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Q-T interval prolongation in cirrhosis: Relationship and severity.

Hajiaghamohammadi AA, Daee MM, Zargar A, Ahmadi-Gooraji S, Rahban A, Attaran F.

Caspian J Intern Med. 2018 Summer;9(3):239-243. doi: 10.22088/cjim.9.3.239.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121343/

Liver Fibrosis Is Associated With Corrected QT Prolongation During Ledipasvir/Sofosbuvir Treatment for Patients With Chronic Hepatitis C.

Tahata Y, Sakamori R, Urabe A, Morishita N, Yamada R, Yakushijin T, Hiramatsu N, Doi Y, Kaneko A, Hagiwara H, Yamada Y, Hijioka T, Inada M, Tamura S, Imai Y, Furuta K, Kodama T, Hikita H, Tatsumi T, Takehara T.

Hepatol Commun. 2018 Aug 6;2(8):884-892. doi: 10.1002/hep4.1206. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078212/

Limited Evidence for Risk Factors for Proarrhythmia and Sudden Cardiac Death in Patients Using Antidepressants: Dutch Consensus on ECG Monitoring.

Simoons M, Seldenrijk A, Mulder H, Birkenhäger T, Groothedde-Kuyvenhoven M, Kok R, Kramers C, Verbeeck W, Westra M, van Roon E, Bakker R, Ruhé H.

Drug Saf. 2018 Feb 26. doi: 10.1007/s40264-018-0649-z.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29484613

QT length during methadone maintenance treatment: Gene x dose interaction.

Zerdazi EH, Vorspan F, Marees AT, Naccache F, Lepine JP, Laplanche JL, Prince N, Marie-Claire C, Bellivier F, Mouly S, Bloch V.

Fundam Clin Pharmacol. 2018 Aug 7. doi: 10.1111/fcp.12405.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/30086202

Prolongation of the QTc interval in HIV-infected individuals compared to the general population

Reinsch, N., Arendt, M., Geisel, M.H. et al. Infection (2017) 45: 659. doi.org/10.1007/s15010-017-1053-9

Abstract

https://link.springer.com/article/10.1007%2Fs15010-017-1053-9

Opioids and Cardiac Arrhythmia: A Literature Review.

Behzadi M, Joukar S, Beik A.

Med Princ Pract. 2018 Aug 2. doi: 10.1159/000492616.

https://www.karger.com/Article/Pdf/492616

The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na⁺ channel, Na(v)1.5.

Schulze V, Stoetzer C, O'Reilly AO, Eberhardt E, Foadi N, Ahrens J, Wegner F, Lampert A, de la Roche J, Leffler A.

Br J Pharmacol. 2014 Jan;171(2):427-37. doi: 10.1111/bph.12465.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904262/

QTc interval prolongation in critically ill patients: Prevalence, risk factors and associated medications.

Fernandes FM, Silva EP, Martins RR, Oliveira AG (2018) 

PLoS ONE 13(6): e0199028. doi.org/10.1371/journal.pone.0199028

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199028

EKG: QT - Verlängerung durch Methadon

FOSUMOS – Forum Suchtmedizin Ostschweiz, Themenseite

https://www.fosumos.ch/fosumos/index.php/de/heroin/methadon/qt-verlaengerung

Malignant Ventricular Arrhythmias Resulting From Drug-Induced QTc Prolongation: A Retrospective Study.

De Vecchis R, Ariano C, Di Biase G, Noutsias M.

J Clin Med Res. 2018 Jul;10(7):593-600. doi: 10.14740/jocmr3470w. Epub 2018 Jun 4.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997417/

Psychopharmakaassoziierte QTc-Intervall-Verlängerung und Torsade de Pointes

QTc Prolongation by Psychotropic Drugs and the Risk of Torsade de Pointes

Dtsch Arztebl Int 2011; 108(41): 687-93; DOI: 10.3238/arztebl.2011.0687

Wenzel-Seifert, Katharina; Wittmann, Markus; Haen, Ekkehard

https://www.aerzteblatt.de/archiv/108561/Psychopharmakaassoziierte-QTc-Intervall-Verlaengerung-und-Torsade-de-Pointes

Significance of prolonged QTc in acute exacerbations of COPD requiring hospitalization.

