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Methadone maintenance patients lack analgesic response to a cumulative intravenous dose of 32 mg of hydromorphone. 

Agin-Liebes G, Huhn AS, Strain EC, Bigelow GE, Smith MT, Edwards RR, Gruber VA, Tompkins DA.

Drug Alcohol Depend. 2021 Sep 1;226:108869. doi: 10.1016/j.drugalcdep.2021.108869. Epub 2021 Jun 25. PMID: 34216862.

https://www.sciencedirect.com/science/article/abs/pii/S0376871621003641

High-dose intravenous hydromorphone for patients who use opioids in the hospital setting: time to reduce the barriers.

Labonté, L.E., Young, S. 

Harm Reduct J 18, 87 (2021). doi.org/10.1186/s12954-021-00533-0

https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-021-00533-0

Treatment of opium addiction in persian medicine: A review study. 

Kamali M, Kamali H, Doustmohammadi M, Sheikhbardsiri H, Moghadari M. 

J Educ Health Promot. 2021 May 20;10:157. doi: 10.4103/jehp.jehp_5_21. PMID: 34222532; PMCID: PMC8224515.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224515/

USA. TIP 63: Medications for Opioid Use Disorder - Executive Summary

The Executive Summary of this Treatment Improvement Protocol provides an overview on the use of the three Food and Drug Administration-approved medications used to treat opioid use disorder—methadone, naltrexone, and buprenorphine—and the other strategies and services needed to support recovery. (SAMHSA - Substance Abuse and Mental Health Services Administration, USA, 10.08.2021)

https://store.samhsa.gov/sites/default/files/SAMHSA_Digital_Download/PEP21-02-01-003.pdf

USA. TIP 63: Medications for Opioid Use Disorder - For Healthcare and Addiction Professionals, Policymakers, Patients, and Families - Full Document

This Treatment Improvement Protocol (TIP) reviews the use of the three Food and Drug Administration (FDA)-approved medications used to treat OUD—methadone, naltrexone, and buprenorphine—and the other strategies and services needed to support recovery for people with OUD. This is a revision. (SAMHSA - Substance Abuse and Mental Health Services Administration, USA, Juli 2021)

https://store.samhsa.gov/sites/default/files/SAMHSA_Digital_Download/PEP21-02-01-002.pdf

Opium tincture-assisted treatment for opioid use disorder: A systematic review. 

Noroozi A, Kebriaeezadeh A, Mirrahimi B, Armoon B, Ahounbar E, Narenjiha H, Salehi M, Karamouzian M. 

J Subst Abuse Treat. 2021 Jun 4;129:108519. doi: 10.1016/j.jsat.2021.108519. Epub ahead of print. PMID: 34119894.

Abstract

https://pubmed.ncbi.nlm.nih.gov/34119894/

A novel maintenance therapeutic for Opioid Use Disorder. 

Youngblood B, Li K, Gehlert DR, Medina JC, Schwartz N.

J Pharmacol Exp Ther. 2021 May 19:JPET-AR-2020-000214. doi: 10.1124/jpet.120.000214. Epub ahead of print. PMID: 34011529.

https://jpet.aspetjournals.org/content/jpet/early/2021/05/19/jpet.120.000214.full.pdf

Association of Opioid Agonist Treatment With All-Cause Mortality and Specific Causes of Death Among People With Opioid Dependence: A Systematic Review and Meta-analysis. 

Santo T, Clark B, Hickman M, et al. 

JAMA Psychiatry. Published online June 02, 2021. doi:10.1001/jamapsychiatry.2021.0976

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2780655?guestAccessKey=ab364a20-821d-46cf-9c2c-b11559624b33

Opioid Agonist Therapy reduces mortality risk among people with opioid dependence

A new global review has found that receiving Opioid Agonist Therapy (OAT) is associated with lower risk of multiple causes of death among people with opioid dependence. (University of Bristol, UK, 02.06.2021)

https://www.bristol.ac.uk/news/2021/june/opioid-agonist-therapy.html

Opioid Agonist Therapy (OAT) associated with lower risk of multiple causes of death for people with opioid dependence

A new global review has found that receiving Opioid Agonist Therapy (OAT) is associated with lower risk of multiple causes of death among people with opioid dependence. 

The review found that people with opioid dependence were less likely to experience overdose-related, suicide, alcohol-related, cancer, and cardiovascular-related mortality while receiving OAT. 

