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Vitamin B12-Mangel: Freizeitdroge Lachgas kann zu bleibenden neurologischen Schäden führen

Toronto – Die zunehmende Beliebtheit von Distickstoffmonoxid (Lachgas) als Partydroge hat das Canadian Medical Association Journal (CMAJ 2023; DOI: 10.1503/cmaj.230196) veranlasst, die Ärzte auf die Risiken hinzuweisen und ihnen Hinweise zu Diagnose und Therapie der neurologischen Schäden zu geben. Auch in Europa hat der Missbrauch zugenommen. (aerzteblatt.de, 24.08.2023)


Diagnosis and management of toxicity associated with the recreational use of nitrous oxide

Cyrille De Halleux, David N. Juurlink

CMAJ Aug 2023, 195 (32) E1075-E1081; DOI: 10.1503/cmaj.230196 


Abnormal cerebral metabolism and metabolic connectivity in individuals with heroin dependence: an integrated resting-state PET/fMRI study in large-scale networks.

Jin L, Yuan M, Chen J, Zhang W, Wang L, Wei Y, Li Y, Guo Z, Wang W, Wei L, Li Q. 

J Psychiatry Neurosci. 2023 Jul 12;48(4):E295-E304. doi: 10.1503/jpn.220171. PMID: 37437921; PMCID: PMC10355996.


A Challenging Case of Managing Septic Arthritis of the Sternoclavicular Joint in a Patient With a History of Intravenous Opioid Use Disorder: A Case Report and Literature Review. 

Khalid N, Afzal MA, Haider SU, Michael P, Abdullah M. 

Cureus. 2023 Jul 29;15(7):e42635. doi: 10.7759/cureus.42635. PMID: 37644935; PMCID: PMC10461129.


A multicomponent holistic care pathway for people who use drugs in Tayside, Scotland. 

Byrne CJ, Radley A, Fletcher E, Thain D, Stephens BP, Dillon JF. 

Int J Drug Policy. 2023 Aug 11;120:104159. doi: 10.1016/j.drugpo.2023.104159. Epub ahead of print. PMID: 37574644.


Inhalational Heroin Use and Leukoencephalopathy: A Case Report. 

Knopp BW, Weiss HZ, Retrouvey M, Luck G. 

Cureus. 2023 Jul 23;15(7):e42323. doi: 10.7759/cureus.42323. PMID: 37614254; PMCID: PMC10443436.


Prevalence of and Factors Influencing Suicide Ideation, Attempt, and Completion in Heroin Users: A Systematic Review and Meta-Analysis. 

Khanjani MS, Younesi SJ, Abdi K, Mardani-Hamooleh M, Sohrabnejad S. 

Addict Health. 2023 Apr;15(2):119-127. doi: 10.34172/ahj.2023.1363. Epub 2023 Apr 29. PMID: 37560393; PMCID: PMC10408759.


Depression and Suicidal Ideation among Patients Receiving Opioid Maintenance Treatments Considering Cognitive Flexibility. 

Rajabpour M, Mirmohammadkhani M, Paknazar F. 

Iran J Psychiatry. 2023 Jul;18(3):285-293. doi: 10.18502/ijps.v18i3.13005. PMID: 37575602; PMCID: PMC10422939.


Adrenal Crisis Masked as Septic Shock in a Patient With Opioid Use Disorder on Buprenorphine. 

Ebersole AM, McKnight L, Vijayaraman A, Guarneri A, Bonny AE. 

Cureus. 2023 Jul 12;15(7):e41794. doi: 10.7759/cureus.41794. PMID: 37575858; PMCID: PMC10421734.


Reduced anterior insular cortex volume in male heroin addicts: a postmortem study. 

Müller UJ, Schmalenbach LJ, Dobrowolny H, Guest PC, Schlaaff K, Mawrin C, Truebner K, Bogerts B, Gos T, Bernstein HG, Steiner J. 

Eur Arch Psychiatry Clin Neurosci. 2023 Sep;273(6):1233-1241. doi: 10.1007/s00406-023-01553-6. Epub 2023 Jan 31. PMID: 36719479; PMCID: PMC9888352.


Suicidal behaviour and its risk factors in patients with opioid use disorder

Authors: Güzelce İ.B., Gultekin B.K., and Kılıç M.K.

Heroin Addiction and Related Clinical Problems, Published Ahead of Print, August 8, 2023


Association between substance-induced psychosis and suicide attempt: A Danish nation-wide register-based study.

Munch, SD, Madsen, T, Nordentoft, M, Erlangsen, A, Hjorthøj, C. 

Addiction. 2023doi.org/10.1111/add.16311


Xylazine-Associated Skin Injury

O'Neil J, Kovach S. Xylazine-Associated Skin Injury. 

N Engl J Med. 2023 Jun 15;388(24):2274. doi: 10.1056/NEJMicm2303601. PMID: 37314708.


Prevalence of Right- and Left-Sided Endocarditis Among Intravenous Drug Use Patients at a Large Academic Medical Center. 

Leungsuwan K, Vyasabattu M, Arshad H, Abdelfattah A, Heier KR, Arshad S. 

Cardiol Res. 2023 Jun;14(3):176-182. doi: 10.14740/cr1484. Epub 2023 May 26. PMID: 37304915; PMCID: PMC10257500.


Pulmonary-Renal Syndrome from Levamisole-Adulterated Cocaine-Induced Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: A Systematic Review. 

Bucur P, Weber M, Agrawal R, Madera-Acosta AI, Elam RE. 

Pharmaceuticals (Basel). 2023 Jun 6;16(6):846. doi: 10.3390/ph16060846. PMID: 37375793; PMCID: PMC10301056.


