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Gabapentinoids: repeating mistakes of the past?. 

Murnion, B., Schaffer, A., Cairns, R. and Brett, J. (2022), Addiction. doi.org/10.1111/add.15970


Toxicological Relevance of Pregabalin in Heroin Users: A Two-Year Postmortem Population Study. 

Nahar LK, Murphy K, Paterson S. 

J Anal Toxicol. 2022 May 20;46(5):471-478. doi: 10.1093/jat/bkab070. PMID: 34114622; PMCID: PMC9122506.


Notes from the Field: Trends in Gabapentin Detection and Involvement in Drug Overdose Deaths - 23 States and the District of Columbia, 2019-2020. 

Mattson CL, Chowdhury F, Gilson TP. 

MMWR Morb Mortal Wkly Rep. 2022 May 13;71(19):664-666. doi: 10.15585/mmwr.mm7119a3. PMID: 35552367; PMCID: PMC9098248.


Pregabalin (Lyrica): findings of safety study on risks during pregnancy 

A new study has suggested pregabalin may slightly increase the risk of major congenital malformations if used in pregnancy. Patients should continue to use effective contraception during treatment and avoid use in pregnancy unless clearly necessary. (gov.uk, UK, 19.04.2022)


Fatalities associated with gabapentinoids in England (2004-2020). 

Kalk NJ, Chiu CT, Sadoughi R, Baho H, Williams BD, Taylor D, Copeland CS. 

Br J Clin Pharmacol. 2022 Apr 18. doi: 10.1111/bcp.15352. Epub ahead of print. PMID: 35435281.


An algorithm to identify gabapentin misuse and/or abuse in administrative claims data. 

Zhao D, Nunes AP, Baek J, Lapane KL. 

Drug Alcohol Depend. 2022 Mar 26;235:109429. doi: 10.1016/j.drugalcdep.2022.109429. Epub ahead of print. PMID: 35427982.


Nonmedical use of gabapentin and opioid agonist medications in treatment-seeking individuals with opioid use disorder. 

Ellis MS, Buttram ME, Kasper ZA. 

Drug Alcohol Depend. 2022 Mar 9;234:109400. doi: 10.1016/j.drugalcdep.2022.109400. Epub ahead of print. PMID: 35290917.



The Effects of Prenatal Exposure to Pregabalin on the Development of Ventral Midbrain Dopaminergic Neurons. 

Alsanie WF, Alhomrani M, Gaber A, Habeeballah H, Alkhatabi HA, Felimban RI, Abdelrahman S, Hauser CAE, Chaudhary AG, Alamri AS, Raafat BM, Alamri A, Anwar S, Alswat KA, Althobaiti YS, Asiri YA. 

Cells. 2022 Mar 1;11(5):852. doi: 10.3390/cells11050852. PMID: 35269474; PMCID: PMC8909856.


Pregabalin Abuse - A Case Report. 

Svalina T, Kokalj Palandacic A. 

Psychiatr Danub. 2021 Spring-Summer;33(Suppl 4):1238-1239. PMID: 35354195.


The Role of Gabapentinoids in the Substance Use Pattern of Adult Germans Seeking Inpatient Detoxification Treatment - A Pilot Study. 

Bonnet U, Kanti AK, Scherbaum N, Specka M. 

J Psychoactive Drugs. 2022 Mar 15:1-10. doi: 10.1080/02791072.2022.2050858. Epub ahead of print. PMID: 35290159.



Pregabalin as adjunctive therapy in adult and pediatric patients with generalized tonic-clonic seizures: A randomized, placebo-controlled trial. 

Driscoll J, Almas M, Gregorian G, Kyrychenko A, Makedonska I, Liu J, Patrick J, Scavone JM, Antinew J; 1105 Study Group. 

Epilepsia Open. 2021 Jun;6(2):381-393. doi: 10.1002/epi4.12492. Epub 2021 May 16. PMID: 34033265; PMCID: PMC8166786.


USA. FDA, DEA Pushed to Make Gabapentin a Controlled Substance to Stop 'Widespread Misuse'

In a bid to stop abuse and diversion of the anticonvulsant gabapentin, a watchdog group is petitioning federal regulators to make the drug a controlled substance. (Medscape, USA, 07.03.2022)


Pregabalin abuse and dependence during insomnia and protocol for short-term withdrawal management with diazepam: examples from case reports. 

Papanna B, Lazzari C, Kulkarni K, Perumal S, Nusair A. 

Sleep Sci. 2021 Apr-Jun;14(Spec 2):193-197. doi: 10.5935/1984-0063.20200129. PMID: 35082992; PMCID: PMC8764940.


Chronic Pregabalin Abuse with Subacute Encephalopathy Mimicking Autoimmune Encephalitis. 

Harsha KJ, Joshy EV, Aravinda RV, Poornima R. 

Neurol India. 2021 Nov-Dec;69(6):1785-1788. doi: 10.4103/0028-3886.333486. PMID: 34979689.