Researchers from the National Drug and Alcohol Research Centre (NDARC) at UNSW Sydney, University of Bristol and several other global institutions reviewed the relationship between OAT and mortality across type of drug, setting and participant groups from over 700,000 participants, which is six times the number of any other previous review. (National Drug and Alcohol Research Centre (NDARC), Australien, 03.06.2021)

https://ndarc.med.unsw.edu.au/news/opioid-agonist-therapy-oat-associated-lower-risk-multiple-causes-death-people-opioid-dependence

New Approaches in Drug Dependence: Opioids. 

Mielau J, Vogel M, Gutwinski S, Mick I. 

Curr Addict Rep. 2021 May 26:1-8. doi: 10.1007/s40429-021-00373-9. Epub ahead of print. PMID: 34055568; PMCID: PMC8149259.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149259/

Quality of Life in Opioid Replacement Therapy: A Naturalistic Cross-Sectional Comparison of Methadone/Levomethadone, Buprenorphine, and Diamorphine Patients. 

Guillery SPE, Hellweg R, Kronenberg G, Bohr U, Kunte H, Enge S. 

Eur Addict Res. 2021 Mar 30:1-10. doi: 10.1159/000514192. Epub ahead of print. PMID: 33784698.

https://www.karger.com/Article/FullText/514192

Berlin. 15 Jahre Erhebungen zum sogenannten „Beikonsum“ - Was und wieviel konsumieren unsere Klienten* neben ihrem verschriebenen Substitutionsmedikament?

2005 ging es los – erstmals fragten wir das „Handlungswissen“ derjenigen ab, die im Notdienst Berlin e.V. die psychosoziale Betreuung von Menschen durchführen, welche sich in einer ärztlichen Substitutionsbehandlung befinden. Im Fokus unserer standardisierten Fragebögen stand und steht der zusätzliche Konsum psychoaktiver Substanzen neben dem jeweils verwendeten Substitutionsmedikament.

Die Befragung, die jährlich über einen gesamten Monat in allen relevanten Einrichtungen durchgeführt wird, zeigt längs- und quervalidierte Massendaten in einzigartiger Qualität, Umfänglichkeit und Differenziertheit. Über nun mittlerweile 15 Jahre sehen wir kurz-, mittel- und langfristige Veränderungen von Konsummustern, differenziert nach Alter, Geschlecht und Behandlungsdauer. Das ermöglicht es uns, fundierter und gezielter mit angemessenen Interventionen zu reagieren, wo immer dies erforderlich ist. (Notdienst für Suchtmittelgefährdete und -abhängige Berlin e.V., 16.03.2021)

https://drogennotdienst.de/2021/03/16/15-jahre-erhebungen-zum-sogenannten-beikonsum/

When Physical and Social Pain Coexist: Insights Into Opioid Therapy

Mark D. Sullivan, Jane C. Ballantyne

The Annals of Family Medicine Jan 2021, 19 (1) 79-82; DOI: 10.1370/afm.2591 

https://www.annfammed.org/content/19/1/79

Opioid agonist and antagonist use and the gut microbiota: associations among people in addiction treatment. 

Gicquelais RE, Bohnert ASB, Thomas L, Foxman B. 

Sci Rep. 2020 Nov 10;10(1):19471. doi: 10.1038/s41598-020-76570-9. PMID: 33173098; PMCID: PMC7655955.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655955/

Barriers and facilitators to a novel low-barrier hydromorphone distribution program in Vancouver, Canada: a qualitative study. 

Ivsins A, Boyd J, Mayer S, Collins A, Sutherland C, Kerr T, McNeil R. 

Drug Alcohol Depend. 2020 Nov 1;216:108202. doi: 10.1016/j.drugalcdep.2020.108202. Epub 2020 Sep 15. PMID: 32948372; PMCID: PMC7490624.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490624/

Opioid-Agonisten-Therapie bei Opioidabhängigkeit [Opioid Agonist Therapy (OAT) for opioid dependency

Köck P, Strasser J. 

Ther Umsch. 2020;77(1):29-36. German. doi: 10.1024/0040-5930/a001148. PMID: 32486990.