Hot weather and death related to acute cocaine, opioid and amphetamine toxicity in British Columbia, Canada: a time-stratified case-crossover study. 

Henderson SB, McLean KE, Ding Y, Yao J, Turna NS, McVea D, Kosatsky T. 

CMAJ Open. 2023 Jun 27;11(3):E569-E578. doi: 10.9778/cmajo.20210291. PMID: 37369523; PMCID: PMC10310343.


Substance Use Disorders (SUDs) and Risk of Cardiovascular Disease (CVD) and Cerebrovascular Disease (CeVD): Analysis of the Nationwide Inpatient Sample (NIS) Database. 

Patel H, Patel UK, Chowdhury M, Assaf AD, Avanthika C, Nor MA, Rage M, Madapu A, Konatham S, Vodapally M, Bhat V, Gnawali A, Mohamed M, Abdi N, Malik FA, Zughaib M. 

Cureus. 2023 May 22;15(5):e39331. doi: 10.7759/cureus.39331. PMID: 37351248; PMCID: PMC10284563.


Xylazine-induced acute skin necrosis in two patients who inject fentanyl. 

Rose L, Kirven R, Tyler K, Chung C, Korman AM. 

JAAD Case Rep. 2023 Apr 26;36:113-115. doi: 10.1016/j.jdcr.2023.04.010. PMID: 37288443; PMCID: PMC10242481.


Gender-specific differences in comorbidities, in-hospital complications and outcomes in emergency patients with ethanol intoxication with and without multisubstance use. 

Schwegler E, Bachmann M, Kube F, Eriksson U. 

Swiss Med Wkly. 2023 Apr 22;153:40061. doi: 10.57187/smw.2023.40061. PMID: 37155832.


Hidden in plain sight: how to look behind the veil of cocaine-induced vasculitis. 

van Leuven SI. 

Rheumatol Adv Pract. 2023 May 5;7(2):rkad047. doi: 10.1093/rap/rkad047. PMID: 37207269; PMCID: PMC10191674.


Cocaine Destroys Gray Matter Brain Cells and Accelerates Brain Aging. 

Beheshti I. 

Biology (Basel). 2023 May 21;12(5):752. doi: 10.3390/biology12050752. PMID: 37237564; PMCID: PMC10215125.


Challenges of Treating ADHD with Comorbid Substance Use Disorder: Considerations for the Clinician. 

Barbuti M, Maiello M, Spera V, Pallucchini A, Brancati GE, Maremmani AGI, Perugi G, Maremmani I. 

J Clin Med. 2023 Apr 24;12(9):3096. doi: 10.3390/jcm12093096. PMID: 37176536; PMCID: PMC10179386.


Osteoporose, Obstipation und andere Nebenwirkungen in der (Langzeit-)OAT: Klinik und Therapie

Philip Bruggmann, Co-Chefarzt Innere Medizin, Arud Zentrum für Suchtmedizin, Zürich, Schweiz

25. Substitutions-Forum, 6.Mai 2023, Mondsee



Social and structural determinants of injection drug use-associated bacterial and fungal infections: a qualitative systematic review and thematic synthesis. 

Brothers, TD, Bonn, M, Lewer, D, et al. 

Addiction. 2023: 000– 000. doi.org/10.1111/add.16257


Can Breaking Heroin Addiction Lead to a Broken Heart? A Case of Reverse Takotsubo Cardiomyopathy in a Patient With Heroin Withdrawal. 

Launer H, Nelson D, Dietzen A, Singla A. 

Tex Heart Inst J. 2023 Mar 1;50(2):e217604. doi: 10.14503/THIJ-21-7604. PMID: 37043755.


An fMRI analysis of verbal and non-verbal working memory in people with a past history of opioid dependence. 

Berenbaum JG, Nadkarni PA, Marvel CL. 

Front Neurosci. 2023 Apr 5;17:1053500. doi: 10.3389/fnins.2023.1053500. PMID: 37090800; PMCID: PMC10113507.


Heroin-induced osteoporosis presented with bilateral femoral neck insufficiency fractures in a male adult: a case report. 

Shih YJ, Chang WN, Yang SW. 

BMC Musculoskelet Disord. 2023 Apr 14;24(1):296. doi: 10.1186/s12891-023-06377-y. PMID: 37060059; PMCID: PMC10103486.


Novel Circovirus in Blood from Intravenous Drug Users, Yunnan, China. 

Li Y, Zhang P, Ye M, Tian RR, Li N, Cao L, Ma Y, Liu FL, Zheng YT, Zhang C. 

Emerg Infect Dis. 2023 May;29(5):1015-1019. doi: 10.3201/eid2905.221617. PMID: 37081583; PMCID: PMC10124637.


Observational Study Examining Kidney Transplantation Outcomes Following Donation From Individuals That Died of Drug Toxicity in British Columbia, Canada. 

Xie MW, Kennan SP, Slaunwhite A, Rose C. 

Can J Kidney Health Dis. 2023 Apr 4;10:20543581231156853. doi: 10.1177/20543581231156853. PMID: 37051047; PMCID: PMC10084533.


Epidemiology and Management of invasive infections among people who Use drugs (EMU): protocol for a prospective, multicentre cohort study. 

Attwood LO, Bryant M, Lee SJ, Vujovic O, Higgs P, Doyle JS, Stewardson AJ; EMU Study Group. 

BMJ Open. 2023 Apr 3;13(4):e070236. doi: 10.1136/bmjopen-2022-070236. PMID: 37012020; PMCID: PMC10083776.