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The war on drugs is incompatible with the fight against HIV

The Lancet HIV , Volume 6 , Issue 5 , e269  (Editorial)

https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(19)30112-2/fulltext

HIV Disease Severity is Sensitive to Temporal Changes in Alcohol Use: A National Study of VA Patients with HIV.

Williams EC, McGinnis KA, Tate JP, Matson TE, Rubinsky AD, Bobb JF, Lapham GT, Edelman EJ, Catz SL, Satre DD, Bryant KJ, Marshall BDL, Kraemer KL, Bensley KM, Richards JE, Skanderson M, Justice AC, Fiellin DA, Bradley KA.

J Acquir Immune Defic Syndr. 2019 Apr 15. doi: 10.1097/QAI.0000000000002049. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/30973541

Re-emergence of HIV related to injecting drug use despite a comprehensive harm reduction environment: a cross-sectional analysis

McAuley, Andrew et al.

The Lancet HIV , Volume 6 , Issue 5 , e315 - e324 

https://www.thelancet.com/journals/lanhiv/article/PIIS2352-3018(19)30036-0/fulltext

Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study

Rodger, Alison JColl, Pep et al.

The Lancet , Volume 0 , Issue 0 

Published: May 02, 2019, doi.org/10.1016/S0140-6736(19)30418-0

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30418-0/fulltext

Antikörper unterdrückt HIV-Infektion bis zu vier Monate lang

New York – Infusionen eines monoklonalen Antikörpers, der nicht an den HI-Viren selbst bindet, sondern deren Rezeptor auf den CD4-Zellen blockiert, hat in einer offenen Phase-2-Studie im New England Journal of Medicine(2019; 380: 1535-1545) die Virusreplikation zuverlässig unterdrückt. (aerzteblatt.de, 23.04.2019)

https://www.aerzteblatt.de/nachrichten/102599/Antikoerper-unterdrueckt-HIV-Infektion-bis-zu-vier-Monate-lang

Researchers verify new method of HIV transmission among injection drug users and effective prevention technique

“Cook your Wash” campaign reduces risk of HIV transmission

LONDON, ON – New studies from Lawson Health Research Institute and Western University have found for the first time that HIV can be transmitted through the sharing of equipment used to prepare drugs before injection and that a simple intervention – heating the equipment with a cigarette lighter for 10 seconds – can destroy the HIV virus, preventing that transmission. The findings, used to inform a public health campaign called ‘Cook Your Wash,’ have helped reduce rates of HIV transmission in London, Ontario. (Lawson Health Research Institute, Kanada, 25.04.2019)

https://www.lawsonresearch.ca/researchers-verify-new-method-hiv-transmission

Outbreak of Human Immunodeficiency Virus Infection Among Heterosexual Persons Who Are Living Homeless and Inject Drugs — Seattle, Washington, 2018.

Golden MR, Lechtenberg R, Glick SN, et al. 

MMWR Morb Mortal Wkly Rep 2019;68:344–349. doi.org/10.15585/mmwr.mm6815a2

https://www.cdc.gov/mmwr/volumes/68/wr/mm6815a2.htm

Conformation of the native HIV-1 envelope protein raises questions for vaccine design

The HIV-1 envelope protein is the target of antibodies that neutralize the virus. A fresh look into the conformational states of this protein relaunches the quest to identify those relevant for vaccine design. 

Nature 568, 321-322 (2019), NEWS AND VIEWS, 10 April 2019, doi: 10.1038/d41586-019-01085-x

https://www.nature.com/articles/d41586-019-01085-x

Understanding hepatitis B, hepatitis C and HIV among people who inject drugs in South Africa: findings from a three-city cross-sectional survey

Andrew Scheibe, Katherine Young, Lorraine Moses, Rudolph L. Basson, Anna Versfeld, C. Wendy Spearman, Mark W. Sonderup, Nishi Prabdial-Sing, Jack Manamela, Adrian J. Puren, Kevin Rebe and Harry Hausler

Harm Reduction Journal 2019, 16:28, doi.org/10.1186/s12954-019-0298-2

https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-019-0298-2

HIV Incidence and Risk Behaviours of People Who Inject Drugs in Bangkok, 1995–2012

Martin, Michael et al.

EClinicalMedicine , Volume 0 , Issue 0 , Published:March 31, doi.org/10.1016/j.eclinm.2019.03.012

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(19)30052-5/fulltext

HIV früh erkennen und behandeln - Ein Leitfaden für die Suchtmedizin 

Die Broschüre richtet sich an Suchtmediziner_innen generell und Substitutionsärzt_innen im Besonderen. Sie informiert über die Problematik von späten HIV-Diagnosen und spätem Therapiezugang bei Menschen die intravenös Drogen konsumieren oder substituiert werden. Mit Informationen zu Compliance, Abrechnung von Tests und Gesprächsführung zu heiklen Themen unterstützt die Broschüre bei der Vermeidung von Aidserkrankungen bei Drogenkonsument_innen. (DAH – Deutsche AIDS-Hilfe, April 2019)

https://www.aidshilfe.de/shop/pdf/10456

Suchtmedizin kann Aids verhindern

Bei Drogenkonsument_innen und Substituierten wird HIV oft zu spät diagnostiziert oder bleibt lange unbehandelt. Ein Leitfaden der Deutschen Aidshilfe unterstützt Ärzt_innen in der täglichen Praxis. 

