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Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism. 

Kharasch ED, Regina KJ, Blood J, Friedel C. 

Anesthesiology. 2015 Nov;123(5):1142-53. doi: 10.1097/ALN.0000000000000867. PMID: 26389554; PMCID: PMC4667947.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667947/