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Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers.

Eap CB, Crettol S, Rougier JS, Schläpfer J, Sintra Grilo L, Déglon JJ, Besson J, Croquette-Krokar M, Carrupt PA, Abriel H.

Clin Pharmacol Ther. 2007 May;81(5):719-28.

Abstract

https://www.ncbi.nlm.nih.gov/pubmed/17329992