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Videos in Clinical Medicine: Intranasal Naloxone Administration

Rafael Ortega, M.D., Ala Nozari, M.D., Ph.D., William Baker, M.D., Sannoor Surani, M.D., and Melinda Edwards, M.D.
N Engl J Med 2021; 384:e44, March 25, 2021, DOI: 10.1056/NEJMvcm2020745

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Empfehlungen zur substitutionsgestützten Behandlung bei Minderjährigen

Erbas B, Gift S, Koller G, Pogarell O, Seiler J

Bayerische Akademiefür Suchtfragen in Forschung und Praxis BAS, 3. überarbeitete und ergänzte Auflage, März 2021 


Behandlung opioidabhängiger Inhaftierter - Einstellungen und Behandlungspraxis des medizinischen Personals in bayerischen Justizvollzugsanstalten

Maren Weiss, Kerstin Geißelsöder, Maike Breuer, Norbert Wodarz

Das Gesundheitswesen, March 2021, DOI: 10.1055/a-1399-9286



Drug Checking as Strategy for Harm Reduction in Recreational Contests: Evaluation of Two Different Drug Analysis Methodologies. 

Fregonese M, Albino A, Covino C, Gili A, Bacci M, Nicoletti A, Gambelunghe C.

Front Psychiatry. 2021 Feb 22;12:596895. doi: 10.3389/fpsyt.2021.596895. PMID: 33692707; PMCID: PMC7938318.


Findings among Indigenous participants of the Tracks survey of people who inject drugs in Canada, Phase 4, 2017-2019. 

Tarasuk J, Sullivan M, Bush D, Hui C, Morris M, Starlight T, Cholette F, Jonah L, Bryson M, Paquette D, Masching R. 

Can Commun Dis Rep. 2021 Jan 29;47(1):37-46. doi: 10.14745/ccdr.v47i01a07. PMID: 33679247; PMCID: PMC7919774.


Shifting the paradigm: physician-authorized, student-led efforts to provide harm reduction services amidst legislative opposition. 

McMullen TP, Naeim M, Newark C, Oliphant H, Suchard J, Banimahd F. 

Subst Abuse Treat Prev Policy. 2021 Mar 24;16(1):27. doi: 10.1186/s13011-021-00362-1. PMID: 33761954; PMCID: PMC7992799.


Harm Reduction, By Mail: the Next Step in Promoting the Health of People Who Use Drugs. 

Hayes BT, Favaro J, Davis CS, Gonsalves GS, Beletsky L, Vlahov D, Heimer R, Fox AD. 

J Urban Health. 2021 Mar 12:1–6. doi: 10.1007/s11524-021-00534-1. Epub ahead of print. PMID: 33710493; PMCID: PMC7953942.


Acute cannabis intoxication in the emergency department: the effect of legalization. 

Baraniecki R, Panchal P, Malhotra DD, Aliferis A, Zia Z. 

BMC Emerg Med. 2021 Mar 17;21(1):32. doi: 10.1186/s12873-021-00428-0. PMID: 33731003; PMCID: PMC7968301.


Loperamide: an emerging drug of abuse and cause of prolonged QTc. 

Whittaker G, Newman J. 

Clin Med (Lond). 2021 Mar;21(2):150-152. doi: 10.7861/clinmed.2020-1046. PMID: 33762378; PMCID: PMC8002798.


Antipsychotics in routine treatment are minor contributors to QT prolongation compared to genetics and age. 

Hommers L, Scherf-Clavel M, Stempel R, Roth J, Falter M, Deckert J, Mattheisen M, Unterecker S, Gawlik M. 

J Psychopharmacol. 2021 Mar 28:2698811211003477. doi: 10.1177/02698811211003477. Epub ahead of print. PMID: 33779379.


A Fatal Case of Opioid Intoxication After Raw Poppy Plant Ingestion. 

Bozan G, Ulukapi HB, Oncul U, Levent S, Dinleyici EC. 

Cureus. 2021 Feb 6;13(2):e13176. doi: 10.7759/cureus.13176. PMID: 33717721; PMCID: PMC7939539.


Death after emergency department visits for opioid overdose in British Columbia: a retrospective cohort analysis. 

Moe J, Chong M, Zhao B, Scheuermeyer FX, Purssell R, Slaunwhite A. 

CMAJ Open. 2021 Mar 17;9(1):E242-E251. doi: 10.9778/cmajo.20200169. PMID: 33731425.


WHO. Community management of opioid overdose. 

World Health Organization. (‎2014)‎. apps.who.int/iris/handle/10665/137462


Circumstances of overdose among suburban women who use opioids: Extending an urban analysis informed by drug, set, and setting. 

Lamonica AK, Boeri M, Turner J. 

Int J Drug Policy. 2020 Dec 26;90:103082. doi: 10.1016/j.drugpo.2020.103082. Epub ahead of print. PMID: 33373906.


Cannabis Use and Nonfatal Opioid Overdose among Patients Enrolled in Methadone Maintenance Treatment. 

Bryson WC, Morasco BJ, Cotton BP, Thielke SM. 

Subst Use Misuse. 2021;56(5):697-703. doi: 10.1080/10826084.2021.1892137. Epub 2021 Mar 22. PMID: 33749499.



The Impact of Supervised Consumption Services on Fentanyl-related Deaths: Lessons Learned from Alberta's Provincial Data. 

Marshall T, Abba-Aji A, Tanguay R, Greenshaw AJ. 

