A- A A+

Gabapentinoids: The rise of a new misuse epidemics? 

Hofmann M, Besson M. 

Psychiatry Res. 2021 Aug 28;305:114193. doi: 10.1016/j.psychres.2021.114193. Epub ahead of print. PMID: 34534775.

https://www.sciencedirect.com/science/article/pii/S0165178121004893?via%3Dihub

Analysis of Gabapentinoids Abuse-Reports in the Middle East and North Africa Region

Alsheikh MY, et al.

PTB Reports, Vol 7, Issue 1, Jan-Apr, 2021

http://ptbreports.org/sites/default/files/PTBReports-7-1-05_0.pdf

Characteristics of fatal gabapentinoid-related poisoning in Australia, 2000-2020. 

Darke S, Duflou J, Peacock A, Farrell M, Lappin J. 

Clin Toxicol (Phila). 2021 Aug 17:1-7. doi: 10.1080/15563650.2021.1965159. Epub ahead of print. PMID: 34402696.

Abstract

https://www.tandfonline.com/doi/abs/10.1080/15563650.2021.1965159?journalCode=ictx20

Australien. ‘Pregabalin is not a harmless drug.

A pharmacist tried to warn a GP that his patient was a known “doctor shopper” – but the man still obtained large amounts of pregabalin and diazepam, and subsequently died. (Australian Journal of Pharmacy, 10.08.2021)

https://ajp.com.au/news/pregabalin-is-not-a-harmless-drug/

Potential Adverse Consequences of Combination Therapy with Gabapentin and Pregabalin. 

Ghayur MN. 

Case Rep Med. 2021 Jun 2;2021:5559981. doi: 10.1155/2021/5559981. PMID: 34122553; PMCID: PMC8189818.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189818/

Non-medical Use of Prescription Gabapentinoids (Gabapentin and Pregabalin) in Five European Countries. 

Fonseca F, Lenahan W, Dart RC, Papaseit E, Dargan PI, Wood DM, Guareschi M, Maremmani I, Auriacombe M, Farré M, Scherbaum N, Torrens M. 

Front Psychiatry. 2021 Apr 28;12:676224. doi: 10.3389/fpsyt.2021.676224. PMID: 33995154; PMCID: PMC8113698.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113698/

Do gabapentin or pregabalin directly modulate the µ receptor? 

Manandhar P, Murnion BP, Grimsey NL, Connor M, Santiago M. 

PeerJ. 2021 Apr 12;9:e11175. doi: 10.7717/peerj.11175. PMID: 33954038; PMCID: PMC8048397.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048397/

Involvement of the dopaminergic system in the reward-related behavior of pregabalin. 

Althobaiti, Y.S., Almutairi, F.M., Alshehri, F.S. et al. 

Sci Rep 11, 10577 (2021). doi.org/10.1038/s41598-021-88429-8

https://www.nature.com/articles/s41598-021-88429-8

Pregabalin dependence. 

Singh A, Sidana A, Agrawal A, Arun P.

Indian J Psychiatry. 2020 Nov-Dec;62(6):738-739. doi: 10.4103/psychiatry.IndianJPsychiatry_475_19. Epub 2020 Dec 12. PMID: 33896987; PMCID: PMC8052884.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052884/

Doc-Hopping bei Benzodiazepin- und Pregabalinverordnungen

Wie lässt sich vermeiden, dass Patienten verschiedene Praxen aufsuchen, um an möglichst große mengen bestimmter medikamente zu kommen? (R.Ullmann in KVHH Journal, 12/2020, Seiten 26/27)

https://www.kvhh.net/_Resources/Persistent/3/e/a/4/3ea4979c6d3f19755778b20928ee0c42525cf8e7/12_20_www_KVH_Journal_RZ02.pdf

Pregabalin use among a sample of people who inject drugs in Canberra, ACT.

Julia Uporova, Olivia Price, Rachel Sutherland and Amy Peacock

National Drug and Alcohol Research Centre, UNSW Sydney, April 2021

https://ndarc.med.unsw.edu.au/sites/default/files/ndarc/resources/Pregabalin%20Bulletin%20ACT_FINAL.pdf

Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update. 

