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Fentanyl depression of respiration: comparison with heroin and morphine.

Hill R, Santhakumar R, Dewey W, Kelly E, Henderson G.

Br J Pharmacol. 2019 Sep 9. doi: 10.1111/bph.14860. 



Identification of a novel fentanyl analogue: p-hydroxy-butyrylfentanyl.

Oldenhof S, Ten Pierick A, Bruinsma J, Eustace S, Hulshof J, van den Berg J, Hoitink M.

Drug Test Anal. 2019 Sep 13. doi: 10.1002/dta.2695. 



Physiology, Opioid Receptor

Dhaliwal A, Gupta M.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-.
2019 Aug 29.

PMID: 31536249


Use of Kratom, an Opioid-like Traditional Herb, in Pregnancy.

Smid MC, Charles JE, Gordon AJ, Wright TE.

Obstet Gynecol. 2018 Oct;132(4):926-928. doi: 10.1097/AOG.0000000000002871.



Opioids and their endocrine effects: A systematic review and meta-analysis.

de Vries F, Bruin M, Lobatto DJ, Dekkers OM, Schoones JW, van Furth WR, Pereira AM, Karavitaki N, Biermasz NR, Zamanipoor Najafabadi AH.

J Clin Endocrinol Metab. 2019 Sep 12. pii: dgz022. doi: 10.1210/clinem/dgz022.



Preference for drugs containing fentanyl from a cross-sectional survey of people who use illicit opioids in three United States cities

Kenneth B.Morales, Ju NyeongPark, Jennifer L.Glick, SabaRouhani, Traci C.Green, Susan G.Sherman

Drug and Alcohol Dependence, Volume 204, 1 November 2019, doi.org/10.1016/j.drugalcdep.2019.107547


Fentanyl auf Europareise

In manchen Nachbarländern sind synthetische Opioide bereits gefragter als Heroin. Wird Fentanyl bald die neue deutsche Welle auf dem Drogenmarkt? (doccheck.com, 25.09.2019)


Diskussion. Schlusswort - In Reply (zu dem Beitrag Schätzung der Anzahl von Personen mit einer Opioidabhängigkeit)

Kraus, Ludwig

Dtsch Arztebl Int 2019; 116: 459; DOI: 10.3238/arztebl.2019.0459b

zu dem Beitrag Schätzung der Anzahl von Personen mit einer Opioidabhängigkeit von Prof. Dr. phil. Ludwig Kraus, Dr. phil. Nicki-Nils Seitz, Dr. rer. medic. Bernd Schulte, Dr. med. Peter Cremer-Schaeffer, Dr. phil. Barbara Braun, PD Dr. phil. Uwe Verthein, Dr. hum. biol. Tim Pfeiffer-Gerschel in Heft 9/2019


Diskussion: Auch bei uns Süchtige - Number ofAddicts Underestimated (zu dem Beitrag Schätzung der Anzahl von Personen mit einer Opioidabhängigkeit)

Abholz, Heinz-Harald

Dtsch Arztebl Int 2019; 116: 459; DOI: 10.3238/arztebl.2019.0459a

zu dem Beitrag Schätzung der Anzahl von Personen mit einer Opioidabhängigkeit von Prof. Dr. phil. Ludwig Kraus, Dr. phil. Nicki-Nils Seitz, Dr. rer. medic. Bernd Schulte, Dr. med. Peter Cremer-Schaeffer, Dr. phil. Barbara Braun, PD Dr. phil. Uwe Verthein, Dr. hum. biol. Tim Pfeiffer-Gerschel in Heft 9/2019


Prescribing trends of gabapentin, pregabalin, and oxycodone: a secondary analysis of primary care prescribing patterns in England

Katlyn Green, Nora Cooke O'Dowd, Hilary Watt, Azeem Majeed, Richard J Pinder

BJGP bjgpopen.org/content/early/2019/09/16/bjgpopen19X101662 Open 17 September 2019; bjgpopen19X101662. DOI: 10.3399/bjgpopen19X101662


Opioid-Epidemie: Panikmache in Deutschland

Die Zahl an Opioid-Erstverschreibungen nimmt in Deutschland zu. Ist das ein Grund, alarmiert zu sein? Wir vergleichen die Situation in Deutschland mit der in den USA. (DocCheck, 06.09.2019)


Opioid Prescribing After Surgery in the United States, Canada, and Sweden.

Ladha KS, Neuman MD, Broms G, et al. 

JAMA Netw Open.Published online September 04, 20192(9):e1910734. doi:10.1001/jamanetworkopen.2019.10734


Trends in use and misuse of opioids in the Netherlands: a retrospective, multi-source database study.

Kalkman GA, Kramers C, van Dongen RT, van den Brink W, Schellekens A.

