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Gabapentin-related suicide: Myth or fact?

Ghaly RF, Plesca A, Rana S, Candido KD, Knezevic NN.

Surg Neurol Int. 2018 Oct 23;9:210. doi: 10.4103/sni.sni_420_17. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213802/

Bilateral Serous Macular Detachment After Attempted Suicide with Pregabalin.

Tanyıldız B, Kandemir B, Mangan MS, Tangılntız A, Göktaş E, Şimşek Ş.

Turk J Ophthalmol. 2018 Oct;48(5):254-257. doi: 10.4274/tjo.70923.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216534/

Gabapentin use, abuse, and the US opioid epidemic: the case for reclassification as a controlled substance and the need for pharmacovigilance.

Peckham AM, Ananickal MJ, Sclar DA.

Risk Manag Healthc Policy. 2018 Aug 17;11:109-116. doi: 10.2147/RMHP.S168504.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103607/

Pfizer hit by UK Supreme Court ruling on Lyrica patent

Pfizer has lost its protracted patent battle in the UK for big-selling drug Lyrica, potentially exposing it to claims for hundreds of millions of pounds from the NHS. (pharmaphorum, UK, 15.11.2018)

https://pharmaphorum.com/news/pfizer-hit-by-uk-supreme-court-ruling-on-lyrica-patent/

A pharmacokinetic drug-drug interaction study between pregabalin and tramadol in healthy volunteers.

Lee S, Kim Y, Lee JJS, Im G, Cho JY, Chung JY, Yoon S.

Eur J Clin Pharmacol. 2018 Aug 22. doi: 10.1007/s00228-018-2543-0.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/30136102

BfArM. Gabapentin zur Behandlung der Spastik im Rahmen der Multiplen Sklerose

Bewertung der Expertengruppe off-Label im Bereich Neurologie/Psychiatrie nach §35C Absatz 1 SGB V zur Off-Label-Indikation von Gabapentin zur Behandlung der Spastik im Rahmen der Multiplen Sklerose

BfArM, November 2018

https://www.bfarm.de/SharedDocs/Downloads/DE/Arzneimittel/Zulassung/BereitsZugelAM/offlabel/Bewertungen/Gabapentin.pdf?__blob=publicationFile&v=6

Rising pregabalin use and misuse in Australia: trends in utilisation and intentional poisonings.

Cairns, R., Schaffer, A. L., Ryan, N., Pearson, S.A., and Buckley, N. A. (2018)

Addiction, doi.org/10.1111/add.14412.

Abstract

https://onlinelibrary.wiley.com/doi/10.1111/add.14412

Acute harms associated with pregabalin misuse in Victoria: a 6-year examination of ambulance attendances

Rose Crossin, Debbie Scott, Shalini Arunogiri, Karen Smith, Paul M Dietze and Dan I Lubman

Med J Aust || doi: 10.5694/mja2.12036, Published online: 26 November 2018

https://www.mja.com.au/system/files/2018-11/MJA2_12036_Rev.pdf

Gabapentin is a potent activator of KCNQ3 and KCNQ5 potassium channels.

Manville RW, Abbott G.

Mol Pharmacol. 2018 Jul 18. pii: mol.118.112953. doi: 10.1124/mol.118.112953.

http://molpharm.aspetjournals.org/content/early/2018/07/18/mol.118.112953.long

Australien. Ambulance call-outs for pregabalin have spiked – here’s why

(...) Until recently, researchers and doctors did not think pregabalin was addictive. But now studies suggest pregabalin may also have an indirect effect on the brain’s reward chemical, dopamine. 

Our research, published today in the Medical Journal of Australia, shows ambulance call-outs associated with the misuse of pregabalin have increased tenfold in Victoria since 2012. This mirrors an increase in prescription rates. (The Conversation, Australien, 25.11.2018)

https://theconversation.com/ambulance-call-outs-for-pregabalin-have-spiked-heres-why-106163

The FDA and the Next Wave of Drug Abuse - Proactive Pharmacovigilance.

