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Norwegen. 'The entire pharmaceutical compendium' in the treatment of substance use disorders

Jørg Mørland, Helge Waal

Tidsskr Nor Legeforen 2019, doi: 10.4045/tidsskr.18.0678

https://tidsskriftet.no/en/2019/02/kronikk/entire-pharmaceutical-compendium-treatment-substance-use-disorders

Prediction of Drug-Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation.

Ji B, Liu S, Xue Y, He X, Man VH, Xie XQ, Wang J.

Drugs R D. 2019 Sep;19(3):297-305. doi: 10.1007/s40268-019-00282-3.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738369/

Reduction of Benzodiazepine Use in Patients Prescribed Medical Cannabis.

Purcell C, Davis A, Moolman N, Taylor SM.

Cannabis Cannabinoid Res. 2019 Sep 23;4(3):214-218. doi: 10.1089/can.2018.0020.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757237/

An Approach to Evaluate the Effects of Concomitant Prescribing of Opioids and Benzodiazepines on Veteran Deaths and Suicides.

National Academies of Sciences, Engineering, and Medicine. 2019. 

Washington, DC: The National Academies Press. doi.org/10.17226/25532.

https://www.nap.edu/download/25532

Originalarbeit: Problematische Medikation von Benzodiazepinen, Z-Substanzen und Opioid-Analgetika - Analyse von Verschreibungsdaten der Gesetzlichen Krankenversicherung der Jahre 2006–2016

Problematic medication with benzodiazepines, “Z-drugs”, and opioid analgesics—an analysis of national health insurance prescription data from 2006–2016

Buth, Sven; Holzbach, Rüdiger; Martens, Marcus-Sebastian; Neumann-Runde, Eike; Meiners, Ommo; Verthein, Uwe

Dtsch Arztebl Int 2019; 116: 607-14; DOI: 10.3238/arztebl.2019.0607

https://www.aerzteblatt.de/medizin/originalarbeiten?aid=209655

Considerations for the use of a loading dose of diazepam for the treatment of benzodiazepine dependence.

Azanza Balmori A, García Álvarez G, Rodríguez Turiel C, Povedano Suárez EA, Muquebil Ali Al Shaban Rodríguez OW.

Adicciones. 2018 Jul 12;30(3):227-228. doi: 10.20882/adicciones.1116. English, Spanish. 

http://adicciones.es/index.php/adicciones/article/view/1116

Association of Maternal Use of Benzodiazepines and Z-Hypnotics During Pregnancy With Motor and Communication Skills and Attention-Deficit/Hyperactivity Disorder Symptoms in Preschoolers.

Lupattelli A, Chambers CD, Bandoli G, Handal M, Skurtveit S, Nordeng H.

JAMA Netw Open. 2019 Apr 5;2(4):e191435. doi: 10.1001/jamanetworkopen.2019.1435. Erratum in: JAMA Netw Open. 2019 May 3;2(5):e194291. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450329/

Association of prenatal exposure to benzodiazepines and child internalizing problems: A sibling-controlled cohort study.

Brandlistuen RE, Ystrom E, Hernandez-Diaz S, Skurtveit S, Selmer R, Handal M, et al. (2017) 

PLoS ONE 12(7): e0181042. doi.org/10.1371/journal.pone.0181042

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181042

Rates of Physician Coprescribing of Opioids and Benzodiazepines After the Release of the Centers for Disease Control and Prevention Guidelines in 2016.

Jeffery MM, Hooten WM, Jena AB, Ross JS, Shah ND, Karaca-Mandic P.

JAMA Netw Open. 2019 Aug 2;2(8):e198325. doi: 10.1001/jamanetworkopen.2019.8325.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2740781

The Emergence of New Psychoactive Substance (NPS) Benzodiazepines. A Survey of their Prevalence in Opioid Substitution Patients using LC-MS

S.Mc Namara, S.Stokes, J.Nolan

Issue: Ir Med J; Vol 112; No. 7; P970

http://imj.ie/wp-content/uploads/2019/08/The-Emergence-of-New-Psychoactive-Substance-NPS-Benzodiazepines.-A-Survey-of-their-Prevalence-in-Opioid-Substitution-Patients-using-LC-MS.pdf

Therapie der Benzodiazepinabhängigkeit - Treatment of benzodiazepine dependence

Michael Soyka

Fortschr Neurol Psychiatr 2019; 87(04): 259-270, DOI: 10.1055/a-0836-7514

Abstract

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-0836-7514

Altered cerebral benzodiazepine receptor binding in post-traumatic stress disorder.