Lancet Public Health. 2019 Aug 20. pii: 


The Kappa Opioid Receptor Is Associated With Naltrexone-Induced Reduction of Drinking and Craving.

de Laat B, Goldberg A, Shi J, Tetrault JM, Nabulsi N, Zheng MQ, Najafzadeh S, Gao H, Kapinos M, Ropchan J, O'Malley SS, Huang Y, Morris ED, Krishnan-Sarin S.

Biol Psychiatry. 2019 Jun 8. pii: S0006-3223(19)31413-1. doi: 10.1016/j.biopsych.2019.05.021. 


Opioid prescription patterns in Germany and the global opioid epidemic: Systematic review of available evidence.

Rosner B, Neicun J, Yang JC, Roman-Urrestarazu A (2019) 

PLoS ONE 14(8): e0221153. doi.org/10.1371/journal.pone.0221153


Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids.

Makunts T, U A, Atayee RS, Abagyan R.

Sci Rep. 2019 Aug 28;9(1):12490. doi: 10.1038/s41598-019-48955-y.


Tramadol könnte Hypoglykämien auslösen

San Diego – Das Schmerzmittel Tramadol, das zunehmend als sichere Alternative zu anderen Opioiden betrachtet wird, kann offenbar schwere Hypoglykämien auslösen. Dies kam in einer Analyse von Datenbanken der US-Arzneimittelbehörde FDA in Scientific Reports(2019; 9: 12490) heraus. (aerzteblatt.de, 29.08.2019)


Opioid Prescription Patterns and Risk Factors Associated With Opioid Use in the Netherlands.

Bedene A, Lijfering WM, Niesters M, et al. 

JAMA Netw Open.Published online August 28, 20192(8):e1910223. doi:10.1001/jamanetworkopen.2019.10223


The Future of Fentanyl and Other Synthetic Opioids.

Pardo, Bryce, Jirka Taylor, Jonathan P. Caulkins, Beau Kilmer, Peter Reuter, and Bradley D. Stein

Santa Monica, CA: RAND Corporation, 2019. 



The Emergence of "Coachella" Heroin in the Midwest.

Sethi R, Luvisi J, Ahonen K, Irwin T.

Prim Care Companion CNS Disord. 2019 Jul 18;21(4). pii: 18l02394. doi: 10.4088/PCC.18l02394.


Novel synthetic opioids - toxicological aspects and analysis.

Tabarra I, Soares S, Rosado T, Gonçalves J, Luís Â, Malaca S, Barroso M, Keller T, Restolho J, Gallardo E.

Forensic Sci Res. 2019 Jul 3;4(2):111-140. doi: 10.1080/20961790.2019.1588933. 


A chemically contiguous hapten approach for a heroin-fentanyl vaccine.

Natori Y, Hwang CS, Lin L, Smith LC, Zhou B, Janda KD.

Beilstein J Org Chem. 2019 May 3;15:1020-1031. doi: 10.3762/bjoc.15.100.


Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids.

Olson KM, Duron DI, Womer D, Fell R, Streicher JM (2019) 

PLoS ONE 14(6): e0217371. doi.org/10.1371/journal.pone.0217371


Australien. Weekly Dose: Krokodil, the Russian ‘flesh-eating’ drug, makes a rare appearance in Australia

A young man recently turned up at a rural drug and alcohol service in New South Wales seeking help because of an infection in his arm. He said he had injected the drug Krokodil, which had not previously been reported in Australia. (The Conversation, Australien, 19.06.2019)


Tapentadol use among people who regularly inject drugs in Australia

Sutherland,R., Memedovic,S., Degenhardt,L., Farrell,M.,& Peacock,A. (2019).


Tapentadol is a centrally acting opioid analgesic registered for use in Australia to treat moderate to severe pain. A recent review has suggested a lack of data regarding ‘abuse, dependence, diversion, or recreational use’ of tapentadol. This paper addresses this research gap by examining patterns of tapentadol use among a sentinel sample of people who regularly inject drugs in Australia.


Rate of Fentanyl Positivity Among Urine Drug Test Results Positive for Cocaine or Methamphetamine.

LaRue L, Twillman RK, Dawson E, et al. 

JAMA Netw Open.2019;2(4):e192851. doi:10.1001/jamanetworkopen.2019.2851


A Promising Alternative to Opioid Pain Medications. 

NIDA. (2019, February 12). 


Chronic use of tramadol after acute pain episode: cohort study 

Thiels Cornelius A, Habermann Elizabeth B, Hooten W Michael, Jeffery Molly M. 

BMJ 2019; 365 :l1849 


US-Studie sieht Abhängigkeitspotenzial bei Tramadol

Rochester – (...) Die Autoren einer Studie im Britischen Ärzteblatt(BMJ2019; 365: l1849) vermuten (..), dass das Abhängigkeitspotenzial von Tramadol unterschätzt wird. (aerzteblatt.de, 15.05.2019)


Opioids in the immune system: from experimental studies to clinical practice.

Moyano J, Aguirre L.

Rev Assoc Med Bras (1992). 2019 Feb;65(2):262-269. doi: 10.1590/1806-9282.65.2.262. Review.