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Moderators and mediators of outcomes of parents with substance use problems: further evaluation of the Parents under Pressure programme, 

Dawe, S., Harnett, P., Gullo, M. J., Eggins, E., and Barlow, J. (2021)

Addiction. doi: doi.org/10.1111/add.15579.

https://onlinelibrary.wiley.com/doi/full/10.1111/add.15579

Adverse Childhood Experiences Predict Early Initiation of Opioid Use Behaviors. 

Guarino H, Mateu-Gelabert P, Quinn K, Sirikantraporn S, Ruggles KV, Syckes C, Goodbody E, Jessell L, Friedman SR. 

Front Sociol. 2021 May 13;6:620395. doi: 10.3389/fsoc.2021.620395. PMID: 34055961; PMCID: PMC8158934.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158934/

Brain responses to drug cues predict craving changes in abstinent heroin users: A preliminary study. 

Liu S, Wang S, Zhang M, Xu Y, Shao Z, Chen L, Yang W, Liu J, Yuan K. 

Neuroimage. 2021 May 15;237:118169. doi: 10.1016/j.neuroimage.2021.118169. Epub ahead of print. PMID: 34000396.

https://www.sciencedirect.com/science/article/pii/S1053811921004468

AddictGene: An integrated knowledge base for differentially expressed genes associated with addictive substance. 

Shi L, Wang Y, Li C, Zhang K, Du Q, Zhao M. 

Comput Struct Biotechnol J. 2021 Apr 19;19:2416-2422. doi: 10.1016/j.csbj.2021.04.027. PMID: 34025933; PMCID: PMC8113760.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113760/

AddictGene: an integrated knowledge base for differentially expressed genes associated with psychostimulants

Motivation of AddictGene

Addiction, a chronic, relapsing brain disease, is characterized by loss of control over psychostimulant drug intake and compulsive drug consumption despite serious adverse consequences. Alteration of gene expression has been linked to dependence, withdrawal, and relapse of psychostimulant-dependent individuals in both animal and human studies. As the gene expression data relating to changes induced by psychostimulants are accumulating rapidly in last decade, there is a growing need to integrate and annotate the current multi-omic data from multiple studies for convenient retrieval by bench researchers and clinicians. To fulfill this need, AddictGene is thus developed. AddictGene integrated gene expression, gene-gene interaction, gene-drug interaction and regulatory annotation for over 33,821 items of differentially expressed genes associated with psychostimulants across three species (human, mouse, rat) from 205 publications. Importantly, it contains 1,010 addiction-associated genes that have been experimentally validated by RT-PCR, Northern blot, and in situ hybridization. (Institute of Psychology, Chinese Academy of Sciences, Juni 2021)

http://159.226.67.237/sun/addictgedb/welcome/index.html

A morphometric approach to track opium poppy domestication. 

Jesus A, Bonhomme V, Evin A, Ivorra S, Soteras R, Salavert A, Antolín F, Bouby L. 

Sci Rep. 2021 May 7;11(1):9778. doi: 10.1038/s41598-021-88964-4. PMID: 33963241; PMCID: PMC8105347.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105347/

Effects of psychosocial support interventions on survival in inpatient and outpatient healthcare settings: A meta-analysis of 106 randomized controlled trials. 

Smith TB, Workman C, Andrews C, Barton B, Cook M, Layton R, et al. (2021) 

PLoS Med 18(5): e1003595. doi.org/10.1371/journal.pmed.1003595

https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003595

Drug Use for Grown-Ups: A Conversation with Carl Hart

In conversation with Kasia Malinowska, director of the Open Society Global Drug Policy Program, Carl Hart, one of the world’s foremost experts on drugs, argues that the greatest damage from drugs flows from their being illegal. (Open Society Foundations, Global Drug Policy Program, 05.04.2021, Video, 01:19:03)

https://www.opensocietyfoundations.org/events/drug-use-for-grown-ups-a-conversation-with-carl-hart

Risikofaktoren für multiplen Drogenkonsum - Konsum von Cannabis in der Jugend, Missbrauchserfahrungen oder Migration erhöhen die Gefahr für eine extreme Form des Drogenkonsums