Reuveni I, Nugent AC, Gill J, Vythilingam M, Carlson PJ, Lerner A, Neumeister A, Charney DS, Drevets WC, Bonne O.

Transl Psychiatry. 2018 Oct 4;8(1):206. doi: 10.1038/s41398-018-0257-9.

https://www.nature.com/articles/s41398-018-0257-9

Tackling benzodiazepine misuse.

Hayhoe B, Lee-Davey J.

BMJ. 2018 Jul 27;362:k3208. doi: 10.1136/bmj.k3208.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065205/

Long-term use of benzodiazepines and Z drugs: a qualitative study of patients’ and healthcare professionals’ perceptions and possible levers for change

Aliaksandra Mokhar, Silke Kuhn, Janine Topp, Jörg Dirmaier, Martin Härter, Uwe Verthein

BJGP Open 19 February 2019; bjgpopen18X101626. DOI: 10.3399/bjgpopen18X101626

https://bjgpopen.org/content/early/2019/02/19/bjgpopen18X101626

Comparing the effects of oxazepam and diazepam in actual highway driving and neurocognitive test performance: a validation study.

Jongen S, Vuurman EFPM, Ramaekers JG, Vermeeren A.

Psychopharmacology (Berl). 2018 Apr;235(4):1283-1294. doi: 10.1007/s00213-018-4844-5.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869943/

Schottland. Drugs Deaths Warning Over Lethal Street Valium

Glasgow. Addictions experts today voiced fears that street drugs being sold as Valium are responsible for an unprecedented number of drug related deaths in Glasgow.

Concerns were raised that "Street Valium" (also known as Street Blues) may be linked to a sharp rise in the number of fatal and non-fatal overdoses in the city. (Glasgow, City Council, 28.01.2019)

https://www.glasgow.gov.uk/index.aspx?articleid=23805

Benzodiazepine withdrawal in pregnant women with opioid use disorders: An observational study of current clinical practices at a tertiary obstetrical hospital.

Gopalan P, Moses-Kolko E, Valpey R, Shenai N, Smith E.

Gen Hosp Psychiatry. 2018 Dec 11;57:29-33. doi: 10.1016/j.genhosppsych.2018.12.005.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/30669023

Benzodiazepine and Opioid Co-Usage in the United States Population, 1999–2014: An Exploratory Analysis.

Nicholas T Vozoris

Sleep, zsy264, doi.org/10.1093/sleep/zsy264

Abstract

https://academic.oup.com/sleep/advance-article-abstract/doi/10.1093/sleep/zsy264/5283516

Frequency, risk factors and symptomatology of iatrogenic withdrawal from opioids and benzodiazepines in critically Ill neonates, children and adults: A systematic review of clinical studies.

Duceppe MA, Perreault MM, Frenette AJ, Burry LD, Rico P, Lavoie A, Gélinas C, Mehta S, Dagenais M, Williamson DR.

J Clin Pharm Ther. 2018 Dec 19. doi: 10.1111/jcpt.12787. 

https://onlinelibrary.wiley.com/doi/full/10.1111/jcpt.12787

Evaluating the Impact of Prescribed Versus Nonprescribed Benzodiazepine Use in Methadone Maintenance Therapy: Results from a Population-based Retrospective Cohort Study.

Eibl JK, Wilton AS, Franklyn AM, Kurdyak P, Marsh DC.

