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Dextromethorphan Dampens Neonatal Astrocyte Activation and Endoplasmic Reticulum Stress Induced by Prenatal Exposure to Buprenorphine. 

Lin CH, Tao PL, Tsay HJ, Chiang YC, Chang WT, Ho IK, Shie FS. 

Behav Neurol. 2021 Jul 10;2021:6301458. doi: 10.1155/2021/6301458. PMID: 34336001; PMCID: PMC8289573.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289573/

Ear Acupuncture Points in Neonates From Drug-Dependent Mothers: A Prospective Study. 

Stähler van Amerongen K, Kuhn A, Surbek D, Nelle M. 

Front Pediatr. 2021 Jun 17;9:668248. doi: 10.3389/fped.2021.668248. PMID: 34222143; PMCID: PMC8247637.

https://www.frontiersin.org/articles/10.3389/fped.2021.668248/full

Cochrane. Opioid treatment for opioid withdrawal in newborn infants. 

Zankl A, Martin J, Davey JG, Osborn DA. 

Cochrane Database of Systematic Reviews 2021, Issue 7. Art. No.: CD002059. DOI: 10.1002/14651858.CD002059.pub4.

Abstract

https://www.cochrane.org/CD002059/NEONATAL_opioid-treatment-opioid-withdrawal-newborn-infants

Prenatal Methamphetamine Exposure: Effects on Child Development. 

Harst L, Deckert S, Haarig F, Reichert J, Dinger J, Hellmund P, Schmitt J, Rüdiger M.

Dtsch Arztebl Int. 2021 May 7;118(18):313-319. doi: 10.3238/arztebl.m2021.0128. PMID: 34140080.

https://www.aerzteblatt.de/int/archive/article/218924

Poverty and Excess Length of Hospital Stay in Neonatal Opioid Withdrawal Syndrome. 

Vesoulis ZA, Lust CE, Cohlan BA, Liao SM, Mathur AM. 

J Addict Med. 2020 Mar/Apr;14(2):113-118. doi: 10.1097/ADM.0000000000000540. PMID: 31149915; PMCID: PMC6881526.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881526/

The Negative Impact of Maternal Perinatal Opioid Use on Neonatal Outcomes. 

Gandhi KD, Schak KM, Vande JL, Shekunov J, Lynch BA, Rummans TA, Geske JR, Pease ER, Limbeck MG, Desai J, Croarkin PE, Romanowicz M. 

Prim Care Companion CNS Disord. 2021 Jun 10;23(3):20m02737. doi: 10.4088/PCC.20m02737. PMID: 34115451.

https://www.psychiatrist.com/pcc/addiction/negative-impact-maternal-perinatal-opioid-use-neonatal-outcomes/

A Retrospective Review Following the Addition of Clonidine to a Neonatal Abstinence Syndrome Treatment Algorithm. 

Bader MY, Zaghloul N, Repholz A, Nagy N, Ahmed MN, Thompson L, Kylat RI. 

Front Pediatr. 2021 Jun 7;9:632836. doi: 10.3389/fped.2021.632836. PMID: 34164354; PMCID: PMC8215153.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215153/

Project Console: a quality improvement initiative for neonatal abstinence syndrome in a children's hospital level IV neonatal intensive care unit. 

Ponder KL, Egesdal C, Kuller J, Joe P. 

BMJ Open Qual. 2021 May;10(2):e001079. doi: 10.1136/bmjoq-2020-001079. PMID: 33941537; PMCID: PMC8098972.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098972/

Stability-indicating LC-MS Method for Determination of Stability of Extemporaneously Compounded Buprenorphine Oral Syringes for Neonatal Abstinence Syndrome. 

Rochani A, Nguyen V, Becker R, Kraft W, Kaushal G. 

J Pediatr Pharmacol Ther. 2021;26(4):395-404. doi: 10.5863/1551-6776-26.4.395. Epub 2021 May 19. PMID: 34035685; PMCID: PMC8139563.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139563/

Utilizing Pediatric Physiologically Based Pharmacokinetic Models to Examine Factors That Contribute to Methadone Pharmacokinetic Variability in Neonatal Abstinence Syndrome Patients. 

