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The Problematic Use of Tramadol Is Increasing in France

Caroline Guignot

Medscape - Apr 18, 2022.

https://www.medscape.com/viewarticle/972311

USA. Challenges in Identifying Novel Psychoactive Substances and a Stronger Path Forward

The importance of non-targeted testing to keep pace with a rapidly evolving synthetic opioid market. (NIJ – National Institute of Justice, USA, 11.06.2022)

https://nij.ojp.gov/topics/articles/challenges-identifying-novel-psychoactive-substances-and-stronger-path-forward

P300 Event-Related Potentials as a Marker of Craving in Opioid Use Disorder: a Systematic Literature Review 

Skrenes A., Labonté L.E., Muñoz-Violant S., Khehra J., Krigolson O., and Schütz C

HEROIN ADDICTION AND RELATED CLINICAL PROBLEMS - Vol. 24 • No. N3 • June 2022

Anmeldung erforderlich

https://www.heroinaddictionrelatedclinicalproblems.org/harcp-archives.php?year=2022

Opioidreport 2022 (begleitender Foliensatz)

Gerd Glaeske 

unter Mitarbeit von Andrea Ernst, Friederike Höfel, Elisabeth Horn, Mona Lorenz, Julia Misonow, Lutz Muth, Anna Nymbach-Dietrich, Jonas Poskowsky 

März 2022, Universität Bremen, SOCIUM, Mary-Somerville-Str. 5, 28359 Bremen 

Begleitender Foliensatz

https://www.hkk.de/fileadmin/dateien/allgemeines_uebergeordnet/reports/gesundheitsreports/2022_foliensatz_hkk_gesundheitsreport_opioide_aktualisiert.pdf

Opioidreport 2022 

Gerd Glaeske 

unter Mitarbeit von Andrea Ernst, Friederike Höfel, Elisabeth Horn, Mona Lorenz, Julia Misonow, Lutz Muth, Anna Nymbach-Dietrich, Jonas Poskowsky 

März 2022, Universität Bremen, SOCIUM, Mary-Somerville-Str. 5, 28359 Bremen 

https://www.hkk.de/fileadmin/dateien/allgemeines_uebergeordnet/reports/gesundheitsreports/2022_hkk_gesundheitsreport_opioide_web.pdf

Zu früh, zu oft: Werden Opioide von Ärzten unterschätzt? Studie unter Leitung des Arzneimittelexperten Prof. Dr. Gerd Glaeske

Forscherteam der Universität Bremen ermittelt steigende Vergabe bei zweifelhaften Indikationen - trotz hoher Suchtgefahr

Kritik: Leichtfertige Verordnung von Opioiden wie Fentanyl

Aktionstag gegen den Schmerz am 7. Juni

(HKK - Handelskrankenkasse, Bremen, 02.06.2022)

https://www.hkk.de/presse/pressemitteilungen/2022-06-02-hkk-gesundheitsreport-opioide

Kamini, a little recognised source of illicit opioid: A case series of 12 patients. 

Khan T, Ariyawansa P, Quinn J, Hayllar J. 

Drug Alcohol Rev. 2022 May 12. doi: 10.1111/dar.13475. Epub ahead of print. PMID: 35555819.

Abstract

https://pubmed.ncbi.nlm.nih.gov/35555819/

Trace residue identification, characterization, and longitudinal monitoring of the novel synthetic opioid β-U10, from discarded drug paraphernalia. 

West H, Fitzgerald JL, Hopkins KL, Leeming MG, DiRago M, Gerostamoulos D, Clark N, Dietze P, White JM, Ziogas J, Reid GE. 

Drug Test Anal. 2022 May 13. doi: 10.1002/dta.3284. Epub ahead of print. PMID: 35562123.

https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3284

Non-fentanyl-derived synthetic opioids emerging during recent years. 

Hasegawa K, Minakata K, Suzuki M, Suzuki O. 

Forensic Toxicol. 2022 Apr 29:1-10. doi: 10.1007/s11419-022-00624-y. Epub ahead of print. PMID: 35528111; PMCID: PMC9052731.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9052731/

Kanada. CCENDU Drug Alert - Nitazenes

What Are Nitazenes?

Nitazenes are potent synthetic opioids from a drug class known as benzimidazole-opioids.

Some nitazenes are estimated to be several times more potent than fentanyl.

They were developed 60 years ago as potential pain relief medication, but were never approved for clinical use.

They were first identified in the unregulated drug supply in Canada in 2019.

They typically appear unexpectedly in drugs expected to contain other, more traditional opioids (e.g., fentanyl, oxycodone tablets or “down”), often alongside non-medical benzodiazepines (NMBs). (Canadian Centre on Substance Use and Addiction, 2022)

https://www.ccsa.ca/sites/default/files/2022-03/CCSA-CCENDU-Drug-Alert-Nitazenes-2022-en_0.pdf

New Synthetic Opioids Use among Patients in Treatment for an Opioid Use Disorder in Barcelona. 

