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Vitamin D deficiency exacerbates UV/endorphin and opioid addiction. 

Beyer T, Loh YE, Lo JA, van der Sande AAJ, Sarnie W, Kotler D, Hsiao JJ, Su MY, Kato S, Kotler J, Bilbo SD, Chopra V, Salomon MP, Shen S, Hoon DSB, Asgari MM, Wakeman SE, Nestler EJ, Fisher DE. 

Sci Adv. 2021 Jun 11;7(24):eabe4577. doi: 10.1126/sciadv.abe4577. PMID: 34117054; PMCID: PMC8195487.

https://advances.sciencemag.org/content/7/24/eabe4577

Lessons learned — and lost — from a Vietnam-era study of addiction

(…) The team’s finding that the availability of a given drug is a key to how much it’s used is obvious and uncontroversial. The rest of what they learned was not.

Eight to 12 months after the soldiers returned to the U.S., Robins and her team conducted confidential interviews and requested urine samples for drug testing. Surprisingly, they learned that heroin use was uncommon, even among those who had become addicted in Vietnam. In the first year back home, only 5% had relapsed to addiction. (Stat News, USA, 19.07.2021)

https://www.statnews.com/2021/07/19/lessons-learned-and-lost-vietnam-era-addiction-study/

PSYCHOACTIVE (Podcasts)

Drugs, drugs, drugs. Almost everyone uses them. Almost everyone has an opinion about them. Drug policy pioneer Ethan Nadelmann gets to the bottom of our strange relationship to drugs by talking with those who love them, hate them, and study them. (Psychoactive, Ethan Nadelmann, USA, Start am 15.07.2021)

https://www.iheart.com/podcast/1119-psychoactive-84544756/

Umfrage. Stand der Implementierung von Strategien „Guter Praxis“ in der Versorgung geflüchteter Menschen

Mit dieser Umfrage wird der Stand der Umsetzung wissenschaftlich identifizierter Strategien „Guter Praxis“ in der Versorgung geflüchteter Menschen in allen Suchthilfe-Einrichtungen in Deutschland erhoben. Diese Erhebung ist Teil des vom Bundesministerium für Bildung & Forschung finanzierten Verbundprojektes PREPARE. 

Die Teilnahme ist bis zum 31. Juli 2021 möglich. (Prepare und Charité, 2021)

https://prepare.limequery.org/739945?lang=de

Neues Online-Rechercheportal: Sucht und Flucht – Hilfen für geflüchtete Menschen mit Suchtproblemen

Ein neues Rechercheportal zum Thema Sucht bei geflüchteten Menschen ist ab sofort online: sucht-und-flucht.de. Das Rechercheportal möchte Fachkräfte im Bereich der Arbeit mit Geflüchteten im Zusammenhang mit Substanzgebrauch, Konsum- und suchtbezogenen Problemen unterstützen. Neben den Fachkräften können auch Betroffene, deren Angehörige, die Selbsthilfe und sogenannte Key Persons, also Menschen mit zumeist eigenem Migrationshintergrund, das Portal nutzen. (DHS – Deutsche Hauptstelle für Suchtfragen und ZIS – Zentrum für interdisziplinäre Suchtforschung der Universität Hamburg, Juni 2021)

www.sucht-und-flucht.de

Blockade of β-Adrenergic Receptors by Propranolol Disrupts Reconsolidation of Drug Memory and Attenuates Heroin Seeking. 

Chen L, Huang S, Yang C, Wu F, Zheng Q, Yan H, Yan J, Luo Y, Galaj E. 

Front Pharmacol. 2021 May 25;12:686845. doi: 10.3389/fphar.2021.686845. PMID: 34113256; PMCID: PMC8185332.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185332/

Treatment Trajectories During and After a Medication Trial for Opioid Use Disorder: Moving from Research as Usual to Treatment as Usual. 

Fishman M, Vo HT, Burgower R, Ruggiero M, Rotrosen J, Lee J, Nunes E. 

J Addict Med. 2020 Jul/Aug;14(4):331-336. doi: 10.1097/ADM.0000000000000592. PMID: 31972765; PMCID: PMC7358110.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358110/

"I'm pretty sure it's either food poisoning or Covid-19": Lived experience versus medical knowledge in diagnosing substance use problems. 

Frank D. 

Int J Drug Policy. 2021 Jun 14:103348. doi: 10.1016/j.drugpo.2021.103348. Epub ahead of print. PMID: 34183237; PMCID: PMC8200310.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200310/

Substance Use Disorder: A Model for Integration in Undergraduate Medical Education. 

Pavuluri H, Poupore N, Schmidt WM, Boniface SG, Jindal M, Demosthenes L. 

J Med Educ Curric Dev. 2021 Jun 15;8:23821205211025859. doi: 10.1177/23821205211025859. PMID: 34189271; PMCID: PMC8212362.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212362/

Heroin delay discounting and impulsivity: Modulation by DRD1 genetic variation. 

Moses TEH, Burmeister M, Greenwald MK. 

