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Benzodiazepine
- Comment: The growing problem of co-treatment with opioids and benzodiazepines
Therapie der Benzodiazepinabhängigkeit - Treatment of benzodiazepine dependence
Michael Soyka
Fortschr Neurol Psychiatr 2019; 87(04): 259-270, DOI: 10.1055/a-0836-7514
Abstract
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-0836-7514
Altered cerebral benzodiazepine receptor binding in post-traumatic stress disorder.
Reuveni I, Nugent AC, Gill J, Vythilingam M, Carlson PJ, Lerner A, Neumeister A, Charney DS, Drevets WC, Bonne O.
Transl Psychiatry. 2018 Oct 4;8(1):206. doi: 10.1038/s41398-018-0257-9.
https://www.nature.com/articles/s41398-018-0257-9
Tackling benzodiazepine misuse.
Hayhoe B, Lee-Davey J.
BMJ. 2018 Jul 27;362:k3208. doi: 10.1136/bmj.k3208.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065205/
Long-term use of benzodiazepines and Z drugs: a qualitative study of patients’ and healthcare professionals’ perceptions and possible levers for change
Aliaksandra Mokhar, Silke Kuhn, Janine Topp, Jörg Dirmaier, Martin Härter, Uwe Verthein
BJGP Open 19 February 2019; bjgpopen18X101626. DOI: 10.3399/bjgpopen18X101626
https://bjgpopen.org/content/early/2019/02/19/bjgpopen18X101626
Comparing the effects of oxazepam and diazepam in actual highway driving and neurocognitive test performance: a validation study.
Jongen S, Vuurman EFPM, Ramaekers JG, Vermeeren A.
Psychopharmacology (Berl). 2018 Apr;235(4):1283-1294. doi: 10.1007/s00213-018-4844-5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869943/
Schottland. Drugs Deaths Warning Over Lethal Street Valium
Glasgow. Addictions experts today voiced fears that street drugs being sold as Valium are responsible for an unprecedented number of drug related deaths in Glasgow.
Concerns were raised that "Street Valium" (also known as Street Blues) may be linked to a sharp rise in the number of fatal and non-fatal overdoses in the city. (Glasgow, City Council, 28.01.2019)
https://www.glasgow.gov.uk/index.aspx?articleid=23805
Benzodiazepine withdrawal in pregnant women with opioid use disorders: An observational study of current clinical practices at a tertiary obstetrical hospital.
Gopalan P, Moses-Kolko E, Valpey R, Shenai N, Smith E.
Gen Hosp Psychiatry. 2018 Dec 11;57:29-33. doi: 10.1016/j.genhosppsych.2018.12.005.
Abstract
https://www.ncbi.nlm.nih.gov/pubmed/30669023
Benzodiazepine and Opioid Co-Usage in the United States Population, 1999–2014: An Exploratory Analysis.
Nicholas T Vozoris
Sleep, zsy264, doi.org/10.1093/sleep/zsy264
Abstract
https://academic.oup.com/sleep/advance-article-abstract/doi/10.1093/sleep/zsy264/5283516
Frequency, risk factors and symptomatology of iatrogenic withdrawal from opioids and benzodiazepines in critically Ill neonates, children and adults: A systematic review of clinical studies.
Duceppe MA, Perreault MM, Frenette AJ, Burry LD, Rico P, Lavoie A, Gélinas C, Mehta S, Dagenais M, Williamson DR.
J Clin Pharm Ther. 2018 Dec 19. doi: 10.1111/jcpt.12787.
https://onlinelibrary.wiley.com/doi/full/10.1111/jcpt.12787
Evaluating the Impact of Prescribed Versus Nonprescribed Benzodiazepine Use in Methadone Maintenance Therapy: Results from a Population-based Retrospective Cohort Study.
Eibl JK, Wilton AS, Franklyn AM, Kurdyak P, Marsh DC.
J Addict Med. 2018 Dec 12. doi: 10.1097/ADM.0000000000000476.
Abstract
https://www.ncbi.nlm.nih.gov/pubmed/30543543
We Need to Talk About Benzodiazepines—Including Their Use in Drug Combinations
Opioids like heroin and fentanyl have grabbed the media and legislative spotlight—from soaring overdose fatalities to the misguided prescription restrictions and drug-induced homicide laws ostensibly intended to combat them. What’s glossed over is that our overdose crisis primarily relates to polysubstance use. Around 80 percent of deaths involving a synthetic opioid in 2016, for example, also involved another drug. When we only focus on partial data, we only come up with partially effective solutions. With our cultural narrative failing to acknowledge this, people who use drugs need to make the effort to learn more to keep ourselves safer. (Filter, USA, 04.12.2018)
Patient-centered care interventions to reduce the inappropriate prescription and use of benzodiazepines and z-drugs: a systematic review.
Mokhar A, Topp J, Härter M, Schulz H, Kuhn S, Verthein U, Dirmaier J.
PeerJ. 2018 Oct 8;6:e5535. doi: 10.7717/peerj.5535.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190800/
Designer Benzodiazepines: Another Class of New Psychoactive Substances.
Moosmann B, Auwärter V.
Handb Exp Pharmacol. 2018 Oct 27. doi: 10.1007/164_2018_154.
Abstract
https://www.ncbi.nlm.nih.gov/pubmed/30367253
Use of sedative-hypnotics and the risk of Alzheimer’s dementia: A retrospective cohort study.
Lee J, Jung SJ, Choi J-w, Shin A, Lee YJ (2018)
PLoS ONE 13(9): e0204413. doi.org/10.1371/journal.pone.0204413
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204413
The risk of Alzheimer's disease associated with benzodiazepines and related drugs: a nested case-control study.