Viele Drogenabhängige nehmen nicht nur eine Substanz ein, sondern mehrere. Wissenschaftler des Max-Planck-Instituts für experimentelle Medizin in Göttingen haben untersucht, welche Rolle Gene und Umwelt bei der Entstehung eines solchen multiplen Substanzgebrauchs spielen. Ihre Ergebnisse zeigen, dass neben genetischen Faktoren gerade die Anhäufung mehrerer ungünstiger Umweltfaktoren dazu führt, dass Menschen in eine solch extreme Form des Drogenkonsums abrutschen. Unter den Risikofaktoren waren neben sexuellem und körperlichem Missbrauch, dem Leben in der Großstadt und Migrationserfahrungen auch der Konsum von Cannabis und Alkohol vor dem 18. Lebensjahr. So könnten Cannabis und Alkohol für anfällige Personen geradezu als Einstiegsdrogen fungieren und den Weg hin zu problematischerem Substanzgebrauch ebnen. (Max-Planck-Gesellschaft, 29.04.2021)

https://www.mpg.de/16812450/polytoxikomanie-risikofaktoren

Obituary. Mary Jeanne Kreek

Green, Andrew

The Lancet, Volume 397, Issue 10290, 2144 

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01201-0/fulltext

EMCDDA. Wastewater analysis and drugs — a European multi-city study

Introduction

Analysing communal wastewaters for drugs and their metabolic products in order to estimate their consumption in the community is a developing field, involving scientists working in different research areas, including analytical chemistry, physiology and biochemistry, sewage engineering, spatial epidemiology and statistics, and conventional drug epidemiology. This page presents the findings from studies since 2011. Data from all studies may be explored through an interactive tool, and a detailed an analayis of the findings of the most recent study in 2020 is presented. (EMCDDA, Lissabon, 18.05.2021)

https://www.emcdda.europa.eu/topics/pods/waste-water-analysis

A Novel Precision Approach to Overcome the "Addiction Pandemic" by Incorporating Genetic Addiction Risk Severity (GARS) and Dopamine Homeostasis Restoration. 

Blum K, Kazmi S, Modestino EJ, Downs BW, Bagchi D, Baron D, McLaughlin T, Green R, Jalali R, Thanos PK, Elman I, Badgaiyan RD, Bowirrat A, Gold MS. 

J Pers Med. 2021 Mar 16;11(3):212. doi: 10.3390/jpm11030212. PMID: 33809702; PMCID: PMC8002215.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002215/

The effects of repetitive transcranial magnetic stimulation on cue-induced craving in male patients with heroin use disorder. 

Liu X, Zhao X, Liu T, Liu Q, Tang L, Zhang H, Luo W, Daskalakis ZJ, Yuan TF. 

EBioMedicine. 2020 Jun;56:102809. doi: 10.1016/j.ebiom.2020.102809. Epub 2020 Jun 5. PMID: 32512513; PMCID: PMC7276507.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276507/

The cost of opioid use disorder and the value of aversion. 

Murphy SM. 

Drug Alcohol Depend. 2020 Dec 1;217:108382. doi: 10.1016/j.drugalcdep.2020.108382. Epub 2020 Oct 26. PMID: 33183909; PMCID: PMC7737485.

https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(20)30547-0

Why Women Experience Addiction Differently ...and why women-centric approaches are fast gaining ground. 

When it comes to addiction, gender matters. Women often get addicted for different reasons than men, they go into treatment for different reasons, and they get and stay sober for different reasons. (Psychology Today, 14.05.2021)

https://www.psychologytoday.com/us/blog/use-your-brain/202105/why-women-experience-addiction-differently

Berlin/Charité. SysMedSUDs-Studie - Wie wirkt sich der Konsum unterschiedlicher Suchtmittel auf das Gehirn aus? Studienteilnehmende gesucht!

Welches Ziel verfolgt die Studie? 

In dieser Studie möchten wir die neurobiologischen Grundlagen von Suchterkrankungen erforschen. Konkret möchten wir mithilfe von Magnetresonanztomographie (MRT) die Konzentration spezifi-scher Botenstoffe im Gehirn untersuchen, welche zur Entstehung von Abhängigkeitserkrankungen beitragen können. (…)

Wie können Sie an der Studie teilnehmen? 

Sie können an der Studie teilnehmen, wenn bei Ihnen eine der folgenden Erkrankungen diagnostiziert wurde: 

Opiatabhängigkeit (in Substitutionstherapie)

Cannabisabhängigkeit 

Nikotinabhängigkeit

Charité – Universitätsmedizin Berlin, Klinik für Psychiatrie und Psychotherapie

Flyer_SysMedSUDs_Charité

Effectiveness of psychosocial interventions for reducing parental substance misuse. 

McGovern R, Newham JJ, Addison MT, Hickman M, Kaner EFS. 

