USA. Increase in Fatal Overdoses Linked to Novel Synthetic Opioid N-Propionitrile Chlorphine (Cychlorphine)
USA. Increase in Fatal Overdoses Linked to Novel Synthetic Opioid N-Propionitrile Chlorphine (Cychlorphine)
N-Propionitrile chlorphine belongs to an emergent subclass of novel synthetic opioids often referred to as “orphine analogues” (or more simply “orphines”) and bears structural similarity to other benzimidazolones (e.g., brorphine, chlorphine). These drugs have ties to pharmaceutical drug discovery conducted in the 1960s and 1970s, beginning with substances like bezitramide and R-6890 (now referred to as “spirochlorphine”). The orphine analogues first emerged in recreational drug markets in 2020 with the proliferation of brorphine (a drug first synthesized and published on in 2018). This novel opioid subclass continues to diversify, with at least six analogues confirmed in recent years. N-Propionitrile chlorphine was first detected at the Center for Forensic Science Research and Education (CFSRE) in mid-2024. In vitro pharmacology data show this drug to be approximately 10x more potent than fentanyl [Vandeputte & Stove, personal communication]. (Center for Forensic Science Research and Education (CFSRE), USA, 30.01.2026)
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