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Toward precision prescribing for methadone: Determinants of methadone deposition.

Talal AH, Ding Y, Venuto CS, Chakan LM, McLeod A, Dharia A, et al. (2020) 

PLoS ONE 15(4): e0231467. doi.org/10.1371/journal.pone.0231467


USA. Medications for Opioid Use Disorder. Treatment Improvement Protocol (TIP) Series 63, Full Document.

This updated Treatment Improvement Protocol (TIP) reviews the use of the three Food and Drug Administration (FDA)-approved medications used to treat OUD—methadone, naltrexone, and buprenorphine—and the other strategies and services needed to support recovery for people with OUD. (SAMHSA - Substance Abuse & Mental Health Services Administration, USA, Mai 2020)


The Use of the Methadone/Metabolite Ratio (MMR) to Identify an Individual Metabolic Phenotype and Assess Risks of Poor Response and Adverse Effects: Towards Scientific Methadone Dosing.

McCarthy JJ, Graas J, Leamon MH, Ward C, Vasti EJ, Fassbender C.

J Addict Med. 2020 Feb 6. doi: 10.1097/ADM.0000000000000620. 



Sexual Inactivity in Methadone Maintenance Treatment Patients.

Ramli FF, Tg Abu Bakar Sidik TMI, Naina Mohamed I.

Int J Environ Res Public Health. 2020 Mar 18;17(6). pii: E1993. doi: 10.3390/ijerph17061993.


Differences in Gut Microbial Diversity are Driven by Drug Use and Drug Cessation by Either Compulsory Detention or Methadone Maintenance Treatment.

Li Q, Chen S, Liu K, Long D, Liu D, Jing Z, Huang X.

Microorganisms. 2020 Mar 13;8(3). pii: E411. doi: 10.3390/microorganisms8030411.


Comparative Effectiveness of Different Treatment Pathways for Opioid Use Disorder.

Wakeman SE, Larochelle MR, Ameli O, Chaisson CE, McPheeters JT, Crown WH, Azocar F, Sanghavi DM.

JAMA Netw Open. 2020 Feb 5;3(2):e1920622. doi: 10.1001/jamanetworkopen.2019.20622.


Increases in body mass index and cardiovascular risk factors during methadone maintenance treatment.

Sweeney MM, Antoine DG, Nanda L, Géniaux H, Lofwall MR, Bigelow GE, Umbricht A.

J Opioid Manag. 2019 Sep/Oct;15(5):367-374. doi: 10.5055/jom.2019.0526.



Transition From Methadone to Buprenorphine Using a Short-acting Agonist Bridge in the Inpatient Setting: A Case Study.

Callan J, Pytell J, Ross J, Rastegar DA.

J Addict Med. 2020 Jan 22. doi: 10.1097/ADM.0000000000000623. 



Factors Related to Relapse in Patients with Substance-related Disorders under Methadone Maintenance Therapy: Decision Tree Analysis.

Moradinazar M, Farnia V, Alikhani M, Karyani AK, Rezaei S, Rezaeian S, Matin BK, Najafi F.

Oman Med J. 2020 Jan 23;35(1):e89. doi: 10.5001/omj.2020.07. 


Outcome of Patients With High Depressive Symptoms on Admission to Methadone Maintenance Treatment.

Malik E, Adelson M, Sason A, Schreiber S, Peles E.

J Dual Diagn. 2019 Oct-Dec;15(4):281-290. doi: 10.1080/15504263.2019.1656353.



Factors Associated with Sleep Disorders among Methadone-Maintained Drug Users in Vietnam.

Le TA, Dang AD, Tran AHT, Nguyen LH, Nguyen THT, Phan HT, Latkin CA, Tran BX, Ho CSH, Ho RCM.

Int J Environ Res Public Health. 2019 Nov 6;16(22). pii: E4315. doi: 10.3390/ijerph16224315.


Health-Seeking Behavior for Erectile Dysfunction in Methadone Maintenance Treatment Patients.

Ramli FF, Shuid AN, Pakri Mohamed RM, Tg Abu Bakar Sidik TMI, Naina Mohamed I.

Int J Environ Res Public Health. 2019 Nov 1;16(21). pii: E4249. doi: 10.3390/ijerph16214249.


Preparation, Characterization and Dermal Delivery of Methadone.

Kung CP, Sil BC, Hadgraft J, Lane ME, Patel B, McCulloch R.

Pharmaceutics. 2019 Oct 2;11(10). pii: E509. doi: 10.3390/pharmaceutics11100509.


The association between health conditions and cannabis use in patients with opioid use disorder receiving methadone maintenance treatment.

Shams I, Sanger N, Bhatt M, Rosic T, Luo C, Shahid H, Mouravska N, Tam SL, Hillmer A, Chawar C, D'Elia A, Hudson J, Marsh D, Thabane L, Samaan Z.

BJPsych Open. 2019 Oct 18;5(6):e91. doi: 10.1192/bjo.2019.78.


A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment.

Yee A, Loh HS, Loh HH, Riahi S, Ng CG, Sulaiman AHB.

Ann Gen Psychiatry. 2019 Oct 22;18:25. doi: 10.1186/s12991-019-0249-z. 


