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UK. 'It's absolutely rife': Drug linked to hundreds of deaths is being sold to Manchester's homeless for just 50p a pill

Pregabalin, normally used to treat nerve damage, epilepsy and anxiety, is being widely used among the city centre's rough sleepers and drug addicts because Spice and heroin are 'not as strong as they used to be'. (Manchester Evening News, UK, 21.11.2021)


Abuse liability of gabapentin in the Saudi population after the pregabalin restriction: A cross-sectional study. 

Alkhalaf AA, Bukhari RA, Alshehri EA, Alshehri SO, Badr AF. 

J Taibah Univ Med Sci. 2021 Jun 3;16(5):700-705. doi: 10.1016/j.jtumed.2021.04.009. PMID: 34690650; PMCID: PMC8498723.


Gabapentinoids: The rise of a new misuse epidemics? 

Hofmann M, Besson M. 

Psychiatry Res. 2021 Aug 28;305:114193. doi: 10.1016/j.psychres.2021.114193. Epub ahead of print. PMID: 34534775.


Analysis of Gabapentinoids Abuse-Reports in the Middle East and North Africa Region

Alsheikh MY, et al.

PTB Reports, Vol 7, Issue 1, Jan-Apr, 2021


Characteristics of fatal gabapentinoid-related poisoning in Australia, 2000-2020. 

Darke S, Duflou J, Peacock A, Farrell M, Lappin J. 

Clin Toxicol (Phila). 2021 Aug 17:1-7. doi: 10.1080/15563650.2021.1965159. Epub ahead of print. PMID: 34402696.



Australien. ‘Pregabalin is not a harmless drug.

A pharmacist tried to warn a GP that his patient was a known “doctor shopper” – but the man still obtained large amounts of pregabalin and diazepam, and subsequently died. (Australian Journal of Pharmacy, 10.08.2021)


Potential Adverse Consequences of Combination Therapy with Gabapentin and Pregabalin. 

Ghayur MN. 

Case Rep Med. 2021 Jun 2;2021:5559981. doi: 10.1155/2021/5559981. PMID: 34122553; PMCID: PMC8189818.


Non-medical Use of Prescription Gabapentinoids (Gabapentin and Pregabalin) in Five European Countries. 

Fonseca F, Lenahan W, Dart RC, Papaseit E, Dargan PI, Wood DM, Guareschi M, Maremmani I, Auriacombe M, Farré M, Scherbaum N, Torrens M. 

Front Psychiatry. 2021 Apr 28;12:676224. doi: 10.3389/fpsyt.2021.676224. PMID: 33995154; PMCID: PMC8113698.


Do gabapentin or pregabalin directly modulate the µ receptor? 

Manandhar P, Murnion BP, Grimsey NL, Connor M, Santiago M. 

PeerJ. 2021 Apr 12;9:e11175. doi: 10.7717/peerj.11175. PMID: 33954038; PMCID: PMC8048397.


Involvement of the dopaminergic system in the reward-related behavior of pregabalin. 

Althobaiti, Y.S., Almutairi, F.M., Alshehri, F.S. et al. 

Sci Rep 11, 10577 (2021). doi.org/10.1038/s41598-021-88429-8


Pregabalin dependence. 

Singh A, Sidana A, Agrawal A, Arun P.

Indian J Psychiatry. 2020 Nov-Dec;62(6):738-739. doi: 10.4103/psychiatry.IndianJPsychiatry_475_19. Epub 2020 Dec 12. PMID: 33896987; PMCID: PMC8052884.


Doc-Hopping bei Benzodiazepin- und Pregabalinverordnungen

Wie lässt sich vermeiden, dass Patienten verschiedene Praxen aufsuchen, um an möglichst große mengen bestimmter medikamente zu kommen? (R.Ullmann in KVHH Journal, 12/2020, Seiten 26/27)


Pregabalin use among a sample of people who inject drugs in Canberra, ACT.

Julia Uporova, Olivia Price, Rachel Sutherland and Amy Peacock

National Drug and Alcohol Research Centre, UNSW Sydney, April 2021


Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update. 

Evoy KE, Sadrameli S, Contreras J, Covvey JR, Peckham AM, Morrison MD. 

Drugs. 2021 Jan;81(1):125-156. doi: 10.1007/s40265-020-01432-7. PMID: 33215352.



Comment on "Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update". 

Bonnet U, McAnally H, Scherbaum N. 

Drugs. 2021 Mar 18. doi: 10.1007/s40265-021-01494-1. Epub ahead of print. PMID: 33738757.


Prescription of Opioids and Gabapentinoids Associated With Subsequent Overdose, Especially at High Doses and in Combination

Gabapentinoid prescriptions have increased substantially over the last 2 decades, and there is increasing evidence of a heightened risk of overdose among patients prescribed these medications, especially in combination with opioids. (Alcohol, Other Drugs, and Health: Current Evidence, Boston University, Januar-Februar 2021)


Gabapentinoid Abuse in France: Evidence on Health Consequences and New Points of Vigilance. 

Tambon M, Ponté C, Jouanjus E, Fouilhé N, Micallef J, Lapeyre-Mestre M; French Addictovigilance Network (FAN). 