Can J Psychiatry. 2021 Mar 19:706743721999571. doi: 10.1177/0706743721999571. Epub ahead of print. PMID: 33739168.


The Effectiveness and Tolerability of Anti‐Seizure Medication in Alcohol Withdrawal Syndrome: A Systematic Review, Meta‐Analysis and GRADE of the evidence. 

Lai, J.‐Y., Kalk, N., and Roberts, E. (2021) 

Addiction, doi.org/10.1111/add.15510. 


Opioid use disorder and overdose among youth following an initial opioid prescription. 

Hadland, S. E., Bagley, S. M., Gai, M. J., Earlywine, J. J., Schoenberger, S. F., Morgan, J. R., and Barocas, J. A. (2021) 

Addiction, doi.org/10.1111/add.15487.


Take-home naloxone programs for suspected opioid overdose in community settings: a scoping umbrella review. 

Moustaqim-Barrette A, Dhillon D, Ng J, Sundvick K, Ali F, Elton-Marshall T, Leece P, Rittenbach K, Ferguson M, Buxton JA. 

BMC Public Health. 2021 Mar 26;21(1):597. doi: 10.1186/s12889-021-10497-2. PMID: 33771150; PMCID: PMC8004425.


"They're not doing enough.": women's experiences with opioids and naloxone in Toronto. 

Macleod ER, Tajbakhsh I, Hamilton-Wright S, Laliberte N, Wiese JL, Matheson FI. 

Subst Abuse Treat Prev Policy. 2021 Mar 20;16(1):26. doi: 10.1186/s13011-021-00360-3. PMID: 33743756; PMCID: PMC7980746.


Naloxone-Induced Acute Pulmonary Edema is Dose-Dependent: A Case Series. 

Al-Azzawi M, Alshami A, Douedi S, Al-Taei M, Alsaoudi G, Costanzo E. 

Am J Case Rep. 2021 Mar 17;22:e929412. doi: 10.12659/AJCR.929412. PMID: 33730013; PMCID: PMC7983320.


Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update. 

Evoy KE, Sadrameli S, Contreras J, Covvey JR, Peckham AM, Morrison MD. 

Drugs. 2021 Jan;81(1):125-156. doi: 10.1007/s40265-020-01432-7. PMID: 33215352.



Comment on "Abuse and Misuse of Pregabalin and Gabapentin: A Systematic Review Update". 

Bonnet U, McAnally H, Scherbaum N. 

Drugs. 2021 Mar 18. doi: 10.1007/s40265-021-01494-1. Epub ahead of print. PMID: 33738757.


Clinical Practice Guideline on Pharmacological and Psychological management of adult patients with Schizophrenia Spectrum Disorders and a comorbid substance use. 

Arranz B, Garriga M, Bernardo M, Gonzalez-Pinto A, Arrojo M, Torrens M, Tirado-Muñoz J, Fonseca F, Saiz PA, Florez G, Goikolea JM, Zorrilla I, Cunill R, Castells X, Becoña E, Lopez A, San L. 

Adicciones. 2021 Mar 11;0(0):1504. English, Spanish. doi: 10.20882/adicciones.1504. Epub ahead of print. PMID: 33768260.


Clinical practice guideline on pharmacological and psychological management of adult patients with depression and a comorbid substance use disorder. 

Torrens M, Tirado-Muñoz J, Fonseca F, Farré M, Gonzalez-Pinto A, Arrojo M, Bernardo M, Arranz B, Garriga M, Saiz PA, Florez G, Goikolea JM, Zorrilla I, Cunill R, Castells X, Becoña E, Lopez A, San L. 

Adicciones. 2021 Mar 12;0(0):1559. English, Spanish. doi: 10.20882/adicciones.1559. Epub ahead of print. PMID: 33768269.


Concomitant drugs associated with increased mortality for MDMA users reported in a drug safety surveillance database.  

Cohen IV, Makunts T, Abagyan R, Thomas K. 

Sci Rep. 2021 Mar 16;11(1):5997. doi: 10.1038/s41598-021-85389-x. PMID: 33727616; PMCID: PMC7966744.


Methamphetazine: A Harm Reduction Guide 

(harmreductionactioncenter.org, Denver/USA, 16.06.2018)


Opioid Use Disorder: Treatments and Barriers. 

Patel K, Bunachita S, Agarwal AA, Lyon A, Patel UK. 

Cureus. 2021 Feb 6;13(2):e13173. doi: 10.7759/cureus.13173. PMID: 33717718; PMCID: PMC7938868.


Frequency of health-care utilization by adults who use illicit drugs: a systematic review and meta-analysis. 

Lewer D, Freer J, King E, Larney S, Degenhardt L, Tweed EJ, Hope VD, Harris M, Millar T, Hayward A, Ciccarone D, Morley KI. 

Addiction. 2020 Jun;115(6):1011-1023. doi: 10.1111/add.14892. Epub 2020 Feb 10. PMID: 31705770; PMCID: PMC7210080.


Findings from the recovery initiation and management after overdose (RIMO) pilot study experiment. 

Scott CK, Dennis ML, Grella CE, Nicholson L, Sumpter J, Kurz R, Funk R. 

J Subst Abuse Treat. 2020 Jan;108:65-74. doi: 10.1016/j.jsat.2019.08.004. Epub 2019 Aug 7. PMID: 31493942; PMCID: PMC6893133.