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Community Distribution of Naloxone: A Systematic Review of Economic Evaluations. 

Cherrier N, Kearon J, Tetreault R, Garasia S, Guindon E. 

Pharmacoecon Open. 2021 Nov 11:1–14. doi: 10.1007/s41669-021-00309-z. Epub ahead of print. PMID: 34762276; PMCID: PMC8581604.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581604/

Frequently asked questions about naloxone: Part 2. 

Cid A, Patten A, Grindrod K, Beazely MA. 

Can Pharm J (Ott). 2021 Oct 4;154(6):385-387. doi: 10.1177/17151635211045966. PMID: 34777648; PMCID: PMC8581805.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581805/

Reversal of Opioid Intoxication in an Infant With Intrauterine Growth Restriction With a Single Dose of Naloxone. 

Timalsina U, Andrasovich A, Kupferman FE, Viswanathan K, Ericksen K. 

Cureus. 2021 Oct 19;13(10):e18908. doi: 10.7759/cureus.18908. PMID: 34804741; PMCID: PMC8599436.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599436/

Do naloxone access laws affect perceived risk of heroin use? Evidence from national US data. 

Kelly, BC, Vuolo, M. 

Addiction. 2021; 1– 11. doi.org/10.1111/add.15682

https://onlinelibrary.wiley.com/doi/10.1111/add.15682

UK. Weston-super-Mare: Former drug user being trained to save lives

Former drug users are being trained in how to use medication which can save the lives of people who have overdosed. (BBC, UK, 30.11.2021)

https://www.bbc.com/news/uk-england-somerset-59482427

Australien. Improved naloxone access can prevent prescription opioid overdose deaths

Making the opioid overdose antidote naloxone easily accessible and available free-of-charge to people who are prescribed opioids in Australia would be cost-effective and save hundreds of lives, new Burnet Institute research demonstrates. (Burnet Institute, Australien, 19.11.2021)

https://www.burnet.edu.au/news/1546_improved_naloxone_access_can_prevent_prescription_opioid_overdose_deaths

Does naloxone provision lead to increased substance use? A systematic review to assess if there is evidence of a 'moral hazard' associated with naloxone supply. 

Tse WC, Djordjevic F, Borja V, Picco L, Lam T, Olsen A, Larney S, Dietze P, Nielsen S. 

Int J Drug Policy. 2021 Nov 16;100:103513. doi: 10.1016/j.drugpo.2021.103513. Epub ahead of print. PMID: 34798434.

https://www.sciencedirect.com/science/article/abs/pii/S095539592100431X?dgcid=coauthor#!

Long-term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox. 

Zamora JC, Smith HR, Jennings EM, Chavera TS, Kotipalli V, Jay A, Husbands SM, Disney A, Berg KA, Clarke WP. 

Pharmacol Res Perspect. 2021 Dec;9(6):e00887. doi: 10.1002/prp2.887. PMID: 34713624; PMCID: PMC8554411.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554411/

Adverse events related to bystander naloxone administration in cases of suspected opioid overdose in British Columbia: An observational study. 

Moustaqim-Barrette A, Papamihali K, Williams S, Ferguson M, Moe J, Purssell R, Buxton JA. 

PLoS One. 2021 Oct 29;16(10):e0259126. doi: 10.1371/journal.pone.0259126. PMID: 34714854; PMCID: PMC8555799.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555799/

Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators. 

Ayoub SM, Piscitelli F, Silvestri C, Limebeer CL, Rock EM, Smoum R, Farag M, de Almeida H, Sullivan MT, Lacroix S, Boubertakh B, Nallabelli N, Lichtman AH, Leri F, Mechoulam R, Di Marzo V, Parker LA. 

Front Pharmacol. 2021 Sep 15;12:706703. doi: 10.3389/fphar.2021.706703. PMID: 34603019; PMCID: PMC8479102.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479102/

Multi-informant Implementation and Intervention Outcomes of Opioid Overdose Education and Naloxone Distribution in New York City. 

Brandt L, Yanagida T, Campbell ANC, Jones JD, Schultes MT, Martinez S, Comer SD. 

Glob Implement Res Appl. 2021 Sep 20;1(3):1-14. doi: 10.1007/s43477-021-00021-4. Epub ahead of print. PMID: 34622215; PMCID: PMC8450721.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450721/

UK. Lifesaving antidote to be given to drug users as they leave custody

West Midlands Police has begun offering people with Class A drug addictions a lifesaving overdose antidote as they are released from custody as part of our wider harm reduction strategy.