Addict Biol. 2020 May;25(3):e12777. doi: 10.1111/adb.12777. Epub 2019 Jun 13. PMID: 31192519; PMCID: PMC6908785.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908785/

A mu-opioid feedback model of human social behavior. 

Meier IM, van Honk J, Bos PA, Terburg D. 

Neurosci Biobehav Rev. 2021 Feb;121:250-258. doi: 10.1016/j.neubiorev.2020.12.013. Epub 2020 Dec 20. PMID: 33359094.

https://www.sciencedirect.com/science/article/pii/S0149763420306898

Fragen und Antworten zur digitalen Suchtberatung

Im Rahmen der Umsetzung des Onlinezugangsgesetzes (OZG) soll im Laufe des Jahres 2021 ein bundesweit und trägerübergreifend nutzbares Themenportal für Sozialleistungen („Sozialplattform“) online gehen, welches auch erste Funktionalitäten für die digitale Suchtberatung enthalten wird.

Mit der Umsetzung beauftragt, ist das Ministerium für Arbeit, Gesundheit und Soziales in Nordrhein-Westfalen (MAGS NRW). Unterstützt wird das MAGS NRW durch das vom Bundesministerium für Gesundheit geförderte DigiSucht Projekt.

Auf dieser Webseite des DigiSucht Projektes finden Sie Antworten auf häufig gestellte Fragen und weitere Informationen zum Vorhaben. (AG DigiSucht c/o delphi Gesellschaft für Forschung, Beratung und Projektentwicklung mbH, 2021)

https://digisucht.delphi.de/

Substance Use Disorder: A Model for Integration in Undergraduate Medical Education. 

Pavuluri H, Poupore N, Schmidt WM, Boniface SG, Jindal M, Demosthenes L. 

Journal of Medical Education and Curricular Development. January 2021. doi:10.1177/23821205211025859

https://journals.sagepub.com/doi/full/10.1177/23821205211025859

Why comparative epidemiological indicators suggest that New Zealand is unlikely to experience a severe opioid epidemic. 

Fischer B, O-Keefe-Markman C, Daldegan-Bueno D, Walters C. 

Int J Drug Policy. 2021 Feb 16;93:103166. doi: 10.1016/j.drugpo.2021.103166. Epub ahead of print. PMID: 33607479.

https://www.sciencedirect.com/science/article/pii/S0955395921000645

Moderators and mediators of outcomes of parents with substance use problems: further evaluation of the Parents under Pressure programme, 

Dawe, S., Harnett, P., Gullo, M. J., Eggins, E., and Barlow, J. (2021)

Addiction. doi: doi.org/10.1111/add.15579.

https://onlinelibrary.wiley.com/doi/full/10.1111/add.15579

Adverse Childhood Experiences Predict Early Initiation of Opioid Use Behaviors. 

Guarino H, Mateu-Gelabert P, Quinn K, Sirikantraporn S, Ruggles KV, Syckes C, Goodbody E, Jessell L, Friedman SR. 

Front Sociol. 2021 May 13;6:620395. doi: 10.3389/fsoc.2021.620395. PMID: 34055961; PMCID: PMC8158934.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158934/

Brain responses to drug cues predict craving changes in abstinent heroin users: A preliminary study. 

Liu S, Wang S, Zhang M, Xu Y, Shao Z, Chen L, Yang W, Liu J, Yuan K. 

Neuroimage. 2021 May 15;237:118169. doi: 10.1016/j.neuroimage.2021.118169. Epub ahead of print. PMID: 34000396.

https://www.sciencedirect.com/science/article/pii/S1053811921004468

AddictGene: An integrated knowledge base for differentially expressed genes associated with addictive substance. 

Shi L, Wang Y, Li C, Zhang K, Du Q, Zhao M. 

Comput Struct Biotechnol J. 2021 Apr 19;19:2416-2422. doi: 10.1016/j.csbj.2021.04.027. PMID: 34025933; PMCID: PMC8113760.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113760/

AddictGene: an integrated knowledge base for differentially expressed genes associated with psychostimulants

Motivation of AddictGene

Addiction, a chronic, relapsing brain disease, is characterized by loss of control over psychostimulant drug intake and compulsive drug consumption despite serious adverse consequences. Alteration of gene expression has been linked to dependence, withdrawal, and relapse of psychostimulant-dependent individuals in both animal and human studies. As the gene expression data relating to changes induced by psychostimulants are accumulating rapidly in last decade, there is a growing need to integrate and annotate the current multi-omic data from multiple studies for convenient retrieval by bench researchers and clinicians. To fulfill this need, AddictGene is thus developed. AddictGene integrated gene expression, gene-gene interaction, gene-drug interaction and regulatory annotation for over 33,821 items of differentially expressed genes associated with psychostimulants across three species (human, mouse, rat) from 205 publications. Importantly, it contains 1,010 addiction-associated genes that have been experimentally validated by RT-PCR, Northern blot, and in situ hybridization. (Institute of Psychology, Chinese Academy of Sciences, Juni 2021)

http://159.226.67.237/sun/addictgedb/welcome/index.html

A morphometric approach to track opium poppy domestication. 