Throckmorton DC, Gottlieb S, Woodcock J.

N Engl J Med. 2018 Jul 19;379(3):205-207. doi: 10.1056/NEJMp1806486. 

https://www.nejm.org/doi/10.1056/NEJMp1806486

Gabapentin for Adults with Neuropathic Pain: A Review of the Clinical Effectiveness [Internet].

Narain T, Adcock L.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Mar 12.

https://www.ncbi.nlm.nih.gov/books/NBK531934/

Gabapentin.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

https://www.ncbi.nlm.nih.gov/books/NBK501224/

UK. Pregabalin and gabapentin to be controlled as class C drugs - New controls over prescription drugs pregabalin and gabapentin following rising fatalities. 

Prescription drugs pregabalin and gabapentin are to be reclassified as class C controlled substances from next April, the government announced today.

Today’s move comes after experts highlighted rising numbers of fatalities linked to the drugs. The change means it will be illegal to possess pregabalin and gabapentin without a prescription and it will be illegal to supply or sell them to others.

The drugs, which are used to treat nerve pain, epilepsy and anxiety, can bring about an elevated mood in users but can also have serious side effects, particularly when used in combination with other drugs. (gov.uk/government, Home Office, 15.10.2018)

https://www.gov.uk/government/news/pregabalin-and-gabapentin-to-be-controlled-as-class-c-drugs

Pregabalin.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

https://www.ncbi.nlm.nih.gov/books/NBK501821/

UK. Correspondence: Addendum to advice on the anticonvulsant drugs Pregabalin and Gabapentin, October 2018 

(...) Revised Section 6. Recommendations

The ACMD recommends that both Pregabalin and Gabapentin, their salts and their esters are: controlled under the Misuse of Drugs Act 1971 as Class C substances, andscheduled under the Misuse of Drugs Regulations 2001 (as amended) as Schedule 3, so as not to preclude legitimate use on prescription. (ACMD - Advisory Council on the Misuse of Drugs (gov.uk), Updated 17 October 2018)

https://www.gov.uk/government/publications/advice-on-the-anticonvulsant-drugs-pregabalin-and-gabapentin

Pregabalin Misuse and Abuse in Jordan: a Qualitative Study of User Experiences.

Al-Husseini A, Wazaify M, Van Hout MC.

Int J Ment Health Addict. 2018;16(3):642-654. doi: 10.1007/s11469-017-9813-4. Epub 2017 Sep 15.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986847/

UK. Pregabalin and gabapentin to be controlled as class C drugs 

New controls over prescription drugs pregabalin and gabapentin following rising fatalities. (Home Office and Victoria Atkins MP, UK, 15.10.2018)

https://www.gov.uk/government/news/pregabalin-and-gabapentin-to-be-controlled-as-class-c-drugs

On the addictive power of gabapentinoids: a mini-review.

Bonnet U, Richter EL, Isbruch K, Scherbaum N.

Psychiatr Danub. 2018 Jun;30(2):142-149. doi: 10.24869/psyd.2018.142.

http://www.hdbp.org/psychiatria_danubina/pdf/dnb_vol30_no2/dnb_vol30_no2_142.pdf

UK. Consultation outcome: Pregabalin and gabapentin: proposal to schedule under the Misuse of Drugs Regulations 2001 

Detail of outcome

On 13 November 2017, the Home Office asked for views on options whether, and how, to schedule pregabalin and gabapentin under the Misuse of Drugs Regulations 2001. This followed the recommendation by the Advisory Council on the Misuse of Drugs (ACMD) that pregabalin and gabapentin should be controlled as Class C drugs under the Misuse of Drugs Act 1971 (‘the 1971 Act’) and placed in Schedule 3 to the Misuse of Drugs Regulations 2001. The consultation lasted until 22 January 2018 and was UK-wide.