Van Oekelen O, Vermeersch K, Everaerts S, Vandenberk B, Willems R, Janssens W.

Int J Chron Obstruct Pulmon Dis. 2018 Jun 14;13:1937-1947. doi: 10.2147/COPD.S157630. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005315/

Gefährliche QTc-Verlängerung durch Methadon

Barbara Dezulian, Nadjibulah Gholami, Philip Bruggmann

Arud Zentren für Suchtmedizin, Zürich

SWISS MEDICAL FORUM – SCHWEIZERISCHES MEDIZIN-FORUM 2016;16(7):173–175

https://medicalforum.ch/de/resource/jf/journal/file/download/article/smf/de/smf.2016.02543/smf_02543.pdf/

QT prolongation and cardiac toxicity of new tuberculosis drugs in Europe: A Tuberculosis Network European Trialsgroup (TBnet) study.

Guglielmetti L, Tiberi S, Burman M, Kunst H, Wejse C, Togonidze T, Bothamley G, Lange C; TBNET.

Eur Respir J. 2018 Jun 7. pii: 1800537. doi: 10.1183/13993003.00537-2018.

Abstract

http://erj.ersjournals.com/content/early/2018/05/31/13993003.00537-2018

Methadon induzierte QTc Verlängerungen im EKG - ein dosis- und geschlechterabhängiger Effekt

Nathalie Brunner, Luis Falcato, Philip Bruggmann

ARUD Zürich (Arbeitsgemeinschaft für risikoarmen Umgang mit Drogen) Schweiz, www.arud-zh.ch

Präsentiert am 9. Interdisziplinären Kongress für Suchtmedizin, München, 3. – 5. Juli 2008

https://praxis-suchtmedizin.ch/fosumos/images/stories/heroin/qtc%20nathalie%20brunner%20poster%20arud%20juli%2008.pdf

Tramadol Hydrochloride at Steady State Lacks Clinically Relevant QTc Interval Increases in Healthy Adults.

Massarella J, Ariyawansa J, Natarajan J, Francke S, Murtaugh T, DeLemos B, Vaughan S, Fonseca S.

Clin Pharmacol Drug Dev. 2018 May 18. doi: 10.1002/cpdd.473.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29775246

Presence or Absence of QTc Prolongation in Buprenorphine-Naloxone Among Youth With Opioid Dependence.

Poole SA, Pecoraro A, Subramaniam G, Woody G, Vetter VL.

J Addict Med. 2016 Jan-Feb;10(1):26-33. doi: 10.1097/ADM.0000000000000176.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733605/

Effects of Methadone on Corrected Q-T Interval Prolongation in Critically Ill Children.

Heath TS, Greenberg RG, Hupp SR, Turner DA, Hornik CP, Zimmerman KO.

J Pediatr Pharmacol Ther. 2018 Mar-Apr;23(2):119-124. doi: 10.5863/1551-6776-23.2.119.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916439/

Sustained release oral morphine as an alternative to methadone for the treatment of opioid-use disorder post Torsades de Pointes cardiac arrest.

Walton G, Nolan S, Sutherland C, Ahamad K.

BMJ Case Rep. 2015 Sep 21;2015. pii: bcr2015210239. doi: 10.1136/bcr-2015-210239.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577656/

Drug-induced Proarrhythmia and Torsade de Pointes: A Primer for Students and Practitioners of Medicine and Pharmacy.

Turner JR, Rodriguez I, Mantovani E, Gintant G, Kowey PR, Klotzbaugh RJ, Prasad K, Sager PT, Stockbridge N, Strnadova C; Cardiac Safety Research Consortium.

J Clin Pharmacol. 2018 Apr 19. doi: 10.1002/jcph.1129.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29672845

QTc interval screening in an opioid treatment program.

Katz DF, Sun J, Khatri V, Kao D, Bucher-Bartelson B, Traut C, Lundin-Martinez J, Goodman M, Mehler PS, Krantz MJ.

Am J Cardiol. 2013 Oct 1;112(7):1013-8. doi: 10.1016/j.amjcard.2013.05.037.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361084/

Impact of Drug Induced Long QT Syndrome: A Systematic Review.

Arunachalam K, Lakshmanan S, Maan A, Kumar N, Dominic P.