Cochrane Database of Systematic Reviews 2021, Issue 3. Art. No.: CD012823. DOI: 10.1002/14651858.CD012823.pub2. Accessed 11 May 2021.

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012823.pub2/full

Peer2Peer - Reinforcing Peer's Involvement in Outreach Work

The EU Drugs Strategy 2013-2020 develops an approach to the phenomenon of drugs use. In that context several actions are proposed to achieve the overall objective of the EU Drugs Strategy with three cross-disciplinary themes of (i) coordination, (ii) international cooperation and (iii) information, research, monitoring and evaluation. The Peer2Peer project aims at the capacity-building of CSO through the use of scientific knowledge to increase the efficacy of cooperation practices between key-actors in the outreach work (professionals, outreach workers (OW), peers, small-scale drug dealers and police forces), emphasising the focus on the dyad “peer - Professional”. The principles inspiring this approach come from the long European tradition of rights and liberties that empower citizens to actively participate in society. (Stand Mai 2021)

https://peer2peerproject.com

The Failed Globalization of Psychedelic Drugs in the Early Modern World. 

Breen, B. (2021). 

The Historical Journal, 1-18. doi:10.1017/S0018246X21000224

https://www.cambridge.org/core/journals/historical-journal/article/failed-globalization-of-psychedelic-drugs-in-the-early-modern-world/6ADA9DE0F3FAC7E18591C7A96A53AA58

Projekt „Bundesweite Vernetzung von Akteuren des Hilfesystems für Kinder suchtkranker Eltern“ 

Das 2020 gestartete Projekt fördert den bundesweiten Aufbau von Kommunikationsstrukturen zwischen Fachkräften der Suchthilfe, Jugendhilfe und des Gesundheitswesens. Erreicht wird der interdisziplinäre Austausch aller Akteure, die mit suchtbelasteten Familien insbesondere den Kindern suchtkranker Eltern zusammenarbeiten, durch eine Kommunikationsplattform mit einer interaktiven onlinebasierten Übersicht aller Angebote sowie begleitenden Veranstaltungen. (NACOA Deutschland - Interessenvertretung für Kinder aus Suchtfamilien e.V., 2021)

https://nacoa.de/projekte/bundesweite-vernetzung

Fragen und Antworten zur digitalen Suchtberatung

Worum geht es?

Im Rahmen der Umsetzung des Onlinezugangsgesetzes (OZG) soll im Laufe des Jahres 2021 ein bundesweit und trägerübergreifend nutzbares Themenportal für Sozialleistungen („Sozialplattform“) online gehen, welches auch erste Funktionalitäten für die digitale Suchtberatung enthalten wird.

Mit der Umsetzung beauftragt, ist das Ministerium für Arbeit, Gesundheit und Soziales in Nordrhein-Westfalen (MAGS NRW). Unterstützt wird das MAGS NRW durch das vom Bundesministerium für Gesundheit geförderte DigiSucht Projekt.

Auf dieser Webseite des DigiSucht Projektes finden Sie Antworten auf häufig gestellte Fragen und weitere Informationen zum Vorhaben. (AG DigiSucht c/o delphi Gesellschaft für Forschung, Beratung und Projektentwicklung mbH, Berlin, 2021)

https://digisucht.delphi.de/

EMCDDA. European Web Survey on Drugs: patterns of use

A new round of the European Web Survey on Drugs was launched on 18 March 2021. Each country provides the survey in multiple languages. (EMCDDA, Lissabon, 18.03.2021)

https://www.emcdda.europa.eu/activities/european-web-survey-on-drugs

DHS Jahrbuch Sucht 2021 erschienen

Das DHS Jahrbuch Sucht 2021 der Deutschen Hauptstelle für Suchtfragen (DHS) liefert die neuesten Zahlen und Fakten zum Konsum legaler und illegaler Drogen in Deutschland. Renommierte Expertinnen und Experten aus Forschung und Praxis informieren über aktuelle Trends bei einzelnen Suchtstoffen, zu abhängigem Verhalten und über die Versorgung Suchtkranker. (DHS, 14.04.2021)

https://www.dhs.de/service/presse/pressemeldungen/meldung/dhs-jahrbuch-sucht-2021-erschienen

DHS Jahrbuch Sucht 2021 ist erschienen: Hoher Alkoholkonsum - Mehrausgaben für Tabakwaren 