Evoy KE, Sadrameli S, Contreras J, Covvey JR, Peckham AM, Morrison MD. 

Drugs. 2021 Jan;81(1):125-156. doi: 10.1007/s40265-020-01432-7. PMID: 33215352.

Abstract

https://pubmed.ncbi.nlm.nih.gov/33215352/

Comment on "Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update". 

Bonnet U, McAnally H, Scherbaum N. 

Drugs. 2021 Mar 18. doi: 10.1007/s40265-021-01494-1. Epub ahead of print. PMID: 33738757.

https://link.springer.com/article/10.1007/s40265-021-01494-1

Prescription of Opioids and Gabapentinoids Associated With Subsequent Overdose, Especially at High Doses and in Combination

Gabapentinoid prescriptions have increased substantially over the last 2 decades, and there is increasing evidence of a heightened risk of overdose among patients prescribed these medications, especially in combination with opioids. (Alcohol, Other Drugs, and Health: Current Evidence, Boston University, Januar-Februar 2021)

http://www.bu.edu/aodhealth/2021/03/09/prescription-of-opioids-and-gabapentinoids-associated-with-subsequent-overdose-especially-at-high-doses-and-in-combination/

Gabapentinoid Abuse in France: Evidence on Health Consequences and New Points of Vigilance. 

Tambon M, Ponté C, Jouanjus E, Fouilhé N, Micallef J, Lapeyre-Mestre M; French Addictovigilance Network (FAN). 

Front Psychiatry. 2021 Feb 3;12:639780. doi: 10.3389/fpsyt.2021.639780. PMID: 33613345; PMCID: PMC7886797.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886797/

Pregabalin (Lyrica): reports of severe respiratory depression 

Pregabalin has been associated with infrequent reports of severe respiratory depression, including some cases without the presence of concomitant opioid medicines. Patients with compromised respiratory function, respiratory or neurological disease, renal impairment; those using concomitant central nervous system (CNS) depressants; and people older than 65 years might be at higher risk of experiencing these events and adjustments in dose or dosing regimen may be necessary. (gov.uk, Medicines and Healthcare products Regulatory Agency, UK, 18.02.2021)

https://www.gov.uk/drug-safety-update/pregabalin-lyrica-reports-of-severe-respiratory-depression

Gabapentin add-on treatment for drug-resistant focal epilepsy. 

Panebianco M, Al-Bachari S, Hutton JL, Marson AG. 

Cochrane Database of Systematic Reviews 2021, Issue 1. Art. No.: CD001415. DOI: 10.1002/14651858.CD001415.pub4.

https://www.cochrane.org/CD001415/EPILEPSY_gabapentin-add-drug-resistant-focal-epilepsy

Pregabalin Misuse: Motives, Pattern, and Knowledge about Its Risks among Patients in Methadone Maintenance Treatment. 

Peles E, Sason A, Schreiber S, Adelson M. 

J Psychoactive Drugs. 2020 Dec 24:1-9. doi: 10.1080/02791072.2020.1861392. Epub ahead of print. PMID: 33357129.

Abstract

https://pubmed.ncbi.nlm.nih.gov/33357129/

Association of Gabapentinoids With the Risk of Opioid-Related Adverse Events in Surgical Patients in the United States. 

Bykov K, Bateman BT, Franklin JM, Vine SM, Patorno E. 

JAMA Netw Open. 2020 Dec 1;3(12):e2031647. doi: 10.1001/jamanetworkopen.2020.31647. PMID: 33372975.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2774489

Gabapentin for Alcohol-Related Disorders: Critical Appraisal of the Symptom-Driven Approach. 

Andrade C. 

J Clin Psychiatry. 2020 Nov 24;81(6):20f13775. doi: 10.4088/JCP.20f13775. PMID: 33238082.

https://www.psychiatrist.com/JCP/article/Pages/gabapentin-for-alcohol-related-disorders.aspx

Drug-Induced Gingival Overgrowth: A Pilot Study on the Effect of Diphenylhydantoin and Gabapentin on Human Gingival Fibroblasts. 

Lauritano D, Moreo G, Limongelli L, Tregambi E, Palmieri A, Carinci F. 

