A- A A+

Opioid Addiction/Pregnancy and Neonatal Abstinence Syndrome (NAS): A Preliminary Open-Label Study of Buprenorphine Maintenance and Drug Use Targeted Psychotherapy (DUST) on Cessation of Addictive Drug Use. 

Tabi S, Heitner SA, Shivale S, Minchenberg S, Faraone SV, Johnson B. 

Front Psychiatry. 2020 Sep 23;11:563409. doi: 10.3389/fpsyt.2020.563409. PMID: 33173512; PMCID: PMC7538830.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538830/

Methadone interrupts neural growth and function in human cortical organoids. 

Yao H, Wu W, Cerf I, Zhao HW, Wang J, Negraes PD, Muotri AR, Haddad GG. 

Stem Cell Res. 2020 Dec;49:102065. doi: 10.1016/j.scr.2020.102065. Epub 2020 Oct 27. PMID: 33137567.

https://www.sciencedirect.com/science/article/pii/S1873506120303664

Opioid Litigation and Maternal-Child Health-Investing in the Future. 

Patrick SW, Davis CS, Stein BD. 

JAMA Pediatr. 2020 Feb 1;174(2):119-120. doi: 10.1001/jamapediatrics.2019.5009. PMID: 31841585; PMCID: PMC7295661.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295661/

Rooming-in for Infants at Risk for Neonatal Abstinence Syndrome: Outcomes 5 Years following Its Introduction as the Standard of Care at One Hospital. 

Newman AI, Mauer-Vakil D, Coo H, Newton L, Wilkerson E, McKnight S, Brogly SB. 

Am J Perinatol. 2020 Nov 17. doi: 10.1055/s-0040-1719182. Epub ahead of print. PMID: 33202425.

https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0040-1719182.pdf

The Infant Cuddler Study: Evaluating the effectiveness of volunteer cuddling in infants with neonatal abstinence syndrome. 

Hignell A, Carlyle K, Bishop C, Murphy M, Valenzano T, Turner S, Sgro M. 

Paediatr Child Health. 2019 Oct 9;25(7):414-418. doi: 10.1093/pch/pxz127. PMID: 33173551; PMCID: PMC7606161.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606161/

Neurobehavior of newborn infants exposed prenatally to methadone and identification of a neurobehavioral profile linked to poorer neurodevelopmental outcomes at age 24 months. 

Wouldes TA, Woodward LJ (2020) 

PLoS ONE 15(10): e0240905. doi.org/10.1371/journal.pone.0240905

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240905

Navigating NAS - Themenseite der American Academy of Pediatrics

The #NavigatingNAS Campaign will feature four quarters, each devoted to a different aspect of the continuum of neonatal abstinence syndrome (NAS). Each quarter will provide educational materials for clinical practice and resources for families in addition to webinars, podcasts, and social media outreach.

https://www.aap.org/en-us/about-the-aap/aap-press-room/campaigns/navigating-nas/Pages/default.aspx

Will Simplifying the Finnegan Neonatal Abstinence Scoring Tool Improve Outcomes for Infants With Opioid Exposure? 

Oei JL, Wouldes T. 

JAMA Netw Open. 2020 Apr 1;3(4):e202271. doi: 10.1001/jamanetworkopen.2020.2271. PMID: 32267511.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2764194

Prenatal Exposures Are Associated With Worse Neurodevelopmental Outcomes in Infants With Neonatal Opioid Withdrawal Syndrome. 

Benninger KL, Borghese T, Kovalcik JB, Moore-Clingenpeel M, Isler C, Bonachea EM, Stark AR, Patrick SW, Maitre NL. 

Front Pediatr. 2020 Aug 27;8:462. doi: 10.3389/fped.2020.00462. PMID: 32974241; PMCID: PMC7481438.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481438/

Characteristics and causes of death in children with neonatal abstinence syndrome. 

Uebel H, Wright IM, Burns L, Hilder L, Bajuk B, Breen C, Abdel-Latif ME, Falconer J, Clews S, Ward M, Eastwood J, Oei JL. 

