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Risk of major adverse events associated with gabapentinoid and opioid combination therapy: A systematic review and meta-analysis. 

Hahn J, Jo Y, Yoo SH, Shin J, Yu YM, Ah YM. 

Front Pharmacol. 2022 Oct 11;13:1009950. doi: 10.3389/fphar.2022.1009950. PMID: 36304170; PMCID: PMC9593000.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593000/

Hamburg, Verordnungen für den Schwarzmarkt

Ein einträgliches Geschäftsmodell ist erfolgreicher geworden: Mehr Doc-Hopper bekommen von mehr Praxen mehr Pregabalin. Auch einzelnen Patienten wird mehr verordnet

R.Ullmann

KVH Journal, KV Hamburg, 10/22

https://www.kvhh.net/_Resources/Persistent/9/d/5/1/9d51bd958aaa5e6db468c8187070c4b0cf2c6421/10_22_www_iAktiv_KVH-Journal_RZ02.pdf

Pregabalin Toxicity-Induced Posterior Reversible Encephalopathy Syndrome. 

Hsiao F, Ma A, Muthukanagaraj P. 

Cureus. 2022 Jun 4;14(6):e25656. doi: 10.7759/cureus.25656. PMID: 35784981; PMCID: PMC9249023.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249023/

Patterns of pregabalin prescribing in four German federal states: analysis of routine data to investigate potential misuse of pregabalin. 

Flemming R. 

BMJ Open. 2022 Jul 25;12(7):e060104. doi: 10.1136/bmjopen-2021-060104. PMID: 35879005.

https://bmjopen.bmj.com/content/12/7/e060104

Warnhinweis zur Verordnung von Pregabalin

Anlässlich des zunehmenden missbräuchlichen Einsatzes des Medikaments Pregabalin weist die Qualitätssicherungskommission „Substitution“ bei der KV Bremen auf einige Gesichtspunkte bei der Verordnung von Pregabalin hin. (KVHB – Kassenärztliche Vereinigung Bremen, 29.11.2021)

https://www.kvhb.de/praxen/nachrichten/detail/warnhinweis-zur-verordnung-von-pregabalin

Notes from the Field: Trends in Gabapentin Detection and Involvement in Drug Overdose Deaths — 23 States and the District of Columbia, 2019–2020. 

Mattson CL, Chowdhury F, Gilson TP. 

MMWR Morb Mortal Wkly Rep 2022;71:664–666. doi.org/10.15585/mmwr.mm7119a3

https://www.cdc.gov/mmwr/volumes/71/wr/mm7119a3.htm

Gabapentinoids: repeating mistakes of the past?. 

Murnion, B., Schaffer, A., Cairns, R. and Brett, J. (2022), Addiction. doi.org/10.1111/add.15970

https://onlinelibrary.wiley.com/doi/full/10.1111/add.15970

Toxicological Relevance of Pregabalin in Heroin Users: A Two-Year Postmortem Population Study. 

Nahar LK, Murphy K, Paterson S. 

J Anal Toxicol. 2022 May 20;46(5):471-478. doi: 10.1093/jat/bkab070. PMID: 34114622; PMCID: PMC9122506.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122506/

Notes from the Field: Trends in Gabapentin Detection and Involvement in Drug Overdose Deaths - 23 States and the District of Columbia, 2019-2020. 

Mattson CL, Chowdhury F, Gilson TP. 

MMWR Morb Mortal Wkly Rep. 2022 May 13;71(19):664-666. doi: 10.15585/mmwr.mm7119a3. PMID: 35552367; PMCID: PMC9098248.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098248/

Pregabalin (Lyrica): findings of safety study on risks during pregnancy 

A new study has suggested pregabalin may slightly increase the risk of major congenital malformations if used in pregnancy. Patients should continue to use effective contraception during treatment and avoid use in pregnancy unless clearly necessary. (gov.uk, UK, 19.04.2022)

https://www.gov.uk/drug-safety-update/pregabalin-lyrica-findings-of-safety-study-on-risks-during-pregnancy

Fatalities associated with gabapentinoids in England (2004-2020). 