Responses were accepted from members of the public, healthcare professionals, institutions, all sectors within the supply chain including the pharmaceutical industry, wholesalers, and community pharmacies in the UK.

The Home Office is grateful for the views of those who responded to the consultation. On balance, the government is of the view that option 2 – to schedule the drugs under Schedule 3 to the 2001 Regulations but without the safe custody requirements – provides appropriate and necessary safeguards while ensuring that there are not unduly onerous storage requirements for pharmacists, wholesalers and others. (Home Office, UK, 15.10.2018)

https://www.gov.uk/government/consultations/pregabalin-and-gabapentin-proposal-to-schedule-under-the-misuse-of-drugs-regulations-2001

Concomitant drug abuse of opioid dependent patients in maintenance treatment detected with a multi-target screening of oral fluid.

Wagner E, Raabe F, Martin G, Winter C, Plörer D, Krause DL, Adorjan K, Koller G, Pogarell O.

Am J Addict. 2018 May 24. doi: 10.1111/ajad.12737.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29797622

Triphasic Waves and Encephalopathy in the Setting of Pregabalin Toxicity.

Anand P, Kaplan PW.

J Clin Neurophysiol. 2018 Sep 11. doi: 10.1097/WNP.0000000000000511. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/30222638

Effect of preoperative gabapentin and acetaminophen on opioid consumption in video-assisted thoracoscopic surgery: a retrospective study.

Qiu R, Perrino AC Jr, Zurich H, Sukumar N, Dai F, Popescu W.

Rom J Anaesth Intensive Care. 2018 Apr;25(1):43-48. doi: 10.21454/rjaic.7518.251.gab.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931182/

Gabapentin for Off-Label Use: Evidence-Based or Cause for Concern?

Peckham AM, Evoy KE, Ochs L, Covvey JR.

Subst Abuse. 2018 Sep 23;12:1178221818801311. doi: 10.1177/1178221818801311. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153543/

Pregabalin misuse in methadone maintenance treatment patients in Israel: Prevalence and risk factors.

Sason A, Adelson M, Schreiber S, Peles E.

Drug Alcohol Depend. 2018 May 29;189:8-11. doi: 10.1016/j.drugalcdep.2018.04.025.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29857329

USA. Health officials are sounding an alarm on the drug gabapentin. And it's not even an opioid.

People are using the prescription painkiller gabapentin to boost their highs, doctors say. (...) Kentucky last year became the first state to classify gabapentin as a controlled substance after the drug showed up in a third of the state’s fatal overdoses in 2016. (NBC News, 01.04.2018)

https://www.nbcnews.com/storyline/americas-heroin-epidemic/health-officials-are-sounding-alarm-drug-gabapentin-it-s-not-n861111

Willis-Ekbom disease/restless legs syndrome in patients with opioid withdrawal.

Gupta R, Ali R, Ray R.

Sleep Med. 2018 May;45:39-43. doi: 10.1016/j.sleep.2017.09.028. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29680426

The Association of Gabapentin Use and Dose With Substance Use Disorders Prior to Inpatient Mental Health Treatment: A Cross-Sectional Study.

Tomko JR, Prasad KM, Kubas S, Simpson T.

Prim Care Companion CNS Disord. 2018 Aug 2;20(4). pii: 18m02291. doi: 10.4088/PCC.18m02291.

http://www.psychiatrist.com/PCC/article/Pages/2018/v20n04/18m02291.aspx

Gabapentin (Neurontin).

Yasaei R, Saadabadi A.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.
2018 Mar 16.

https://www.ncbi.nlm.nih.gov/books/NBK493228/

Hold the Gaba: A Case of Gabapentin-induced Hepatotoxicity.

Jackson CD, Clanahan MJ, Joglekar K, Decha-Umphai ST.

Cureus. 2018 Mar 4;10(3):e2269. doi: 10.7759/cureus.2269.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093755/