J Paediatr Child Health. 2020 Aug 20. doi: 10.1111/jpc.15091. Epub ahead of print. PMID: 32815631.

Abstract

https://pubmed.ncbi.nlm.nih.gov/32815631/

The Role of Stigma in the Nursing Care of Families Impacted by Neonatal Abstinence Syndrome. 

Recto P, McGlothen-Bell K, McGrath J, Brownell E, Cleveland LM. 

Adv Neonatal Care. 2020 Oct;20(5):354-363. doi: 10.1097/ANC.0000000000000778. PMID: 32868585; PMCID: PMC7467149.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467149/

Perinatal Opioid Exposure Primes the Peripheral Immune System Toward Hyperreactivity. 

Newville J, Maxwell JR, Kitase Y, Robinson S, Jantzie LL. 

Front Pediatr. 2020;8:272. Published 2020 Jun 26. doi:10.3389/fped.2020.00272

Perinatal Opioid Exposure Primes the Peripheral Immune System Toward Hyperreactivity. 

Identification of Substance-Exposed Newborns and Neonatal Abstinence Syndrome Using ICD-10-CM - 15 Hospitals, Massachusetts, 2017. 

Goyal S, Saunders KC, Moore CS, et al. 

MMWR Morb Mortal Wkly Rep. 2020;69(29):951-955. Published 2020 Jul 24. doi:10.15585/mmwr.mm6929a2

Identification of Substance-Exposed Newborns and Neonatal Abstinence Syndrome Using ICD-10-CM - 15 Hospitals, Massachusetts, 2017. 

Sex Differences in Early Cognitive Development After Prenatal Exposure to Opioids

Martine Skumlien, MRES; Inge Olga Ibsen, MD; Ulrik Schiøler Kesmodel, PHD; Egil Nygaard, PHD

J Pediatr Psychol. 2020;45(5):475-485. 

Sex Differences in Early Cognitive Development After Prenatal Exposure to Opioids

Strategies for the Prevention and Treatment of Iatrogenic Withdrawal from Opioids and Benzodiazepines in Critically Ill Neonates, Children and Adults: A Systematic Review of Clinical Studies 

Sneyers B, Duceppe MA, Frenette AJ, et al. 

[published online ahead of print, 2020 Jun 26]. Drugs. 2020;1-23. doi:10.1007/s40265-020-01338-4

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317263/

Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates. 

Kovar L, Schräpel C, Selzer D, et al. 

Pharmaceutics. 2020;12(6):E578. Published 2020 Jun 23. doi:10.3390/pharmaceutics12060578

https://www.mdpi.com/1999-4923/12/6/578

Associations of Maternal Prenatal Drug Abuse With Measures of Newborn Brain Structure, Tissue Organization, and Metabolite Concentrations 

Peterson BS, Rosen T, Dingman S, et al. 

[published online ahead of print, 2020 Jun 15]. JAMA Pediatr. 2020;e201622. 

https://jamanetwork.com/journals/jamapediatrics/article-abstract/2766728

Association of a Simplified Finnegan Neonatal Abstinence Scoring Tool With the Need for Pharmacologic Treatment for Neonatal Abstinence Syndrome.

Devlin LA, Breeze JL, Terrin N, Gomez Pomar E, Bada H, Finnegan LP, O'Grady KE, Jones HE, Lester B, Davis JM.

JAMA Netw Open. 2020 Apr 1;3(4):e202275. doi: 10.1001/jamanetworkopen.2020.2275.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142377/

Prenatal exposure to methadone or buprenorphine and long-term outcomes: A meta-analysis.

Andersen JM, Høiseth G, Nygaard E.

Early Hum Dev. 2020 Apr;143:104997. doi: 10.1016/j.earlhumdev.2020.104997. 

https://www.sciencedirect.com/science/article/pii/S0378378219306966?via%3Dihub

Cognitive Outcomes of Young Children After Prenatal Exposure to Medications for Opioid Use Disorder: A Systematic Review and Meta-analysis.

Nelson LF, Yocum VK, Patel KD, Qeadan F, Hsi A, Weitzen S.