Front Psychiatry. 2021 Feb 3;12:639780. doi: 10.3389/fpsyt.2021.639780. PMID: 33613345; PMCID: PMC7886797.


Pregabalin (Lyrica): reports of severe respiratory depression 

Pregabalin has been associated with infrequent reports of severe respiratory depression, including some cases without the presence of concomitant opioid medicines. Patients with compromised respiratory function, respiratory or neurological disease, renal impairment; those using concomitant central nervous system (CNS) depressants; and people older than 65 years might be at higher risk of experiencing these events and adjustments in dose or dosing regimen may be necessary. (gov.uk, Medicines and Healthcare products Regulatory Agency, UK, 18.02.2021)


Gabapentin add-on treatment for drug-resistant focal epilepsy. 

Panebianco M, Al-Bachari S, Hutton JL, Marson AG. 

Cochrane Database of Systematic Reviews 2021, Issue 1. Art. No.: CD001415. DOI: 10.1002/14651858.CD001415.pub4.


Pregabalin Misuse: Motives, Pattern, and Knowledge about Its Risks among Patients in Methadone Maintenance Treatment. 

Peles E, Sason A, Schreiber S, Adelson M. 

J Psychoactive Drugs. 2020 Dec 24:1-9. doi: 10.1080/02791072.2020.1861392. Epub ahead of print. PMID: 33357129.



Association of Gabapentinoids With the Risk of Opioid-Related Adverse Events in Surgical Patients in the United States. 

Bykov K, Bateman BT, Franklin JM, Vine SM, Patorno E. 

JAMA Netw Open. 2020 Dec 1;3(12):e2031647. doi: 10.1001/jamanetworkopen.2020.31647. PMID: 33372975.


Gabapentin for Alcohol-Related Disorders: Critical Appraisal of the Symptom-Driven Approach. 

Andrade C. 

J Clin Psychiatry. 2020 Nov 24;81(6):20f13775. doi: 10.4088/JCP.20f13775. PMID: 33238082.


Drug-Induced Gingival Overgrowth: A Pilot Study on the Effect of Diphenylhydantoin and Gabapentin on Human Gingival Fibroblasts. 

Lauritano D, Moreo G, Limongelli L, Tregambi E, Palmieri A, Carinci F. 

Int J Environ Res Public Health. 2020 Nov 7;17(21):8229. doi: 10.3390/ijerph17218229. PMID: 33171749; PMCID: PMC7664415.


Pregabalin prescribing patterns in Australian general practice, 2012-2018: a cross-sectional study. 

Schaffer AL, Busingye D, Chidwick K, Brett J, Blogg S. 

BJGP Open. 2020 Dec 1:bjgpopen20X101120. doi: 10.3399/bjgpopen20X101120. Epub ahead of print. PMID: 33172853.


Retrospective Analysis of Gabapentin for Alcohol Withdrawal in the Hospital Setting: The Mayo Clinic Experience. 

Bates RE, Leung JG, Morgan RJ 3rd, Fischer KM, Philbrick KL, Kung S. 

Mayo Clin Proc Innov Qual Outcomes. 2020 Aug 19;4(5):542-549. doi: 10.1016/j.mayocpiqo.2020.06.002. PMID: 33083703; PMCID: PMC7560568.


Pregabalin-associated movement disorders: A literature review. 

Rissardo JP, Caprara ALF. 

Brain Circ. 2020 Jun 26;6(2):96-106. doi: 10.4103/bc.bc_57_19. PMID: 33033779; PMCID: PMC7511912.


Treating anxious syndromes with pregabalin in patients with psychosis. 

Garel N, Bloom D, Joober R. 

J Psychiatry Neurosci. 2020;45(5):370. doi:10.1503/jpn.200033


Gabapentin for Post-Hospitalization Alcohol Relapse Prevention; Should Gabapentin Be Considered for FDA Approval in the Treatment of Alcohol Use Disorder?: A Case Presentation and Literature Review. 

Neuhut S. 

Cureus. 2020;12(6):e8931. Published 2020 Jun 30. doi:10.7759/cureus.8931


Is the non-medical use of pregabalin related to reward/relief craving coupled to an unbalanced opioid system?

Della Rocca F., Cosentino V., Carbone M.G., Maremmani A.G.I., and Maremmani I.

Conclusions: This paper adds to the growing body of literature suggesting that pregabalin has a non-medical use potential. When prescribing pregabalin, clinicians should consider completing a risk assessment for non-medical use, especially in patients with a Substance Use Disorder history. Therefore, pregabalin off-label prescriptions should be carefully considered.

Heroin Addiction and Related Clinical Problems, Published Ahead of Print, July 14, 2020

Is the non-medical use of pregabalin related to reward/relief craving coupled to an unbalanced opioid system?

Gabapentin-induced drug-seeking-like behavior: a potential role for the dopaminergic system.

Althobaiti YS, Alghorabi A, Alshehri FS, et al. 

Sci Rep. 2020;10(1):10445. Published 2020 Jun 26. doi:10.1038/s41598-020-67318-6