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Association of a Common NOS1AP Variant with Attenuation of QTc Prolongation in Men with Heroin Dependence Undergoing Methadone Treatment. 

Chang KC, Chen KW, Huang CL, Liao WL, Wu MY, Lin YK, Shiao YT, Chung WH, Lin YN, Lane HY. 

J Pers Med. 2022 May 20;12(5):835. doi: 10.3390/jpm12050835. PMID: 35629257; PMCID: PMC9143734.


In vitro-in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans. 

Shi M, Dong Y, Bouwmeester H, Rietjens IMCM, Strikwold M.

Arch Toxicol. 2022 May 23. doi: 10.1007/s00204-022-03309-y. Epub ahead of print. PMID: 35604418.


Antipsychotic Polypharmacy-Related Cardiovascular Morbidity and Mortality: A Comprehensive Review. 

Edinoff AN, Ellis ED, Nussdorf LM, Hill TW, Cornett EM, Kaye AM, Kaye AD. 

Neurol Int. 2022 Mar 17;14(1):294-309. doi: 10.3390/neurolint14010024. PMID: 35324580; PMCID: PMC8954521.


Diphenhydramine-Induced Torsade De Pointes With Pharmacological Cardioversion in a Patient With Methadone-Induced QT Prolongation. 

Hoffman JP, Serdiuk AA, Escher AR Jr, Bordoni B, Evans R. 

Cureus. 2022 Feb 23;14(2):e22534. doi: 10.7759/cureus.22534. PMID: 35228984; PMCID: PMC8865736.


A Case Report on QTc Prolongation: Understanding the Medication Risks and Electrolyte Imbalance. 

Jha S. 

Cureus. 2022 Jan 19;14(1):e21421. doi: 10.7759/cureus.21421. PMID: 35198326; PMCID: PMC8855979.


The best QT correction formula in a non-hospitalized population: the Fasa PERSIAN cohort study. 

Yazdanpanah MH, Naghizadeh MM, Sayyadipoor S, Farjam M. 

BMC Cardiovasc Disord. 2022 Feb 16;22(1):52. doi: 10.1186/s12872-022-02502-2. PMID: 35172723; PMCID: PMC8851728.


Open-access database of literature derived drug-related Torsade de Pointes cases. 

Krumpholz L, Wiśniowska B, Polak S. 

BMC Pharmacol Toxicol. 2022 Jan 10;23(1):7. doi: 10.1186/s40360-021-00548-0. Erratum in: BMC Pharmacol Toxicol. 2022 Jan 31;23(1):11. PMID: 35012678; PMCID: PMC8750847.


Brugada syndrome: should we be screening patients before prescribing psychotropic medication? 

Attard A, Stanniland C, Attard S, Iles A, Rajappan K. 

Ther Adv Psychopharmacol. 2022 Jan 28;12:20451253211067017. doi: 10.1177/20451253211067017. PMID: 35111298; PMCID: PMC8801628.


Loperamide-Induced Torsades de Pointes. 

Isang E, Shali L, Morris CB, Mahlow J. 

Cureus. 2021 Dec 9;13(12):e20299. doi: 10.7759/cureus.20299. PMID: 35028205; PMCID: PMC8747988.


Rapid Transition to Buprenorphine in a Patient With Methadone-Related QTc Interval Prolongation. 

Brogdon H, Facer KL, Cox EJ, Carlson RH Jr, Wurzel JF 3rd. 

J Addict Med. 2021 Dec 3. doi: 10.1097/ADM.0000000000000935. Epub ahead of print. PMID: 34864786.



20 drug-drug interactions, polypharmacy, and analysis of the nature of risk factors due to QT interval prolonging drug use and potentially inappropriate psychotropic use in elderly psychiatry outpatients. 

Das B, Ramasubbu SK, Agnihotri A, Kumar B, Rawat VS. Leading 

Ther Adv Cardiovasc Dis. 2021 Jan-Dec;15:17539447211058892. doi: 10.1177/17539447211058892. PMID: 34841978; PMCID: PMC8641120.


De novo electrocardiographic abnormalities in persons living with HIV. 

Knudsen AD, Graff C, Nielsen JB, Thomsen MT, Høgh J, Benfield T, Gerstoft J, Køber L, Kofoed KF, Nielsen SD. 

Sci Rep. 2021 Oct 21;11(1):20750. doi: 10.1038/s41598-021-00290-x. PMID: 34675281; PMCID: PMC8531322.


Accuracy of a single-lead mobile smartphone electrocardiogram for QT interval measurement in patients undergoing maintenance methadone therapy. 

Titus-Lay, E.N., Jaynes, H.A., Tomaselli Muensterman, E., Ott, C.A., Walroth, T.A., Williams, G., Moe, P.R., Wilbrandt, M. and Tisdale, J.E. (2021), 

Pharmacotherapy, 41: 494-500. doi.org/10.1002/phar.2521



Methadone Destabilizes Cardiac Repolarization During Sleep. 

Solhjoo S, Punjabi NM, Ivanescu AE, Crainiceanu C, Gaynanova I, Wicken C, Buckenmaier C 3rd, Haigney MC. 

Clin Pharmacol Ther. 2021 Jul 19. doi: 10.1002/cpt.2368. Epub ahead of print. PMID: 34287835.