Hamm. Welche Trends gibt es beim Konsum von Alkohol, Tabak und illegalen Drogen in Deutschland? Welche Tendenzen zeichnen sich beim Missbrauch von Medikamenten ab? Wie entwickelt sich der Glücksspielmarkt? Das heute veröffentlichte DHS Jahrbuch Sucht 2021 der Deutschen Hauptstelle für Suchtfragen e.V. (DHS) fasst die neuesten Zahlen, Daten und Fakten zu legalen und illegalen Suchtstoffen sowie zum Thema Glücks-spiel zusammen und informiert über die Suchthilfe in Deutschland. (DHS, 14.04.2021)

https://www.dhs.de/fileadmin/user_upload/pdf/Jahrbuch_Sucht/DHS_Jahrbuch_Sucht_2021-Daten_und_Fakten.pdf

Adopting a child in the age of opioids (Video)

Carrie Brady had no idea the impact that opioids had on birth mothers and their children, but at age 40 she decided to start a family and open her heart to adopting a child in need. 

Find out how that decision reshaped her and her family’s life forever. (BBC, 05.04.2021, Video, 07:37)

https://www.bbc.com/news/av/world-us-canada-56581394

Dr. Mary Jeanne Kreek: Mourning the Loss of a Great Addiction Pioneer 

We are profoundly saddened at the passing of Dr. Mary Jeanne Kreek last week, at age 84. A longtime NIH grantee, Mary Jeanne contributed enormously to the study of addiction, and her work has been crucial in eroding the stigma that still surrounds this disease and its treatment. She also served as a towering role model for women in science, busily breaking glass ceilings (as she put it in this oral history interview) through her tireless scientific work and leadership.

Although she made many contributions to our science, Mary Jeanne is best known for her work developing the first medication for opioid use disorder, methadone. During her medical residency in 1964, she joined the laboratory of Vincent Dole at The Rockefeller Institute for Medical Research, which was studying the neurobiology of heroin addiction with an aim to develop a medication to treat it. They identified methadone—a long-acting oral opioid analgesic—as potentially able to quell the cravings felt by patients without producing the destructive intense highs and lows produced by heroin, which both enters and leaves the brain much more quickly.

Nora D. Volkow, Director, NIDA, and George F. Koob, Director, NIAAA, 06.04.2021

https://www.drugabuse.gov/about-nida/noras-blog/2021/04/mourning-loss-great-addiction-pioneer

Attributable fractions for substance use in relation to crime. 

Young, M. M., De Moor, C., Kent, P., Stockwell, T., Sherk, A., Zhao, J., Sorge, J. T., Farrell MacDonald, S., Weekes, J., Biggar, E., and Maloney‐Hall, B. (2021) 

Addiction, doi.org/10.1111/add.15494. 

https://onlinelibrary.wiley.com/doi/full/10.1111/add.15494

Mary Jeanne Kreek, M.D. - Oral History Excerpts (Video)

The Rockefeller University Oral History Project, 2019, Video, 09:58

https://www.youtube.com/watch?v=azpvNkMS1s8

Dr. Mary Jeanne Kreek – 1937-2021

Dear colleagues, It is with great sadness that I share the news that Mary Jeanne Kreek, a beloved colleague and pioneering physician-scientist, passed away last night. Mary Jeanne was the Patrick E. and Beatrice M. Haggerty Professor and Head of the Laboratory of the Biology of Additive Diseases, as well as Senior Physician at the Rockefeller University Hospital. Mary Jeanne was a pioneer in the biology of addiction research and made seminal contributions that led to methadone’s successful use as a treatment for heroin addiction. Beyond her scientific endeavors, she was a champion for her patients, often speaking out against the societal stigma they faced. (The Rockefeller University, New York, USA, Office of the President, 28.03.2021)

https://files.constantcontact.com/55b56c59001/d67a1d20-22e2-45b2-90d5-20b0052e6527.pdf

Mary Jeanne Kreek, pioneer in studies of addiction, has died

Physician-scientist Mary Jeanne Kreek, the Patrick E. and Beatrice M. Haggerty Professor and a senior attending physician at The Rockefeller University, died March 27 at the age of 84. Kreek was best known for her research into the biology of drug and alcohol addiction. Her work not only yielded new treatments for these disorders, but also influenced societal attitudes toward them.

Kreek conducted landmark studies that led to the establishment of methadone as a treatment for heroin addiction. The drug, which Kreek and her colleagues developed more than 50 years ago, has been widely used in treatment programs across the globe. It has saved countless lives and allowed millions of heroin users to transition into normal lives. (The Rockefeller University, New York, USA, 29.03.2021)

https://www.rockefeller.edu/news/30284-mary-jeanne-kreek-pioneer-studies-addiction-died/