Alías-Ferri M, Marchei E, Pacifici R, Pichini S, Pellegrini M, Pérez-Mañá C, Papaseit E, Muga R, Fonseca F, Farré M, Torrens M. 

Eur Addict Res. 2022 Apr 4:1-8. doi: 10.1159/000524011. Epub ahead of print. PMID: 35378545.

https://www.karger.com/Article/FullText/524011

New Synthetic Opioids Use among Patients in Treatment for an Opioid Use Disorder in Barcelona. 

Alías-Ferri M, Marchei E, Pacifici R, Pichini S, Pellegrini M, Pérez-Mañá C, Papaseit E, Muga R, Fonseca F, Farré M, Torrens M. 

Eur Addict Res. 2022 Apr 4:1-8. doi: 10.1159/000524011. Epub ahead of print. PMID: 35378545.

https://www.karger.com/Article/FullText/524011

Unspecified opioids among opioid overdoses in Oslo, Norway. 

Iqbal ZZ, Nguyen TMT, Brekke M, Vallersnes OM. 

BMC Res Notes. 2022 Apr 9;15(1):134. doi: 10.1186/s13104-022-06022-2. PMID: 35397589; PMCID: PMC8994352.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994352/

Indien. 'Chitta' reaching Himachal via Punjab more lethal

Consuming ‘chitta’ regularly for three to four months could result in platelets falling below 10,000, which could prove fatal. (The Tribune, Indien, 15.04.2022)

https://www.tribuneindia.com/news/himachal/chitta-reaching-hp-via-punjab-more-lethal-386393

Warnmeldung: Hochpotente synthetische Opioide im Umlauf, z.T. enthalten in gefälschten Medikamenten

Aus Deutschland liegen Berichte zu mindestens drei Todesfällen vor, bei denen der Verdacht auf eine (Misch-)Intoxikation mit synthetischen Opioiden aus der Gruppe der Benzimidazole besteht. (National Early Warning System, Adebar, IFT München, März 2022)

Warnmeldung Hochpotente synthetische Opioide im Umlauf, März 2022

Global, regional, and national consumption of controlled opioids: a cross-sectional study of 214 countries and non-metropolitan territories. 

Richards GC, Aronson JK, Mahtani KR, Heneghan C. 

Br J Pain. 2022 Feb;16(1):34-40. doi: 10.1177/20494637211013052. Epub 2021 May 4. PMID: 35111312; PMCID: PMC8801686.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801686/

Clinical Management of Opioid Withdrawal,

Torres-Lockhart, K., Lu, T. Y., Weimer, M. B., Stein, M. R., and Cunningham, C. O. (2022)

Addiction. doi.org/10.1111/add.15818. 

Abstract

https://onlinelibrary.wiley.com/doi/abs/10.1111/add.15818

USA. New Opioids Called Nitazenes May Be 20 Times Stronger Than Fentanyl

A potent synthetic opioid class called nitazenes has been discovered after people overdosed on them.

The nitazene class of medication was created over 60 years ago as a potential pain-relief medication, according to the WHOTrusted Source.

Medical experts say this opioid may be up to 20 times more powerful than fentanyl. (Healthline, USA, 08.12.2021)

https://www.healthline.com/health-news/new-opioids-called-nitazenes-may-be-20-times-stronger-than-fentanyl

Etazene induces developmental toxicity in vivo Danio rerio and in silico studies of new synthetic opioid derivative. 

Kurach Ł, Chłopaś-Konowałek A, Budzyńska B, Zawadzki M, Szpot P, Boguszewska-Czubara A. 

Sci Rep. 2021 Dec 20;11(1):24269. doi: 10.1038/s41598-021-03804-9. PMID: 34931035; PMCID: PMC8688443.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688443/

USA/Kanada. Etodesnitazene — New Synthetic Opioid Identified During Forensic Death Investigations in the United States and Canada

Purpose: The objective of this announcement is to notify public health and safety, law enforcement, first responders, clinicians, medical examiners and coroners, forensic and clinical laboratory personnel, and all other related communities about new information surrounding the emergent synthetic opioid etodesnitazene. (NPS Discovery, USA, Dezember 2021)

https://www.npsdiscovery.org/wp-content/uploads/2021/12/Public-Alert_Etodesnitazene_NPS-Discovery_121421.pdf

USA/Kanada. NPS Alerts: New Synthetic Opioid and ‘Unusual’ Overdose Symptoms (protonitazene)

