USA. Public Health Alert: Cychlorphine, a Highly Potent Emerging Synthetic Opioid
USA. Public Health Alert: Cychlorphine, a Highly Potent Emerging Synthetic Opioid
Public health and safety partners nationwide are warning about cychlorphine, an emerging synthetic opioid identified in the illicit drug supply across the United States. Cychlorphine belongs to a class of novel synthetic opioids known as “orphines.” It has been found on its own and in combination with fentanyl and other substances, including methamphetamine, cocaine, and counterfeit pills made to resemble prescription medications.
The Office of National Drug Control Policy (ONDCP) at the White House reported 106 drug-supply reports across 10 states in 2025, with detections in all four U.S. Census regions. Cychlorphine has been linked to at least 55 deaths nationally from 2025 to 2026, with the highest prevalence in Ohio, Texas, and Tennessee. These data are evolving as surveillance and toxicology testing expand. (Addiction Policy Forum, USA, 25.09.2026)
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