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Prevention of Opioid Overdose.

Babu KM, Brent J, Juurlink DN.

N Engl J Med. 2019 Jun 6;380(23):2246-2255. doi: 10.1056/NEJMra1807054.

https://www.nejm.org/doi/full/10.1056/NEJMra1807054

Mortality and causes of death among patients with opioid use disorder receiving opioid agonist treatment: a national register study.

Bech AB, Clausen T, Waal H, Šaltytė Benth J, Skeie I.

BMC Health Serv Res. 2019 Jul 2;19(1):440. doi: 10.1186/s12913-019-4282-z.

https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-019-4282-z

Factors associated with willingness to wear an electronic overdose detection device.

Ahamad K, Dong H, Johnson C, Hyashi K, DeBeck K, Milloy MJ, Wood E.

Addict Sci Clin Pract. 2019 Jul 3;14(1):23. doi: 10.1186/s13722-019-0153-5.

https://ascpjournal.biomedcentral.com/articles/10.1186/s13722-019-0153-5

USA. Opioids study shows high-risk counties across the country, suggests local solutions

In a study of more than 3,000 counties across the U.S., the researchers found that residents of 412 counties are at least twice as likely to be at high risk for opioid overdose deaths and to lack providers who can deliver medications to treat opioid use disorder. (MedicalXpress, USA, 28.06.2019)

https://medicalxpress.com/news/2019-06-opioids-high-risk-counties-country-local.html

UNODC. Weltweit 585.000 Drogentote

Wien – 585.000 Menschen sind 2017 weltweit wegen ihres Drogenkonsums und damit zusammenhängender Krankheiten gestorben. Das erklärten Experten des UN-Büros für Drogen- und Verbrechensbekämpfung (UNODC) heute in Wien. (aerzteblatt.de, 26.06.2019)

https://www.aerzteblatt.de/nachrichten/104179/Weltweit-585-000-Drogentote

One-Year Mortality of Patients After Emergency Department Treatment for Nonfatal Opioid Overdose.

Weiner SG, Baker O, Bernson D, Schuur JD.

Ann Emerg Med. 2019 Jun 19. pii: S0196-0644(19)30343-9. doi: 10.1016/j.annemergmed.2019.04.020.

https://www.annemergmed.com/article/S0196-0644(19)30343-9/fulltext

Cold weather increases the risk of fatal opioid overdoses

Cold weather snaps are followed by a marked increase in fatal opioid overdoses, a new study finds. 

A research team led by Brandon Marshall, an associate professor of epidemiology at Brown University's School of Public Health, found a 25 percent increase in fatal opioid overdoses after periods of freezing temperatures compared to days with an average temperature of 52 degrees. (medicalxpress.com, 17.06.2019)

https://medicalxpress.com/news/2019-06-cold-weather-fatal-opioid-overdoses.html

Increased risk of opioid overdose death following cold weather: A case-crossover study.

Goedel WC, Marshall BDL, Spangler KR, Alexander-Scott N, Green TC, Wellenius GA, Weinberger KR.

Epidemiology. 2019 Jun 11. doi: 10.1097/EDE.0000000000001041.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/31205291

Schottland. Methadone overdose figures slammed by Scottish Conservatives

The Conservatives have called for alternative treatments for drug addicts as figures indicate hundreds of people were taken to hospital after overdosing on the heroin replacement methadone.

A total of 222 people were admitted to hospital in 2017-18 due to methadone overdoses. (ITV, UK, 14.06.2019)

https://www.itv.com/news/2019-06-14/methadone-overdose-figures-slammed-by-scottish-conservatives/

Association between medical cannabis laws and opioid overdose mortality has reversed over time

Chelsea L. Shover, Corey S. Davis, Sanford C. Gordon, Keith Humphreys

Proceedings of the National Academy of Sciences Jun 2019, 201903434; DOI: 10.1073/pnas.1903434116 

https://www.pnas.org/content/early/2019/06/04/1903434116

A conceptual model for understanding post-release opioid-related overdose risk.

