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Multidisciplinary Management of Opioid Use-Related Infective Endocarditis: Treatment, QTc Values, and Cardiac Arrests due to Ventricular Fibrillation. 

Rosenfeld LE, Jain S, Amabile A, Geirsson A, Krane M, Weimer MB. 

J Clin Med. 2023 Jan 22;12(3):882. doi: 10.3390/jcm12030882. PMID: 36769531; PMCID: PMC9917424.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917424/

One-year survey of methadone-induced cardiac complications. 

Taheri SK, Bawand R, Sanginabadi F, Khansari N, Moradi A. 

Caspian J Intern Med. 2023 Winter;14(1):43-46. doi: 10.22088/cjim.14.1.43. PMID: 36741481; PMCID: PMC9878909.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878909/

High-Throughput Assessment of Real-World Medication Effects on QT Interval Prolongation: Observational Study. 

Yuan N, Oesterle A, Botting P, Chugh S, Albert C, Ebinger J, Ouyang D. 

JMIR Cardio. 2023 Jan 20;7:e41055. doi: 10.2196/41055. PMID: 36662566; PMCID: PMC9898836.

https://cardio.jmir.org/2023//e41055/

QT Ratio: A simple solution to individual QT correction. 

Ether ND, Leishman DJ, Bailie MB, Lauver DA. 

J Pharmacol Toxicol Methods. 2022 Aug 22:107211. doi: 10.1016/j.vascn.2022.107211. Epub ahead of print. PMID: 36007862.

https://linkinghub.elsevier.com/retrieve/pii/S1056-8719(22)00058-2

Increasing Adiposity Is Associated With QTc Interval Prolongation and Increased Ventricular Arrhythmic Risk in the Context of Metabolic Dysfunction: Results From the UK Biobank. 

Patel KHK, Li X, Xu X, Sun L, Ardissino M, Punjabi PP, Purkayastha S, Peters NS, Ware JS, Ng FS. 

Front Cardiovasc Med. 2022 Jun 29;9:939156. doi: 10.3389/fcvm.2022.939156. PMID: 35845082; PMCID: PMC9277510.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277510/

Arrhythmogenesis and Prolonged Repolarization From Synthetic Opioids: Finally Sorted? 

Eckhardt LL. 

J Am Heart Assoc. 2022 Jun 7;11(11):e025778. doi: 10.1161/JAHA.122.025778. Epub 2022 Jun 6. PMID: 35658484; PMCID: PMC9238742.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238742/

Estimation of cardiac QTc intervals in people prescribed antipsychotics: a comparison of correction factors. 

Andric T, Winckel K, Tanzer TD, Hollingworth S, Smith L, Isoardi K, Tan O, Siskind D. 

Ther Adv Psychopharmacol. 2022 Jun 16;12:20451253221104947. doi: 10.1177/20451253221104947. PMID: 35747226; PMCID: PMC9210090.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210090/

Methadone Blockade of Cardiac Inward Rectifier K+ Current Augments Membrane Instability and Amplifies U Waves on Surface ECGs: A Translational Study. 

Klein MG, Krantz MJ, Fatima N, Watters A, Colon-Sanchez D, Geiger RM, Goldstein RE, Solhjoo S, Mehler PS, Flagg TP, Haigney MC. 

J Am Heart Assoc. 2022 Jun 7;11(11):e023482. doi: 10.1161/JAHA.121.023482. Epub 2022 Jun 6. PMID: 35658478; PMCID: PMC9238736.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238736/

Association of Medication-Assisted Therapy with New Onset of Cardiac Arrhythmia in Patients Diagnosed with Opioid Use Disorders. 

Raji MA, Priyadarshni S, Yu X, Digbeu B, Kuo YF. 

Am J Med. 2022 Jul;135(7):864-870.e3. doi: 10.1016/j.amjmed.2022.01.032. Epub 2022 Feb 6. PMID: 35139325; PMCID: PMC9232850.

https://www.sciencedirect.com/science/article/abs/pii/S000293432200095X

Association of a Common NOS1AP Variant with Attenuation of QTc Prolongation in Men with Heroin Dependence Undergoing Methadone Treatment. 

