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Potential Pharmacokinetic Drug-Drug Interactions between Cannabinoids and Drugs Used for Chronic Pain. 

Vázquez M, Guevara N, Maldonado C, Guido PC, Schaiquevich P 

Biomed Res Int. 2020 Aug 13;2020:3902740. doi: 10.1155/2020/3902740. PMID: 32855964; PMCID: PMC7443220.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443220/

Evaluation of Drug‐Drug Interaction Liability for Buprenorphine Extended‐Release Monthly Injection Administered by Subcutaneous Route. 

Kharidia, J., Howgate, E.M., Laffont, C.M., Liu, Y. and Young, M.A. (2021), 

Clinical Pharmacology in Drug Development. doi.org/10.1002/cpdd.934

https://accp1.onlinelibrary.wiley.com/doi/10.1002/cpdd.934

Opioids and antidepressants: which combinations to avoid. 

Perananthan V, Buckley NA. 

Aust Prescr 2021;44:41-4. doi.org/10.18773

https://www.nps.org.au/australian-prescriber/articles/opioids-and-antidepressants-which-combinations-to-avoid

Drug-Drug Interactions of Newly Approved Direct-Acting Antiviral Agents in Patients with Hepatitis C. 

Gao LH, Nie QH, Zhao XT. 

Int J Gen Med. 2021 Jan 28;14:289-301. doi: 10.2147/IJGM.S283910. PMID: 33536776; PMCID: PMC7850569.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850569/

Methadone, Metoclopramide and Metronidazole Interaction Causing Torsades de Pointes. 

Gnanapandithan K, Karthik N, Gerber J. 

Clin Pract. 2021 Feb 7;11(1):101-105. doi: 10.3390/clinpract11010015. PMID: 33562182; PMCID: PMC7931031.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931031/

Comparison of two algorithms to support medication surveillance for drug-drug interactions between QTc-prolonging drugs. 

Berger FA, van der Sijs H, van Gelder T, Kuijper AFM, van den Bemt PMLA, Becker ML. 

Int J Med Inform. 2021 Jan;145:104329. doi: 10.1016/j.ijmedinf.2020.104329. Epub 2020 Nov 4. PMID: 33181445.

https://www.sciencedirect.com/science/article/pii/S1386505620302847?via%3Dihub

Review of Clinically Relevant Drug Interactions with Next Generation Hepatitis C Direct-acting Antiviral Agents. 

Hong J, Wright RC, Partovi N, Yoshida EM, Hussaini T. 

J Clin Transl Hepatol. 2020 Sep 28;8(3):322-335. doi: 10.14218/JCTH.2020.00034. Epub 2020 Jul 30. PMID: 33083256; PMCID: PMC7562806.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562806/

Clinically Significant Drug-Drug Interaction Between Methadone and Cannabidiol. 

Madden K, Tanco K, Bruera E. Clinically 

Pediatrics. 2020;145(6):e20193256. doi:10.1542/peds.2019-3256

Abstract

https://pubmed.ncbi.nlm.nih.gov/32444381/

Potential Adverse Drug Events with Tetrahydrocannabinol (THC) Due to Drug–Drug Interactions.

Brown, J.D. 

J. Clin. Med. 2020, 9, 919.

https://www.mdpi.com/2077-0383/9/4/919/htm

Leberzirrhose: Empfehlungen zur sicheren Anwendung von Arzneimitteln

Berlin – Eine Leberzirrhose bei einem Patienten kann bekanntlich den Stoffwechsel und die Dosis-Wirkungsbeziehung von Arzneimitteln verändern und das Risiko von Nebenwirkungen erhöhen. Eine niederländische Arbeitsgruppe hat nun evidenzbasierte Empfehlungen für den Einsatz und die Dosierung zahlreicher praxisrelevanter Arzneimittel bei Leberzirrhose erarbeitet. (aerzteblatt.de, 04.02.2020)

https://www.aerzteblatt.de/nachrichten/109152/Leberzirrhose-Empfehlungen-zur-sicheren-Anwendung-von-Arzneimitteln

Direct‐acting antivirals interactions with opioids, alcohol or illicit drugs of abuse in HCV‐infected patients.

Ing Lorenzini, K, Girardin, F. 

Liver Int. 2020; 40: 32– 44. doi.org/10.1111/liv.14283

https://onlinelibrary.wiley.com/doi/full/10.1111/liv.14283

Wechselwirkungen mit HCV-DAA-Medikamenten – Update on hep-druginteractions.org

We have added some new comedications to the interaction checker, at the request of some of our users. You can now look up interactions with alcohol, cannabidiol (CBD), carfentanil, clofazimine, heroin and mesna. (The University of Liverpool’s HEP Drug Interactions Checker, UK, 06.01.2020)

https://hep-druginteractions.org/checker

Improving Recognition and Reporting of Adverse Drug Reactions in the NICU: A Quality Improvement Project.

Cammack B, Oschman A, Lewis T.

Pediatr Qual Saf. 2019 Aug 30;4(5):e203. doi: 10.1097/pq9.0000000000000203.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831056/

Direct-acting antiviral interactions with opioids, alcohol or illicit drugs of abuse in HCV-infected patients.

Ing Lorenzini K, Girardin F.

Liver Int. 2019 Oct 26. doi: 10.1111/liv.14283. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/31654604

Prediction of Drug-Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation.

Ji B, Liu S, Xue Y, He X, Man VH, Xie XQ, Wang J.

Drugs R D. 2019 Sep;19(3):297-305. doi: 10.1007/s40268-019-00282-3.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738369/

Opioid Toxidrome Following Grapefruit Juice Consumption in the Setting of Methadone Maintenance.

