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Association of Opioid Dose Reduction With Opioid Overdose and Opioid Use Disorder Among Patients Receiving High-Dose, Long-term Opioid Therapy in North Carolina. 

DiPrete BL, Ranapurwala SI, Maierhofer CN, et al. 

JAMA Netw Open. 2022;5(4):e229191. doi:10.1001/jamanetworkopen.2022.9191


Trends in Mortality From Novel Psychoactive Substances as “Legal Highs”: Gender Differences in Manner of Death and Implications for Risk Differences for Women

Lucy Webb, Xin Shi, Christine Goodair and Survjit Cheeta

Front. Psychiatry, 21 April 2022, doi.org/10.3389/fpsyt.2022.890840


USA. Overdoses, not COVID-19, drive spike in LA homeless deaths

Nearly 2,000 homeless people died in Los Angeles County during the first year of the pandemic, an increase of 56% from the previous year, driven mainly by drug overdoses, authorities said. 

The findings released Friday in a report from the county's Department of Public Health showed that despite initial fears, the virus itself was not the main culprit in deaths among California's largest-in-the-nation unhoused population. But it did cut people off from mental health and substance abuse treatment after services were drastically reduced to prevent the spread of the virus. (MedXpress, USA, 24.04.2022)


Identifying the changing age distribution of opioid-related mortality with high-frequency data. 

Paul LA, Li Y, Leece P, Gomes T, Bayoumi AM, Herring J, et al. (2022) 

PLoS ONE 17(4): e0265509. doi.org/10.1371/journal.pone.0265509


Schottland. For those at risk, isolation can be fatal

Evidence is clear that isolation from friends, family and support can place people who use drugs at higher risk of a fatal overdose. Equally, initial case studies have suggested that the distribution of digital devices and building the skills and confidence to use them can have a transformative effect. (Digital Lifelines, Schottland, April 2022)


Schottland. Mapping of Overdose Detection and Alert Technologies: A Summary

This report is produced by the Overdose Detection and Responder Alert Technologies (ODART) Project, a partnership between the University of Stirling and St Andrews University and is supported by the Digital Lifelines Scotland of the Drugs Research Network for Scotland (DRNS). In October 2020, the DRNS secured funding from the Scottish Government’s Technology Enabled Care (TEC) Program and ODART was launched in February 2021. This report gives a summary of an overview of different technologies developed nationally and internationally to avoid fatal drugs overdose. This report is produced for the Drugs Death Taskforce, Digital Lifelines Scotland and the Drugs Research Network Scotland. (Februar 2022)


The Role of Alcohol in the Overdose Crisis

Much of the recent discourse in the addiction treatment and recovery community has touched upon the record-breaking rise in overdose deaths in the United States, as well as the sharp uptick in alcohol use that came about at the beginning of the COVID-19 pandemic. But very rarely is alcohol discussed as being a part of the overdose crisis. (Ireta - Institute for Research, Education and Training in Addictions, 13.04.2022)


USA. Provisional Drug Overdose Death Counts

This data visualization presents provisional counts for drug overdose deaths based on a current flow of mortality data in the National Vital Statistics System. (National Center for Health Statistics, USA, 06.02.2022)


Addiction, Volume 117, Issue 5, Pages: 1185-1503, May 2022

Responding to 100 000 annual drug overdose deaths in the United States: a special section of commentaries


Intervention in an opioid overdose event increases interest in treatment among individuals with opioid use disorder. 

Jones JD, Campbell AN, Brandt L, Castillo F, Abbott R, Comer SD. 

Subst Abus. 2021;42(4):407-411. doi: 10.1080/08897077.2020.1809607. Epub 2020 Aug 19. PMID: 32814002; PMCID: PMC8040323.


Fourth Wave of Opioid (Illicit Drug) Overdose Deaths and Diminishing Access to Prescription Opioids and Interventional Techniques: Cause and Effect. 

Manchikanti L, Singh VM, Staats PS, Trescot AM, Prunskis J, Knezevic NN, Soin A, Kaye AD, Atluri S, Boswell MV, Abd-Elsayed A, Hirsch JA. 

Pain Physician. 2022 Mar;25(2):97-124. PMID: 35322965.


Wearable device aims to cut overdose deaths 

A University of Dundee academic is to head up the clinical trial of a wearable device that aims to reduce the growing number of fatal opioid overdoses in Scotland. (University of Dundee, UK, 28.02.2022)


USA. Provisional drug overdose death counts. National Center for Health Statistics. 2021.

Ahmad FB, Rossen LM, Sutton P. 

Designed by LM Rossen, A Lipphardt, FB Ahmad, JM Keralis, and Y Chong: National Center for Health Statistics.


Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid overdose. 

Corradin, O., Sallari, R., Hoang, A.T. et al.

Mol Psychiatry (2022). doi.org/10.1038/s41380-022-01477-y


Emergency department visits and trends related to cocaine, psychostimulants, and opioids in the United States, 2008-2018. 

Suen LW, Davy-Mendez T, LeSaint KT, Riley ED, Coffin PO. 

BMC Emerg Med. 2022 Feb 4;22(1):19. doi: 10.1186/s12873-022-00573-0. PMID: 35120449; PMCID: PMC8814795.


Polysubstance use poisoning deaths in Canada: an analysis of trends from 2014 to 2017 using mortality data. 

Konefal S, Sherk A, Maloney-Hall B, Young M, Kent P, Biggar E. 