The Center for Forensic Science Research and Education (CFSRE) (…) warns of the emergence of protonitazene, an opioid that is approximately three times more potent than fentanyl. (CFSRE - Center for Forensic Science Research and Education, USA, 13.12.2021)

https://www.forensicmag.com/581896-NPS-Alerts-New-Synthetic-Opioid-and-Unusual-Overdose-Symptoms/

Info-Folder "Benzos + Opiate"

Dieser Info-Folder befasst sich mit den Risiken und Wirkungsweisen von verschreibungspflichtigen Medikamenten (Benzodiazepine und Opiate), die missbräuchlich zu Rauschzwecken konsumiert werden. Er wendet sich mit speziellen risikomindernden Hinweisen vorwiegend an Konsumierende und konsuminteressierte Jugendliche. (Mindzone, Dezember 2021)

https://mindzone.info/wp-content/uploads/2021/11/Benzos-Opiate-info-flyer-2021-mindzone-a7-web.pdf

Opioid Analgesia and Opioid-Induced Adverse Effects: A Review. 

Paul AK, Smith CM, Rahmatullah M, Nissapatorn V, Wilairatana P, Spetea M, Gueven N, Dietis N. 

Pharmaceuticals (Basel). 2021 Oct 27;14(11):1091. doi: 10.3390/ph14111091. PMID: 34832873; PMCID: PMC8620360.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620360/

USA. PUBLIC ALERT December 2021: Adverse Effects Linked to Next Generation Opioids Reported in Patients Presenting to Emergency Departments After Suspected Opioid Overdose

Purpose: The objective of this announcement is to notify public health and safety, clinicians, law enforcement, first responders, medical examiners and coroners, forensic and clinical laboratory personnel, and all other related communities about new information surrounding new generation synthetic opioids in clinical settings after suspected opioid overdoses and presentation to emergency departments, including: metonitazene, N-piperidinyl etonitazene, isotonitazene, and brorphine. (npsdiscovery.org, USA, Dezember 2021)

https://www.npsdiscovery.org/wp-content/uploads/2021/12/Public-Alert_Next-Generation-Opioids-in-Clincial-Cases_NPS-Discovery_120321.pdf

Teuer erkaufte Schmerzstillung? Unter Tramadol kommt es häufiger zu Todesfällen als unter Codein

Tramadol wird immer häufiger in der Behandlung chronischer, nicht krebsbedingter Schmerzen eingesetzt, doch scheint es im Vergleich zu anderen Opioiden mit einem höheren Risiko für unerwünschte Wirkungen verbunden zu sein, wie neue Daten zeigen. Die Arbeit wurde im JAMA veröffentlicht [1]. (Medscape, Deutschland, 11.11.2021)

https://deutsch.medscape.com/artikelansicht/4910524

Association of Tramadol vs Codeine Prescription Dispensation With Mortality and Other Adverse Clinical Outcomes. 

Xie J, Strauss VY, Martinez-Laguna D, et al. 

JAMA. 2021;326(15):1504–1515. doi:10.1001/jama.2021.15255

Abstract

https://jamanetwork.com/journals/jama/article-abstract/2785265

The Role of Mu-Opioids for Reward and Threat Processing in Humans: Bridging the Gap from Preclinical to Clinical Opioid Drug Studies. 

Meier IM, Eikemo M, Leknes S. 

Curr Addict Rep. 2021;8(2):306-318. doi: 10.1007/s40429-021-00366-8. Epub 2021 Apr 15. PMID: 34722114; PMCID: PMC8550464.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550464/

Atypical opioid receptors: unconventional biology and therapeutic opportunities. 

Palmer CB, Meyrath M, Canals M, Kostenis E, Chevigné A, Szpakowska M. 

Pharmacol Ther. 2021 Oct 5:108014. doi: 10.1016/j.pharmthera.2021.108014. Epub ahead of print. PMID: 34624426.

https://www.sciencedirect.com/science/article/pii/S0163725821002163

Poppies as a sleep aid for infants: The "Hypnos" remedy of Cretan folk medicine. 

Mathianaki K, Tzatzarakis M, Karamanou M. 

Toxicol Rep. 2021 Oct 4;8:1729-1733. doi: 10.1016/j.toxrep.2021.10.002. PMID: 34692423; PMCID: PMC8511716.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511716/

Full Opioid Agonists and Tramadol: Pharmacological and Clinical Considerations. 

Edinoff AN, Kaplan LA, Khan S, Petersen M, Sauce E, Causey CD, Cornett EM, Imani F, Moradi Moghadam O, Kaye AM, Kaye AD. 

Anesth Pain Med. 2021 Sep 6;11(4):e119156. doi: 10.5812/aapm.119156. PMID: 34692448; PMCID: PMC8520671.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520671/