Int J Environ Res Public Health. 2020 Nov 7;17(21):8229. doi: 10.3390/ijerph17218229. PMID: 33171749; PMCID: PMC7664415.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664415/

Pregabalin prescribing patterns in Australian general practice, 2012-2018: a cross-sectional study. 

Schaffer AL, Busingye D, Chidwick K, Brett J, Blogg S. 

BJGP Open. 2020 Dec 1:bjgpopen20X101120. doi: 10.3399/bjgpopen20X101120. Epub ahead of print. PMID: 33172853.

https://bjgpopen.org/content/early/2020/11/30/bjgpopen20X101120.long

Retrospective Analysis of Gabapentin for Alcohol Withdrawal in the Hospital Setting: The Mayo Clinic Experience. 

Bates RE, Leung JG, Morgan RJ 3rd, Fischer KM, Philbrick KL, Kung S. 

Mayo Clin Proc Innov Qual Outcomes. 2020 Aug 19;4(5):542-549. doi: 10.1016/j.mayocpiqo.2020.06.002. PMID: 33083703; PMCID: PMC7560568.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560568/

Pregabalin-associated movement disorders: A literature review. 

Rissardo JP, Caprara ALF. 

Brain Circ. 2020 Jun 26;6(2):96-106. doi: 10.4103/bc.bc_57_19. PMID: 33033779; PMCID: PMC7511912.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511912/

Treating anxious syndromes with pregabalin in patients with psychosis. 

Garel N, Bloom D, Joober R. 

J Psychiatry Neurosci. 2020;45(5):370. doi:10.1503/jpn.200033

http://jpn.ca/wp-content/uploads/2020/08/45-5-370.pdf

Gabapentin for Post-Hospitalization Alcohol Relapse Prevention; Should Gabapentin Be Considered for FDA Approval in the Treatment of Alcohol Use Disorder?: A Case Presentation and Literature Review. 

Neuhut S. 

Cureus. 2020;12(6):e8931. Published 2020 Jun 30. doi:10.7759/cureus.8931

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392371/

Is the non-medical use of pregabalin related to reward/relief craving coupled to an unbalanced opioid system?

Della Rocca F., Cosentino V., Carbone M.G., Maremmani A.G.I., and Maremmani I.

Conclusions: This paper adds to the growing body of literature suggesting that pregabalin has a non-medical use potential. When prescribing pregabalin, clinicians should consider completing a risk assessment for non-medical use, especially in patients with a Substance Use Disorder history. Therefore, pregabalin off-label prescriptions should be carefully considered.

Heroin Addiction and Related Clinical Problems, Published Ahead of Print, July 14, 2020

Is the non-medical use of pregabalin related to reward/relief craving coupled to an unbalanced opioid system?

Gabapentin-induced drug-seeking-like behavior: a potential role for the dopaminergic system.

Althobaiti YS, Alghorabi A, Alshehri FS, et al. 

Sci Rep. 2020;10(1):10445. Published 2020 Jun 26. doi:10.1038/s41598-020-67318-6

https://www.nature.com/articles/s41598-020-67318-6

Australien. Pregabalin use found to be relatively common among people who regularly inject drugs

The use of pregabalin, a medicine for neuropathic pain, is relatively common among a sample of people who regularly inject drugs (PWID) in Australia, a new study by researchers at the National Drug and Alcohol Research Centre (NDARC), UNSW Sydney has found. 

In a sample of 905 participants from the 2018 Illicit Drug Reporting System, it was identified that 25 per cent of PWID reported using pregabalin in the previous six months.

Lead author, Dr Rachel Sutherland said; “10 per cent of the sample reported using pregabalin that was prescribed to them, while 15 per cent reported using pregabalin that was not prescribed to them.” (ndarc - National Drug and Alcohol Research Centre, Australien, 17.06.2020)

https://ndarc.med.unsw.edu.au/news/pregabalin-use-found-be-relatively-common-among-people-who-regularly-inject-drugs

Problematic Medication With Benzodiazepines, "Z-drugs", and Opioid Analgesics.

Buth S, Holzbach R, Martens MS, Neumann-Runde E, Meiners O, Verthein U.

Dtsch Arztebl Int. 2019 Sep 13;116(37):607-614. doi: 10.3238/arztebl.2019.0607.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819700/