The difference in the effect of methadone and protracted abstinence on the coupling among key large-scale brain networks of individuals with heroin use disorder: A resting-state fMRI study.  Chen J, Wu N, Jin L, Zhu J, Li Y, Wang Z, Wang F, Wa…

Evaluation of a Novel Patient-Centered Methadone Restart Protocol.  Christine PJ, Blum J, Tillman AR, et al.  JAMA Netw Open. 2025;8(8):e2529393. doi:10.1001/jamanetworkopen.2025.29393 https://jamanetwork.com/journals/jamanetworkopen/fu…

Initiation and Dose of Methadone Monotherapy vs Combination Therapy, 2015 to 2023.  Garg R, Luo J, Bozinoff N, et al.  JAMA Netw Open. 2025;8(8):e2527290. doi:10.1001/jamanetworkopen.2025.27290 https://jamanetwork.com/journals/jamanetwo…

Kanada. Canada’s Methadone Prescribing Changes With Drug Supply Canadian physicians have responded to recent guidelines suggesting an increase in methadone initiation dosages in unexposed patients, especially those using fentanyl. Still, substantia…

Methadone treatment for people who use fentanyl: Recommendations.  Bromley L, Kahan M, Regenstreif L, Srivastava A, Wyman J.  Toronto, ON: META:PHI; 2021. www.metaphi.ca., Version date: 30 June 2021 https://www.metaphi.ca/wp-content/upl…

Accidental Methadone Toxicity in a 3-Year-Old Leading to Severe Cerebellitis and Death: A Case Report.  Pappin J, Hansen G, Holt T.  Case Rep Pediatr. 2025 Jul 10;2025:1045330. doi: 10.1155/crpe/1045330. PMID: 40686917; PMCID: PMC1227170…