J Addict Med. 2018 Dec 12. doi: 10.1097/ADM.0000000000000476. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/30543543

We Need to Talk About Benzodiazepines—Including Their Use in Drug Combinations

Opioids like heroin and fentanyl have grabbed the media and legislative spotlight—from soaring overdose fatalities to the misguided prescription restrictions and drug-induced homicide laws ostensibly intended to combat them. What’s glossed over is that our overdose crisis primarily relates to polysubstance use. Around 80 percent of deaths involving a synthetic opioid in 2016, for example, also involved another drug. When we only focus on partial data, we only come up with partially effective solutions. With our cultural narrative failing to acknowledge this, people who use drugs need to make the effort to learn more to keep ourselves safer. (Filter, USA, 04.12.2018)

https://filtermag.org/2018/12/04/we-need-to-talk-about-benzodiazepines-including-their-use-in-drug-combinations/

Patient-centered care interventions to reduce the inappropriate prescription and use of benzodiazepines and z-drugs: a systematic review.

Mokhar A, Topp J, Härter M, Schulz H, Kuhn S, Verthein U, Dirmaier J.

PeerJ. 2018 Oct 8;6:e5535. doi: 10.7717/peerj.5535. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190800/

Designer Benzodiazepines: Another Class of New Psychoactive Substances.

Moosmann B, Auwärter V.

Handb Exp Pharmacol. 2018 Oct 27. doi: 10.1007/164_2018_154.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/30367253

Use of sedative-hypnotics and the risk of Alzheimer’s dementia: A retrospective cohort study.

Lee J, Jung SJ, Choi J-w, Shin A, Lee YJ (2018) 

PLoS ONE 13(9): e0204413. doi.org/10.1371/journal.pone.0204413

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204413

The risk of Alzheimer's disease associated with benzodiazepines and related drugs: a nested case-control study.

Tapiainen V, Taipale H, Tanskanen A, Tiihonen J, Hartikainen S, Tolppanen AM.

Acta Psychiatr Scand. 2018 May 31. doi: 10.1111/acps.12909. 

Abstract

https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.12909

„Besorgniserregende“ Studienergebnisse: Erneut Hinweise zu erhöhtem Alzheimer-Risiko durch Benzodiazepine

In einer aktuellen Studie ist erneut der Einsatz von Benzodiazepinen mit einem erhöhten Risiko für die Alzheimer-Demenz in Verbindung gebracht worden. „Obwohl der Zusammenhang zwischen Benzodiazepin-Einnahme und Alzheimer-Krankheit in dieser Studie nicht groß war, sollte die Schwelle für die Verschreibung dieser Medikamente aufgrund ihres gesamten Nebenwirkungsprofils einschließlich eines erhöhten Risikos für Stürze und Hüftfrakturen hochgehalten werden“, sagt der Hauptautor Dr. Vesa Tapiainen von der Universität von Ost-Finnland in Kuopio gegenüber Medscape. Die Studie ist in der August-Ausgabe von Acta Psychiatrica Scandinavicaveröffentlicht worden [1]. (Medscape, 10.09.2018)

https://deutsch.medscape.com/artikelansicht/4907261

Benzodiazepine: Jede vierte Verordnung bei älteren Menschen führt zur Abhängigkeit

Ann Arbor – Das Abhängigkeitspotenzial von Benzodiazepinen wird häufig unter­schätzt. Nach einer Studie in JAMA Internal Medicine(2018; doi: 10.1001/jamainternmed.2018.2413) erhielt ein Viertel aller älteren Patienten, denen Nichtpsychiater Benzodiazepine verschrieben hatten, auch nach einem Jahr weiterhin Rezepte. (aerzteblatt.de, 11.09.2018)

https://www.aerzteblatt.de/nachrichten/97784/Benzodiazepine-Jede-vierte-Verordnung-bei-aelteren-Menschen-fuehrt-zur-Abhaengigkeit

Lorazepam.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

https://www.ncbi.nlm.nih.gov/books/NBK501231/

Diazepam

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

https://www.ncbi.nlm.nih.gov/books/NBK501214/

Clonazepam

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

https://www.ncbi.nlm.nih.gov/books/NBK501209/

  1. Oxazepam
  2. Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects.
  3. EMCDDA. The misuse of benzodiazepines among high-risk opioid users in Europe
  4. Potentially inappropriate use of benzodiazepines and z-drugs in the older population-analysis of associations between long-term use and patient-related factors.
  5. Benzodiazepines and risk for hepatic encephalopathy in patients with cirrhosis and ascites.