However, synthetic opioids create a new problem. While some nitazenes are broken down quickly by the body and can feel shorter-acting than traditional heroin, the exact duration varies by compound. And there are so many analogues.
UK. Separating the “zombie drug” myth from operational reality: Xylazine, medetomidine and bromazolam
The presence of xylazine, medetomidine, and bromazolam in UK heroin is not accidental.
Since April 2022’s Afghan opium poppy ban, European heroin purity and availability have declined across Europe. Traffickers now deliberately adulterate heroin and other drugs with synthetic opioids (nitazenes), sedatives (xylazine, medetomidine) and novel benzodiazepines (bromazolam) to mimic the high users expect.
However, synthetic opioids create a new problem. While some nitazenes are broken down quickly by the body and can feel shorter-acting than traditional heroin, the exact duration varies by compound. And there are so many analogues.
To compensate, non-opioid sedatives and novel benzodiazepines are added to the supply.
Why they’re added
Deepen and prolong sedation: xylazine and medetomidine depress the CNS differently from opioids.
Mask the comedown: bromazolam and other benzos smooth the comedown and hide the short-acting opioid crash.
Boost potency: these combinations make smaller opioid doses feel stronger and longer-lasting.
This creates a dangerous mix of drugs.
(Tony D'Agostino, Director COCA / TD Consultancy. LinkedIn, 19.01.2026)
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