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Drug-induced Proarrhythmia and Torsade de Pointes: A Primer for Students and Practitioners of Medicine and Pharmacy.

Turner JR, Rodriguez I, Mantovani E, Gintant G, Kowey PR, Klotzbaugh RJ, Prasad K, Sager PT, Stockbridge N, Strnadova C; Cardiac Safety Research Consortium.

J Clin Pharmacol. 2018 Apr 19. doi: 10.1002/jcph.1129.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29672845

Impact of Drug Induced Long QT Syndrome: A Systematic Review.

Arunachalam K, Lakshmanan S, Maan A, Kumar N, Dominic P.

J Clin Med Res. 2018 May;10(5):384-390. doi: 10.14740/jocmr3338w.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862085/

EKG: QT - Verlängerung durch Methadon

FOSUMOS – Forum Suchtmedizin Ostschweiz, Themenseite

https://www.fosumos.ch/fosumos/index.php/de/heroin/methadon/qt-verlaengerung

Electrocardiogram Changes with Acute Alcohol Intoxication: A Systematic Review.

Raheja H, Namana V, Chopra K, Sinha A, Gupta SS, Kamholz S, Moskovits N, Shani J, Hollander G.

Open Cardiovasc Med J. 2018 Feb 12;12:1-6. doi: 10.2174/1874192401812010001.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838641/

Psychopharmakaassoziierte QTc-Intervall-Verlängerung und Torsade de Pointes

QTc Prolongation by Psychotropic Drugs and the Risk of Torsade de Pointes

Dtsch Arztebl Int 2011; 108(41): 687-93; DOI: 10.3238/arztebl.2011.0687

Wenzel-Seifert, Katharina; Wittmann, Markus; Haen, Ekkehard

https://www.aerzteblatt.de/archiv/108561/Psychopharmakaassoziierte-QTc-Intervall-Verlaengerung-und-Torsade-de-Pointes

QTc prolongation after ADHD medication.

Snircova E, Marcincakova Husarova V, Ondrejka I, Hrtanek I, Farsky I, Nosalova G.

Neuro Endocrinol Lett. 2018 Feb 6;38(8):549-554.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29504733

Gefährliche QTc-Verlängerung durch Methadon

Barbara Dezulian, Nadjibulah Gholami, Philip Bruggmann

Arud Zentren für Suchtmedizin, Zürich

SWISS MEDICAL FORUM – SCHWEIZERISCHES MEDIZIN-FORUM 2016;16(7):173–175

https://medicalforum.ch/de/resource/jf/journal/file/download/article/smf/de/smf.2016.02543/smf_02543.pdf/

The Clue Is in the U Wave: Torsades de Pointes Ventricular Tachycardia in a Hypokalemic Woman on Methadone.

Fitzpatrick JK, Goldschlager N.

Ann Emerg Med. 2018 Apr;71(4):473-476. doi: 10.1016/j.annemergmed.2017.09.007.

http://www.annemergmed.com/article/S0196-0644(17)31656-6/fulltext

Methadon induzierte QTc Verlängerungen im EKG - ein dosis- und geschlechterabhängiger Effekt

Nathalie Brunner, Luis Falcato, Philip Bruggmann

ARUD Zürich (Arbeitsgemeinschaft für risikoarmen Umgang mit Drogen) Schweiz, www.arud-zh.ch

Präsentiert am 9. Interdisziplinären Kongress für Suchtmedizin, München, 3. – 5. Juli 2008

https://praxis-suchtmedizin.ch/fosumos/images/stories/heroin/qtc%20nathalie%20brunner%20poster%20arud%20juli%2008.pdf

Regarding Methadone and the QTc Interval: Paucity of Clinically Significant Factors in a Retrospective Cohort, Gavin Bart et al.

Stoklosa T, Haber P.

