeed M. 

Indian Heart J. 2019;71(6):434-439. doi:10.1016/j.ihj.2019.11.259


QTc Prolongation Secondary to Zolpidem Use.

Suarez L, Kolla BP, Hall-Flavin D, Mansukhani MP.

Prim Care Companion CNS Disord. 2020 Mar 19;22(2). pii: 19l02506. doi: 10.4088/PCC.19l02506. 


Effect of direct-acting antivirals on corrected QT interval and cardiac functions in patients with chronic hepatitis C virus infection.

Ibrahim MG, Sharafeldin AA, Mousa NI, Mousa TK, El Missiri AM.

Egypt Heart J. 2020 Feb 7;72(1):7. doi: 10.1186/s43044-020-0042-y.


Loperamide overdose causing torsades de pointes and requiring Impella temporary mechanical support: a case report.

Cicci JD, Jagielski SM, Clarke MM, Rayson RA, Cavender MA.

Eur Heart J Case Rep. 2019 Dec;3(4):1-6. doi: 10.1093/ehjcr/ytz150. 


Liver Stiffness, Not Fat Liver Content, Predicts the Length of QTc Interval in Patients with Chronic Liver Disease.

Bellan M, Rigamonti C, Giacomini GM, Makmur G, Marconi C, Nicosia F, Panero A, De Benedittis C, Burlone ME, Minisini R, Pirisi M.

Gastroenterol Res Pract. 2019 Dec 23;2019:6731498. doi: 10.1155/2019/6731498.


Mirtazapine's effect on the QT interval in medically hospitalized patients.

Allen ND, Leung JG, Palmer BA.

Ment Health Clin. 2020 Jan 9;10(1):30-33. doi: 10.9740/mhc.2020.01.030. 


Prevalence of ECG abnormalities and risk factors for QTc interval prolongation in hospitalized psychiatric patients.

Ansermot N, Bochatay M, Schläpfer J, Gholam M, Gonthier A, Conus P, Eap CB.

Ther Adv Psychopharmacol. 2019 Dec 12;9:2045125319891386. doi: 10.1177/2045125319891386. 


Electrocardiographic Corrected QT (QTc) Dispersion Value as a Predictor for Estimation of Neonatal Mortality in Pre-Term Neonates.

Shabestari AA, Dalirrooyfard M, Mazloomzadeh S.

Acta Inform Med. 2019 Sep;27(3):158-161. doi: 10.5455/aim.2019.27.158-161.


Risk Factors and Prevalence of QTc Prolongation in Adult Burn Patients Receiving Methadone.

Walroth TA, Boyd AN, Hester AM, Schoenle M, Hartman BC, Sood R.

J Burn Care Res. 2019 Dec 6. pii: irz200. doi: 10.1093/jbcr/irz200. 



Effect of lofexidine on cardiac repolarization during treatment of opioid withdrawal.

Darpö B, Pirner M, Longstreth J, Ferber G.

Drug Alcohol Depend. 2019 Sep 27;205:107596. doi: 10.1016/j.drugalcdep.2019.107596.


Direct-acting antiviral interactions with opioids, alcohol or illicit drugs of abuse in HCV-infected patients.

Ing Lorenzini K, Girardin F.

Liver Int. 2019 Oct 26. doi: 10.1111/liv.14283. 



Prevalence of prolonged QT interval in patients with HCV-related chronic liver disease.

Gaafar AE, Abd El-Aal A, Alboraie M, Hassan HM, ElTahan A, AbdelRahman Y, Wifi MN, Omran D, Mansour SA, Hassan WM, Ismail M, ElKassas M.

Egypt Heart J. 2019 Sep 7;71(1):15. doi: 10.1186/s43044-019-0016-0. Erratum in: Egypt Heart J. 2019 Oct 29;71(1):21. 



Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings.

Zwartsen A, de Korte T, Nacken P, de Lange DW, Westerink RHS, Hondebrink L.

J Mol Cell Cardiol. 2019 Sep 14. pii: S0022-2828(19)30189-0. doi: 10.1016/j.yjmcc.2019.09.007. 


Comprehensive review on methadone-induced QT prolongation and torsades.

Treece JM, Al Madani M, El Khoury G, Khraisha O, Martin JE, Baumrucker SJ, Neglia CA, Paul TK. 

J Pharmacol Pharmacother 2018;9:66-75


Prevalence and risk factors of prolonged QT interval and electrocardiographic abnormalities in persons living with HIV.

Knudsen AD, Kofoed KF, Gelpi M, Sigvardsen PE, Mocroft A, Kühl JT, Fuchs A, Køber L, Nordestgaard BG, Benfield T, Graff C, Skov MW, Lundgren J, Nielsen SD; Copenhagen Comorbidity in HIV Infection (COCOMO) Study.

AIDS. 2019 Aug 1. doi: 10.1097/QAD.0000000000002327. 


Association between Use of Methadone, Other Central Nervous System Depressants, and QTc Interval-Prolonging Medications and Risk of Mortality in a Large Cohort of Women Living with or at Risk for Human Immunodeficiency Virus Infection.

Tamraz B, Reisner L, French AL, King ST, Fischl MA, Ofotokun I, Kashuba A, Milam J, Murphy K, Augenbraun M, Liu C, Finley PR, Aouizerat B, Cocohoba J, Gange S, Bacchetti P, Greenblatt RM.

Pharmacotherapy. 2019 Jul 22. doi: 10.1002/phar.2312.