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Opioid use and dropout from extended-release naltrexone in a controlled trial: implications for mechanism.

Nunes EV, Bisaga A, Krupitsky E, Nangia N, Silverman BL, Akerman SC, Sullivan MA.

Addiction. 2019 Jul 17. doi: 10.1111/add.14735.



Circumstances of death of opioid users being treated with naltrexone.

Darke S, Farrell M, Duflou J, Larance B, Lappin J.

Addiction. 2019 Jul 6. doi: 10.1111/add.14729. 



Opiate Antagonists Do Not Interfere With the Clinical Benefits of Stimulants in ADHD: A Double-Blind, Placebo-Controlled Trial of the Mixed Opioid Receptor Antagonist Naltrexone.

Spencer TJ, Bhide P, Zhu J, Faraone SV, Fitzgerald M, Yule AM, Uchida M, Spencer AE, Hall AM, Koster AJ, Biederman J.

J Clin Psychiatry. 2018 Jan/Feb;79(1). pii: 16m11012. doi: 10.4088/JCP.16m11012.


Implementing an Opioid Risk Reduction Program in the Acute Comprehensive Inpatient Rehabilitation Setting.

Van SP, Yao AL, Tang T, Kott M, Noles A, Dabai N, Coslick A, Rojhani S, Sprankle LA, Hoyer EH.

Arch Phys Med Rehabil. 2019 May 20. pii: S0003-9993(19)30307-7. doi: 10.1016/j.apmr.2019.04.011.



Extended-Release Naltrexone Improves Viral Suppression Among Incarcerated Persons Living With HIV With Opioid Use Disorders Transitioning to the Community: Results of a Double-Blind, Placebo-Controlled Randomized Trial.

Springer SA, Di Paola A, Azar MM, Barbour R, Biondi BE, Desabrais M, Lincoln T, Skiest DJ, Altice FL.

J Acquir Immune Defic Syndr. 2018 May 1;78(1):43-53. doi: 10.1097/QAI.0000000000001634.


Naltrexone-associated Visual Hallucinations: A Case Report.

Lee DB, Woo YS, Bahk WM.

Clin Psychopharmacol Neurosci. 2019 May 31;17(2):329-331. doi: 10.9758/cpn.2019.17.2.329.


Fighting fire with fire: development of intranasal nalmefene to treat synthetic opioid overdose.

Krieter P, Gyaw S, Crystal R, Skolnick P.

J Pharmacol Exp Ther. 2019 Apr 2. pii: jpet.118.256115. doi: 10.1124/jpet.118.256115.


Rapid transition from methadone to buprenorphine using naltrexone-induced withdrawal: A case report.

Ward HB, Barnett BS, Suzuki J.

Subst Abus. 2019 Mar 19:1-6. doi: 10.1080/08897077.2019.1573776.



Slow-release naltrexone implant versus oral naltrexone for improving treatment outcomes in people with HIV who are addicted to opioids: a double-blind, placebo-controlled, randomised trial.

Krupitsky E, Blokhina E, Zvartau E, Verbitskaya E, Lioznov D, Yaroslavtseva T, Palatkin V, Vetrova M, Bushara N, Burakov A, Masalov D, Mamontova O, Langleben D, Poole S, Gross R, Woody G.

Lancet HIV. 2019 Mar 14. pii: S2352-3018(18)30362-X. doi: 10.1016/S2352-3018(18)30362-X. 

(Registrierung erforderlich)


Naltrexone: A History and Future Directions.

Srivastava B, Gold MS.

Cerebrum. 2018 Sep 1;2018. pii: cer-13-18.


No increased pain among opioid-dependent individuals treated with extended-release naltrexone or buprenorphine-naloxone: A 3-month randomized study and 9-month open-treatment follow-up study.

Latif ZE, Solli KK, Opheim A, Kunoe N, Benth JŠ, Krajci P, Sharma-Haase K, Tanum L.

Am J Addict. 2019 Jan 31. doi: 10.1111/ajad.12859. 



Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis

Monica Bolton, Alex Hodkinson, Shivani Boda, Alan Mould, Maria Panagioti, Sarah Rhodes, Lisa Riste and Harm van Marwijk

BMC Medicine2019, 17:10, doi.org/10.1186/s12916-018-1242-0


Drug combo shows promise in treatment of depression and addiction

The combination of naltrexone and ketamine can help treat both symptoms of addiction and depression, a preliminary study by Yale University researchers suggests. (Yale News, USA, 09.01.2019)



Singh D, Saadabadi A.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.2018 Nov 27., PMID: 30521232


Anxiety, Depression, and Insomnia Among Adults With Opioid Dependence Treated With Extended-Release Naltrexone vs Buprenorphine-Naloxone: A Randomized Clinical Trial and Follow-up Study. 

Latif Z, Šaltytė Benth J, Solli KK, et al. 