J Addict Med. 2018 Mar/Apr;12(2):167. doi: 10.1097/ADM.0000000000000382.

https://journals.lww.com/journaladdictionmedicine/Citation/2018/04000/Regarding_Methadone_and_the_QTc_Interval___Paucity.14.aspx

Presence or Absence of QTc Prolongation in Buprenorphine-Naloxone Among Youth With Opioid Dependence.

Poole SA, Pecoraro A, Subramaniam G, Woody G, Vetter VL.

J Addict Med. 2016 Jan-Feb;10(1):26-33. doi: 10.1097/ADM.0000000000000176.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733605/

Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity.

Tsiompanidis E, Siakavellas SI, Tentolouris A, Eleftheriadou I, Chorepsima S, Manolakis A, Oikonomou K, Tentolouris N.

World J Gastrointest Pathophysiol. 2018 Feb 15;9(1):28-36. doi: 10.4291/wjgp.v9.i1.28.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823700/

Sustained release oral morphine as an alternative to methadone for the treatment of opioid-use disorder post Torsades de Pointes cardiac arrest.

Walton G, Nolan S, Sutherland C, Ahamad K.

BMJ Case Rep. 2015 Sep 21;2015. pii: bcr2015210239. doi: 10.1136/bcr-2015-210239.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577656/

The Use of First Line Highly Active Anti-Retroviral Therapy (HAART) is Not Associated with Qtc Prolongation in HIV Patients.

Ogunmodede J, Kolo P, Katibi I, Omotoso A.

Ethiop J Health Sci. 2017 Nov;27(6):613-620.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811940/

QTc interval screening in an opioid treatment program.

Katz DF, Sun J, Khatri V, Kao D, Bucher-Bartelson B, Traut C, Lundin-Martinez J, Goodman M, Mehler PS, Krantz MJ.

Am J Cardiol. 2013 Oct 1;112(7):1013-8. doi: 10.1016/j.amjcard.2013.05.037.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361084/

Long QT Syndrome.

Alders M, Bikker H, Christiaans I.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018.
2003 Feb 20 [updated 2018 Feb 8].

PMID: 20301308

https://www.ncbi.nlm.nih.gov/books/NBK1129/

Methadone, QTc prolongation and torsades de pointes: Current concepts, management and a hidden twist in the tale?

Mujtaba S, Romero J, Taub CC.

J Cardiovasc Dis Res. 2013 Dec;4(4):229-35. doi: 10.1016/j.jcdr.2013.10.001.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953689/

Limited Evidence for Risk Factors for Proarrhythmia and Sudden Cardiac Death in Patients Using Antidepressants: Dutch Consensus on ECG Monitoring.

Simoons M, Seldenrijk A, Mulder H, Birkenhäger T, Groothedde-Kuyvenhoven M, Kok R, Kramers C, Verbeeck W, Westra M, van Roon E, Bakker R, Ruhé H.

Drug Saf. 2018 Feb 26. doi: 10.1007/s40264-018-0649-z.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29484613

Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.

Kao DP, Haigney MC, Mehler PS, Krantz MJ.

Addiction. 2015 Sep;110(9):1468-75. doi: 10.1111/add.13013.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521976/

Prolongation of the QTc interval in HIV-infected individuals compared to the general population

Reinsch, N., Arendt, M., Geisel, M.H. et al. Infection (2017) 45: 659. doi.org/10.1007/s15010-017-1053-9

Abstract

https://link.springer.com/article/10.1007%2Fs15010-017-1053-9

Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem.

Vieweg WV, Hasnain M, Howland RH, Clausen T, Koneru JN, Kogut C, Crouse EL, Hancox JC, Fernandez A, Pandurangi AK.

Ther Adv Psychopharmacol. 2013 Aug;3(4):219-32. doi: 10.1177/2045125312469982.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805428/

The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na⁺ channel, Na(v)1.5.

Schulze V, Stoetzer C, O'Reilly AO, Eberhardt E, Foadi N, Ahrens J, Wegner F, Lampert A, de la Roche J, Leffler A.

Br J Pharmacol. 2014 Jan;171(2):427-37. doi: 10.1111/bph.12465.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904262/