McPhail BT, Emoto C, Fukuda T, Butler D, Wiles JR, Akinbi H, Vinks AA. 

J Clin Pharmacol. 2020 Apr;60(4):453-465. doi: 10.1002/jcph.1538. Epub 2019 Dec 9. PMID: 31820437; PMCID: PMC7336467.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336467/

Pränatale Methamphetamin-Exposition: Auswirkungen auf die kindliche Entwicklung - Ein systematisches Review

Prenatal methamphetamine exposure: effects on child development

Dtsch Arztebl Int 2021; 118: 313-9; DOI: 10.3238/arztebl.m2021.0128

Harst, Lorenz; Deckert, Stefanie; Haarig, Frederik; Reichert, Jörg; Dinger, Jürgen; Hellmund, Peter; Schmitt, Jochen; Rüdiger, Mario

https://www.aerzteblatt.de/archiv/218922

The Time is NOW: Filling the Gaps in Treatment of Opioid-Exposed Infants: A Prospective, Pragmatic, Randomized Control Drug Trial. 

Czynski AJ, Laptook AR. 

R I Med J (2013). 2021 Apr 1;104(3):17-21. PMID: 33789403.

http://rimed.org/rimedicaljournal/2021/04/2021-04-17-research-czynski.pdf

Preschool Language Development of Children Born to Women with an Opioid Use Disorder. 

Kim HM, Bone RM, McNeill B, Lee SJ, Gillon G, Woodward LJ. 

Children (Basel). 2021 Mar 31;8(4):268. doi: 10.3390/children8040268. PMID: 33807265.

https://www.mdpi.com/2227-9067/8/4/268

Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study. 

Wachman EM, Wang A, Isley BC, Boateng J, Beierle JA, Hansbury A, Shrestha H, Bryant C, Zhang H. 

Explor Med. 2020 Jun;1(3):124-135. doi: 10.37349/emed.2020.00009. Epub 2020 Jun 29. PMID: 33763662; PMCID: PMC7985727.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985727/

Using buprenorphine to treat neonatal abstinence syndrome: a quality improvement study. 

Bhandary S, Lambeth T, Holmes A, Pylipow M. J Perinatol. 2021 Mar 23. doi: 10.1038/s41372-021-01035-4. Epub ahead of print. PMID: 33758394.

Abstract

https://www.nature.com/articles/s41372-021-01035-4

Paralytic ileus in the neonate as a rare complication of maternal methadone treatment - a case report. 

Emery JD, Samedi VM, Bingham WT. 

Oxf Med Case Reports. 2021 Mar 8;2021(3):omab004. doi: 10.1093/omcr/omab004. PMID: 33732483; PMCID: PMC7947274.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947274/

Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression. 

Hocker AD, Morrison NR, Selby ML, Huxtable AG. 

Front Physiol. 2021 Feb 25;12:604593. doi: 10.3389/fphys.2021.604593. PMID: 33716765; PMCID: PMC7946987.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946987/

Necrotizing enterocolitis and its association with the neonatal abstinence syndrome. 

Andrews L, Davies TH, Haas J, Loudin S, Heyward A, Werthammer J. 

J Neonatal Perinatal Med. 2020;13(1):81-85. doi: 10.3233/NPM-180154. PMID: 32280068; PMCID: PMC7242835.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242835/

Prenatal Opioid Exposure and ADHD Childhood Symptoms: A Meta-Analysis. 

Schwartz AN, Reyes LM, Meschke LL, Kintziger KW. 

Children (Basel). 2021 Feb 4;8(2):106. doi: 10.3390/children8020106. PMID: 33557208; PMCID: PMC7913969.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913969/

Pharmacometric Evaluation of Umbilical Cord Blood Concentration-Based Early Initiation of Treatment in Methadone-Exposed Preterm Neonates. 

Samiee-Zafarghandy S, van Donge T, Allegaert K, van den Anker J. 

