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Inhaled Heroin Tied to 'Peculiar, Often Catastrophic' Brain Damage

"Chasing the dragon" (CTD) — a method of inhaling heroin in which users heat heroin over aluminium foil with a lighter and then chase the fumes — is growing in popularity and may lead to "peculiar and often catastrophic brain complications," new research shows. (Medscape, 09.07.2018)
https://www.medscape.com/viewarticle/899079

Fixed Drug Eruption Due to Lorazepam.

Agulló-García A, Garcés Sotillos M, Colás Sanz C.

J Investig Allergol Clin Immunol. 2018 Jun;28(3):185-186. doi: 10.18176/jiaci.0225. 

http://www.jiaci.org/revistas/vol28issue3_6.pdf

Deutschland. Kein weiterer Anstieg von ADHS

Berlin – Im Jahr 2016 haben Ärzte bei knapp 260.000 Kindern und Jugend­lichen eine Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) diagnostiziert. Das entsprach einer Diagnosehäufigkeit von 4,3 Prozent. (aerzteblatt.de, 18.06.2018)

https://www.aerzteblatt.de/nachrichten/95903/Kein-weiterer-Anstieg-von-ADHS

Invasive Methicillin-Resistant Staphylococcus aureus Infections Among Persons Who Inject Drugs - Six Sites, 2005-2016.

Jackson KA, Bohm MK, Brooks JT, Asher A, Nadle J, Bamberg WM, Petit S, Ray SM, Harrison LH, Lynfield R, Dumyati G, Schaffner W, Townes JM, See I.

MMWR Morb Mortal Wkly Rep. 2018 Jun 8;67(22):625-628. doi: 10.15585/mmwr.mm6722a2.

https://www.cdc.gov/mmwr/volumes/67/wr/mm6722a2.htm

Studie sieht Überlebensvorteile durch mäßigen Alkoholkonsum trotz steigenden Krebsrisikos

Belfast – Hin und wieder ein Bier oder ein Glas Wein oder ein Grappa sollen gesund für Herz und Kreislauf sein, während ein hoher Alkoholkonsum schadet. Eine Studie in PLOS Medicine(2018; doi: 10.1371/journal.pmed.1002585) bestätigt erneut die „J-Kurve“ der Herz-Kreislauf-Sterblichkeit. Der günstige Effekt war auch dann noch nachweisbar, wenn ein erhöhtes Krebsrisiko berücksichtigt wurde, für das es keinen Schwellenwert gibt.

https://www.aerzteblatt.de/nachrichten/95961/Studie-sieht-Ueberlebensvorteile-durch-maessigen-Alkoholkonsum-trotz-steigenden-Krebsrisikos

'Chasing the dragon' on the intensive care unit.

Zante B, Hammel EM, Lauber A, Schefold JC.

Anaesthesiol Intensive Ther. 2018 Jun 22. doi: 10.5603/AIT.a2018.0014.

https://journals.viamedica.pl/anaesthesiology_intensivetherapy/article/view/AIT.a2018.0014/44705

The association of lifetime alcohol use with mortality and cancer risk in older adults: A cohort study. 

Kunzmann AT, Coleman HG, Huang W-Y, Berndt SI (2018) 

PLoS Med 15(6): e1002585. doi.org/10.1371/journal.pmed.1002585

http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002585

Limb Pain as Unusual Presentation of a Parietal Intraparenchymal Bleeding Associated with Crack Cocaine Use: A Case Report.

Lucerna A, Espinosa J, Zaman T, Hertz R, Stranges D.

Case Rep Neurol Med. 2018 May 31;2018:9598675. doi: 10.1155/2018/9598675.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000842/

Association of Cannabis Use With Adolescent Psychotic Symptoms. 

Bourque J, Afzali MH, Conrod PJ. 

JAMA Psychiatry.Published online June 06, 2018. doi:10.1001/jamapsychiatry.2018.1330

https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2681642

Alveolar hemorrhage associated with cocaine consumption.

Jiménez-Zarazúa O, López-García JA, Arce-Negrete LR, Vélez-Ramírez LN, Casimiro-Guzmán L, Mondragón JD.

Heart Lung. 2018 Jun 26. pii: S0147-9563(18)30157-2. doi: 10.1016/j.hrtlng.2018.05.022. 

https://www.heartandlung.org/article/S0147-9563(18)30157-2/fulltext

Both localized and systemic bacterial infections are predicted by injection drug use: A prospective follow-up study in Swedish criminal justice clients.

Dahlman D, Berge J, Björkman P, Nilsson AC, Håkansson A (2018) 

PLoS ONE 13(5): e0196944. doi.org/10.1371/journal.pone.0196944

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196944

Magnesium in drug abuse and addiction.

Nechifor M. 

In: Vink R, Nechifor M, editors. Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011. 

https://www.ncbi.nlm.nih.gov/books/NBK507260/

Myocardial Infarction in a Young Cocaine User with Atrial Myxoma: What is the Central Cause?

Santos EL, Gonçalves RM, Holanda AC, Nogueira VO, Correia LC.

Cureus. 2018 Mar 14;10(3):e2325. doi: 10.7759/cureus.2325.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951598/

Heroin Abuse Results in Shifted RNA Expression to Neurodegenerative Diseases and Attenuation of TNFα Signaling Pathway.

Zhu M, Xu Y, Wang H, Shen Z, Xie Z, Chen F, Gao Y, Chen X, Zhang Y, Wu Q, Li X, Yu J, Luo H, Wang K.