Chang KC, Chen KW, Huang CL, Liao WL, Wu MY, Lin YK, Shiao YT, Chung WH, Lin YN, Lane HY. 

J Pers Med. 2022 May 20;12(5):835. doi: 10.3390/jpm12050835. PMID: 35629257; PMCID: PMC9143734.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143734/

In vitro-in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans. 

Shi M, Dong Y, Bouwmeester H, Rietjens IMCM, Strikwold M.

Arch Toxicol. 2022 May 23. doi: 10.1007/s00204-022-03309-y. Epub ahead of print. PMID: 35604418.

https://link.springer.com/article/10.1007/s00204-022-03309-y

Antipsychotic Polypharmacy-Related Cardiovascular Morbidity and Mortality: A Comprehensive Review. 

Edinoff AN, Ellis ED, Nussdorf LM, Hill TW, Cornett EM, Kaye AM, Kaye AD. 

Neurol Int. 2022 Mar 17;14(1):294-309. doi: 10.3390/neurolint14010024. PMID: 35324580; PMCID: PMC8954521.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954521/

Diphenhydramine-Induced Torsade De Pointes With Pharmacological Cardioversion in a Patient With Methadone-Induced QT Prolongation. 

Hoffman JP, Serdiuk AA, Escher AR Jr, Bordoni B, Evans R. 

Cureus. 2022 Feb 23;14(2):e22534. doi: 10.7759/cureus.22534. PMID: 35228984; PMCID: PMC8865736.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8865736/

A Case Report on QTc Prolongation: Understanding the Medication Risks and Electrolyte Imbalance. 

Jha S. 

Cureus. 2022 Jan 19;14(1):e21421. doi: 10.7759/cureus.21421. PMID: 35198326; PMCID: PMC8855979.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855979/

The best QT correction formula in a non-hospitalized population: the Fasa PERSIAN cohort study. 

Yazdanpanah MH, Naghizadeh MM, Sayyadipoor S, Farjam M. 

BMC Cardiovasc Disord. 2022 Feb 16;22(1):52. doi: 10.1186/s12872-022-02502-2. PMID: 35172723; PMCID: PMC8851728.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851728/

Open-access database of literature derived drug-related Torsade de Pointes cases. 

Krumpholz L, Wiśniowska B, Polak S. 

BMC Pharmacol Toxicol. 2022 Jan 10;23(1):7. doi: 10.1186/s40360-021-00548-0. Erratum in: BMC Pharmacol Toxicol. 2022 Jan 31;23(1):11. PMID: 35012678; PMCID: PMC8750847.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750847/

Brugada syndrome: should we be screening patients before prescribing psychotropic medication? 

Attard A, Stanniland C, Attard S, Iles A, Rajappan K. 

Ther Adv Psychopharmacol. 2022 Jan 28;12:20451253211067017. doi: 10.1177/20451253211067017. PMID: 35111298; PMCID: PMC8801628.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801628/

Loperamide-Induced Torsades de Pointes. 

Isang E, Shali L, Morris CB, Mahlow J. 

Cureus. 2021 Dec 9;13(12):e20299. doi: 10.7759/cureus.20299. PMID: 35028205; PMCID: PMC8747988.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747988/

Rapid Transition to Buprenorphine in a Patient With Methadone-Related QTc Interval Prolongation. 

Brogdon H, Facer KL, Cox EJ, Carlson RH Jr, Wurzel JF 3rd. 

J Addict Med. 2021 Dec 3. doi: 10.1097/ADM.0000000000000935. Epub ahead of print. PMID: 34864786.

Abstract

https://pubmed.ncbi.nlm.nih.gov/34864786/

20 drug-drug interactions, polypharmacy, and analysis of the nature of risk factors due to QT interval prolonging drug use and potentially inappropriate psychotropic use in elderly psychiatry outpatients. 

Das B, Ramasubbu SK, Agnihotri A, Kumar B, Rawat VS. Leading 

Ther Adv Cardiovasc Dis. 2021 Jan-Dec;15:17539447211058892. doi: 10.1177/17539447211058892. PMID: 34841978; PMCID: PMC8641120.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641120/

De novo electrocardiographic abnormalities in persons living with HIV. 