Ershad M, Cruz MD, Mostafa A, Mckeever R, Vearrier D, Greenberg MI.

J Addict Med. 2019 Jun 13. doi: 10.1097/ADM.0000000000000535. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/31206401

Improving the use of methadone for drug users with tuberculosis to prevent withdrawal

Drug users on methadone programmes who contract tuberculosis (TB) should receive effective treatment while maintaining the correct level of methadone in their bodies, following a virtual clinical trial by pharmacy researchers at Aston University in partnership with drugs charity Addaction. (medicalxpress.com, 21.05.2019)

https://medicalxpress.com/news/2019-05-methadone-drug-users-tuberculosis.html

The optimization of methadone dosing whilst treating with rifampicin: A pharmacokinetic modeling study.

Badhan RKS, Gittins R, Al Zabit D.

Drug Alcohol Depend. 2019 May 16. pii: S0376-8716(19)30145-0. doi: 10.1016/j.drugalcdep.2019.03.013. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/31122724

Drug-Drug Interaction Studies of Methadone and Antiviral Drugs: Lessons Learned.

Younis IR, Lakota EA, Volpe DA, Patel V, Xu Y, Sahajwalla CG.

J Clin Pharmacol. 2019 Apr 11. doi: 10.1002/jcph.1405.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/30973652

Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and γ-Hydroxybutyric Acid.

Singh AK.

Biomedicines. 2019 Mar 7;7(1). pii: E16. doi: 10.3390/biomedicines7010016. Review.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466217/

Medicinal Cannabis-Potential Drug Interactions.

Alsherbiny MA, Li CG.

Medicines (Basel). 2018 Dec 23;6(1). pii: E3. doi: 10.3390/medicines6010003. Review.

https://www.mdpi.com/2305-6320/6/1/3/htm

Drug Interactions With New Synthetic Opioids.

Pérez-Mañá C, Papaseit E, Fonseca F, Farré A, Torrens M, Farré M.

Front Pharmacol. 2018 Oct 11;9:1145. doi: 10.3389/fphar.2018.01145.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193107/

Nebenwirkungen online melden

Hier können Sie Nebenwirkungen (unerwünschte Wirkungen von Arzneimitteln und Impfstoffen) melden. Sie können für sich oder im Namen einer anderen Person melden. Die Meldung für andere Personen ist möglich, wenn Sie diese betreuen, z.B.im Namen Ihres Kindes oder eines Angehörigen. Die Meldung geht direkt an die zuständigen Bundesoberbehörden. (BfArM / Paul-Ehrlich-Institut, September 2018)

https://nebenwirkungen.pei.de/nw/DE/home/home_node.html

Methadone Metabolism And Drug-Drug Interactions: In Vitro And In Vivo Literature Review.

Volpe DA, Xu Y, Sahajwalla CG, Younis IR, Patel V.

J Pharm Sci. 2018 Sep 8. pii: S0022-3549(18)30526-4. doi: 10.1016/j.xphs.2018.08.025.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/30205091

Nebenwirkungen online einfacher melden

Langen – Das Paul-Ehrlich-Institut (PEI) und des Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM) haben eine modernisierte und barrierefreie Version der Internetseite für die Meldung von Verdachtsfällen unerwünschter Arzneimittel­wirkungen vorgestellt. (aerzteblatt.de, 28.09.2018)

https://www.aerzteblatt.de/nachrichten/98195/Nebenwirkungen-online-einfacher-melden

Using routinely collected data to understand and predict adverse outcomes in opioid agonist treatment: Protocol for the Opioid Agonist Treatment Safety (OATS) Study.

Larney S, Hickman M, Fiellin DA, Dobbins T, Nielsen S, Jones NR, Mattick RP, Ali R, Degenhardt L.

BMJ Open. 2018 Aug 5;8(8):e025204. doi: 10.1136/bmjopen-2018-025204.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078240/

Management of drug interactions with direct-acting antivirals in Dutch HIV/hepatitis C virus-coinfected patients: adequate but not perfect.

Smolders EJ, Smit C, de Kanter C, Dofferhoff A, Arends JE, Brinkman K, Rijnders B, van der Valk M, Reiss P, Burger DM; ATHENA National HIV Observational Cohort.

HIV Med. 2018 Mar;19(3):216-226. doi: 10.1111/hiv.12570.

https://www.medscape.com/viewarticle/893358

Inhibition of In Vitro Metabolism of Opioids by Skeletal Muscle Relaxants.

Moody DE, Fu Y, Fang WB.

Basic Clin Pharmacol Toxicol. 2018 Mar 5. doi: 10.1111/bcpt.12999.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29504673

MEDIZINREPORT. Psychopharmaka: Unerwartete Nebenwirkungen

Dtsch Arztebl 2017; 114(51-52): A-2468 / B-2041 / C-1995

Gahr, Maximilian; Connemann, Bernhard J.; Schönfeldt-Lecuona, Carlos; Freudenmann, Roland W.; Stein, Jamal M.; Hawlik, Anna-Katharina

Ergebnisse einer explorativen Querschnittbefragung von Zahnärzten und Nervenärzten zur Bewertung von zahnmedizinisch relevanten Nebenwirkungen unter Psychopharmakotherapie.

https://www.aerzteblatt.de/archiv/195499/Psychopharmaka-Unerwartete-Nebenwirkungen

A physiologically-based pharmacokinetic modeling approach to predict drug-drug interactions of buprenorphine after subcutaneous administration of CAM2038 with perpetrators of CYP3A4.

Liu T, Gobburu JVS.

J Pharm Sci. 2017 Nov 1. pii: S0022-3549(17)30774-8. doi: 10.1016/j.xphs.2017.10.035.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29102550

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