Joudrey PJ, Khan MR, Wang EA, Scheidell JD, Edelman EJ, McInnes DK, Fox AD.

Addict Sci Clin Pract. 2019 Apr 15;14(1):17. doi: 10.1186/s13722-019-0145-5.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463640/

Suspected Heroin Overdoses in US Emergency Departments, 2017–2018

Alana Marie Vivolo-Kantor, Brooke Hoots, Felicita David, and R. Matthew Gladden, 0: 

American Journal of Public Health0,e1_e3, doi.org/10.2105/AJPH.2019.305053

Abstract

https://ajph.aphapublications.org/doi/abs/10.2105/AJPH.2019.305053

USA. In Cities Where It Once Reigned, Heroin Is Disappearing

The rise of the more potent fentanyl in its place has put a generation of older users, who had managed their addiction, at far greater risk of overdose. (New York Times, 18.05.2019)

https://www.nytimes.com/2019/05/18/health/heroin-fentanyl-deaths-baltimore.html

Drug Overdose Deaths Involving Cocaine and Psychostimulants with Abuse Potential — United States, 2003–2017.

USA. Kariisa M, Scholl L, Wilson N, Seth P, Hoots B. 

MMWR Morb Mortal Wkly Rep 2019;68:388–395. doi.org/10.15585/mmwr.mm6817a3

https://www.cdc.gov/mmwr/volumes/68/wr/mm6817a3.htm

Opioid overdose deaths and potentially inappropriate opioid prescribing practices (PIP): A spatial epidemiological study.

Stopka TJ, Amaravadi H, Kaplan AR, Hoh R, Bernson D, Chui KKH, Land T, Walley AY, LaRochelle MR, Rose AJ.

Int J Drug Policy. 2019 Apr 10;68:37-45. doi: 10.1016/j.drugpo.2019.03.024. 

https://www.sciencedirect.com/science/article/pii/S0955395919300908

Overdose Risk and Client Characteristics Associated With the Injection of Buprenorphine at a Medically Supervised Injecting Center in Sydney, Australia.

Power J, Salmon AM, Latimer J, Jauncey M, Day CA.

Subst Use Misuse. 2019 Apr 11:1-8. doi: 10.1080/10826084.2019.1600147. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/30973286

USA. 'I don’t want to overdose and die:' one woman's death, one country's shame 

Saige Earley, who was found dead of a heroin overdose in a toilet stall at Syracuse airport, is the face of ‘real people’ devastated by the worst drug epidemic in American history. (The Guardian, UK, 29.04.2019)

https://www.theguardian.com/us-news/2019/apr/29/i-dont-want-to-overdose-and-die-one-womans-death-one-countrys-shame

Association Between Opioid Dose Variability and Opioid Overdose Among Adults Prescribed Long-term Opioid Therapy. Glanz JM, Binswanger IA, Shetterly SM, Narwaney KJ, Xu S. 

JAMA Netw Open.2019;2(4):e192613. doi:10.1001/jamanetworkopen.2019.2613

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2730786

STOP OVERDOSE NOW - Real-Time Overdose Prevention Networks 

SON – Stop Overdose Now! (April 2019)

https://stopoverdosenow.org/

How the complex pharmacology of the fentanyls contributes to their lethality.

Gill, H., Kelly, E., and Henderson, G. ( 2019) 

Addiction, doi.org/10.1111/add.14614.

https://onlinelibrary.wiley.com/doi/10.1111/add.14614

EMCDDA. An analysis of post-mortem toxicology practices in drug-related death cases in Europe

Summary

The objective of this report is to provide an updated analysis of the post-mortem toxicology practices of drug-related deaths (DRD) in Europe and to discuss the effect of these practices on the monitoring of DRDs. (EMCDDA,Lissabon,April 2019)

http://www.emcdda.europa.eu/system/files/publications/10544/Analysis%20of%20practices%20of%20PM%20toxicology%20of%20DRD%20in%20Europe_EMCDDA%20Technical%20report.pdf

Notes from the Field: Unintentional Drug Overdose Deaths with Kratom Detected — 27 States, July 2016–December 2017. 