Jesus A, Bonhomme V, Evin A, Ivorra S, Soteras R, Salavert A, Antolín F, Bouby L. 

Sci Rep. 2021 May 7;11(1):9778. doi: 10.1038/s41598-021-88964-4. PMID: 33963241; PMCID: PMC8105347.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105347/

Effects of psychosocial support interventions on survival in inpatient and outpatient healthcare settings: A meta-analysis of 106 randomized controlled trials. 

Smith TB, Workman C, Andrews C, Barton B, Cook M, Layton R, et al. (2021) 

PLoS Med 18(5): e1003595. doi.org/10.1371/journal.pmed.1003595

https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003595

Drug Use for Grown-Ups: A Conversation with Carl Hart

In conversation with Kasia Malinowska, director of the Open Society Global Drug Policy Program, Carl Hart, one of the world’s foremost experts on drugs, argues that the greatest damage from drugs flows from their being illegal. (Open Society Foundations, Global Drug Policy Program, 05.04.2021, Video, 01:19:03)

https://www.opensocietyfoundations.org/events/drug-use-for-grown-ups-a-conversation-with-carl-hart

Risikofaktoren für multiplen Drogenkonsum - Konsum von Cannabis in der Jugend, Missbrauchserfahrungen oder Migration erhöhen die Gefahr für eine extreme Form des Drogenkonsums

Viele Drogenabhängige nehmen nicht nur eine Substanz ein, sondern mehrere. Wissenschaftler des Max-Planck-Instituts für experimentelle Medizin in Göttingen haben untersucht, welche Rolle Gene und Umwelt bei der Entstehung eines solchen multiplen Substanzgebrauchs spielen. Ihre Ergebnisse zeigen, dass neben genetischen Faktoren gerade die Anhäufung mehrerer ungünstiger Umweltfaktoren dazu führt, dass Menschen in eine solch extreme Form des Drogenkonsums abrutschen. Unter den Risikofaktoren waren neben sexuellem und körperlichem Missbrauch, dem Leben in der Großstadt und Migrationserfahrungen auch der Konsum von Cannabis und Alkohol vor dem 18. Lebensjahr. So könnten Cannabis und Alkohol für anfällige Personen geradezu als Einstiegsdrogen fungieren und den Weg hin zu problematischerem Substanzgebrauch ebnen. (Max-Planck-Gesellschaft, 29.04.2021)

https://www.mpg.de/16812450/polytoxikomanie-risikofaktoren

Obituary. Mary Jeanne Kreek

Green, Andrew

The Lancet, Volume 397, Issue 10290, 2144 

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01201-0/fulltext

EMCDDA. Wastewater analysis and drugs — a European multi-city study

Introduction

Analysing communal wastewaters for drugs and their metabolic products in order to estimate their consumption in the community is a developing field, involving scientists working in different research areas, including analytical chemistry, physiology and biochemistry, sewage engineering, spatial epidemiology and statistics, and conventional drug epidemiology. This page presents the findings from studies since 2011. Data from all studies may be explored through an interactive tool, and a detailed an analayis of the findings of the most recent study in 2020 is presented. (EMCDDA, Lissabon, 18.05.2021)

https://www.emcdda.europa.eu/topics/pods/waste-water-analysis

A Novel Precision Approach to Overcome the "Addiction Pandemic" by Incorporating Genetic Addiction Risk Severity (GARS) and Dopamine Homeostasis Restoration. 

Blum K, Kazmi S, Modestino EJ, Downs BW, Bagchi D, Baron D, McLaughlin T, Green R, Jalali R, Thanos PK, Elman I, Badgaiyan RD, Bowirrat A, Gold MS. 

J Pers Med. 2021 Mar 16;11(3):212. doi: 10.3390/jpm11030212. PMID: 33809702; PMCID: PMC8002215.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002215/

The effects of repetitive transcranial magnetic stimulation on cue-induced craving in male patients with heroin use disorder. 

Liu X, Zhao X, Liu T, Liu Q, Tang L, Zhang H, Luo W, Daskalakis ZJ, Yuan TF. 

EBioMedicine. 2020 Jun;56:102809. doi: 10.1016/j.ebiom.2020.102809. Epub 2020 Jun 5. PMID: 32512513; PMCID: PMC7276507.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276507/

The cost of opioid use disorder and the value of aversion. 

Murphy SM. 

Drug Alcohol Depend. 2020 Dec 1;217:108382. doi: 10.1016/j.drugalcdep.2020.108382. Epub 2020 Oct 26. PMID: 33183909; PMCID: PMC7737485.

https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(20)30547-0

Why Women Experience Addiction Differently ...and why women-centric approaches are fast gaining ground. 

When it comes to addiction, gender matters. Women often get addicted for different reasons than men, they go into treatment for different reasons, and they get and stay sober for different reasons. (Psychology Today, 14.05.2021)

https://www.psychologytoday.com/us/blog/use-your-brain/202105/why-women-experience-addiction-differently