Methadone-Induced Polymorphic Ventricular Tachycardia Complicated by Takotsubo Cardiomyopathy in a Malnourished Patient. 

Ali M, Adam O, Subahi A, Awadelkarim A, Fatiwala L, Singh MM, Alhusain R, Lieberman R. 

J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211005100. doi: 10.1177/23247096211005100. PMID: 33843317; PMCID: PMC8042543.


Opium Addiction and Correlation with Early and Six-month Outcomes of Presenting with ST Elevation Myocardial Infarction Treated Initially with Thrombolytic Therapy. 

Mousavi M, Kalhor S, Alizadeh M, Movahed MR. 

Am J Cardiovasc Dis. 2021 Feb 15;11(1):115-123. PMID: 33815927; PMCID: PMC8012279.


Loperamide: an emerging drug of abuse and cause of prolonged QTc. 

Whittaker G, Newman J. 

Clin Med (Lond). 2021 Mar;21(2):150-152. doi: 10.7861/clinmed.2020-1046. PMID: 33762378; PMCID: PMC8002798.


Antipsychotics in routine treatment are minor contributors to QT prolongation compared to genetics and age. 

Hommers L, Scherf-Clavel M, Stempel R, Roth J, Falter M, Deckert J, Mattheisen M, Unterecker S, Gawlik M. 

J Psychopharmacol. 2021 Mar 28:2698811211003477. doi: 10.1177/02698811211003477. Epub ahead of print. PMID: 33779379.


Methadone, Metoclopramide and Metronidazole Interaction Causing Torsades de Pointes. 

Gnanapandithan K, Karthik N, Gerber J. 

Clin Pract. 2021 Feb 7;11(1):101-105. doi: 10.3390/clinpract11010015. PMID: 33562182; PMCID: PMC7931031.


Safety of ibogaine administration in detoxification of opioid dependent individuals: a descriptive open-label observational study. 

Knuijver T, Schellekens A, Belgers M, Donders R, van Oosteren T, Kramers C, Verkes RJ. 

Addiction. 2021 Feb 23. doi: 10.1111/add.15448. Epub ahead of print. PMID: 33620733.



Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study. 

Javadi HR, Mirakbari SM, Allami A, Yazdi Z, Katebi K. 

Indian J Crit Care Med. 2021 Jan;25(1):43-47. doi: 10.5005/jp-journals-10071-23596. PMID: 33603300; PMCID: PMC7874289.


Effect of heroin on right ventricular cardiac performance. 

Selcuk M, Yildirim E, Saylik F, Deniz O, Mutluer FO. 

Cardiovasc J Afr. 2020 Sep/Oct;31(5):241-244. doi: 10.5830/CVJA-2020-002. Epub 2020 Mar 5. PMID: 32140699.


Effect of Heroin on Electrocardiographic Parameters. 

Yildirim E, Selcuk M, Saylik F, Mutluer FO, Deniz O. 

Arq Bras Cardiol. 2020 Dec;115(6):1135-1141. English, Portuguese. doi: 10.36660/abc.20190296. PMID: 33470313.


Comparison of two algorithms to support medication surveillance for drug-drug interactions between QTc-prolonging drugs. 

Berger FA, van der Sijs H, van Gelder T, Kuijper AFM, van den Bemt PMLA, Becker ML. 

Int J Med Inform. 2021 Jan;145:104329. doi: 10.1016/j.ijmedinf.2020.104329. Epub 2020 Nov 4. PMID: 33181445.


Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use. 

Tam WC, Lam UP, Mok TM, Chang T, Ho W, De Brito Lima Evora MA 

Case Rep Cardiol. 2020 Sep 23;2020:4504657. doi: 10.1155/2020/4504657. PMID: 33029432; PMCID: PMC7532395.


Development and validation of a tool to assess the risk of QT drug-drug interactions in clinical practice. 

Berger FA, van der Sijs H, Becker ML, van Gelder T, van den Bemt PMLA. 

BMC Med Inform Decis Mak. 2020;20(1):171. Published 2020 Jul 23. doi:10.1186/s12911-020-01181-3

Development and validation of a tool to assess the risk of QT drug-drug interactions in clinical practice. 

QT prolongation in HIV-positive patients: Review article. 

Liu J, Shah SK, Basu-Ray I, Garcia-Diaz J, Khalid K, Saeed M. 

Indian Heart J. 2019;71(6):434-439. doi:10.1016/j.ihj.2019.11.259


QTc Prolongation Secondary to Zolpidem Use.

Suarez L, Kolla BP, Hall-Flavin D, Mansukhani MP.

Prim Care Companion CNS Disord. 2020 Mar 19;22(2). pii: 19l02506. doi: 10.4088/PCC.19l02506. 


Effect of direct-acting antivirals on corrected QT interval and cardiac functions in patients with chronic hepatitis C virus infection.

Ibrahim MG, Sharafeldin AA, Mousa NI, Mousa TK, El Missiri AM.

Egypt Heart J. 2020 Feb 7;72(1):7. doi: 10.1186/s43044-020-0042-y.


Loperamide overdose causing torsades de pointes and requiring Impella temporary mechanical support: a case report.

Cicci JD, Jagielski SM, Clarke MM, Rayson RA, Cavender MA.

Eur Heart J Case Rep. 2019 Dec;3(4):1-6. doi: 10.1093/ehjcr/ytz150.