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Variation in the Gene for the μ-Opioid Receptor May Influence Responses to Methadone

This study found that:

A single nucleotide polymorphism (SNP) in the messenger RNA of the µ-opioid receptor gene was associated with patients’ responses to methadone treatment for opioid dependence.

The association may occur because one variant of the SNP produces fewer µ-opioid receptors than the alternate form. (NIDA Notes, By William Ross Perlman, Ph.D., CMPP, 23.08.2017)