Sci Rep. 2018 Jun 18;8(1):9231. doi: 10.1038/s41598-018-27419-9.

https://www.nature.com/articles/s41598-018-27419-9

Protocol for a systematic review of psychological treatment for methamphetamine use: an analysis of methamphetamine use and mental health symptom outcomes.

Stuart A, Baker AL, Bowman J, McCarter K, Denham AMJ, Lee N, Colyvas K, Dunlop A.

BMJ Open. 2017 Sep 7;7(9):e015383. doi: 10.1136/bmjopen-2016-015383. Review.

http://bmjopen.bmj.com/content/7/9/e015383.long

6 Steps for Helping a Friend Through a Bad Psychedelic Trip

Start by not calling it a "bad trip." 

In The Festival Harm Reduction Project series, we examine drug use at music festivals and clubs across the globe, and explore what artists, organizers, harm reductiongroups, and concert-goers are doing to make nightlife safer. (The Festival Harm Reduction Series, 2017)

https://www.zendoproject.org/articles-about-zendo-project/6-steps-for-helping-a-friend-through-a-bad-psychedelic-trip/

Loperamide abuse cardiotoxicity. Should loperamide still be an over the counter medication?

Idris A, Kaye K.

Am J Emerg Med. 2018 May 18. pii: S0735-6757(18)30404-2. doi: 10.1016/j.ajem.2018.05.027.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29779679

Is Use of Prescription Medications With Depression as Possible Side Effect Common?

Bottom Line: More than one-third of U.S. adults may use prescription medications that have depression as a possible side effect.

Why The Research Is Interesting: Prescription medications are widely used among adults and many prescriptions, such as hormonal contraceptives and beta-blockers, are associated with increased risk of depression.

Results:An estimated 37 percent of adults used prescription medications that had depression as a potential side effect; the use of multiple medications with depression as a possible side effect was associated with a greater likelihood of depression. (JAMA, Pressemitteilung, 11.06.2018)

https://media.jamanetwork.com/news-item/is-use-of-prescription-medications-with-depression-as-possible-side-effect-common/

Constipation: opioid antagonists in people prescribed opioids.

Ahmedzai SH, Boland JW.

BMJ Clin Evid. 2015 Sep 11;2015. pii: 2407. Review.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566814/

PTSD symptom presentation among people with alcohol and drug use disorders: Comparisons by substance of abuse.

Dworkin ER, Wanklyn S, Stasiewicz PR, Coffey SF.

Addict Behav. 2018 Jan;76:188-194. doi: 10.1016/j.addbeh.2017.08.019. 

https://www.sciencedirect.com/science/article/pii/S0306460317303179?via%3Dihub

Both localized and systemic bacterial infections are predicted by injection drug use: A prospective follow-up study in Swedish criminal justice clients.

Dahlman D, Berge J, Björkman P, Nilsson AC, Håkansson A (2018) 

PLoS ONE 13(5): e0196944. doi.org/10.1371/journal.pone.0196944

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196944

Depressionen häufige Nebenwirkung von Medikamenten

Chicago – Die Polypharmazie führt dazu, dass immer mehr Patienten gleich mehrere Wirkstoffe verschrieben bekommen, zu deren Nebenwirkungen depressive Verstimmungen gehören. In einer Querschnittstudie im US-amerikanischen Ärzteblatt (JAMA 2018; 319: 2289–2298) war die Einnahme der Medikamente tatsächlich mit einer deutlich erhöhten Rate von Depressionen assoziiert. (aerzteblatt.de, 13.06.2018)

https://www.aerzteblatt.de/nachrichten/95818/Depressionen-haeufige-Nebenwirkung-von-Medikamenten

Adults with Comorbid Posttraumatic Stress Disorder, Alcohol Use Disorder, and Opioid Use Disorder: The Effectiveness of Modified Prolonged Exposure.

Peck KR, Schumacher JA, Stasiewicz PR, Coffey SF.

J Trauma Stress. 2018 May 22. doi: 10.1002/jts.22291.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29786898

Cognitive impairment associated with cocaine use: The role of co-existent alcohol abuse/dependence.

Blanco-Presas L, Moreno-Alcázar A, Alonso-Lana S, Salvador R, Pomarol-Clotet E, McKenna P.

Drug Alcohol Depend. 2018 May 29;189:70-75. doi: 10.1016/j.drugalcdep.2018.03.054.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29886366

How treatment improvement in ADHD and cocaine dependence are related to one another: A secondary analysis.

Levin FR, Choi CJ, Pavlicova M, Mariani JJ, Mahony A, Brooks DJ, Nunes EV, Grabowski J.

Drug Alcohol Depend. 2018 May 1;188:135-140. doi: 10.1016/j.drugalcdep.2018.03.043.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29775957

Wie Komasaufen die Gedächtnisleistungen auf Dauer beschädigt

Bristol und New York – Jugendliche, die mit 15 Jahren bereits häufiger einen Vollrausch hatten, wiesen in einer prospektiven Beobachtungsstudie in Alcohol and Alcoholism (2018; 53: 251–258) im Alter von 18 Jahren häufiger Störungen des Arbeitsgedächtnisses auf, was langfristig ihre kognitiven Fähigkeiten einschränken könnte. Tierexperimentelle Studien im Journal of Neuroscience (2018; doi: 10.1523/JNEUROSCI.0550-18.2018) zeigen, zu welchen neurologischen Schäden es im Gehirn kommen kann. (aerzteblatt.de, 19.06.2018)

https://www.aerzteblatt.de/nachrichten/95910/Wie-Komasaufen-die-Gedaechtnisleistungen-auf-Dauer-beschaedigt