Olsen EO, O’Donnell J, Mattson CL, Schier JG, Wilson N. 

MMWR Morb Mortal Wkly Rep 2019;68:326–327. doi.org/10.15585/mmwr.mm6814a2.

https://www.cdc.gov/mmwr/volumes/68/wr/mm6814a2.htm

Smokeless tobacco mortality risks: an analysis of two contemporary nationally representative longitudinal mortality studies

Michael T. Fisher, Susan Marie Tan-Torres, Charles L. Gaworski, Ryan A. Black and Mohamadi A. Sarkar

Harm Reduction Journal 2019, 16:27, doi.org/10.1186/s12954-019-0294-6

https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-019-0294-6

Kanada / British Columbia. New drug mix causing harder-to-revive overdoses, sparking panic in Vancouver - Etizolam is described as having 10 times the potency of Valium

'The morgues are full and they've had to rent cooling trucks to store bodies' (CBC, Kanada, 12.04.2019)

https://www.cbc.ca/news/canada/british-columbia/new-kind-of-overdose-dtes-benzo-filler-anxiety-depression-drug-making-narcan-fail-1.5096395

Kanada. National report: Apparent opioid-related deaths in Canada (January 2016 to September 2018). Web Based Report. 

Special Advisory Committee on the Epidemic of Opioid Overdoses. 

Ottawa: Public Health Agency of Canada; April 2019. 

https://infobase.phac-aspc.gc.ca/datalab/national-surveillance-opioid-harms-mortality.html

Kanada. In Vancouver, front-line workers are facing ‘a different kind of overdose’ in new synthetic drug

A drug chemically similar to medication for anxiety and sleep disorders that is being cut into heroin and fentanyl is suspected of contributing to a spate of overdoses that leave some users unconscious for hours at a time. (The Globe and Mail, Kanada, 11.04.2019)

https://www.theglobeandmail.com/canada/article-in-vancouver-front-line-workers-face-a-different-kind-of-overdose/

Non drug-related and opioid-specific causes of 3262 deaths in Scotland's methadone-prescription clients, 2009-2015.

Gao L, Robertson JR, Bird SM.

Drug Alcohol Depend. 2019 Apr 1;197:262-270. doi: 10.1016/j.drugalcdep.2019.01.019. 

https://www.sciencedirect.com/science/article/pii/S0376871618305647?via%3Dihub

A retrospective cohort study of mortality rates in patients with an opioid use disorder treated with implant naltrexone, oral methadone or sublingual buprenorphine.

Kelty E, Joyce D, Hulse G.

Am J Drug Alcohol Abuse. 2019 Mar 8:1-7. doi: 10.1080/00952990.2018.1545131.

https://www.tandfonline.com/doi/full/10.1080/00952990.2018.1545131

Kanada. 43 overdoses in a single night in Vancouver: firefighters

A local official posted a startling statistic on Monday about the overdose crisis in Vancouver.

There were 43 overdoses in a single night in the city, Deputy Fire Chief Tyler Moore said. The overdose calls all came in overnight Friday, he said. (CTV News, Kanada, 26.03.2019)

https://bc.ctvnews.ca/43-overdoses-in-a-single-night-in-vancouver-firefighters-1.4352500

USA. Drug overdose deaths involving fentanyl, 2011–2016. 

Spencer MR, Warner M, Bastian BA, Trinidad JP, Hedegaard H. 

National Vital Statistics Reports; vol 68 no 3. Hyattsville, MD: National Center for Health Statistics. 2019.

https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_03-508.pdf