BMC Public Health. 2022 Feb 10;22(1):269. doi: 10.1186/s12889-022-12678-z. PMID: 35144586; PMCID: PMC8830122.


Evaluation of Increases in Drug Overdose Mortality Rates in the US by Race and Ethnicity Before and During the COVID-19 Pandemic. 

Friedman JR, Hansen H. 

JAMA Psychiatry. Published online March 02, 2022. doi:10.1001/jamapsychiatry.2022.0004


Risk of Opioid Overdose Associated With Concomitant Use of Oxycodone and Selective Serotonin Reuptake Inhibitors. 

Yunusa I, Gagne JJ, Yoshida K, Bykov K. 

JAMA Netw Open. 2022;5(2):e220194. doi:10.1001/jamanetworkopen.2022.0194


Kanada. Let’s Talk Overdose 2022 (6.-7.4.2022)

April 6, 2022: Prevention and early intervention in high-risk substance use and overdose among youth

April 7, 2022: Synergy for Change!

Submissions for e-Posters, Lightning Talks and videos will be accepted on a rolling basis until March 14, 2022. We recommend submitting your abstract as early as possible. Submissions are open to everyone. The abstract selection committee will be accepting submissions focused on critical topics related to substance use care, overdose prevention and early intervention for youth, current best practices, or other topics related to the overdose crisis.  Presenters will be sharing their work with international experts, students and industry professionals. There is no cost to present at this event.

Veranstalterin: University of Vancouver, Addictions and Concurrent Disorders Research Group | Department of Psychiatry, BC, Kanada


Overdose deaths involving non-BZD hypnotic/sedatives in the USA: Trends analyses

Tardelli, Vitor S. et al.

The Lancet Regional Health – Americas, Volume 0, Issue 0, 100190 


USA – San Francisco. Are The City’s overdose treatments working? It’s impossible to tell

As drug crisis grows more urgent, experts say there’s a murky path ahead. (San Francisco Examiner, USA, 02.02.2022)


Study examines years of life lost for adolescents, young adults to drug overdose

The Ohio State University Wexner Medical Center and College of Medicine examined the unintentional drug overdose mortality in years of life lost among adolescents and young people in the United States. (MedicalXpress, USA, 31.01.2022)


"It's called overamping": experiences of overdose among people who use methamphetamine. 

Harding RW, Wagner KT, Fiuty P, Smith KP, Page K, Wagner KD. 

Harm Reduct J. 2022 Jan 16;19(1):4. doi: 10.1186/s12954-022-00588-7. PMID: 35034643; PMCID: PMC8762891.


USA. Suicides by drug overdose increased among young people, elderly people, and Black women, despite overall downward trend

A new study of intentional drug overdose deaths, or suicides by an overdose of a medication or drug, found an overall decline in recent years in the United States, but an increase in young people aged 15-24, older people aged 75-84, and non-Hispanic Black women. The study also found that women were consistently more likely than men to die from intentional drug overdoses, with the highest rates observed in women ages 45 to 64. In addition, factors such as time of year, length of day, and day of the week appeared to be associated with intentional overdose death rates. The study published today in the American Journal of Psychiatry and was led by investigators at the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health. (NIDA – National Institute on Drug Abuse, USA, 02.02.02022)


Factors Associated With Opioid Overdose After an Initial Opioid Prescription. 

Weiner SG, El Ibrahimi S, Hendricks MA, Hallvik SE, Hildebran C, Fischer MA, Weiss RD, Boyer EW, Kreiner PW, Wright DA, Flores DP, Ritter GA. 

JAMA Netw Open. 2022 Jan 4;5(1):e2145691. doi: 10.1001/jamanetworkopen.2021.45691. PMID: 35089351.


Notes from the Field: Increased Incidence of Fentanyl-Related Deaths Involving Para-fluorofentanyl or Metonitazene — Knox County, Tennessee, November 2020–August 2021. 

Trecki J, Gerona RR, Ellison R, Thomas C, Mileusnic-Polchan D. 

MMWR Morb Mortal Wkly Rep 2022;71:153–155. doi.org/10.15585/mmwr.mm7104a3external icon.


Disparities by Sex and Race and Ethnicity in Death Rates Due to Opioid Overdose Among Adults 55 Years or Older, 1999 to 2019. 

Mason M, Soliman R, Kim HS, Post LA. 

JAMA Netw Open. 2022;5(1):e2142982. doi:10.1001/jamanetworkopen.2021.42982


Drug overdose deaths in the United States, 1999–2020. 

Hedegaard H, Miniño AM, Spencer MR, Warner M. 

NCHS Data Brief, no 428. Hyattsville, MD: National Center for Health Statistics. 2021. doi.org/10.15620/cdc:112340


Drug Overdose Mortality Among People Experiencing Homelessness, 2003 to 2018. 

Fine DR, Dickins KA, Adams LD, et al. 

JAMA Netw Open. 2022;5(1):e2142676. doi:10.1001/jamanetworkopen.2021.42676


USA/Kanada. NPS Alerts: New Synthetic Opioid and ‘Unusual’ Overdose Symptoms (protonitazene)

The Center for Forensic Science Research and Education (CFSRE) (…) warns of the emergence of protonitazene, an opioid that is approximately three times more potent than fentanyl. (CFSRE - Center for Forensic Science Research and Education, USA, 13.12.2021)