Abstract

https://econtent.hogrefe.com/doi/10.1024/0040-5930/a001148

Betäubungsmittel im Fokus: Sonderfall Substitutionstherapie 

Verordnungen von Substitutionsmitteln sind ein Fall für sich. Bei der Bearbeitung eines solchen Rezepts gilt es zahlreiche Regelungen zu beachten. Der siebte Teil der PZ-Serie »Betäubungsmittel im Fokus« beleuchtet die verschiedenen Therapieformen und deren Besonderheiten. (PZ – Pharmazeutische Zeitung, 05.10.2020)

https://www.pharmazeutische-zeitung.de/sonderfall-substitutionstherapie-120716/seite/alle/

Hospital Initiated Injectable Opioid Agonist Therapy for the Treatment of Severe Opioid Use Disorder: A Case Series

Brar R, Fairbairn N, Colizza K, Ryan A, Nolan S. 

[published online ahead of print, 2020, Aug 4]. J Addict Med. 2020;10.1097/ADM.0000000000000713. doi:10.1097/ADM.0000000000000713

Abstract

https://pubmed.ncbi.nlm.nih.gov/32769776/

Medications for opioid use disorders: clinical and pharmacological considerations. 

Volkow ND, Blanco C. 

J Clin Invest. 2020;130(1):10-13. doi:10.1172/JCI134708

Medications for opioid use disorders: clinical and pharmacological considerations. 

Precision therapeutic opioid dosing implications from genetic biomarkers and craving score.

Chang HW, Ho WC, Huang CL, Wang RY. 

Medicine (Baltimore). 2020;99(22):e20429. doi:10.1097/MD.0000000000020429

https://journals.lww.com/md-journal/FullText/2020/05290/Precision_therapeutic_opioid_dosing_implications.89.aspx

Consequences of Opioid Abuse and their Treatments in Persian Medicine: A Review Study. 

Kamali M, Tajadini H, Mehrabani M, Moghadari M. 

Addict Health. 2020;12(1):46-57. doi:10.22122/ahj.v12i1.250

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291898/

Effects of Medication-Assisted Treatment (MAT) for Opioid Use Disorder on Functional Outcomes: A Systematic Review. 

Maglione MA, Laura R, Christine C, et al. 

Rand Health Q. 2020;8(4):RR-2108-OSD. Published 2020 Jun 15. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302321/

 

Tackling the overdose crisis: The role of safe supply 

Ivsins A, Boyd J, Beletsky L, McNeil R. 

[published online ahead of print, 2020 May 1]. Int J Drug Policy. 2020;80:102769. doi:10.1016/j.drugpo.2020.102769

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252037/

Retention of patients in opioid substitution treatment: A systematic review.

O’Connor AM, Cousins G, Durand L, Barry J, Boland F (2020) 

PLoS ONE 15(5): e0232086. doi.org/10.1371/journal.pone.0232086

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232086

Opioid agonist treatment reduces losses in quality of life and quality-adjusted life expectancy in heroin users: Evidence from real world data.

Chang KC, Lee KY, Lu TH, Hwang JS, Lin CN, Ting SY, Chang CC, Wang JD.

Drug Alcohol Depend. 2019 Aug 1;201:197-204. doi: 10.1016/j.drugalcdep.2019.05.003. 

https://www.sciencedirect.com/science/article/pii/S0376871619301863?via%3Dihub

Defining a recovery-oriented cascade of care for opioid use disorder: A community-driven, statewide cross-sectional assessment.

Yedinak JL, Goedel WC, Paull K, Lebeau R, Krieger MS, Thompson C, et al. (2019) 

PLoS Med 16(11): e1002963. doi.org/10.1371/journal.pmed.1002963

https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002963

Opioid and Polydrug Use Among Patients in Opioid Maintenance Treatment.

Carlsen SL, Lunde LH, Torsheim T.

Subst Abuse Rehabil. 2020 Jan 29;11:9-18. doi: 10.2147/SAR.S221618. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996215/

Hab-o Shefa, a Persian Medicine Compound for Maintenance Treatment of Opioid Dependence: Randomized Placebo-Controlled Clinical Trial.

Moosavyzadeh A, Mokri A, Ghaffari F, Faghihzadeh S, Azizi H, Jafari Hajati R, Naseri M.

J Altern Complement Med. 2020 Feb 28. doi: 10.1089/acm.2019.0390. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/32109133

Initiation of injectable opioid agonist treatment in hospital: A case report.

McAdam M, Brar R, Young S.

Drug Alcohol Rev. 2019 Dec 9. doi: 10.1111/dar.13020.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/31814186