Knudsen AD, Graff C, Nielsen JB, Thomsen MT, Høgh J, Benfield T, Gerstoft J, Køber L, Kofoed KF, Nielsen SD. 

Sci Rep. 2021 Oct 21;11(1):20750. doi: 10.1038/s41598-021-00290-x. PMID: 34675281; PMCID: PMC8531322.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531322/

Accuracy of a single-lead mobile smartphone electrocardiogram for QT interval measurement in patients undergoing maintenance methadone therapy. 

Titus-Lay, E.N., Jaynes, H.A., Tomaselli Muensterman, E., Ott, C.A., Walroth, T.A., Williams, G., Moe, P.R., Wilbrandt, M. and Tisdale, J.E. (2021), 

Pharmacotherapy, 41: 494-500. doi.org/10.1002/phar.2521

Abstract

https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/phar.2521

Methadone Destabilizes Cardiac Repolarization During Sleep. 

Solhjoo S, Punjabi NM, Ivanescu AE, Crainiceanu C, Gaynanova I, Wicken C, Buckenmaier C 3rd, Haigney MC. 

Clin Pharmacol Ther. 2021 Jul 19. doi: 10.1002/cpt.2368. Epub ahead of print. PMID: 34287835.

https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2368

Methadone-Induced Polymorphic Ventricular Tachycardia Complicated by Takotsubo Cardiomyopathy in a Malnourished Patient. 

Ali M, Adam O, Subahi A, Awadelkarim A, Fatiwala L, Singh MM, Alhusain R, Lieberman R. 

J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211005100. doi: 10.1177/23247096211005100. PMID: 33843317; PMCID: PMC8042543.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042543/

Opium Addiction and Correlation with Early and Six-month Outcomes of Presenting with ST Elevation Myocardial Infarction Treated Initially with Thrombolytic Therapy. 

Mousavi M, Kalhor S, Alizadeh M, Movahed MR. 

Am J Cardiovasc Dis. 2021 Feb 15;11(1):115-123. PMID: 33815927; PMCID: PMC8012279.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8012279/

Loperamide: an emerging drug of abuse and cause of prolonged QTc. 

Whittaker G, Newman J. 

Clin Med (Lond). 2021 Mar;21(2):150-152. doi: 10.7861/clinmed.2020-1046. PMID: 33762378; PMCID: PMC8002798.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002798/

Antipsychotics in routine treatment are minor contributors to QT prolongation compared to genetics and age. 

Hommers L, Scherf-Clavel M, Stempel R, Roth J, Falter M, Deckert J, Mattheisen M, Unterecker S, Gawlik M. 

J Psychopharmacol. 2021 Mar 28:2698811211003477. doi: 10.1177/02698811211003477. Epub ahead of print. PMID: 33779379.

https://journals.sagepub.com/doi/10.1177/02698811211003477

Methadone, Metoclopramide and Metronidazole Interaction Causing Torsades de Pointes. 

Gnanapandithan K, Karthik N, Gerber J. 

Clin Pract. 2021 Feb 7;11(1):101-105. doi: 10.3390/clinpract11010015. PMID: 33562182; PMCID: PMC7931031.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931031/

Safety of ibogaine administration in detoxification of opioid dependent individuals: a descriptive open-label observational study. 

Knuijver T, Schellekens A, Belgers M, Donders R, van Oosteren T, Kramers C, Verkes RJ. 

Addiction. 2021 Feb 23. doi: 10.1111/add.15448. Epub ahead of print. PMID: 33620733.

Abstract

https://pubmed.ncbi.nlm.nih.gov/33620733/

Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study. 

Javadi HR, Mirakbari SM, Allami A, Yazdi Z, Katebi K. 

Indian J Crit Care Med. 2021 Jan;25(1):43-47. doi: 10.5005/jp-journals-10071-23596. PMID: 33603300; PMCID: PMC7874289.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874289/

  1. Effect of heroin on right ventricular cardiac performance. 
  2. Effect of Heroin on Electrocardiographic Parameters. 
  3. Comparison of two algorithms to support medication surveillance for drug-drug interactions between QTc-prolonging drugs. 
  4. Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use. 
  5. Development and validation of a tool to assess the risk of QT drug-drug interactions in clinical practice.