Children (Basel). 2021 Feb 25;8(3):174. doi: 10.3390/children8030174. PMID: 33668712.

https://www.mdpi.com/2227-9067/8/3/174/htm

The Complexities Associated with Caring for Hospitalised Infants with Neonatal Abstinence Syndrome: The Perspectives of Nurses and Midwives. 

Shannon J, Blythe S, Peters K. 

Children (Basel). 2021 Feb 17;8(2):152. doi: 10.3390/children8020152. PMID: 33671297; PMCID: PMC7922259.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922259/

The Challenges to Promoting Attachment for Hospitalised Infants with NAS. 

Shannon J, Peters K, Blythe S. 

Children (Basel). 2021 Feb 22;8(2):167. doi: 10.3390/children8020167. PMID: 33671576; PMCID: PMC7926699.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926699/

Toward the use of buprenorphine in infants for neonatal opioid withdrawal syndrome: summary of an NIH workshop. 

Simon AE, Freund MP, Archer SW, Bremer AA. 

J Perinatol. 2021 Jan 25:1–3. doi: 10.1038/s41372-020-00886-7. Epub ahead of print. PMID: 33495535; PMCID: PMC7829319.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829319/

Definitions of neonatal abstinence syndrome in clinical studies of mothers and infants: an expert literature review. 

Jilani SM, Jordan CJ, Jansson LM, Davis JM. 

J Perinatol. 2021 Jan 29. doi: 10.1038/s41372-020-00893-8. Epub ahead of print. PMID: 33514878.

https://www.nature.com/articles/s41372-020-00893-8

Assessment of Neonatal Abstinence Syndrome Surveillance - Pennsylvania, 2019. 

Krause KH, Gruber JF, Ailes EC, Anderson KN, Fields VL, Hauser K, Howells CL, Longenberger A, McClung N, Oakley LP, Reefhuis J, Honein MA, Watkins SM. 

MMWR Morb Mortal Wkly Rep. 2021 Jan 15;70(2):40-45. doi: 10.15585/mmwr.mm7002a3. PMID: 33444296; PMCID: PMC7808717.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808717/

Emotional and Behavioral Trajectories of 2 to 9 Years Old Children Born to Opioid-Dependent Mothers. 

Jaekel, J., Kim, H.M., Lee, S.J. et al.

Res Child Adolesc Psychopathol (2021). https://doi.org/10.1007/s10802-020-00766-w

https://link.springer.com/article/10.1007/s10802-020-00766-w

Exposure-Based Methadone and Lorazepam Weaning Protocol Reduces Wean Length in Children. 

Wilson AK, Ragsdale CE, Sehgal I, Vaughn M, Padilla-Tolentino E, Barczyk AN, Lawson KA. 

J Pediatr Pharmacol Ther. 2021;26(1):42-49. doi: 10.5863/1551-6776-26.1.42. Epub 2021 Jan 4. PMID: 33424499; PMCID: PMC7792140.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792140/

Non-pharmacological care for opioid withdrawal in newborns. 

Pahl A, Young L, Buus-Frank ME, Marcellus L, Soll R. 

Cochrane Database Syst Rev. 2020 Dec 21;12:CD013217. doi: 10.1002/14651858.CD013217.pub2. PMID: 33348423.

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013217.pub2/full

Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome. 

Lappen JR, Stark S, Bailit JL, Gibson KS. 

Am J Obstet Gynecol MFM. 2020 Feb;2(1):100075. doi: 10.1016/j.ajogmf.2019.100075. Epub 2019 Dec 10. PMID: 33345989.

https://www.ajogmfm.org/article/S2589-9333(19)30115-6/fulltext

Medication-assisted treatment vs. detoxification for women who misuse opioids in pregnancy: Associations with dropout, relapse, neonatal opioid withdrawal syndrome (NOWS), and childhood sexual abuse. 

Macfie J, Towers CV, Fortner KB, Stuart GL, Zvara BJ, Kurdziel-Adams G, Kors SB, Noose SK, Gorrondona AM, Cohen CT. 

Addict Behav Rep. 2020 Nov 12;12:100315. doi: 10.1016/j.abrep.2020.100315. PMID: 33364323; PMCID: PMC7752716.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752716/