JAMA Netw Open. 2020 Mar 2;3(3):e201195. doi: 10.1001/jamanetworkopen.2020.1195.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081119/

Outcome reporting in neonates experiencing withdrawal following opioid exposure in pregnancy: a systematic review.

Shan F, MacVicar S, Allegaert K, Offringa M, Jansson LM, Simpson S, Moulsdale W, Kelly LE.

Trials. 2020 Mar 12;21(1):262. doi: 10.1186/s13063-020-4183-9. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069160/

Assessment and treatment of the withdrawal syndrome in paediatric intensive care units: Systematic review.

Ávila-Alzate JA, Gómez-Salgado J, Romero-Martín M, Martínez-Isasi S, Navarro-Abal Y, Fernández-García D.

Medicine (Baltimore). 2020 Jan;99(5):e18502. doi: 10.1097/MD.0000000000018502.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004796/

Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities.

Conradt E, Flannery T, Aschner JL, Annett RD, Croen LA, Duarte CS, Friedman AM, Guille C, Hedderson MM, Hofheimer JA, Jones MR, Ladd-Acosta C, McGrath M, Moreland A, Neiderhiser JM, Nguyen RHN, Posner J, Ross JL, Savitz DA, Ondersma SJ, Lester BM.

Pediatrics. 2019 Sep;144(3). pii: e20190128. doi: 10.1542/peds.2019-0128. Review.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759228/

Neonatal abstinence syndrome management in California birth hospitals: results of a statewide survey.

Clemans-Cope, L., Holla, N., Lee, H.C. et al. 

J Perinatol (2020). doi.org/10.1038/s41372-019-0568-6

https://www.nature.com/articles/s41372-019-0568-6

Development and application of a primer and reference assessment tool for neonatal abstinence syndrome: A phase I pilot study.

Burduli E, Smith CL, Tham P, Shogan M, Johnson RK, McPherson SM.

Contemp Clin Trials Commun. 2019 Dec 3;17:100494. doi: 10.1016/j.conctc.2019.100494. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906735/

Neonatal Abstinence Syndrome.

Anbalagan S, Mendez MD.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-.
2019 Dec 10.

https://www.ncbi.nlm.nih.gov/books/NBK551498/

Antepartum Drug Dependence and Pregnancy- or Birth-related Complications: A Cross-sectional Study of 19 Million Inpatients.

Ahmad N, Robert CA, Jampa A, Ashraf S, Patel RS.

Cureus. 2019 Nov 10;11(11):e6117. doi: 10.7759/cureus.6117.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903893/

Multigenerational Approaches to Fostering Children's Health and Well-Being: The Opioid Crisis as a Case Study: Proceedings of a Workshop.

National Academies of Sciences, Engineering, and Medicine. 2019. National Academies of Sciences, Engineering, and Medicine. 2019. 

Washington, DC: The National Academies Press., doi.org/10.17226/25574.

https://www.nap.edu/catalog/25574/multigenerational-approaches-to-fostering-childrens-health-and-well-being-the

USA. In The Fight For Money For The Opioid Crisis, Will The Youngest Victims Be Left Out?

Babies born to mothers who used opioids during pregnancy represent one of the most distressing legacies of an opioid epidemic that has claimed almost 400,000 lives and ravaged communities.

In fact, many of the ongoing lawsuits filed against drug companies refer to these babies, fighting through withdrawal in hospital nurseries.

The cluster of symptoms they experience, which include tremors, seizures and respiratory distress, is known as neonatal abstinence syndrome, or NAS. Until recently, doctors rarely looked for the condition. Then case numbers quadrupled over a decade. Hospital care for newborns with NAS has cost Medicaid billions of dollars. (KHN – Kaiser Health News, USA, 13.12.2019)

https://khn.org/news/in-the-fight-for-money-for-the-opioid-crisis-will-the-youngest-victims-be-left-out

A New Scoring System for the Assessment of Neonatal Abstinence Syndrome.

Kocherlakota P, Qian EC, Patel VC, Mandru C, Vilar RE, Alpan G, La Gamma EF.

Am J Perinatol. 2019 Nov 27. doi: 10.1055/s-0039-3400310. 

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/31777045