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Multiple Naloxone Administrations Among Emergency Medical Service Providers is Increasing

Mark Faul, Peter Lurie, Jeremiah M. Kinsman, Michael W. Dailey, Charmaine Crabaugh & Scott M. Sasser

Prehospital Emergency Care, Vol. 21 , Iss. 4,2017

http://www.tandfonline.com/doi/full/10.1080/10903127.2017.1315203

Intranasal and Intramuscular Naloxone for Opioid Overdose in the Pre-Hospital Setting: A Review of Comparative Clinical and Cost-Effectiveness, and Guidelines [Internet].

Peprah K, Frey N.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Mar 16.

https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0097397/

NIDA. Naloxone for Opioid Overdose: Life-Saving Science - Themenseite des us-amerikanischen National Institute on Drug Abuse

https://www.drugabuse.gov/related-topics/opioid-overdose-reversal-naloxone-narcan-evzio

Factors associated with naloxone administration in an opioid dependent sample.

Kenney SR, Anderson BJ, Bailey GL, Stein MD.

J Subst Abuse Treat. 2018 Jan;84:17-20. doi: 10.1016/j.jsat.2017.10.008.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29195589

Kanada. Take Home Naloxone Training Programme (online)

In British Columbia, there is a program that is saving lives: Take Home Naloxone

Naloxone (also called Narcan®) reverses an overdose from opioids. People who are likely to experience or witness an opioid overdose can get a free Take Home Naloxone kit from an approved site. (naloxonetraining.com, 2017)

http://www.naloxonetraining.com/

Predictors of seeking emergency medical help during overdose events in a provincial naloxone distribution programme: a retrospective analysis.

Ambrose G, Amlani A, Buxton JA.

BMJ Open. 2016 Jun 21;6(6):e011224. doi: 10.1136/bmjopen-2016-011224.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916577/

Kanada. Overdose crisis: Thousands more naloxone kits to be distributed through pharmacies

Nearly 7,000 life-saving naloxone kits have been used by harm reduction staff in B.C. so far this year and thousands more kits will be distributed by pharmacies to battle the effects of a contaminated drug supply. (Vancouver Sun, 20.12.2017)

http://vancouversun.com/news/local-news/overdose-crisis-life-saving-naloxone-available-at-b-c-pharmacies

An Innovative Model for Naloxone Use Within an OTP Setting: A Prospective Cohort Study.

Katzman JG, Takeda MY, Bhatt SR, Moya Balasch M, Greenberg N, Yonas H.

J Addict Med. 2017 Dec 7. doi: 10.1097/ADM.0000000000000374.

Pdf-Datei mit open access

http://pdfs.journals.lww.com/journaladdictionmedicine/9000/00000/An_Innovative_Model_for_Naloxone_Use_Within_an_OTP.99506.pdf

Kanada. Naloxone nasal spray began as a remedy for binge eating, CEO says

Opiant Pharmaceuticals chief exec Roger Crystal reveals opioid crisis caused company to pivot

Roger Crystal's company was struggling to find new uses for an old drug that reverses overdoses. Then the North American opioid epidemic hit.

Naloxone, a medicine called an antagonist that counteracts the effects of opioids, had first gone on sale in 1971 but is injected with a syringe. It requires a small amount of training to know how to administer it to someone who is overdosing. 

Crystal and his colleagues came up with a naloxone nasal spray, intended to be more appealing and easier to administer than prefilled injectors or the other naloxone alternatives.

Crystal's California-based Opiant Pharmaceuticals Inc. partnered with Irish company Adapt Pharma to market the spray version under the brand name Narcan. (CBC News Kanada, 01.01.2018)

http://www.cbc.ca/news/health/narcan-naloxone-nasal-spray-interview-roger-crystal-1.4469235

Measuring a Crisis: Questioning the Use of Naloxone Administrations as a Marker for Opioid Overdoses in a Large U.S. EMS System.

Grover JM, Alabdrabalnabi T, Patel MD, Bachman MW, Platts-Mills TF, Cabanas JG, Williams JG.

Prehosp Emerg Care. 2018 Jan 3:1-9. doi: 10.1080/10903127.2017.1387628.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29297739

EMCDDA. Preventing opioid overdose deaths with take-home naloxone

EMCDDA, Lissabon, January 2016

http://www.emcdda.europa.eu/publications/insights/take-home-naloxone_en

Comparison of Two Naloxone Regimens in Addicted Methadone-Overdosed Patients, a Clinical Trial Study.

Khosravi N, Zamani N, Hassanian-Moghaddam H, Ostadi A, Rahimi M, Kabir A.

Curr Clin Pharmacol. 2017 Dec 11. doi: 10.2174/1574884713666171212112540.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/29231146

Naloxon (Nyxoid, Nexodal, Narcanti)

Naloxon (Markennamen Monopräparate: Nyxoid, Nexodal, Narcanti, Narcan, Prenoxad; Kombinationspräparate: Zubsolv) ist ein Medikament, das zur Hemmung der Wirkungen von Opioiden, insbesondere bei Überdosierung, eingesetzt wird. (arznei-news.de, 19.11.2017)

https://arznei-news.de/naloxon/

USA. Pharmacists Slow to Dispense Lifesaving Overdose Drug

(...) In the three years since the California law took effect, pharmacists have been slow to dispense naloxone, which reverses the effects of an overdose. They cite several reasons, including low public awareness, heavy workloads, fear that they won’t be adequately paid and reluctance to treat drug-addicted people.

In 48 states and Washington, D.C., pharmacists have flexibility in supplying the drug without a prescription to patients, or to their friends or relatives, according to the National Alliance of State Pharmacy Associations. But as in California, pharmacists in many states, including Wisconsin and Kentucky, have divergent opinions about whether to dispense naloxone. (Medscape, 03.01.2018)

https://www.medscape.com/viewarticle/890852

Knowledge and possession of take-home naloxone kits among street-involved youth in a Canadian setting: a cohort study

Julia Goldman-Hasbun, Kora DeBeck, Jane A. Buxton, Ekaterina Nosova, Evan Wood and Thomas Kerr

Harm Reduction Journal 2017, 14:79, doi.org/10.1186/s12954-017-0206-6

https://harmreductionjournal.biomedcentral.com/articles/10.1186/s12954-017-0206-6

NIDA. Naloxone for Opioid Overdose: Life-Saving Science

Naloxone can quickly restore normal breathing and save the life of a person who is overdosing on opioids. In 2015, over 33,000 people died from an overdose on opioid drugs, including prescription pain relievers, heroin, and fentanyl. Naloxone is a safe medication that is widely used by emergency medical personnel and other first responders to prevent opioid overdose deaths. Unfortunately, by the time a person having an overdose is reached, it is often too late.

Friends, family, and other bystanders can save lives with naloxone. Naloxone distribution programs give naloxone kits to opioid users, their friends and families, and others who may find themselves in a position to save the life of someone at risk of an opioid overdose. (National Institute on Drug Abuse)

https://www.drugabuse.gov/publications/naloxone-opioid-overdose-life-saving-science/naloxone-opioid-overdose-life-saving-science