UK. 'It's absolutely rife': Drug linked to hundreds of deaths is being sold to Manchester's homeless for just 50p a pill

Pregabalin, normally used to treat nerve damage, epilepsy and anxiety, is being widely used among the city centre's rough sleepers and drug addicts because Spice and heroin are 'not as strong as they used to be'. (Manchester Evening News, UK, 21.11.2021)


Abuse liability of gabapentin in the Saudi population after the pregabalin restriction: A cross-sectional study. 

Alkhalaf AA, Bukhari RA, Alshehri EA, Alshehri SO, Badr AF. 

J Taibah Univ Med Sci. 2021 Jun 3;16(5):700-705. doi: 10.1016/j.jtumed.2021.04.009. PMID: 34690650; PMCID: PMC8498723.


Gabapentinoids: The rise of a new misuse epidemics? 

Hofmann M, Besson M. 

Psychiatry Res. 2021 Aug 28;305:114193. doi: 10.1016/j.psychres.2021.114193. Epub ahead of print. PMID: 34534775.


Analysis of Gabapentinoids Abuse-Reports in the Middle East and North Africa Region

Alsheikh MY, et al.

PTB Reports, Vol 7, Issue 1, Jan-Apr, 2021


Characteristics of fatal gabapentinoid-related poisoning in Australia, 2000-2020. 

Darke S, Duflou J, Peacock A, Farrell M, Lappin J. 

Clin Toxicol (Phila). 2021 Aug 17:1-7. doi: 10.1080/15563650.2021.1965159. Epub ahead of print. PMID: 34402696.



Australien. ‘Pregabalin is not a harmless drug.

A pharmacist tried to warn a GP that his patient was a known “doctor shopper” – but the man still obtained large amounts of pregabalin and diazepam, and subsequently died. (Australian Journal of Pharmacy, 10.08.2021)


Potential Adverse Consequences of Combination Therapy with Gabapentin and Pregabalin. 

Ghayur MN. 

Case Rep Med. 2021 Jun 2;2021:5559981. doi: 10.1155/2021/5559981. PMID: 34122553; PMCID: PMC8189818.


Non-medical Use of Prescription Gabapentinoids (Gabapentin and Pregabalin) in Five European Countries. 

Fonseca F, Lenahan W, Dart RC, Papaseit E, Dargan PI, Wood DM, Guareschi M, Maremmani I, Auriacombe M, Farré M, Scherbaum N, Torrens M. 

Front Psychiatry. 2021 Apr 28;12:676224. doi: 10.3389/fpsyt.2021.676224. PMID: 33995154; PMCID: PMC8113698.


Do gabapentin or pregabalin directly modulate the µ receptor? 

Manandhar P, Murnion BP, Grimsey NL, Connor M, Santiago M. 

PeerJ. 2021 Apr 12;9:e11175. doi: 10.7717/peerj.11175. PMID: 33954038; PMCID: PMC8048397.


Involvement of the dopaminergic system in the reward-related behavior of pregabalin. 

Althobaiti, Y.S., Almutairi, F.M., Alshehri, F.S. et al. 

Sci Rep 11, 10577 (2021). doi.org/10.1038/s41598-021-88429-8


Pregabalin dependence. 

Singh A, Sidana A, Agrawal A, Arun P.

Indian J Psychiatry. 2020 Nov-Dec;62(6):738-739. doi: 10.4103/psychiatry.IndianJPsychiatry_475_19. Epub 2020 Dec 12. PMID: 33896987; PMCID: PMC8052884.


Doc-Hopping bei Benzodiazepin- und Pregabalinverordnungen

Wie lässt sich vermeiden, dass Patienten verschiedene Praxen aufsuchen, um an möglichst große mengen bestimmter medikamente zu kommen? (R.Ullmann in KVHH Journal, 12/2020, Seiten 26/27)


Pregabalin use among a sample of people who inject drugs in Canberra, ACT.

Julia Uporova, Olivia Price, Rachel Sutherland and Amy Peacock

National Drug and Alcohol Research Centre, UNSW Sydney, April 2021


Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update. 

Evoy KE, Sadrameli S, Contreras J, Covvey JR, Peckham AM, Morrison MD. 

Drugs. 2021 Jan;81(1):125-156. doi: 10.1007/s40265-020-01432-7. PMID: 33215352.



Comment on "Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update". 

Bonnet U, McAnally H, Scherbaum N. 

Drugs. 2021 Mar 18. doi: 10.1007/s40265-021-01494-1. Epub ahead of print. PMID: 33738757.


Prescription of Opioids and Gabapentinoids Associated With Subsequent Overdose, Especially at High Doses and in Combination

Gabapentinoid prescriptions have increased substantially over the last 2 decades, and there is increasing evidence of a heightened risk of overdose among patients prescribed these medications, especially in combination with opioids. (Alcohol, Other Drugs, and Health: Current Evidence, Boston University, Januar-Februar 2021)