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Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions

Shamema Nasrin, Christy J.W. Watson, Yadira X Perez-Paramo and Philip Lazarus

Drug Metabolism and Disposition December 2021, 49 (12) 1070-1080; DOI: doi.org/10.1124/dmd.121.000442 


Inhibition of UDP-Glucuronosyltransferase Enzymes by Major Cannabinoids and Their Metabolites

Shamema Nasrin, Christy J. W. Watson, Keti Bardhi, Gabriela Fort, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition December 2021, 49 (12) 1081-1089; DOI: doi.org/10.1124/dmd.121.000530 


Effect of HIV, antiretrovirals, and genetics on methadone pharmacokinetics: Results from the methadone antiretroviral pharmacokinetics study. 

Bart G, Giang LM, Yen H, Hodges JS, Brundage RC. 

Drug Alcohol Depend. 2021 Oct 1;227:109025. doi: 10.1016/j.drugalcdep.2021.109025. Epub 2021 Sep 1. PMID: 34482033.



Evaluation of drug-drug interactions in hospitalized patients on medications for OUD. 

Berger O, Rector K, Meredith J, Sebaaly J. 

Ment Health Clin. 2021 Jul 16;11(4):231-237. doi: 10.9740/mhc.2021.07.231. PMID: 34316418; PMCID: PMC8287868.


Adverse drug reactions with naltrexone: Experience from an addiction treatment center. 

Sarkar S, Addagadda SS, Bhatia G, Chadda RK. 

Indian J Psychiatry. 2021 Mar-Apr;63(2):206-207. doi: 10.4103/psychiatry.IndianJPsychiatry_94_20. Epub 2021 Apr 14. PMID: 34194072; PMCID: PMC8214125.


Opioid Toxidrome Following Grapefruit Juice Consumption in the Setting of Methadone Maintenance. 

Ershad M, Cruz MD, Mostafa A, Mckeever R, Vearrier D, Greenberg MI. 

J Addict Med. 2020 Mar/Apr;14(2):172-174. doi: 10.1097/ADM.0000000000000535. PMID: 31206401.



Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain. 

Vázquez M, Guevara N, Maldonado C, Guido PC, Schaiquevich P 

Biomed Res Int. 2020 Aug 13;2020:3902740. doi: 10.1155/2020/3902740. PMID: 32855964; PMCID: PMC7443220.


Evaluation of Drug‐Drug Interaction Liability for Buprenorphine Extended‐Release Monthly Injection Administered by Subcutaneous Route. 

Kharidia, J., Howgate, E.M., Laffont, C.M., Liu, Y. and Young, M.A. (2021), 

Clinical Pharmacology in Drug Development. doi.org/10.1002/cpdd.934


Opioids and antidepressants: which combinations to avoid. 

Perananthan V, Buckley NA. 

Aust Prescr 2021;44:41-4. doi.org/10.18773


Drug-Drug Interactions of Newly Approved Direct-Acting Antiviral Agents in Patients with Hepatitis C. 

Gao LH, Nie QH, Zhao XT. 

Int J Gen Med. 2021 Jan 28;14:289-301. doi: 10.2147/IJGM.S283910. PMID: 33536776; PMCID: PMC7850569.


Methadone, Metoclopramide and Metronidazole Interaction Causing Torsades de Pointes. 

Gnanapandithan K, Karthik N, Gerber J. 

Clin Pract. 2021 Feb 7;11(1):101-105. doi: 10.3390/clinpract11010015. PMID: 33562182; PMCID: PMC7931031.


Comparison of two algorithms to support medication surveillance for drug-drug interactions between QTc-prolonging drugs. 

Berger FA, van der Sijs H, van Gelder T, Kuijper AFM, van den Bemt PMLA, Becker ML. 

Int J Med Inform. 2021 Jan;145:104329. doi: 10.1016/j.ijmedinf.2020.104329. Epub 2020 Nov 4. PMID: 33181445.


Review of Clinically Relevant Drug Interactions with Next Generation Hepatitis C Direct-acting Antiviral Agents. 

Hong J, Wright RC, Partovi N, Yoshida EM, Hussaini T. 

J Clin Transl Hepatol. 2020 Sep 28;8(3):322-335. doi: 10.14218/JCTH.2020.00034. Epub 2020 Jul 30. PMID: 33083256; PMCID: PMC7562806.


Clinically Significant Drug-Drug Interaction Between Methadone and Cannabidiol. 