Opioids and their endocrine effects: A systematic review and meta-analysis.

de Vries F, Bruin M, Lobatto DJ, Dekkers OM, Schoones JW, van Furth WR, Pereira AM, Karavitaki N, Biermasz NR, Zamanipoor Najafabadi AH.

J Clin Endocrinol Metab. 2019 Sep 12. pii: dgz022. doi: 10.1210/clinem/dgz022.



Methadone poisonings: a seven year retrospective study of the French Poison Centers Network focusing on suicide attempts versus misuses.

Torrents R, Glaizal M, Sinno-Tellier S, Richard N, Nisse P, Vodovar D, Bloch J, Simon N, de Haro L.

Fundam Clin Pharmacol. 2019 Sep 9. doi: 10.1111/fcp.12506.



Acute Experimental Pain Responses in Methadone- and Buprenorphine/Naloxone-Maintained Patients Administered Additional Opioid or Gabapentin: A Double-Blind Crossover Pilot Study.

Murnion BP, Rivas C, Demirkol A, Hayes V, Lintzeris N, Nielsen S.

Pain Med. 2019 Aug 24. pii: pnz178. doi: 10.1093/pm/pnz178.



Correlation between interleukin-6 levels and methadone maintenance therapy outcomes.

Lu RB, Wang TY, Lee SY, Chen SL, Chang YH, See Chen P, Lin SH, Chu CH, Huang SY, Tzeng NS, Lee IH, Chin Chen K, Kuang Yang Y, Chen P, Chen SH, Hong JS.

Drug Alcohol Depend. 2019 Aug 30;204:107516. doi: 10.1016/j.drugalcdep.2019.06.018. 



Testing a Neuro-Evolutionary Theory of Social Bonds and Addiction: Methadone Associated With Lower Attachment Anxiety, Comfort With Closeness, and Proximity Maintenance.

Torres N.

Front Psychiatry. 2019 Sep 6;10:602. doi: 10.3389/fpsyt.2019.00602. 


Anästhesievorbereitung: Welche Medikamente vor einer Narkose abgesetzt werden sollten

Schreiner, Mathias J.; Kehl, Franz

Dtsch Arztebl 2019; 116(31-32): A-1428 / B-1183 / C-1167


Early Diagnosis of Hearing Loss in Patients Under Methadone Maintenance Treatment.

Bayat A, Saki N, Mirmomeni G, Yadollahpour A.

Front Neurol. 2019 Jul 16;10:749. doi: 10.3389/fneur.2019.00749. 


Dose Tapering Strategy for Heroin Abstinence among Methadone Maintenance Treatment Participants: Evidence from A Retrospective Study in Guangdong, China.

Lu Q, Zou X, Liu Y, Gong C, Ling L.

Int J Environ Res Public Health. 2019 Aug 6;16(15). pii: E2800. doi: 10.3390/ijerph16152800.


Frequent nightmares in Chinese patients undergoing methadone maintenance therapy: prevalence, correlates, and their association with functional impairment.

Zhong BL, Xu YM, Xie WX, Lu J.

Neuropsychiatr Dis Treat. 2019 Jul 18;15:2063-2072. doi: 10.2147/NDT.S202813. 


Efficacy of Electroacupuncture Combined with Methadone Maintenance Therapy: A Case-Control Study.

Chen YL, Lee TC, Chen YT, Lo LC, Hsu WY, Ouyang WC.

Evid Based Complement Alternat Med. 2019 Jul 21;2019:7032581. doi: 10.1155/2019/7032581. 


Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids.

Makunts T, U A, Atayee RS, Abagyan R.

Sci Rep. 2019 Aug 28;9(1):12490. doi: 10.1038/s41598-019-48955-y.


Tramadol könnte Hypoglykämien auslösen

San Diego – Das Schmerzmittel Tramadol, das zunehmend als sichere Alternative zu anderen Opioiden betrachtet wird, kann offenbar schwere Hypoglykämien auslösen. Dies kam in einer Analyse von Datenbanken der US-Arzneimittelbehörde FDA in Scientific Reports(2019; 9: 12490) heraus. (aerzteblatt.de, 29.08.2019)


Transitioning Hospitalized Patients with Opioid Use Disorder from Methadone to Buprenorphine without a Period of Opioid Abstinence Using a Microdosing Protocol.

Terasaki D, Smith C, Calcaterra SL.

Pharmacotherapy. 2019 Jul 26. doi: 10.1002/phar.2313.



Specificity of personality relationships to particular forms of concurrent substance use among methadone maintenance therapy clients.

Mahu IT, Conrod PJ, Barrett SP, Sako A, Swansburg J, Lawrence M, Laroque F, Morin JF, Chinneck A, Nogueira-Arjona R, Stewart SH.

Addict Behav. 2019 Jul 17;98:106056. doi: 10.1016/j.addbeh.2019.106056.



Decreased Level of Blood MicroRNA-133b in Men with Opioid Use Disorder on Methadone Maintenance Therapy.

Hsu CW, Huang TL, Tsai MC.

J Clin Med. 2019 Jul 25;8(8). pii: E1105. doi: 10.3390/jcm8081105.