The scheme, which is funded by the Police and Crime Commissioner Simon Foster, will hand drug users a medicine called Naloxone, which can reverse the effects of an overdose. (west midlands police and crime commissioner, UK, 03.11.2021)

https://www.westmidlands-pcc.gov.uk/lifesaving-antidote-to-be-given-to-drug-users-as-they-leave-custody/

NALtrain. 1. NALtrain Newsletter erschienen

Der Newsletter des Bundesmodellprojekts NALtrain informiert alle Kooperationspartner*innen und alle Interessierten über den Projektverlauf, die bisher erreichten Meilensteine und Ziele. Wir freuen uns sehr Ihnen den erten Newsletter vorstellen zu können. (DAH – Deutsche AIDS-Hilfe, 01.11.2021)

https://www.naloxontraining.de/wp-content/uploads/2021/11/NALtrainNewsletter1OktNov2021f1.pdf

USA. FDA approves naloxone injection to counteract opioid overdoses

Action: FDA has approved ZIMHI (naloxone hydrochloride) injection as an additional option to treat opioid overdose. ZIMHI is administered using a single-dose, prefilled syringe that delivers 5 milligrams (mg) of naloxone hydrochloride solution through intramuscular (in the muscle) or subcutaneous (under the skin) injection.

FDA has previously approved injectable naloxone hydrochloride products in 0.4 mg and 2 mg doses under the trade name, NARCAN. (FDA – US Food and Drug Administration, USA, 18.10.2021)

https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-naloxone-injection-counteract-opioid-overdoses

USA. Price for drug that reverses opioid overdoses soars amid record deaths

Pfizer manufacturing problems leave nonprofits paying exorbitant prices for dwindling supplies of life-saving naloxone. (The Guardian, UK, 19.10.2021)

https://www.theguardian.com/us-news/2021/oct/19/naloxone-price-soars-opioid-overdoses

Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent. 

Hedrick SL, Luo D, Kaska S, Niloy KK, Jackson K, Sarma R, Horn J, Baynard C, Leggas M, Butelman ER, Kreek MJ, Prisinzano TE. 

J Biomed Sci. 2021 Sep 9;28(1):62. doi: 10.1186/s12929-021-00758-y. PMID: 34503531; PMCID: PMC8427951.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427951/

Frequently asked questions about naloxone: Part 1. 

Cid A, Patten A, Grindrod K, Beazely MA. 

Can Pharm J (Ott). 2021 Aug 16;154(5):301-304. doi: 10.1177/17151635211034528. PMID: 34484479; PMCID: PMC8408911.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408911/

Fentanyl causes naloxone-resistant vocal cord closure: A platform for testing opioid overdose treatments. 

Miner NB, Schutzer WE, Zarnegarnia Y, Janowsky A, Torralva R. 

Drug Alcohol Depend. 2021 Oct 1;227:108974. doi: 10.1016/j.drugalcdep.2021.108974. Epub 2021 Aug 28. PMID: 34492557.

Abstract

https://pubmed.ncbi.nlm.nih.gov/34492557/

UK. Community pharmacy pilot provides hundreds of take-home naloxone kits in one year

Exclusive: The naloxone pilot, set up by charity Turning Point, in Somerset and Wakefield has reported providing more than 330 kits to patients in its first year. (The Pharmaceutical Journal, UK, 07.09.2021)

https://pharmaceutical-journal.com/article/news/community-pharmacy-pilot-provides-hundreds-of-take-home-naloxone-kits-in-one-year

Naloxon: Modellprojekt in Bayern erfolgreich verlaufen

München – Ein Naloxon-Modellprojekt ist nach Aussagen der Landesregierung in Bayern erfolgreich verlaufen. Das teilte heute der bayerische Gesundheitsminister Klaus Holetschek (CSU) mit. Demnach hat das Nasenspray 92 Menschen in Bayern bei Heroin- und anderen Opiatüberdosen das Leben gerettet. (arzteblatt.de, 09.09.2021)

https://www.aerzteblatt.de/nachrichten/127159/Naloxon-Modellprojekt-in-Bayern-erfolgreich-verlaufen

Investigating Community Pharmacy Take Home Naloxone Dispensing during COVID-19: The Impact of One Public Health Crisis on Another. 