Madden K, Tanco K, Bruera E. Clinically 

Pediatrics. 2020;145(6):e20193256. doi:10.1542/peds.2019-3256



Potential Adverse Drug Events with Tetrahydrocannabinol (THC) Due to Drug–Drug Interactions.

Brown, J.D. 

J. Clin. Med. 2020, 9, 919.


Leberzirrhose: Empfehlungen zur sicheren Anwendung von Arzneimitteln

Berlin – Eine Leberzirrhose bei einem Patienten kann bekanntlich den Stoffwechsel und die Dosis-Wirkungsbeziehung von Arzneimitteln verändern und das Risiko von Nebenwirkungen erhöhen. Eine niederländische Arbeitsgruppe hat nun evidenzbasierte Empfehlungen für den Einsatz und die Dosierung zahlreicher praxisrelevanter Arzneimittel bei Leberzirrhose erarbeitet. (aerzteblatt.de, 04.02.2020)


Direct‐acting antivirals interactions with opioids, alcohol or illicit drugs of abuse in HCV‐infected patients.

Ing Lorenzini, K, Girardin, F. 

Liver Int. 2020; 40: 32– 44. doi.org/10.1111/liv.14283


Wechselwirkungen mit HCV-DAA-Medikamenten – Update on hep-druginteractions.org

We have added some new comedications to the interaction checker, at the request of some of our users. You can now look up interactions with alcohol, cannabidiol (CBD), carfentanil, clofazimine, heroin and mesna. (The University of Liverpool’s HEP Drug Interactions Checker, UK, 06.01.2020)


Improving Recognition and Reporting of Adverse Drug Reactions in the NICU: A Quality Improvement Project.

Cammack B, Oschman A, Lewis T.

Pediatr Qual Saf. 2019 Aug 30;4(5):e203. doi: 10.1097/pq9.0000000000000203.


Direct-acting antiviral interactions with opioids, alcohol or illicit drugs of abuse in HCV-infected patients.

Ing Lorenzini K, Girardin F.

Liver Int. 2019 Oct 26. doi: 10.1111/liv.14283. 



Prediction of Drug-Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation.

Ji B, Liu S, Xue Y, He X, Man VH, Xie XQ, Wang J.

Drugs R D. 2019 Sep;19(3):297-305. doi: 10.1007/s40268-019-00282-3.


Opioid Toxidrome Following Grapefruit Juice Consumption in the Setting of Methadone Maintenance.

Ershad M, Cruz MD, Mostafa A, Mckeever R, Vearrier D, Greenberg MI.

J Addict Med. 2019 Jun 13. doi: 10.1097/ADM.0000000000000535. 



Improving the use of methadone for drug users with tuberculosis to prevent withdrawal

Drug users on methadone programmes who contract tuberculosis (TB) should receive effective treatment while maintaining the correct level of methadone in their bodies, following a virtual clinical trial by pharmacy researchers at Aston University in partnership with drugs charity Addaction. (medicalxpress.com, 21.05.2019)


The optimization of methadone dosing whilst treating with rifampicin: A pharmacokinetic modeling study.

Badhan RKS, Gittins R, Al Zabit D.

Drug Alcohol Depend. 2019 May 16. pii: S0376-8716(19)30145-0. doi: 10.1016/j.drugalcdep.2019.03.013. 



Drug-Drug Interaction Studies of Methadone and Antiviral Drugs: Lessons Learned.

Younis IR, Lakota EA, Volpe DA, Patel V, Xu Y, Sahajwalla CG.

J Clin Pharmacol. 2019 Apr 11. doi: 10.1002/jcph.1405.



Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and γ-Hydroxybutyric Acid.

Singh AK.

Biomedicines. 2019 Mar 7;7(1). pii: E16. doi: 10.3390/biomedicines7010016. Review.


Medicinal Cannabis-Potential Drug Interactions.

Alsherbiny MA, Li CG.

Medicines (Basel). 2018 Dec 23;6(1). pii: E3. doi: 10.3390/medicines6010003. Review.


Drug Interactions With New Synthetic Opioids.

Pérez-Mañá C, Papaseit E, Fonseca F, Farré A, Torrens M, Farré M.

Front Pharmacol. 2018 Oct 11;9:1145. doi: 10.3389/fphar.2018.01145.


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Methadone Metabolism And Drug-Drug Interactions: In Vitro And In Vivo Literature Review.

Volpe DA, Xu Y, Sahajwalla CG, Younis IR, Patel V.

J Pharm Sci. 2018 Sep 8. pii: S0022-3549(18)30526-4. doi: 10.1016/j.xphs.2018.08.025.