Tapiainen V, Taipale H, Tanskanen A, Tiihonen J, Hartikainen S, Tolppanen AM.
Acta Psychiatr Scand. 2018 May 31. doi: 10.1111/acps.12909.
Abstract
https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.12909
„Besorgniserregende“ Studienergebnisse: Erneut Hinweise zu erhöhtem Alzheimer-Risiko durch Benzodiazepine
In einer aktuellen Studie ist erneut der Einsatz von Benzodiazepinen mit einem erhöhten Risiko für die Alzheimer-Demenz in Verbindung gebracht worden. „Obwohl der Zusammenhang zwischen Benzodiazepin-Einnahme und Alzheimer-Krankheit in dieser Studie nicht groß war, sollte die Schwelle für die Verschreibung dieser Medikamente aufgrund ihres gesamten Nebenwirkungsprofils einschließlich eines erhöhten Risikos für Stürze und Hüftfrakturen hochgehalten werden“, sagt der Hauptautor Dr. Vesa Tapiainen von der Universität von Ost-Finnland in Kuopio gegenüber Medscape. Die Studie ist in der August-Ausgabe von Acta Psychiatrica Scandinavicaveröffentlicht worden [1]. (Medscape, 10.09.2018)
https://deutsch.medscape.com/artikelansicht/4907261
Benzodiazepine: Jede vierte Verordnung bei älteren Menschen führt zur Abhängigkeit
Ann Arbor – Das Abhängigkeitspotenzial von Benzodiazepinen wird häufig unterschätzt. Nach einer Studie in JAMA Internal Medicine(2018; doi: 10.1001/jamainternmed.2018.2413) erhielt ein Viertel aller älteren Patienten, denen Nichtpsychiater Benzodiazepine verschrieben hatten, auch nach einem Jahr weiterhin Rezepte. (aerzteblatt.de, 11.09.2018)
Lorazepam.
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.
https://www.ncbi.nlm.nih.gov/books/NBK501231/
Diazepam
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.
https://www.ncbi.nlm.nih.gov/books/NBK501214/
Clonazepam
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.
https://www.ncbi.nlm.nih.gov/books/NBK501209/
Oxazepam
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.
https://www.ncbi.nlm.nih.gov/books/NBK501244/
Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects.
Cheng T, Wallace DM, Ponteri B, Tuli M.
Neuropsychiatr Dis Treat. 2018 May 23;14:1351-1361. doi: 10.2147/NDT.S164307.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973310/
EMCDDA. The misuse of benzodiazepines among high-risk opioid users in Europe
Benzodiazepines are a widely prescribed group of medicines with a range of clinical uses that include treating anxiety, insomnia and managing alcohol withdrawal. This group of medicines is often misused by high-risk opioid users, and this is associated with considerable morbidity and mortality. This paper describes the impact of benzodiazepines misuse on the health and treatment of high-risk opioid users. (EMCDDA, Lissabon, 07.06.2018)
http://www.emcdda.europa.eu/topics/pods/benzodiazepines
Potentially inappropriate use of benzodiazepines and z-drugs in the older population-analysis of associations between long-term use and patient-related factors.
Mokhar A, Tillenburg N, Dirmaier J, Kuhn S, Härter M, Verthein U.
PeerJ. 2018 May 22;6:e4614. doi: 10.7717/peerj.4614.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969046/
Benzodiazepines and risk for hepatic encephalopathy in patients with cirrhosis and ascites.
Grønbæk L, Watson H, Vilstrup H, Jepsen P.
United European Gastroenterol J. 2018 Apr;6(3):407-412. doi: 10.1177/2050640617727179.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949964/
Riskante Langzeitverordnungen von Benzodiazepinen und Z-Substanzen betreffen vor allem Senioren
Hamburg – Schlaf- und Beruhigungsmittel werden in Deutschland nicht immer leitliniengerecht verschrieben. Jeder sechste Kassenpatient könnte betroffen sein. Das zeigt eine Analyse von GKV-Abrechnungsdaten aus 4 Bundesländern, die in Suchttherapieerschienen ist (2018; doi: 10.1055/s-0043-109361). Vor allem ältere Patienten bekommen Benzodiazepine und Z-Substanzen oft zu lange und in zu hoher Dosierung, was eine Abhängigkeit zur Folge haben kann. (aerzteblatt.de, 31.05.2018)
Deprescribing benzodiazepine receptor agonists - Evidence-based clinical practice guideline
Kevin Pottie, Wade Thompson, Simon Davies, Jean Grenier, Cheryl A. Sadowski, Vivian Welch, Anne Holbrook, Cynthia Boyd, Robert Swenson, Andy Ma and Barbara Farrell
Canadian Family Physician May 2018, 64 (5) 339-351;
http://www.cfp.ca/content/64/5/339
Management of benzodiazepine misuse and dependence.
Brett J, Murnion B.
Australian Prescriber. 2015;38(5):152-155. doi:10.18773/austprescr.2015.055.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657308/
Physician Prescribing of Opioids to Patients at Increased Risk of Overdose From Benzodiazepine Use in the United States.
Ladapo JA, Larochelle MR, Chen A, et al.
JAMA Psychiatry.Published online April 12, 2018. doi:10.1001/jamapsychiatry.2018.0544
Abstract
https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2678181
Challenges of the pharmacological management of benzodiazepine withdrawal, dependence, and discontinuation.
Fluyau D, Revadigar N, Manobianco BE.
Ther Adv Psychopharmacol. 2018 May;8(5):147-168. doi: 10.1177/2045125317753340. Epub 2018 Feb 9. Review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896864/
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