Suchtmedizinisch tätige Praxen in Deutschland erhalten in diesen Tagen Post von der Deutschen Aidshilfe. Inhalt: Die Broschüre „HIV früh erkennen und behandeln – Ein Leitfaden für die Suchtmedizin“. Sie soll Ärzt_innen dabei unterstützen, HIV zu thematisieren, einen HIV-Test anzubieten und gegebenenfalls den Therapiebeginn einzuleiten, um schwere Erkrankungen zu vermeiden.

Der Leitfaden ist Teil der Kampagne „Kein Aids für alle – bis 2020!“. Er wurde gemeinsam mit Fachleuten aus Suchtmedizin, HIV-Behandlung, Drogenhilfe und Selbsthilfe entwickelt. (Deutsche AIDS-Hilfe, 16.04.2019)

https://www.aidshilfe.de/meldung/suchtmedizin-aids-verhindern

Direct-Acting Antiviral Treatment Failure Among Hepatitis C and HIV-Coinfected Patients in Clinical Care.

Rossi C, Young J, Martel-Laferrière V, Walmsley S, Cooper C, Wong A, Gill MJ, Klein MB; Canadian Co-Infection Cohort Investigators .

Open Forum Infect Dis. 2019 Feb 13;6(3):ofz055. doi: 10.1093/ofid/ofz055. 

https://www.ncbi.nlm.nih.gov/pubmed/30882016

Prolonged QTc in HIV-Infected Patients: A Need for Routine ECG Screening.

Myerson M, Kaplan-Lewis E, Poltavskiy E, Ferris D, Bang H.

J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958219833926. doi: 10.1177/2325958219833926.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435291/

Monthly Shots for HIV Within Reach

SEATTLE — Monthly injections of long-acting cabotegravir (ViiV Healthcare) and rilpivirine (Edurant, Janssen) can suppress HIV as well as daily oral antiretroviral treatment, according to results from the ATLAS (NCT02951052) and FLAIR (NCT02938520) trials. (Medscape, USA, 19.03.2019)

https://www.medscape.com/viewarticle/910616

Integration of care for HIV and opioid use disorder.

Oldfield BJ, Muñoz N, McGovern MP, Funaro M, Villanueva M, Tetrault JM, Edelman EJ.

AIDS. 2019 Apr 1;33(5):873-884. doi: 10.1097/QAD.0000000000002125.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/30882491

UNAIDS. Promises to improve health outcomes for people who inject drugs remain unfulfilled as 99% do not have adequate access to harm reduction services 

New report by UNAIDS highlights the urgent need to implement a human rights and evidence-informed approach to reach people who inject drugs with essential health services. (UNAIDS, Genf, 13.03.2019)

http://www.unaids.org/en/resources/presscentre/pressreleaseandstatementarchive/2019/march/20190313_drugs_report

UNAIDS. HEALTH, RIGHTS AND DRUGS - HARM REDUCTION, DECRIMINALIZATION AND ZERO DISCRIMINATION FOR PEOPLE WHO USE DRUGS

(UNAIDS, 2019)

http://www.unaids.org/sites/default/files/media_asset/JC2954_UNAIDS_drugs_report_2019_en.pdf

Deutsche AIDS-Hilfe: HIV-Test

Manchmal muss man’s einfach wissen. Gerade nach einer Risikosituation ist es wichtig, Gewissheit zu haben, dass nichts passiert ist. Ein HIV-Test schafft Klarheit. 

Inhalt: Überblick zum HIV-Test - Gute Gründe für den HIV-Test - HIV-Tests im Überblick - HIV-Selbsttest - Wo auf HIV testen lassen? (DAH, 2019)

https://www.aidshilfe.de/hiv-test

HIV-Patient symptomfrei nach Knochenmarktransplantation

London – Der „Berliner Patient“ Timothy Ray Brown galt bisher als weltweiter Einzelfall, der von einer HIV-Infektion geheilt werden konnte. Einer Studie in Naturezufolge könnte es nun einen zweiten Fall in London geben (2019; doi: 10.1038/s41586-019-1027-4). (aerzteblatt.de, 05.03.2019)

https://www.aerzteblatt.de/nachrichten/101418/HIV-Patient-symptomfrei-nach-Knochenmarktransplantation

HIV crisis in the Philippines: urgent actions needed

Gangcuangco, Louie Mar A

The Lancet Public Health , Volume 4 , Issue 2 , e84 

https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(18)30265-2/fulltext

Addressing the HIV crisis in the Philippines

Marston, Jez Lim et al.

The Lancet Public Health , Volume 4 , Issue 3 , e126

https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(19)30024-6/fulltext

International AIDS Society. Getting to the Heart of Stigma

“THE PERSISTENCE OF STIGMA IN THE CONTEXT OF HIV ALSO CAUSES IMMENSE HUMAN HARDSHIP AND DIMINISHES US AS A GLOBAL COMMUNITY.”