Daskalakis G, Cid A, Grindrod K, Beazely MA. 

Pharmacy (Basel). 2021 Jul 23;9(3):129. doi: 10.3390/pharmacy9030129. PMID: 34449716; PMCID: PMC8396297.

https://www.mdpi.com/2226-4787/9/3/129

NALtrain/Naloxon-Training – Bundesmodellprojekt

Naloxon-Training: Dein Einsatz im Drogennotfall kann Leben retten. (2021)

https://www.naloxontraining.de/naltrain/

Investigating Community Pharmacy Take Home Naloxone Dispensing during COVID-19: The Impact of One Public Health Crisis on Another. 

Daskalakis G, Cid A, Grindrod K, Beazely MA. 

Pharmacy (Basel). 2021 Jul 23;9(3):129. doi: 10.3390/pharmacy9030129. PMID: 34449716; PMCID: PMC8396297.

https://www.mdpi.com/2226-4787/9/3/129

What is naloxone and why is it important?

Drug overdose continues to be the main cause of death among problem drug users. Heroin or other opioids — often consumed alongside other central nervous system depressants such as benzodiazepines and alcohol — are present in the majority of reported fatal overdoses (1). Overdose is common among opioid users: many of them have experienced a non-fatal overdose and most have witnessed one. Death from opioid overdose is caused primarily by respiratory depression leading to cardiac arrest.

Opioid overdose deaths can be prevented through timely administration of naloxone, a potent opioid antagonist drug that rapidly reverses the effects of opioid analgesics by binding to the opioid receptors in the central nervous system (see Spotlight: Naloxone). Because of its effectiveness, naloxone is used by emergency personnel worldwide (2). (EMCDDA, Lissabon, 31.08.2021)

https://www.emcdda.europa.eu/publications/topic-overviews/take-home-naloxone

Overdose response among trained and untrained women with a history of illicit drug use: a mixed-methods examination. 

Ataiants J, Mazzella S, Roth AM, Sell RL, Robinson LF, Lankenau SE. Overdose 

Drugs (Abingdon Engl). 2021;28(4):328-339. doi: 10.1080/09687637.2020.1818691. Epub 2020 Sep 16. PMID: 34321719; PMCID: PMC8315578.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315578/

Characterization of hospitalized patients who received naloxone while receiving opioids with or without gabapentinoids. 

Desai PH, Taylor O, Shah KJ, Evoy KE, Peckham AM. 

Ment Health Clin. 2021 Jul 16;11(4):225-230. doi: 10.9740/mhc.2021.07.225. PMID: 34316417; PMCID: PMC8287869.

https://meridian.allenpress.com/mhc/article/11/4/225/468019/Characterization-of-hospitalized-patients-who

Community Case Study of Naloxone Distribution by Hospital-Based Harm Reduction Program for People Who Use Drugs in New York City. 

Riazi F, Toribio W, Irani E, Hughes TM, Huxley-Reicher Z, McBratney E, Vu T, Sigel K, Weiss JJ. 

Front Sociol. 2021 Jul 7;6:619683. doi: 10.3389/fsoc.2021.619683. PMID: 34307540; PMCID: PMC8292929.

https://www.frontiersin.org/articles/10.3389/fsoc.2021.619683/full

Associations between Naloxone Prescribing and Opioid Overdose among Patients with Acute and Chronic Pain Conditions.

Qeadan, F., and Madden, E. F. (2021) 

Addiction, doi.org/10.1111/add.15643. 

https://onlinelibrary.wiley.com/doi/abs/10.1111/add.15643

Are opioid receptor antagonists adequate for “Opioid” overdose in a changing reality?.

Peppin, JF, Pergolizzi, JV, Dahan, A, Raffa, RB.

J Clin Pharm Ther. 2021; 46: 861– 866. doi.org/10.1111/jcpt.13320 

https://onlinelibrary.wiley.com/doi/10.1111/jcpt.13320

Study to prevent deaths from opioid overdose shows promising results

A study undertaken in Kazakhstan, Kyrgyzstan, Tajikistan and Ukraine has shown that training people most likely to witness an opioid overdose and providing them with naloxone, a drug that reduces the effects of overdose if administered rapidly, has the potential to significantly reduce the number of deaths in these countries if scaled up nationwide. (WHO, 06.08.2021)

https://www.who.int/news/item/06-08-2021-study-to-prevent-deaths-from-opioid-overdose-shows-promising-results