AddictGene: an integrated knowledge base for differentially expressed genes associated with psychostimulants
Motivation of AddictGene
Addiction, a chronic, relapsing brain disease, is characterized by loss of control over psychostimulant drug intake and compulsive drug consumption despite serious adverse consequences. Alteration of gene expression has been linked to dependence, withdrawal, and relapse of psychostimulant-dependent individuals in both animal and human studies. As the gene expression data relating to changes induced by psychostimulants are accumulating rapidly in last decade, there is a growing need to integrate and annotate the current multi-omic data from multiple studies for convenient retrieval by bench researchers and clinicians. To fulfill this need, AddictGene is thus developed. AddictGene integrated gene expression, gene-gene interaction, gene-drug interaction and regulatory annotation for over 33,821 items of differentially expressed genes associated with psychostimulants across three species (human, mouse, rat) from 205 publications. Importantly, it contains 1,010 addiction-associated genes that have been experimentally validated by RT-PCR, Northern blot, and in situ hybridization. (Institute of Psychology, Chinese Academy of Sciences, Juni 2021)