JAMA Psychiatry.Published online December 19, 2018. doi:10.1001/jamapsychiatry.2018.3537



Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

Blum K, Modestino EJ, Badgaiyan RD, Baron D, Thanos PK, Elman I, Siwicki D, Febo M, Gold MS.

EC Psychol Psychiatr. 2018 Aug;7(8):564-579. 


Blocking drug activation as a therapeutic strategy to attenuate acute toxicity and physiological effects of heroin.

Zhang T, Zheng X, Kim K, Zheng F, Zhan CG.

Sci Rep. 2018 Nov 13;8(1):16762. doi: 10.1038/s41598-018-35196-8.


Long-acting naltrexone has long-acting benefits and 100% induction rates are not difficult to achieve.

Brewer, C., and Streel, E. (2018) 

Addiction, doi.org/10.1111/add.14448.


Extended-release injectable naltrexone (XR-NTX): A response to clinical issues raised by Brewer and Streel.

Jarvis, B. P., Holtyn, A. F., Subramaniam, S., Tompkins, A. D., Oga, E. A., Bigelow, G., and Silverman, K. (2018) 

Addiction, https://doi.org/10.1111/add.14462.


Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization.

Toljan K, Vrooman B.

Med Sci (Basel). 2018 Sep 21;6(4). pii: E82. doi: 10.3390/medsci6040082.


SAMHSA. Medications for opioid use disorder: for healthcare and addiction professionals, policymakers, patients, and families: Treatment Improvement Protocol: TIP 63.

Substance Abuse and Mental Health Services Administration 
[US] Substance Abuse and Mental Health Services Administration, 2018


Ethics and evidence on naltrexone treatment of offenders

Drugs&Alcohol Findings, UK, 2018

High drug related mortality rates following prison release: Assessing the acceptance likelihood of a naltrexone injection and related concerns.

Murphy PN, Mohammed F, Wareing M, Cotton A, McNeill J, Irving P, Jones S, Sharples L, Monk R, Elton P.

J Subst Abuse Treat. 2018 Sep;92:91-98. doi: 10.1016/j.jsat.2018.07.002.




Excerpt: Limited data indicate that naltrexone is minimally excreted into breastmilk. If naltrexone is required by the mother, it is not a reason to discontinue breastfeeding.


- Drug Levels and Effects

- Substance Identification

- Administrative Information

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.


Naltrexon (Naltrexin®)

Naltrexon eignet sich für ein kleines Segment hochmotivierter entgifteter opioidabhängiger Patienten, ohne aktuellen Opioidkonsum (weder im Rahmen einer SGB oder als illegaler Konsum). Polytoxikomanie ist eine Kontraindikation! (fosumos - Praxis Suchtmedizin Schweiz, aktualisiert am 18.05.2018)


Acceptability of Extended-Release Naltrexone by Heroin-Dependent Patients and Addiction Treatment Providers in the Netherlands.

Zaaijer ER, Goudriaan AE, Koeter MW, Booij J, van den Brink W.

Subst Use Misuse. 2016 Dec 5;51(14):1905-11. doi: 10.1080/10826084.2016.1201117. 



Effectiveness, safety and feasibility of extended release naltrexone for opioid dependence: a nine month follow up to a three month randomized trial.

Solli, K. K., Latif, Z., Opheim, A., Krajci, P., SharmaHaase, K., Benth, Jė. Š., Tanum, L., and Kunoe, N. (2018

Addiction, doi: 10.1111/add.14278.



Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial.

Bisaga A, Mannelli P, Yu M, Nangia N, Graham CE, Tompkins DA, Kosten TR, Akerman SC, Silverman BL, Sullivan MA.

Drug Alcohol Depend. 2018 Apr 10;187:171-178. doi: 10.1016/j.drugalcdep.2018.02.023


USA. Trump Opioid Plan Writes in Favoritism to Single Company’s Addiction Medication

The White House’s national strategy to combat the opioid crisis, unveiled last week, would expand a particular kind of addiction treatment in federal criminal justice settings: a single drug, manufactured by a single company, with mixed views on the evidence regarding its use.

Federal prisons should “facilitate naltrexone treatment and access to treatment” to inmates as they transition out of incarceration, according to a fact sheet circulated by the administration. A White House spokesman later confirmed to STAT that the document referred specifically to naltrexone in its injectable form.

Only one manufacturer makes a drug fitting that description: Alkermes, a Massachusetts pharmaceutical company that makes Vivitrol, a monthly injectable drug that blocks the effects of opioids and reduces cravings. (ATForum, USA, 06.04.2018)


Review of Case Narratives from Fatal Overdoses Associated with Injectable Naltrexone for Opioid Dependence.

Saucier R, Wolfe D, Dasgupta N.

Drug Saf. 2018 Mar 20. doi: 10.1007/s40264-018-0653-3.