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Kappa Opioid Receptor Structure Revealed, A Potential Milestone in Medication Development

New research funded by the National Institute on Drug Abuse illuminates the crystal structure of the activated kappa opioid receptor (KOR). The breakthrough could facilitate the development of new medications to treat pain and addiction. (NIDA, Science Spotlight, 04.01.2018)

https://www.drugabuse.gov/news-events/news-releases/2018/01/kappa-opioid-receptor-structure-revealed-potential-milestone-in-medication-development

The Textures of Heroin: User Perspectives on "Black Tar" and Powder Heroin in Two U.S. Cities.

Mars SG, Bourgois P, Karandinos G, Montero F, Ciccarone D.

J Psychoactive Drugs. 2016 Sep-Oct;48(4):270-8. doi: 10.1080/02791072.2016.1207826.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027195/

Doping-Verdacht: Tramadol steigert Leistung im Radsport

Granada – Das Opioid Tramadol, das derzeit nicht auf der Dopingliste der World Anti-Doping Agency (WADA) steht, hat in einer placebokontrollierten Doppelblindstudie die Leistungsfähigkeit auf dem Fahrradergometer gesteigert. Dieser Vorteil wurde laut der Publikation im Journal of Science and Medicine in Sport (2017; doi: 10.1016/j.jsams.2017.10.032) jedoch wieder aufgehoben, wenn die Sportler während des Radelns einen visuellen Aufmerksamkeitstest absolvieren mussten. (aerzteblatt.de, 22.12.2017)

https://www.aerzteblatt.de/nachrichten/87181/Doping-Verdacht-Tramadol-steigert-Leistung-im-Radsport

Multiple fatalities in the North of England associated with synthetic fentanyl analogue exposure: Detection and quantitation a case series from early 2017.

Hikin L, Smith PR, Ringland E, Hudson S, Morley SR.

Forensic Sci Int. 2018 Jan;282:179-183. doi: 10.1016/j.forsciint.2017.11.036.

https://www.ncbi.nlm.nih.gov/pubmed/29216524

USA. New Vaccine Technology Shows Promise as a Tool to Combat the Opioid Crisis - Experimental Vaccine Blocks Effects of Heroin in Preclinical Studies

Researchers with the U.S. Military HIV Research Program at the Walter Reed Army Institute of Research (WRAIR) report that an experimental heroin vaccine induced antibodies that prevented the drug from crossing the blood-brain barrier in mice and rats. The vaccine was co-developed at the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, which funded the preclinical research. (The U.S. Military HIV Research Program (MHRP), 18.12.2017)

https://www.hivresearch.org/sites/default/files/December%2018%20Heroin%20vaccine.pdf

Tramadol for maintenance in opioid dependence: A retrospective chart review.

Sarkar S, Lal R, Varshney M, Balhara YPS.

J Opioid Manag. 2017 Sep/Oct;13(5):329-334. doi: 10.5055/jom.2017.0401.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29199398

USA: Impfstoff gegen Opiate soll Drogenkrise bekämpfen

Bethesda/Maryland – US-Forscher haben einen Impfstoff entwickelt, der Antikörper gegen Heroin und andere Opiate induziert, die die suchterregenden Substanzen abfangen, bevor sie das Gehirn erreichen. Erste tierexperimentelle Studien im Journal of Medicinal Chemistry (2017; doi: 20110.1021/acs.jmedchem.7b01427) belegen eine Wirkung des Impfstoffs. Eine fehlenden Kreuzimmunität zu legalen Opiaten soll die Option einer späteren Schmerzmitteltherapie offen halten. (aerzteblatt.de, 20.12.2017)

https://www.aerzteblatt.de/nachrichten/87124/USA-Impfstoff-gegen-Opiate-soll-Drogenkrise-bekaempfen

A brief review of the genetics and pharmacogenetics of opioid use disorders.

Berrettini W.

Dialogues Clin Neurosci. 2017 Sep;19(3):229-236.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29302220

USA. Fentanyl is so potent doctors don’t know how to fight it

In 2002, Chechen terrorists took 800 people hostage in Moscow Theater, and Russian special forces devised a peculiar way to subdue them. The tactical team gassed the theater with two types of fentanyl, an opioid known for its extreme strength. One version was 2,000 to 5,000 times as potent as heroin.

The gas killed 125 of the 800 hostages during the siege.

Fast forward 15 years, and fentanyl and its derivatives have become the primary driver of overdose deaths in the U.S. These fentanyls caused synthetic opioids to account for one-third of all drug-related deaths in 2016, according to the National Center for Health Statistics. That’s a 700 percent increase from five years ago for manufactured opioids. (pbs – 11.12.2017)

https://www.pbs.org/newshour/science/fentanyl-is-so-potent-doctors-dont-know-how-to-fight-it

U-47700: An Emerging Threat.

Alzghari SK, Fleming SW, Rambaran KA, Long JE, Burkhart S, An J, Furmaga J.

Cureus. 2017 Oct 22;9(10):e1791. doi: 10.7759/cureus.1791.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741271/

Recommended Methods for the Identification and Analysis of Fentanyl and its Analogues in Biological Specimens

MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIEs

UNITED NATIONS OFFICE ON DRUGS AND CRIME, Vienna, Laboratory and Scientific Section, 2017

https://www.unodc.org/documents/scientific/Recommended_methods_for_the_identification_and_analysis_of_Fentanyl.pdf

Misuse of opioids in Europe

Cathy Stannard, Lisbon Addictions 2017, Second European Conference on Addictive Behaviours and Dependencies, Lissabon, 24.-26.10.2017

http://www.emcdda.europa.eu/system/files/attachments/6713/11H00_1_Cathy Stannard.pptx

USA. Kratom: FDA warnt nach Todesfällen vor opioidhaltiger Pflanze

Silver Spring/Maryland – Mehrere Todesfälle nach dem Konsum von Kratom, einem in Südostasien verbreiteten Naturheilmittel zur Schmerzbehandlung, veranlassen die US-Arzneimittelbehörde FDA zu einer Warnung. Das Mittel, das opioidähnliche Substanzen enthalten soll, wird zunehmend an den Grenzen beschlagnahmt. Die Drogenbehörde DEA plant ein Verbot. (aerzteblatt.de, 16.11.2017)

https://www.aerzteblatt.de/nachrichten/83508/Kratom-FDA-warnt-nach-Todesfaellen-vor-opioidhaltiger-Pflanze

The Value of Early-Warning Carfentanil Deaths in Europe

Helgie Danielsson, Lisbon Addictions 2017, Second European Conference on Addictive Behaviours and Dependencies, Lissabon, 24.-26.10.2017

http://www.emcdda.europa.eu/system/files/attachments/6987/11H30_5_Helgi Danielsson.pptx

Reality and responsibility revisited: Stakeholder accountability in the effort to develop safer opioids.

PASSIK, PHD, Steven D.; HEIT, MD, Howard A.; DEGEORGE, PHARMD, Michael.

Journal of Opioid Management, [S.l.], v. 13, n. 6, p. 391-396, dec. 2017. ISSN 1551-7489. doi.org/10.5055/jom.2017.0405.

http://www.wmpllc.org/ojs-2.4.2/index.php/jom/article/view/765/pdf_1

The European experience: prescription drug misuse in France, Germany, Italy and Spain

Jody L. Green, Lisbon Addictions 2017, Second European Conference on Addictive Behaviours and Dependencies, Lissabon, 24.-26.10.2017

http://www.emcdda.europa.eu/system/files/attachments/7618/13H15_3_Jody Green.pptx