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d,l-Methadone causes leukemic cell apoptosis via an OPRM1-triggered increase in IP3R-mediated ER Ca2+ release and decrease in Ca2+ efflux, elevating [Ca2+]i. 

Lee, J., Rosales, J.L., Byun, HG. et al. 

Sci Rep 11, 1009 (2021). doi.org/10.1038/s41598-020-80520-w

https://www.nature.com/articles/s41598-020-80520-w