Kalk NJ, Chiu CT, Sadoughi R, Baho H, Williams BD, Taylor D, Copeland CS. 

Br J Clin Pharmacol. 2022 Apr 18. doi: 10.1111/bcp.15352. Epub ahead of print. PMID: 35435281.

https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.15352

An algorithm to identify gabapentin misuse and/or abuse in administrative claims data. 

Zhao D, Nunes AP, Baek J, Lapane KL. 

Drug Alcohol Depend. 2022 Mar 26;235:109429. doi: 10.1016/j.drugalcdep.2022.109429. Epub ahead of print. PMID: 35427982.

https://www.sciencedirect.com/science/article/pii/S0376871622001661

Nonmedical use of gabapentin and opioid agonist medications in treatment-seeking individuals with opioid use disorder. 

Ellis MS, Buttram ME, Kasper ZA. 

Drug Alcohol Depend. 2022 Mar 9;234:109400. doi: 10.1016/j.drugalcdep.2022.109400. Epub ahead of print. PMID: 35290917.

Abstract

https://pubmed.ncbi.nlm.nih.gov/35290917/

The Effects of Prenatal Exposure to Pregabalin on the Development of Ventral Midbrain Dopaminergic Neurons. 

Alsanie WF, Alhomrani M, Gaber A, Habeeballah H, Alkhatabi HA, Felimban RI, Abdelrahman S, Hauser CAE, Chaudhary AG, Alamri AS, Raafat BM, Alamri A, Anwar S, Alswat KA, Althobaiti YS, Asiri YA. 

Cells. 2022 Mar 1;11(5):852. doi: 10.3390/cells11050852. PMID: 35269474; PMCID: PMC8909856.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909856/

Pregabalin Abuse - A Case Report. 

Svalina T, Kokalj Palandacic A. 

Psychiatr Danub. 2021 Spring-Summer;33(Suppl 4):1238-1239. PMID: 35354195.

https://www.psychiatria-danubina.com/UserDocsImages/pdf/dnb_vol33_noSuppl%204/dnb_vol33_noSuppl%204_1238.pdf

The Role of Gabapentinoids in the Substance Use Pattern of Adult Germans Seeking Inpatient Detoxification Treatment - A Pilot Study. 

Bonnet U, Kanti AK, Scherbaum N, Specka M. 

J Psychoactive Drugs. 2022 Mar 15:1-10. doi: 10.1080/02791072.2022.2050858. Epub ahead of print. PMID: 35290159.

Abstract

https://pubmed.ncbi.nlm.nih.gov/35290159/

Pregabalin as adjunctive therapy in adult and pediatric patients with generalized tonic-clonic seizures: A randomized, placebo-controlled trial. 

Driscoll J, Almas M, Gregorian G, Kyrychenko A, Makedonska I, Liu J, Patrick J, Scavone JM, Antinew J; 1105 Study Group. 

Epilepsia Open. 2021 Jun;6(2):381-393. doi: 10.1002/epi4.12492. Epub 2021 May 16. PMID: 34033265; PMCID: PMC8166786.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166786/

USA. FDA, DEA Pushed to Make Gabapentin a Controlled Substance to Stop 'Widespread Misuse'

In a bid to stop abuse and diversion of the anticonvulsant gabapentin, a watchdog group is petitioning federal regulators to make the drug a controlled substance. (Medscape, USA, 07.03.2022)

https://www.medscape.com/viewarticle/969829

Pregabalin abuse and dependence during insomnia and protocol for short-term withdrawal management with diazepam: examples from case reports. 

Papanna B, Lazzari C, Kulkarni K, Perumal S, Nusair A. 

Sleep Sci. 2021 Apr-Jun;14(Spec 2):193-197. doi: 10.5935/1984-0063.20200129. PMID: 35082992; PMCID: PMC8764940.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764940/

Chronic Pregabalin Abuse with Subacute Encephalopathy Mimicking Autoimmune Encephalitis. 

Harsha KJ, Joshy EV, Aravinda RV, Poornima R. 