IAS – International AIDS Society, Annual Letter, Februar 2019-03-02

https://www.iasociety.org/Who-we-are/About-the-IAS/Annual-Letter-2019

A global meta-analysis on HIV, hepatitis C and hepatitis B among people who inject drugs - do gender differences vary by country-level indicators?

Leung J, Peacock A, Colledge S, Grebely J, Cunningham EB, Hickman M, Vickerman P, Stone J, Trickey A, Dumchev K, Lynskey M, Hines L, Griffiths P, Mattick RP, Degenhardt L, Larney S.

J Infect Dis. 2019 Feb 6. doi: 10.1093/infdis/jiz058. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/30726973

HIV risk behaviours among women who inject drugs in coastal Kenya: findings from secondary analysis of qualitative data. 

Mburu G, Limmer M, Holland P. 

Harm Reduct J. 2019;16(1):10. Published 2019 Feb 6. doi:10.1186/s12954-019-0281-y

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364406/

Medikamente zur HIV-Prophylaxe: DAK-Gesundheit übernimmt Kosten für PrEP

Die DAK-Gesundheit übernimmt als erste Krankenkasse die Kosten für die sogenannte HIV-Präexpositionsprophylaxe (PrEP). Dabei handelt es sich um Medikamente, die eine HIV-Infektion verhindern können. 
Die Arzneimittel werden zusammen mit anderen Arzneistoffen bereits seit Jahren genutzt, um bestehende HIV-Infektionen zu behandeln. Inzwischen sind sie auch zur Vorbeugung zugelassen, gehören jedoch nicht zu den regulären Leistungen der Krankenkassen. (DAK – Deutsche Angestellten Krankenkasse, 13.02.2019)

https://www.dak.de/dak/leistungen/hiv-prophylaxe-2037472.html

USA. Black Americans and HIV/AIDS: The Basics

Key Facts:

- Black Americans have been disproportionately affected by HIV/AIDS since the epidemic’s beginning, and that disparity has deepened over time. 

- Although they represent only 12% of the U.S. population, Blacks account for a much larger share of HIV diagnoses (43%), people estimated to be living with HIV disease (42%), and deaths among people with HIV (43%) than any other racial/ethnic group in the U.S. 

- Among Black Americans, Black women, youth, and gay and bisexual men have been especially hard hit. 

- A number of challenges contribute to the epidemic among Blacks, including poverty, lack of access to health care, higher rates of some sexually transmitted infections and smaller sexual networks, lack of awareness of HIV status, and stigma. 

- Despite this impact, recent data indicate some encouraging trends, including declining new HIV diagnoses among Blacks overall, especially among women, and a leveling off of new diagnoses among Black gay and bisexual men. However, given the epidemic’s continued and disproportionate impact among Blacks, a continued focus is critical to addressing HIV in the United States. (KFF – Kaiser Family Foundation, USA, 07.02.2019)

https://www.kff.org/hivaids/fact-sheet/black-americans-and-hivaids-the-basics

USA. The HIV/AIDS Epidemic in the United States: The Basics

Key Facts

The first cases of what would later become known as AIDS were reported in the United States in June of 1981. Today, there are more than 1.1 million people living with HIV and more than 700,000 people with AIDS have died since the beginning of the epidemic.

HIV continues to have a disproportionate impact on certain populations, particularly racial and ethnic minorities and gay and bisexual men and other men who have sex with men. 

HIV testing is important for both treatment and prevention efforts. Yet, 14% of those infected with HIV are unaware they are infected.

Antiretroviral therapy (ART) has substantially reduced AIDS-related morbidity and mortality and improved long-term outcomes for people with HIV. Treatment guidelines recommend initiating treatment as soon as one is diagnosed with HIV. According to the U.S. Centers for Disease Control and Prevention (CDC), when an individual living with HIV is on antiretroviral therapy and the level of HIV in their body is undetectable, there is “effectively no risk” of sexual transmission. Still, many people with HIV are not in care, on treatment, or have their virus under control.

(...) (Kaiser Family Foundation, USA, 04.02.2019)

https://www.kff.org/hivaids/fact-sheet/the-hivaids-epidemic-in-the-united-states-the-basics

Patient and provider perspectives on implementation barriers and facilitators of an integrated opioid treatment and HIV care intervention.

Cooke A, Saleem H, Hassan S, Mushi D, Mbwambo J, Lambdin B.

Addict Sci Clin Pract. 2019 Jan 28;14(1):3. doi: 10.1186/s13722-019-0133-9.

https://ascpjournal.biomedcentral.com/articles/10.1186/s13722-019-0133-9

Performance indicator as the main and the only goal: a “dark side” of the intervention aims to accelerate HIV treatment entry among people who inject drugs in Kyiv, Ukraine

Alexandra Dmitrieva, Vladimir Stepanov, Ievgeniia-Galyna Lukash and Anna Martynyuk

Harm Reduction Journal2019, 16:8, doi.org/10.1186/s12954-019-0279-5

https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-019-0279-5