J Clin Med Res. 2018 May;10(5):384-390. doi: 10.14740/jocmr3338w.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862085/

Methadone, QTc prolongation and torsades de pointes: Current concepts, management and a hidden twist in the tale?

Mujtaba S, Romero J, Taub CC.

J Cardiovasc Dis Res. 2013 Dec;4(4):229-35. doi: 10.1016/j.jcdr.2013.10.001.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953689/

Electrocardiogram Changes with Acute Alcohol Intoxication: A Systematic Review.

Raheja H, Namana V, Chopra K, Sinha A, Gupta SS, Kamholz S, Moskovits N, Shani J, Hollander G.

Open Cardiovasc Med J. 2018 Feb 12;12:1-6. doi: 10.2174/1874192401812010001.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838641/

Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.

Kao DP, Haigney MC, Mehler PS, Krantz MJ.

Addiction. 2015 Sep;110(9):1468-75. doi: 10.1111/add.13013.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521976/

QTc prolongation after ADHD medication.

Snircova E, Marcincakova Husarova V, Ondrejka I, Hrtanek I, Farsky I, Nosalova G.

Neuro Endocrinol Lett. 2018 Feb 6;38(8):549-554.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29504733

Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem.

Vieweg WV, Hasnain M, Howland RH, Clausen T, Koneru JN, Kogut C, Crouse EL, Hancox JC, Fernandez A, Pandurangi AK.

Ther Adv Psychopharmacol. 2013 Aug;3(4):219-32. doi: 10.1177/2045125312469982.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805428/

The Clue Is in the U Wave: Torsades de Pointes Ventricular Tachycardia in a Hypokalemic Woman on Methadone.

Fitzpatrick JK, Goldschlager N.

Ann Emerg Med. 2018 Apr;71(4):473-476. doi: 10.1016/j.annemergmed.2017.09.007.

http://www.annemergmed.com/article/S0196-0644(17)31656-6/fulltext

Buprenorphine as a safe alternative to methadone in a patient with acquired long QT syndrome: a case report.

de Jong IM, de Ruiter GS.

Neth Heart J. 2013 May;21(5):249-52. doi: 10.1007/s12471-011-0073-9.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636332/

Regarding Methadone and the QTc Interval: Paucity of Clinically Significant Factors in a Retrospective Cohort, Gavin Bart et al.

Stoklosa T, Haber P.

J Addict Med. 2018 Mar/Apr;12(2):167. doi: 10.1097/ADM.0000000000000382.

https://journals.lww.com/journaladdictionmedicine/Citation/2018/04000/Regarding_Methadone_and_the_QTc_Interval___Paucity.14.aspx

Methadone induced torsades de pointes and ventricular fibrillation: A case review.

Khalesi S, Shemirani H, Dehghani-Tafti F.

ARYA Atheroscler. 2014 Nov;10(6):339-42.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354087/

Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity.

Tsiompanidis E, Siakavellas SI, Tentolouris A, Eleftheriadou I, Chorepsima S, Manolakis A, Oikonomou K, Tentolouris N.

World J Gastrointest Pathophysiol. 2018 Feb 15;9(1):28-36. doi: 10.4291/wjgp.v9.i1.28.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823700/

Improving cardiac assessment and monitoring in methadone prescribing at an addiction service.

Ramage M, Fadaka K.

BMJ Qual Improv Rep. 2014 Sep 19;3(1). pii: u201157.w1124. doi: 10.1136/bmjquality.u201157.w1124.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645887/

The Use of First Line Highly Active Anti-Retroviral Therapy (HAART) is Not Associated with Qtc Prolongation in HIV Patients.

Ogunmodede J, Kolo P, Katibi I, Omotoso A.

Ethiop J Health Sci. 2017 Nov;27(6):613-620.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811940/

QTc interval screening for cardiac risk in methadone treatment of opioid dependence.

Pani PP, Trogu E, Maremmani I, Pacini M.

Cochrane Database Syst Rev. 2013 Jun 20;(6):CD008939. doi: 10.1002/14651858.CD008939.pub2. Review.

Abstract

http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD008939.pub2/abstract

Long QT Syndrome.

Alders M, Bikker H, Christiaans I.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018.
2003 Feb 20 [updated 2018 Feb 8].

PMID: 20301308

https://www.ncbi.nlm.nih.gov/books/NBK1129/