Neurol India. 2021 Nov-Dec;69(6):1785-1788. doi: 10.4103/0028-3886.333486. PMID: 34979689.

https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2021;volume=69;issue=6;spage=1785;epage=1788;aulast=Harsha

UK. 'It's absolutely rife': Drug linked to hundreds of deaths is being sold to Manchester's homeless for just 50p a pill

Pregabalin, normally used to treat nerve damage, epilepsy and anxiety, is being widely used among the city centre's rough sleepers and drug addicts because Spice and heroin are 'not as strong as they used to be'. (Manchester Evening News, UK, 21.11.2021)

https://www.manchestereveningnews.co.uk/news/greater-manchester-news/its-absolutely-rife-drug-linked-22135204

Abuse liability of gabapentin in the Saudi population after the pregabalin restriction: A cross-sectional study. 

Alkhalaf AA, Bukhari RA, Alshehri EA, Alshehri SO, Badr AF. 

J Taibah Univ Med Sci. 2021 Jun 3;16(5):700-705. doi: 10.1016/j.jtumed.2021.04.009. PMID: 34690650; PMCID: PMC8498723.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498723/

Gabapentinoids: The rise of a new misuse epidemics? 

Hofmann M, Besson M. 

Psychiatry Res. 2021 Aug 28;305:114193. doi: 10.1016/j.psychres.2021.114193. Epub ahead of print. PMID: 34534775.

https://www.sciencedirect.com/science/article/pii/S0165178121004893?via%3Dihub

Analysis of Gabapentinoids Abuse-Reports in the Middle East and North Africa Region

Alsheikh MY, et al.

PTB Reports, Vol 7, Issue 1, Jan-Apr, 2021

http://ptbreports.org/sites/default/files/PTBReports-7-1-05_0.pdf

Characteristics of fatal gabapentinoid-related poisoning in Australia, 2000-2020. 

Darke S, Duflou J, Peacock A, Farrell M, Lappin J. 

Clin Toxicol (Phila). 2021 Aug 17:1-7. doi: 10.1080/15563650.2021.1965159. Epub ahead of print. PMID: 34402696.

Abstract

https://www.tandfonline.com/doi/abs/10.1080/15563650.2021.1965159?journalCode=ictx20

Australien. ‘Pregabalin is not a harmless drug.

A pharmacist tried to warn a GP that his patient was a known “doctor shopper” – but the man still obtained large amounts of pregabalin and diazepam, and subsequently died. (Australian Journal of Pharmacy, 10.08.2021)

https://ajp.com.au/news/pregabalin-is-not-a-harmless-drug/

Potential Adverse Consequences of Combination Therapy with Gabapentin and Pregabalin. 

Ghayur MN. 

Case Rep Med. 2021 Jun 2;2021:5559981. doi: 10.1155/2021/5559981. PMID: 34122553; PMCID: PMC8189818.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189818/

Non-medical Use of Prescription Gabapentinoids (Gabapentin and Pregabalin) in Five European Countries. 

Fonseca F, Lenahan W, Dart RC, Papaseit E, Dargan PI, Wood DM, Guareschi M, Maremmani I, Auriacombe M, Farré M, Scherbaum N, Torrens M. 

Front Psychiatry. 2021 Apr 28;12:676224. doi: 10.3389/fpsyt.2021.676224. PMID: 33995154; PMCID: PMC8113698.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113698/

Do gabapentin or pregabalin directly modulate the µ receptor? 

Manandhar P, Murnion BP, Grimsey NL, Connor M, Santiago M. 

PeerJ. 2021 Apr 12;9:e11175. doi: 10.7717/peerj.11175. PMID: 33954038; PMCID: PMC8048397.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048397/

Involvement of the dopaminergic system in the reward-related behavior of pregabalin. 

Althobaiti, Y.S., Almutairi, F.M., Alshehri, F.S. et al. 

Sci Rep 11, 10577 (2021). doi.org/10.1038/s41598-021-88429-8

https://www.nature.com/articles/s41598-021-88429-8